Td corrigé Master degree pdf

Master degree

Examination. 1/1 ...... Pollard T. D., Earnshaw W. C.: Cell biology, Saunders, Philadelphia 2004 ...... The measurement of magnetisation characteristics by VSM.




part of the document














Master degree
2-year standard
Study Programmes






















 HYPERLINK \l "_BIOLOGY" BIOLOGY
Cell and Molecular Biology and Genetics 3
Botany and Physiology of Plants 13
Zoology and Animal Physiology 18
 HYPERLINK \l "_CHEMISTRY" CHEMISTRY
Analytical Chemistry 32
Biochemistry 43
Bioorganic Chemistry 50
Chemistry 61
Inorganic Chemistry 81
Organic Chemistry 90
 HYPERLINK \l "_GENERAL_ECOLOGY" GENERAL ECOLOGY
General Ecology and Ecology of Individuals and Populations 99
 HYPERLINK \l "_INFORMATICS" INFORMATICS
Informatics 118
 HYPERLINK \l "_MATHEMATICS" MATHEMATICS
Economical and Financial Mathematics 139
Informatic Mathematics 142
Manager Mathematics 153
Mathematics 159
 HYPERLINK \l "_PHYSICS" PHYSICS
Biophysics 169
Nuclear and Subnuclear Physics 178
Physics 187
Physics of Condensed Matter 205








BIOLOGY
Study programme Cell and Molecular Biology and Genetics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚBEV/IMU1/03Immunology32/-Examination1/1 ÚBEV/MZO1/03Molecular Basis of Ontogenetic Development32/-Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚBEV/AEM/06Applied Embryology42/1Examination1/2 ÚBEV/CTP1/01Cytopathology32/-Examination1/2 ÚBEV/CK1/03Cytogenetics and Karyology41/2Examination1/2 ÚBEV/MOG/03Model Organisms in Genetics51/2Examination1/2ÚBEV/GC1/01Human Genetics52/1Examination1/2 ÚBEV/EB1/99Evolutionary Biology32/- Examination1/2 ÚBEV/DP1a/03Diploma Work2-/-Recognition1/1ÚBEV/DP1b/03Diploma Work6-/-Recognition1/2ÚBEV/DP1c/03Diploma Work8-/-Recognition2/3ÚBEV/DP1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚBEV/BI1/03Basic Bioinformatics62/2Examination1/1 ÚBEV/ETO1/03Ethology62/2Examination1/1 ÚBEV/BTR1/06Plant Biotechnology62/3Examination1/1 ÚBEV/EMZ1/00Vertebrate Embryology32/-Examination1/1 ÚBEV/IMUC/03Practical in Immunology3-/3Assessment1/1 ÚBEV/UGM/03Introduction to Gene Manipulations62/2Examination1/1 ÚBEV/EFZ1/03Animal and Human Ecophysiology62/2Examination1/1 ÚBEV/BIOE/07Bioethics42/-Examination1/2 ÚBEV/GM1/03Gene Manipulations62/2Examination1/2 ÚBEV/MBR1/05Plant Molecular Biology62/3Examination1/2 ÚBEV/SCT1/01Practical in Cytopathology2-/25 (blok)Assessment1/2 ÚBEV/ETB1/99Experimental Techniques in Biology4-/4Assessment1/2 ÚBEV/PG1/03Population Genetics52/1Examination1/2 ÚBEV/VKM/03Selected Topics in Microbiology and Virology32/- Examination1/2 ÚBEV/MEB1/03Cell metabolism62/2Examination2/3 ÚBEV/MEM/99Light and Electron Microscopy Techniques31/2Assessment2/3 ÚBEV/EH1/01Experimental Haematology32/- Examination1/1, 2/3ÚBEV/VKG1/03Selected Topics in Genetics31/1Examination2/3 ÚBEV/FRV1/03Physiology of Plant Growth and Development62/2Examination1/2ÚBEV/MR1/03Plant Metabolism62/2 Examination1/1, 2/3ÚBEV/AEM/06Applied Embryology42/1 Examination1/2ÚCHV/SVK1/00Student Scientific Conference 4-/-Assessment1/2, 2/4
Course units

Compulsory courses

TitleImmunologyCodeÚBEV/IMU1/03TeacherPaulíková EditaECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with knowledge on immunological mechanisms at cell and organism levels.ContentCells and tissues of the immune system. Cooperation between T, B and antigen presenting cells. Non-specific lymphocytic stimulation. Innate immunity. Antigen recognition by lymphocytes. Cell receptors. Immune response. The major histocompatibility complex. The adaptive immune response. T-cells mediated immunity. The humoral immune response. Hypersensitivity. Transplantation immunology. The immune system in health and diseaseExclusive coursesÚBEV/IMUF/03Alternate coursesÚBEV/IMU1/01Recommended reading Janeway, Ch. A. Jr., Travers, P.: Immunobiology. Blackwell Sci. Pub. Oxford, 1994

TitleMolecular Basis of Ontogenetic DevelopmentCodeÚBEV/MZO1/03TeacherMišúrová EvaECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with basic knowledge of the principles and molecular-biological mechanisms of the ontogenetic development of animal and plant organisms.ContentRegulation of the ontogenetic development in eukaryotic organisms. Programme of ontogenetic development. Cell determination and differentiation. Molecular mechanisms of formation of specialised cell types. Epigenetic mechanisms of cellular memory. Imprinting. Combinatory control of eukaryotic genes. Regulatory genes. Establishment of cell position. Formation of the embryonic body plan. Establishment of the main axis of body. Shape formation. Cloning of multicellular organisms.
Alternate coursesÚBEV/VMB1/00 or ÚBEV/VMB1/03Recommended reading Gerhard,J.,Kirschener,M.: Cells, Embryos and Evolution. Blacwell Science Inc., Massachusett, Oxford, London,1997

TitleCytopathologyCodeÚBEV/CTP1/01TeacherFedoro
ko PeterECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide students with a knowledge of the basic biological principles of carcinogenesis.ContentTumor development. Tumor growth and metastatic potential. Cell cycle regulation and pathogenesis of cancer. Apoptosis in tumor growth and metastasis. Oncogenes and cancer. Tumor suppressor genes. Metastasis suppressor genes. Angiogenesis in cancer. Cell surface glycoproteins and their receptors. Proteinases and their inhibitors in cancer invasion. Radio-, chemo- and immunotherapy.Recommended reading Sherbet, G.V., Lakshmi, M. S.: The Genetics of Cancer. Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation. Academic Press, London, 1997
Shebert, G. V.: The biology of tumor malignancy. Academic Press, London, 1982

TitleCytogenetics and KaryologyCodeÚBEV/CK1/03Teacher ellárová EvaECTS credits4Hrs/week1/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge and experience in genetic processes at the cell level using the newest scientific findings of cytogenetics and moleculoar cytology. To have students become acquainted in detail with the results coming from human genome mapping.ContentOrganisation of eukaryotic genome. Nuclear skeleton. Nucleolus; nucleolar skeleton. Chromatin structure and changes of chromatin. Levels of DNA organisation in cell nucleus. Chromosomes. Polythene chromosomes. Cell cycle. Genetic regulation of a cell cycle. Genetic regulation of cell differentiation. Apoptosis. Telomeres and function of telomerase. Molecular cytology. Basic characteristics of the human genome project: what we can learn from it?Alternate coursesÚBEV/CK1/99Recommended reading Russel, J.P.: Genetics, Third Edition, Harper Collins Publisher,
New York 1992
Periodicals, Internet sources

TitleModel Organisms in GeneticsCodeÚBEV/MOG/03Teacher ellárová EvaECTS credits5Hrs/week1/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with information on model systems of prokaryotic and eukaryotic organisms used in genetic research.ContentBasic properties of model organisms used in genetics. Prokaryotic model systems (Escherichia coli, Diplococcus pneumoniae, Agrobacterium tumefaciens and A. rhizogenes). Model systems of simple eukaryotic organisms (Saccharomyces cerevisiae, Neurospora crassa). Plant and animal model systems in vitro and in vivo. Caenorhabditis elegans. Arabidopsis thaliana. Mendel´s laws. Drosophila melanogaster. Morgan´s rules. Mus musculus. Human genome. Transgenic plants and animals. HeLa cells. Stem cells. Genetic importance of the study of twins. Genetic databases. Alternate coursesÚBEV/MOG1/99Recommended reading Genetic periodicals
Internet sources

TitleHuman GeneticsCodeÚBEV/GC1/01TeacherBruHáková Katarína, ellárová EvaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with the basic knowledge concerning human genetics, the role of genetic factors in pathologic processes, the factors of inheritance, and the diagnosis and treatment of genetic disorders.ContentThe genetic basics of physiological variability and pathological traits of individuals; human population genetics; the patterns of inheritance and pedigree problem solving; the basic methods used in human genetics: genealogy, linkage analysis and the gene mapping, cytogenetic analysis and karyotyping, the DNA diagnosis of pathological traits; the treatment of genetic disorders.Recommended reading Thompson JS, Thompson MW (2001): Genetics in Medicine 6/e. W.B.Sounders Company, Philadelphia, Pennsylvania, USA
Friedman JM, Dill FJ, Hayden MR, McGillivray BC (1996): Genetics 2/e. Williams & Wilkins, Baltimore, Maryland, USA


TitleEvolutionary BiologyCodeÚBEV/EB1/99TeacherMártonfi Pavol, Šmajda BeHadik, ellárová EvaECTS credits3Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo familiarise students with the fundamentals of the evolution of living organisms.ContentHistorical overview of evolutionary theories. The origin of life. Elements of evolution: mutations, population waves, and isolation. Natural selection. Molecular evolution. Adaptations and their classification. Concept of species. Macroevolution. Evolution of functions and organs, evolution of ontogeny. Phylogeny of animals. Evolutionary progress. Anthropogenesis. Plant diversity. Primary and secondary speciation of plants. Reproduction-isolation mechanisms. Hybridisation and introgression of plants. Polyploidy. Reproductive systems in plants.
Recommended reading Futuyama, D.J.: Evolutionary biology, Sinauer Associates, Sunderland, 3rd ed., 1997
Dobzhansky T. et al.: Evolution. San Francisco 1977
Compulsory elective courses

TitleBasic BioinformaticsCodeÚBEV/BI1/03TeacherSaxová Patrícia, ellárová EvaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo give students interdisciplinary experience in the application of mathematical methods and computer science approaches to solving some problems in Molecular Biology, as, for example, the analysis of nucleotide and protein sequences, genome study, etc. ContentComparison of nucleotide and protein sequences, molecular evolution, evolutionary trees, work with biological databases, use of neuron networks and HMM in Bioinformatics. Practical work using concrete bioinformatic programs accessible on the Internet.Alternate coursesÚBEV/BI1/01Recommended reading Grau D. & Li W.-H.: Fundamentals of Molecular Evolutions, Sinuar Associates, 2000.
Durbin, R., Eddy, S., Krogh, A. & Mitchison, G.: Biological SequenceAnalysis: Probabilistic Models of Proteins and Nucleic Acids, CUP, 1999

TitleEthologyCodeÚBEV/ETO1/03TeacherMajláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students to know and to be aware of the importance of the behavioural aspect in biological sciences.ContentHistory and development of ethology. Ethological methods. The innate forms of behaviour. The simplest forms of learning: conditioning and instrumental learning. Higher forms of learning. Social behaviour. Sexual behaviour. Play behaviour. Biological rhythms. Orientation in space and animal migrations. Communication systems of animals. Emotions. Aggression in animal and human behaviour. Abnormal forms of behaviourAlternate coursesÚBEV/ETO1/99Recommended reading Franck, D.: Verhaltensbiologie. Einfuhrung in die Ethologie. Georg Thieme-Verlag, 1993
Manning, A., Dawkins, M. S.: An introduction to animal behaviour. Cambridge University Press, 1992

TitlePlant BiotechnologyCodeÚBEV/BTR1/06Teacher ellárová EvaECTS credits6Hrs/week2/3AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo give students theoretical and practical knowledge of plant tissue culture in vitro.ContentGenetics and physiology of plant cell and tissue culture, protoplasts, embryoids and organs cultured in vitro under sterile conditions. Use of tissue culture in research and praxis. Cryopreservation of plant cells and tissues. Immobilised plant systems. Genetic transformation of plants and expression of foreign genes.Recommended reading Dodds, J. H. and Roberts, L. W.: Experiments in Plant Tissue Culture. Cambridge University Press, 1985
Periodicals and Internet sources

TitleVertebrate EmbryologyCodeÚBEV/EMZ1/00TeacherDaxnerová ZuzanaECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with the basic facts of normal development of animals.ContentAsexual and sexual reproduction. Gametogenesis. Embryogenesis: gastrulation and primary organ formation. Organogenesis. Morphogenetic processes in organogenesis. Embryonic membranes in birds and mammals. Placentation.Alternate coursesÚBEV/EMZ1/99Recommended reading Langman, J.: Medical Embryology. Williams & Wilkins, Baltimore, London, 1981
Moore, K. L., Persaud, T. V. N.: Before we are born. W.B. Saunders Company Philadelphia, 1993

TitlePractical in ImmunologyCodeÚBEV/IMUC1/03TeacherPaulíková EditaECTS credits3Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo teach the students the basic techniques used in immunology.ContentThe topics of exercises are determined by the themes of lectures.Prerequisite coursesÚBEV/IMU1/03Alternate coursesÚBEV/CIM1/01Recommended reading Study materials provided by teacher.


TitleIntroduction to Gene ManipulationsCodeÚBEV/UGM1/03TeacherKolesárová Mariana, Vil
ek `tefanECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with the principles of preparation and application of techniques of recombinant DNA.ContentIsolation of nucleic acids. Restriction endonucleases. Digestion and ligation of DNA. Other enzymes used for DNA manipulation. Labeling of DNA. Nucleic acid hybridisation. PCR. Preparation of recombinant DNA. Recombinant vectors. Selection markers. Transfer of recombinant DNA to the cells. Selection of recombinants. Expression of heterologous genes in E. coli. DNA sequencing.Alternate coursesÚBEV/UGM1/99Recommended reading Old, R.W., Primrose, S. B.: Principles of Genetic Manipulation. An Introduction to Genetic Engineering. Blackwell Scientific Publication, London, 1992
Brown, T. A. Gene Cloning. An Inroduction. Champan Hall, London, 1996

TitleAnimal and Human EcophysiologyCodeÚBEV/EFZ1/03TeacherAhlersová Eva, Bojková BiankaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basic mechanisms and principles of the action of environmental conditions on internal physiological processes. To familiarise students with the possible mechanisms of adaptation of animals to extreme values of environmental factors.ContentThe influence of environmental factors in phylogeny and ontogeny. The course of the stress reaction; kinds of adaptation. Pathology of adaptation processes: general symptoms of pathological processes. Adaptations based on vital factors of the environment: adaptations to changes in food intake (starvation and overfeeding), to hypo- and hyperbary, to increased water salinity, to gravitation, to high and low temperatures, to electricity, electromagnetic fields and laser beams, to noise, to both non-ionizing and ionizing radiation, to ultrasound and vibrations in living organisms. Alternate coursesÚBEV/EFZ1a/99

TitlePlant Molecular BiologyCodeÚBEV/MBR1/05Teacher ellárová EvaECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with a knowledge of gene expression in plants.ContentOrganisation of plant genome. Regulation sequences, gene families, repetitive sequences. Genes coding for t-RNA, r-RNA and structural genes. Regulation of gene expression in plants. Structure and function of mtDNA and cpDNA. Mitochondrial plasmids. Biotic and abiotic stress. Plant viruses. Agrobacterium sp. and its genetic importance. Ti and Ri plasmids. Methods of genetic transformation. Transgenes. GMO. Recommended reading Buchanan, B. B., Gruissem, W. and Jones, R. J.: Biochemistry and Molecular Biology of Plants. America Society of Plant Physiologists, Rockville, Maryland, 2000
Hansen E., Harper, G.:Differentially Expressed Genes in Plants, Taylor and Francis, London 1997
Leister, D.: Plant Functional Genomic. The Haworth Press New York, 2004

TitlePractical in CytopathologyCodeÚBEV/SCT1/01TeacherFedoro
ko PeterECTS credits2Hrs/week25/semAssessmentAssessmentSemester2T/L methodPracticalObjectiveTo provide students with experimental work in a cell culture laboratory.ContentCell and tissue culture and associated techniques. General procedures for cell culture. Cell proliferation assay (MTT test). Cell preparation techniques (centrifugal elutriation). Model systems to study differentiation (myeloid HL-60 Leukemia Cells). Tumorigenicity assays; cytotoxic and cell growth assays.Prerequisite coursesÚBEV/CTP1/01Recommended reading Celis, J. E.: Cell Biology. 2nd ed., Academic Press, London, 1997

TitleExperimental Techniques in BiologyCodeÚBEV/ETB1/99TeacherSolár PeterECTS credits4Hrs/week-/4AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo provide the students with the knowledge of basic experimental techniques in biology.ContentManipulation with laboratory animals. Narcotizing of the animals. Operating techniques. Basic research methods. Recommended reading Zutphen, L. F. M., Baumans, V., Beynen, A. C.: Principles of Laboratory Animal Science. Elsevier, Amsterdam, 1993

TitlePopulation GeneticsCodeÚBEV/PG1/03Teacher ellárová Eva, Brezáni PeterECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with an understanding of genetic relations at the population level, the importance of population equilibrium and the consequences of its changes.ContentGenofond and genotype composition of a population. Genetic equilibrium of the population: Hardy-Weinberg law, linkage disequilibrium. Random mating and inbreeding, consequences of inbreeding in population: Bernstein-Wright law, consanguinity, homogamy, Wahlund effect. Mutations and mutation pressure, selection and selection pressure, fitness. Random effects: genetic drift, migration. Genetic isolates and their consequences; genetic polymorphism. Evolutionary significance of genofond changes.Recommended reading Griffiths, A.J.F. et al.: Modern Genetic Analysis, W.H.Freeman and Co., New York, 1999

TitleSelected Topics in Microbiology and VirologyCodeÚBEV/VKM1/03TeacherKropá
ová KatarínaECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide students with an advanced knowledge of micro-organisms.ContentCharacteristics of Chlamydiae, Rickettsiae and Mycoplasmas. The structure of viruses. Reproduction of viruses: lytic and lysogenic cycle of viruses. Principles and pathogenesis of viral diseases. Viral persistence: chronic, latent and slow virus infection. Prevention and treatment of viral infection. Recent trends in microbiology and virology. Recommended reading Fields, B. N., Knipl, D. M.: Virology. Newford, Raven press, 1990
Greenwood, D., Slack, R.C.B., Peuther, J. F.: Medical Microbiology. Longman group UK Limited, 1992 

TitleCell MetabolismCodeÚBEV/MEB1/03TeacherAhlersová Eva, Kassayová MonikaECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with knowledge about the principal metabolic processes in living cells.ContentMetabolism of sugars and lipids and their disorders in human cells. Function of the liver in the metabolism of lipids. Metabolism of serum lipoproteins and its disorders. Metabolism of minerals. Mechanisms of acido-basic balance. Metabolic regulations. Topochemistry of metabolic processes in the organism.Alternate coursesÚBEV/MEB1/99Recommended reading Murray, R. K., Grammer, D. K., Mayes, P. A., Rodwell, V.W.: Harper‘s Biochemistry. Prentice-Hall, Appleton & Lange, 1993

TitleLight and Electron Microscopy TechniquesCodeÚBEV/MEM1/99TeacherDaxnerová ZuzanaECTS credits3Hrs/week1/2AssessmentAssessmentSemester3T/L methodLecture, PracticalObjectiveTo provide students with the methods of light and electron microscopy.ContentLight microscope. Electron microscope; transmission and scanning electron microscope. Specimen preparation for microscopy. Fixation. Embedding. Sectioning. Staining. Special histochemical methods.Recommended reading Bancroft, J. D., Steven, A.: Theory and practice of Histological Techniques. Churchill Livingstone, 1977
Wischnitzer, S.: Introduction to Electron microscopy. Cambridge University Press, 1982 

TitleExperimental HaematologyCodeÚBEV/EH1/01TeacherFedoro
ko PeterECTS credits3Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo provide students with a knowledge of experimental hematology.ContentOntogeny of hematopoietic stem cells. Characterisation of hematopoietic stem cells (HSC). Hematopoietic growth factors and cytokines. Differentiation and self renewal. Mobilisation of hematopoietic stem cells. Barriers to transplantation. Genes affecting formation or differentiation of HSC.Alternate coursesÚBEV/EH1/99Recommended reading Simmons, A.: Hematology. A Combined Theoretical & Technical Approach, W.B.Saunders Company, Philadelphia, 1989
TitleSelected Topics in GeneticsCodeÚBEV/VKG1/03TeacherBruHáková Katarína, ellárová EvaECTS credits3Hrs/week1/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with an advanced knowledge aimed at actual problems in genetics.ContentComplementary topics to the basic course in genetics (topics and their content reflect the interest of students): mapping of human genome, project HUGO, genetics of retroviruses, HIV, molecular medicine, inborn disorders of metabolism, mutations in humans, methods of prenatal diagnostics, gene therapy, transgenes and their influence on human health and environment, methods of recombinant DNA, cloning of mammal embryos, ethical question of cloned genes and oncogenesis, molecular mechanisms of carcinogenesis, chromosome changes in malignant tumours, bacterial genomics, transposones and human health, antibiotic resistance, mitochondrial inheritance and human health, genetic regulation of cell differentiation and cell aging.Alternate coursesÚBEV/VKG1/99Recommended reading Periodicals
Internet sources

TitlePhysiology of Plant Growth and DevelopmentCodeÚBEV/FRV1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of basic methods and approaches in the physiology of plant growth and development.ContentGrowth and morphogenesis: phases and kinetics; differentiation. Hormones: metabolism and transport, physiological and developmental effects; auxin, gibberellins, cytokinnins, ethylene and abscisic acid. Photomorphogenesis and etiolation. Phytochrome: properties, physiology, ecological functions, molecular mechanisms. Blue-light responses. Rhythms. Germination and dormancy. Regulation of flowering. Senescence and programmed cell death. Orientation in space: phototropism, gravitropism and nastic movements. Stress physiology.Alternate coursesÚBEV/FRV1/99Recommended reading Taiz L., Zeiger E., Plant physiology. Third editon. Sinauer ass., Sunderland 2002

TitlePlant MetabolismCodeÚBEV/MR1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the pathways of biosynthesis in plants and the functions of primary and secondary metabolites.ContentPhotosynthesis: structure of photosynthetic apparatus, light absorption, electron and proton transport, photophosphorylation. Calvin cycle, rubisco and photorespiration. C4 and CAM plants. Synthesis of starch and sucrose. Respiration: glycolysis, citric acid cycle, electron transport and ATP synthesis. Lipid biosynthesis and conversion into carbohydrates. Polyacetylenes. Nitrogen metabolism: fixation, nitrate assimilation, ammonium conversion to amino acids. Sulfur assimilation and metabolism. Terpenes: biosynthesis and functions. Phenolic compounds: pathways of biosynthesis, phenylpropanes, flavonoids and lignins. Alkaloids. Mechanisms of plant defense.Alternate coursesÚBEV/MR1/99Recommended reading Lawlor D. W. Photosynthesis. Third edition. BIOS, Oxford 2001;
Taiz L., Zeiger E., Plant physiology. Third editon. Sinauer ass., Sunderland 2002
Study programme Botany and Physiology of Plants
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚBEV/ETO1/03Ethology62/2Examination1/1 ÚBEV/IMU1/03Immunology32/-Examination1/1 ÚBEV/MR1/03Plant Metabolism62/2Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚBEV/FRV1/03Physiology of Plant Growth and Development62/2Examination1/2 ÚBEV/EKR1/03Plant Ecology62/2Examination1/2 ÚBEV/EB1/99Evolutionary Biology32/-Examination2/3 ÚBEV/DP1a/03Diploma Work2-/-Recognition1/1ÚBEV/DP1b/03Diploma Work6-/-Recognition1/2ÚBEV/DP1c/03Diploma Work8-/-Recognition2/3ÚBEV/DP1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚBEV/GB1/03Geobotany42/1Examination ÚBEV/EFZ1/03Animal and Human Ecophysiology62/2Examination ÚBEV/CK1/03Cytogenetics and Karyology41/2Examination ÚBEV/DNR/06Dendrology22/2Examination ÚBEV/UGM1/03Introduction to Gene Manipulations62/2Examination 
Recommended elective courses

ÚBEV/LR1/03Healing Plants32/-Examination ÚBEV/CRO1/03Chronophysiology22/1Examination ÚBEV/BTR1/06Plant Biotechnology62/3Examination ÚBEV/BS1/03Biostatistics62/2Examination Course units

Compulsory courses

TitleEthologyCodeÚBEV/ETO1/03TeacherMajláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students to know and to be aware of the importance of the behavioural aspect in biological sciences.ContentHistory and development of ethology. Ethological methods. The innate forms of behaviour. The simplest forms of learning: conditioning and instrumental learning. Higher forms of learning. Social behaviour. Sexual behaviour. Play behaviour. Biological rhythms. Orientation in space and animal migrations. Communication systems of animals. Emotions. Aggression in animal and human behaviour. Abnormal forms of behaviourAlternate coursesÚBEV/ETO1/99Recommended reading Franck, D.: Verhaltensbiologie. Einfuhrung in die Ethologie. Georg Thieme-Verlag, 1993
Manning, A., Dawkins, M. S.: An introduction to animal behaviour. Cambridge University Press, 1992

TitleImmunologyCodeÚBEV/IMU1/03TeacherPaulíková EditaECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with knowledge on immunological mechanisms at cell and organism levels.ContentCells and tissues of the immune system. Cooperation between T, B and antigen presenting cells. Non-specific lymphocytic stimulation. Innate immunity. Antigen recognition by lymphocytes. Cell receptors. Immune response. The major histocompatibility complex. The adaptive immune response. T-cells mediated immunity. The humoral immune response. Hypersensitivity. Transplantation immunology. The immune system in health and diseaseExclusive coursesÚBEV/IMUF/03Alternate coursesÚBEV/IMU1/01Recommended reading Janeway, Ch. A. Jr., Travers, P.: Immunobiology. Blackwell Sci. Pub. Oxford, 1994

TitlePlant MetabolismCodeÚBEV/MR1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the pathways of biosynthesis in plants and the functions of primary and secondary metabolites.ContentPhotosynthesis: structure of photosynthetic apparatus, light absorption, electron and proton transport, photophosphorylation. Calvin cycle, rubisco and photorespiration. C4 and CAM plants. Synthesis of starch and sucrose. Respiration: glycolysis, citric acid cycle, electron transport and ATP synthesis. Lipid biosynthesis and conversion into carbohydrates. Polyacetylenes. Nitrogen metabolism: fixation, nitrate assimilation, ammonium conversion to amino acids. Sulfur assimilation and metabolism. Terpenes: biosynthesis and functions. Phenolic compounds: pathways of biosynthesis, phenylpropanes, flavonoids and lignins. Alkaloids. Mechanisms of plant defense.Alternate coursesÚBEV/MR1/99Recommended reading Lawlor D. W. Photosynthesis. Third edition. BIOS, Oxford 2001; Taiz L., Zeiger E., Plant physiology. Fourth edition. Sinauer ass., Sunderland 2006

TitlePhysiology of Plant Growth and DevelopmentCodeÚBEV/FRV1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of basic methods and approaches to the physiology of plant growth and development.ContentGrowth and morphogenesis: phases and kinetics; differentiation. Hormones: metabolism and transport, physiological and developmental effects; auxin, gibberellins, cytokinnins, ethylene and abscisic acid. Photomorphogenesis and etiolation. Phytochrome: properties, physiology, ecological functions, molecular mechanisms. Blue-light responses. Rhythms. Germination and dormancy. Regulation of flowering. Senescence and programmed cell death. Orientation in space: phototropism, gravitropism and nastic movements. Stress physiology.Alternate coursesÚBEV/FRV1/99Recommended reading Taiz L., Zeiger E., Plant physiology. Fourth edition. Sinauer ass., Sunderland 2006

TitleEvolutionary BiologyCodeÚBEV/EB1/99TeacherMártonfi Pavol, Šmajda BeHadik, ellárová EvaECTS credits3Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo familiarise students with the fundamentals of the evolution of living organisms.ContentHistorical overview of evolutionary theories. The origin of life. Elements of evolution: mutations, population waves, and isolation. Natural selection. Molecular evolution. Adaptations and their classification. Concept of species. Macroevolution. Evolution of functions and organs, evolution of ontogeny. Phylogeny of animals. Evolutionary progress. Anthropogenesis. Plant diversity. Primary and secondary speciation of plants. Reproduction-isolation mechanisms. Hybridisation and introgression of plants. Polyploidy. Reproductive systems in plants. Recommended reading Futuyama, D.J.: Evolutionary biology, Sinauer Associates, Sunderland, 3rd ed., 1997
Dobzhansky T. et al.: Evolution. San Francisco 1977
Compulsory elective courses

TitleAnimal and Human EcophysiologyCodeÚBEV/EFZ1/03TeacherAhlersová Eva, Bojková BiankaECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basic mechanisms and principles of the action of environmental conditions on internal physiological processes. To familiarise students with the possible mechanisms of adaptation of animals to extreme values of environmental factors.ContentThe influence of environmental factors in phylogeny and ontogeny. The course of the stress reaction; kinds of adaptation. Pathology of adaptation processes: general symptoms of pathological processes. Adaptations based on vital factors of the environment: adaptations to changes in food intake (starvation and overfeeding), to hypo- and hyperbary, to increased water salinity, to gravitation, to high and low temperatures, to electricity, electromagnetic fields and laser beams, to noise, to both non-ionizing and ionizing radiation, to ultrasound and vibrations in living organisms. Alternate coursesÚBEV/EFZ1a/99

TitleCytogenetics and KaryologyCodeÚBEV/CK1/03Teacher ellárová EvaECTS credits4Hrs/week1/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge and experience in genetic processes at the cell level using the newest scientific findings of cytogenetics and moleculoar cytology. To have students become acquainted in detail with the results coming from human genome mapping.ContentOrganisation of eukaryotic genome. Nuclear skeleton. Nucleolus; nucleolar skeleton. Chromatin structure and changes of chromatin. Levels of DNA organisation in cell nucleus. Chromosomes. Polythene chromosomes. Cell cycle. Genetic regulation of a cell cycle. Genetic regulation of cell differentiation. Apoptosis. Telomeres and function of telomerase. Molecular cytology. Basic characteristics of the human genome project: what we can learn from it?Alternate coursesÚBEV/CK1/99Recommended reading Russel, J.P.: Genetics, Third Edition, Harper Collins Publisher,
New York 1992
Periodicals
Internet sources

TitleIntroduction to Gene ManipulationsCodeÚBEV/UGM1/03TeacherKolesárová Mariana, Vil
ek `tefanECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with the principles of preparation and application of techniques of recombinant DNA.ContentIsolation of nucleic acids. Restriction endonucleases. Digestion and ligation of DNA. Other enzymes used for DNA manipulation. Labeling of DNA. Nucleic acid hybridisation. PCR. Preparation of recombinant DNA. Recombinant vectors. Selection markers. Transfer of recombinant DNA to the cells. Selection of recombinants. Expression of heterologous genes in E. coli. DNA sequencing.
Alternate coursesÚBEV/UGM1/99Recommended reading Old, R.W., Primrose, S. B.: Principles of Genetic Manipulation. An Introduction to Genetic Engineering. Blackwell Scientific Publication, London, 1992
Brown, T. A. Gene Cloning. An Introduction. Chapman Hall, London, 1996

Elective courses

TitleHealing PlantsCodeÚBEV/LR1/03TeacherRep
ák MiroslavECTS credits3Hrs/week2/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo provide students knowledge of the principles of using healing plants and of the production of drugs.ContentHistory and present state. Pharmacotherapeutical and toxic effects of drugs. Active substances. Inheritance, chemotypes and breeding. Cultivation and post-harvest technology. Essential oil and extracts production. Special focus: claviceps, angelica, valeriana, drosera, levandula. digitalis, hypericum, althaea, calendula, silybum, chamomilla, arctostaphylos, melissa, mentha, hyssopus, thymus, salvia, agrimonia, rosa, tilia, achillea, plantago, panax and other tonic plants.
Alternate coursesÚBEV/LR1/00Recommended reading Pahlow M.: Healing plants. Barrons Ed. New York 1993 

TitlePlant BiotechnologyCodeÚBEV/BTR1/06Teacher ellárová EvaECTS credits6Hrs/week2/3AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo give students theoretical and practical knowledge of plant tissue culture in vitro.ContentGenetics and physiology of plant cell and tissue culture, protoplasts, embryoids and organs cultured in vitro under sterile conditions. Use of tissue culture in research and praxis. Cryopreservation of plant cells and tissues. Immobilised plant systems. Genetic transformation of plants and expression of foreign genes.
Recommended reading Dodds, J. H. and Roberts, L. W.: Experiments in Plant Tissue Culture. Cambridge University Press, 1985
Periodicals and Internet sources

TitleBiostatisticsCodeÚBEV/BS1/03Teacher`majda BeHadikECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide the students with knowledge of the basic principles of statistical methods used in biology and their scope of application.ContentSources and theoretical background of biostatistics. Basic principles of probability theory. Descriptive statistics: variables, measures of mean value and variability of data. Theoretical and empirical distributions. Experimental sampling from normal distributions. Testing of hypotheses. One-way and multiple analysis of variance. Tests for multiple comparisons. Regression analysis. Correlations. Non-parametric methods.Alternate coursesÚBEV/BST1a/01,ÚBEV/BS1b/99Recommended reading Hassard, T. H.: Understanding biostatistics. Mosby Year Book, 1991
Snedecor,G.W., Cochran,W.G.: Statistical methods. The Iowa state university, Ames, 1972.

Study programme Zoology and Animal Physiology
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚBEV/ETO1/03Ethology62/2Examination1/1 ÚBEV/IMU1/03Immunology32/-Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚBEV/EB1/99Evolutionary Biology32/-Examination2/3 ÚBEV/DP1a/03Diploma Work2-/-Recognition1/1ÚBEV/DP1b/03Diploma Work6-/-Recognition1/2ÚBEV/DP1c/03Diploma Work8-/-Recognition2/3ÚBEV/DP1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚBEV/CRO1/03Chronophysiology52/1Examination1/1 ÚBEV/EFZ1/03Animal and Human Ecophysiology62/2Examination1/1 ÚBEV/IMUC/03Practical in Immunology3-/3Assessment1/1 ÚBEV/MEB1/03Cell metabolism62/2Examination1/1 ÚBEV/BIOE/01Bioethics12/-Examination1/2 ÚBEV/BFA1/03Biopharmacology52/2Examination1/2 ÚBEV/EET1/03Ecological Ethology62/2Examination1/2ÚBEV/VIM1/99Selected Topics in Experimental Immunology52/1Examination1/2 ÚBEV/VKH1/03Selected Topics in Herpetology12/1Examination1/2 ÚBEV/EF1/03Experimental Methods in Physiology51/2Examination1/2 ÚBEV/MOG/03Model Organisms in Genetics51/2Examination2/3ÚBEV/CK1/03Cytogenetics and Karyology11/2Examination 2/3ÚBEV/MZO1/03Molecular Basis of Ontogenetic Development32/-Examination 2/3ÚBEV/FRV1/03Physiology of Plant Growth and Development62/2Examination 2/3ÚBEV/MR1/03Plant Metabolism62/2 Examination2/3ÚBEV/MBR1/05Plant Molecular Biology62/3Examination1/2 ÚBEV/AEM/06Applied Embryology12/1Examination1/2 
Recommended elective courses

ÚBEV/BI1/03Basic Bioinformatics62/2Examination1/1
Course units

Compulsory courses

TitleEthologyCodeÚBEV/ETO1/03TeacherMajláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students to know and to be aware of the importance of the behavioural aspect in biological sciences.ContentHistory and development of ethology. Ethological methods. The innate forms of behaviour. The simplest forms of learning: conditioning and instrumental learning. Higher forms of learning. Social behaviour. Sexual behaviour. Play behaviour. Biological rhythms. Orientation in space and animal migrations. Communication systems of animals. Emotions. Aggression in animal and human behaviour. Abnormal forms of behaviourAlternate coursesÚBEV/ETO1/99Recommended reading Franck, D.: Verhaltensbiologie. Einfuhrung in die Ethologie. Georg Thieme-Verlag, 1993
Manning, A., Dawkins, M. S.: An introduction to animal behaviour. Cambridge University Press, 1992

TitleImmunologyCodeÚBEV/IMU1/03TeacherPaulíková EditaECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with knowledge of immunological mechanisms at cell and organism levels.ContentCells and tissues of the immune system. Cooperation between T, B and antigen presenting cells. Non-specific lymphocytic stimulation. Innate immunity. Antigen recognition by lymphocytes. Cell receptors. Immune response. The major histocompatibility complex. The adaptive immune response. T-cells mediated immunity. The humoral immune response. Hypersensitivity. Transplantation immunology. The immune system in health and diseaseExclusive coursesÚBEV/IMUF/03Alternate coursesÚBEV/IMU1/01Recommended reading `terzl J.: Imunitní systém a jeho fyziol.funkce. Vydavate>stvo Praha 1993
HoYejaí V., BartoHková J.: Základy imunologie. Triton, 2002
Janeway Ch. A., Travers P., Walport M., Schlomchik M.: Immunobiology. Garland Science, 2004

TitleZoogeographyCodeÚBEV/ZOG1/03TeacherKová
 =ubomírECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students knowledge of the basic reasons for the recent distribution of animals on Earth, zoogeographic regionalisation of the Earth´s surface and human influence on the historical distribution of fauna. ContentCurrent understanding of the patterns of animal distribution and the processes that influence distributions of species and their attributes. Historical and current ecology; genetics; physiology of animals and their interaction with environmental processes (continental drift, climate) in regulating geographic distributions. Descriptive and analytical approaches useful in hypothesis testing in zoogeography. Illustration of applied aspects of zoogeography (e.g., refuge design in conservation).Alternate coursesÚBEV/ZOG1/99Recommended reading Darlington, P.J., 1998: Zoogeography: The geographical distribution of animals. Krieger, USA
Lomolino M.V., Brown J.H., Riddle B. R., 2005: Biogeography. Sinauer Associates, 1-845

TitleEvolutionary BiologyCodeÚBEV/EB1/99TeacherMártonfi Pavol, `majda BeHadik, ellárová EvaECTS credits3Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo familiarise students with the fundamentals of the evolution of living organisms.ContentHistorical overview of evolutionary theories. The origin of life. Elements of evolution: mutations, population waves, and isolation. Natural selection. Molecular evolution. Adaptations and their classification. Concept of species. Macroevolution. Evolution of functions and organs, evolution of ontogeny. Phylogeny of animals. Evolutionary progress. Anthropogenesis. Plant diversity. Primary and secondary speciation of plants. Reproduction-isolation mechanisms. Hybridisation and introgression of plants. Polyploidy. Reproductive systems in plants. Recommended reading Futuyama, D.J.: Evolutionary biology, Sinauer Associates, Sunderland, 3rd ed., 1997.
Dobzhansky T. et al.: Evolution. San Francisco 1977.
Compulsory elective courses

TitleChronophysiologyCodeÚBEV/CRO1/03Teacher`majda BeHadikECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentTime structure of physiological variables in animals and man. Basic notions and categories of biological rhythms. The significance of biological rhythms in the evolution of living things. The genetic basis and molecular mechanisms of biological clocks in animals. The endogenous character of biological rhythms. The multioscillatory system of the organism. The significance of circadian and seasonal rhythms for animal and human life. The application of chrono-physiological principles. Alternate coursesÚBEV/CRO1a/99

TitleAnimal and Human EcophysiologyCodeÚBEV/EFZ1/03TeacherAhlersová Eva, Bojková BiankaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basic mechanisms and principles of the action of environmental conditions on internal physiological processes. To familiarise students with the possible mechanisms of adaptation of animals to extreme values of environmental factors.ContentThe influence of environmental factors in phylogeny and ontogeny. The course of the stress reaction; kinds of adaptation. Pathology of adaptation processes: general symptoms of pathological processes. Adaptations based on vital factors of the environment: adaptations to changes in food intake (starvation and overfeeding), to hypo- and hyperbary, to increased water salinity, to gravitation, to high and low temperatures, to electricity, electromagnetic fields and laser beams, to noise, to both non-ionizing and ionizing radiation, to ultrasound and vibrations in living organisms. Alternate coursesÚBEV/EFZ1a/99

TitleMolecular Basis of Ontogenetic DevelopmentCodeÚBEV/MZO1/03TeacherMišúrová EvaECTS credits3Hrs/week2/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo provide students with basic knowledge of the principles and molecular-biological mechanisms of the ontogenetic development of animal and plant organisms.ContentRegulation of the ontogenetic development in eukaryotic organisms. Programme of ontogenetic development. Cell determination and differentiation. Molecular mechanisms of formation of specialised cell types. Epigenetic mechanisms of cellular memory. Imprinting. Combinatory control of eukaryotic genes. Regulatory genes. Establishment of cell position. Formation of the embryonic body plan. Establishment of the main axis of body. Shape formation. Cloning of multicellular organisms.Alternate coursesÚBEV/VMB1/00 orÚBEV/VMB1/03Recommended reading Gerhard, J., Kirschener, M.: Cells, Embryos and Evolution. Blacwell Science Inc., Massachusett,Oxford,London,1997

TitleCytogenetics and KaryologyCodeÚBEV/CK1/03Teacher ellárová EvaECTS credits4Hrs/week1/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge and experience in genetic processes at the cell level using the newest scientific findings of cytogenetics and moleculoar cytology. To have students become acquainted in detail with the results coming from human genome mapping.ContentOrganisation of eukaryotic genome. Nuclear skeleton. Nucleolus; nucleolar skeleton. Chromatin structure and changes of chromatin. Levels of DNA organisation in cell nucleus. Chromosomes. Polythene chromosomes. Cell cycle. Genetic regulation of a cell cycle. Genetic regulation of cell differentiation. Apoptosis. Telomeres and function of telomerase. Molecular cytology. Basic characteristics of the human genome project: what we can learn from it?Alternate coursesÚBEV/CK1/99Recommended reading Russel, J.P.: Genetics, Third Edition, Harper Collins Publisher,
New York 1992
Periodicals and internet sources

TitlePlant MetabolismCodeÚBEV/MR1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge of the pathways of biosynthesis in plants and the functions of primary and secondary metabolites.ContentPhotosynthesis: structure of photosynthetic apparatus, light absorption, electron and proton transport, photophosphorylation. Calvin cycle, rubisco and photorespiration. C4 and CAM plants. Synthesis of starch and sucrose. Respiration: glycolysis, citric acid cycle, electron transport and ATP synthesis. Lipid biosynthesis and conversion into carbohydrates. Polyacetylenes. Nitrogen metabolism: fixation, nitrate assimilation, ammonium conversion to amino acids. Sulfur assimilation and metabolism. Terpenes: biosynthesis and functions. Phenolic compounds: pathways of biosynthesis, phenylpropanes, flavonoids and lignins. Alkaloids. Mechanisms of plant defense.Alternate coursesÚBEV/MR1/99Recommended reading Lawlor D. W. Photosynthesis. Third edition. BIOS, Oxford 2001; Taiz L., Zeiger E., Plant physiology. Fourth edition. Sinauer ass., Sunderland 2006

TitlePractical in ImmunologyCodeÚBEV/IMUC1/03TeacherPaulíková EditaECTS credits3Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo teach the students the basic techniques used in immunology.ContentThe topics of exercises are determined by the themes of lectures.Prerequisite coursesÚBEV/IMU1/03Alternate coursesÚBEV/CIM1/01Recommended reading Study materials provided by teacher.


TitlePlant TaxonomyCodeÚBEV/TR1/99TeacherMártonfi PavolECTS credits5Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo familiarise students with basic methods and approaches in plant taxonomy.ContentPlant taxonomy. Approaches to biological classification. Source of information and taxonomic data. Variation in plants and their study. Numerical taxonomy (phenetics). Cladistics and their utilisation in taxonomy. Molecular data as important in recent systematics. Overview of phylogeny of tracheophytes according to the newest data. Evolution in populations, principles of plant evolutions, primary and secondary speciation. Basics of botanical nomenclature. International code of botanical nomenclature.Recommended reading Stuessy T. F.: Plant Taxonomy. - New York, Oxford 1990.
Judd W. S., Campbell Ch. S., Kellogg E. A., Stevens P. F., Donoghue M. J.: Plant Systematics. A Phylogenetic Approach, 2nd ed. - Sinauer Associates, Sunderland, 2002.

TitleHydrobiologyCodeÚBEV/HDR1/99TeacherHudec IgorECTS credits3Hrs/week1/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentAbiotic and biotic factors of a water environment; typology and characteristics of freshwater habitats; eutrophycation, pollution saprobity and evaluation of habitats with relation to abiotic factors.Recommended reading Horn, A., Goldman, C.: Limnology. Mc Graw Hill. 2nd Edition, 1994
Wetzel, R.G.: Limnological analyses. Springer Verl., 3rd Edition, 2000

TitleCell MetabolismCodeÚBEV/MEB1/03TeacherAhlersová Eva, Kassayová MonikaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with knowledge about the principal metabolic processes in living cells.ContentMetabolism of sugars and lipids and their disorders in human cells. Function of the liver in the metabolism of lipids. Metabolism of serum lipoproteins and its disorders. Metabolism of minerals. Mechanisms of acido-basic balance. Metabolic regulations. Topochemistry of metabolic processes in the organism.Alternate coursesÚBEV/MEB1/99Recommended reading Murray, R. K., Grammer, D. K., Mayes, P. A., Rodwell, V.W.: Harper‘s Biochemistry. Prentice-Hall, Appleton & Lange, 1993

TitleSoil EcologyCodeÚBEV/EKP1/04TeacherKová
 =ubomírECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo give students knowledge of soil as a heterogenous substrate and environment for organisms with special emphasis on the mineral and organic components of the soil essential for existence and development of populations of the living biota. ContentComponents of the soil environment, microclimate, nutrient cycling and energy flow. Soil-forming factors and processes, soil organisms microbial communities, plant roots, invertebrate communities and functioning of the soil system (decomposition, litter system, rhizosphere, drillosphere, termitosphere). Recommended reading Coleman D. C., Crossley D. A. jr.: Fundamentals of soil ecology. Academic Press, 1995
Dunger W., Fiedler H. J.: Methoden in Bodenbiologie. VEB Gustav Fischer Verlag, Jena, 1989
Lavelle P. Spain A. V.: Soil ecology. Kluwer Academic Publishers. Dordrecht-Boston-London, 2001 

TitleModel Organisms in GeneticsCodeÚBEV/MOG/03Teacher ellárová EvaECTS credits5Hrs/week1/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with information on model systems of prokaryotic and eukaryotic organisms used in genetic research.ContentBasic properties of model organisms used in genetics. Prokaryotic model systems (Escherichia coli, Diplococcus pneumoniae, Agrobacterium tumefaciens and A. rhizogenes). Model systems of simple eukaryotic organisms (Saccharomyces cerevisiae, Neurospora crassa). Plant and animal model systems in vitro and in vivo. Caenorhabditis elegans. Arabidopsis thaliana. Mendel´s laws. Drosophila melanogaster. Morgan´s rules. Mus musculus. Human genome. Transgenic plants and animals. HeLa cells. Stem cells. Genetic importance of the study of twins. Genetic databases. Alternate coursesÚBEV/MOG1/99Recommended reading Genetic periodicals
Internet sources

TitlePlant Molecular BiologyCodeÚBEV/MBR1/05Teacher ellárová EvaECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of gene expression in plants.ContentOrganisation of plant genome. Regulation sequences, gene families, repetitive sequences. Genes coding for t-RNA, r-RNA and structural genes. Regulation of gene expression in plants. Structure and function of mtDNA and cpDNA. Mitochondrial plasmids. Biotic and abiotic stress. Plant viruses. Agrobacterium sp. and its genetic importance. Ti and Ri plasmids. Methods of genetic transformation. Transgenes. GMO. Recommended reading Buchanan, B. B., Gruissem, W. and Jones, R. J.: Biochemistry and Molecular Biology of Plants. America Society of Plant Physiologists, Rockville, Maryland, 2000
Hansen E., Harper, G." Differentially Expressed Genes in Plants, Taylor and Francis, London 1997
Leister, D.: Plant Functional Genomic. The Haworth Press New York, 2004

TitlePhysiology of Plant Growth and DevelopmentCodeÚBEV/FRV1/03TeacherRep
ák MiroslavECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge of basic methods and approaches in the physiology of plant growth and development.ContentGrowth and morphogenesis: phases and kinetics; differentiation. Hormones: metabolism and transport, physiological and developmental effects; auxin, gibberellins, cytokinnins, ethylene and abscisic acid. Photomorphogenesis and etiolation. Phytochrome: properties, physiology, ecological functions, molecular mechanisms. Blue-light responses. Rhythms. Germination and dormancy. Regulation of flowering. Senescence and programmed cell death. Orientation in space: phototropism, gravitropism and nastic movements. Stress physiology.Alternate coursesÚBEV/FRV1/99Recommended reading Taiz L., Zeiger E., Plant physiology. Fourth edition. Sinauer ass., Sunderland 2006

TitleBiopharmacologyCodeÚBEV/BFA1/03TeacherGálik JánECTS credits5Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge on the classification and mechanism of action of the most important pharmaceuticals.ContentPharmaceutical principles. Classification of drugs. Absorption, biotransformation and excretion of drugs from the organism. Pharmacogenetics. Molecular mechanisms of drug effects. Drug-receptor interactions. Chronic administration of drugs. Teratogenity and cancerogenity of drugs. Development and introduction of drugs for clinical use. Principle of chronopharmacology.Alternate coursesÚBEV/BFA1/99Recommended reading Clark, W. G., Braber, D.C., Johnen, A.R.: Goth‘s medical pharmacology. Mosby Year Book, 1992

TitleApplied EmbryologyCodeÚBEV/AEM/06TeacherDudᚠMarekECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo develop in students a omplex understanding of current assisted reproduction technologies and methods used in experimental pathology.ContentBasics of the latest techniques in animal and human embryology with emphasis on methods frequently used in clinical medicine and science (e.g., in vitro fertilisation, cloning, preimplantation diagnosis, transgenesis, gene knock-out, disease modelling, tissue-specific gene manipulations). Selected topics from allied basic sciences (embryology, molecular genetics, developmental biology, ethics) will enhance complex understanding of current trends in clinical embryology and experimental pathology.Recommended reading Provided by the teacher in a classroom.

TitleBiospeleologyCodeÚBEV/BSP/04TeacherKová
 =ubomírECTS credits4Hrs/week1/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give students basic knowledge on the diversity of the cave biota, relationships between and adaptations of biota to the specific environment, human influence and protection of the cave biota. ContentMorphology and systematics of the cave fauna and microflora, their adaptations to this specific habitat type, geographic distribution, functioning of the cave system and interactions between its components, human influence and protection of the cave biota. Prerequisite coursesÚBEV/EPZ1/03Recommended reading Culver D. C., 1982: Cave life – evolution and ecology. Harvard University Press, Cambridge, Massachusetts and London
Culver D.C., White W.B., 2005: Encyclopedia of caves. Elsevier, 1-654
Vandel A., 1965: Biospeleology - the biology of cavernicolous animals. Pergamon Press, Oxford
Wilkens H., Culver D.C., Humphreys W.F., 2000: Subterranean Ecosystems. Ecosystems of the World, vol. 30. Elsevier, 1-791

TitleEcological EthologyCodeÚBEV/EET1/03TeacherAhlers Ivan, Majláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give students the means to analyse and comprehend the principles of behavioral strategies in a given ecosystem from the point of view of sociobiology.ContentThe topic of sociobiology and its relations to other disciplines. The evolution of social behavior in animals and in man. Strategies of social interactions and formation of groups in relation to the ecosystem. The choice of appropriate social arrangement, sexual partner, reproductive and parental strategy. Competition among individuals and sexes.Prerequisite coursesÚBEV/ETO1/03

TitleNeurophysiologyCodeÚBEV/NFYZ/07TeacherGálik JánECTS credits4Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalContentThe neuron as the basic functional and morphological unit of the nervous system. The generation of resting membrane potential, ion chanals, ion currents. The rise and conduction of action potential. The synapse: chemical and electrical synapses. Synaptic excitation and inhibition. Neurotransmitters and their receptors. Sensual receptors: classification. Sensoric and motoric functions of the nervous system. Sensoric neural pathways and brain centres. Motoric control centers in the CNS. Monosynaptic and polysynaptic reflexes. Functions of the limbic system. Associative functions of the CNS: sleep and wakefullness, memory and learning, speech, cognition. Neurophysiology of sensory functions. Methods of recording brain activity. 

TitleEcology of Soil AnimalsCodeÚBEV/EPZ1/03TeacherKostúrová NatáliaECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give students basic knowledge on the functioning of the soil system with special reference to dominant systematic groups of soil fauna, their ecology and taxonomic identification.ContentThe soil as an ecological system and type of environment Ecological factors ruling life in soil, soil-dwelling animals and their adaptations to this specific habitat. Functioning of the soil system and understanding of the principal interactions of soil fauna with the plant rhizosphere and soil microflora. Prerequisite coursesÚBEV/EKP1/04Alternate coursesÚBEV/EPZ1/99Recommended reading Coleman, D.C., Crossley, D. A., 1996: Fundamentals of Soil Ecology. Academic Press, London, 1-205
Eisenbeis, G., Wichard, W., 1987: Atlas on the Biology of Soil Arthropods. Springer- Verlag Berlin, Germany, 1-437
Schaller, F. 1968: Soil Animals. The University of Michigan Press, United States of America, 1-144
Wallwork, J. A., 1970: Ecology of Soil Animals. McGraw- Hill, England, 1-283
Wallwork, J. A., 1976: The distribution and Diversity of Soil Fauna. Academis Press, London, 1-355

TitleEcology of Water AnimalsCodeÚBEV/EVZ1/03TeacherHudec IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the ecological characteristics of freshwater groups and prevalent species of invertebrates.ContentBiology of the most common representatives and groups of freshwater animals of the Central Europe temperate region. Mohological adaptations, taxanomical characters, water communities.Alternate coursesÚBEV/EVZ1/99Recommended reading Fryer, G., Murphy, S.: A natural history of the lakes, tarns and streams of the English Lake District. Freshw. Biol. Association Cumbria, 1991
Bronsmark, Ch., Hannsson, L. A.: The biology of Lakes and ponds. Biol. Of Habitats Ser, 1998 

TitleSelected Topics in Experimental ImmunologyCodeÚBEV/VIM1/99TeacherPaulíková EditaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge on control and manipulation of the immune processes.ContentFlow cytometry. Immunofenotyping of leucocytes in diagnostics. Cryopreservation of isolated cells and cell lines. Methods of isolation of immunocompetent cells. Enzymatic immunology.Prerequisite coursesÚBEV/IMU1/03Recommended reading Abbas, A., Abul, K.: Cellular and molecular immunology. Saunders W. B. Comp., 1991
Masseyeff, R. F., Albert, W. H., Staines, N. A.: Methods of immnological analysis I - III., 1993

TitleExperimental Methods in PhysiologyCodeÚBEV/EF1/03TeacherGálik JánECTS credits5Hrs/week1/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo present the basic rules of breeding of laboratoty animals and of the criteria for correct handling of animals during housing and in the course of the experiment.ContentThe experimental animal; the laboratory animal; biomodels. Basics of animal breeding. Biological traits of commonly used laboratory animals. Genetics of laboratory animals. Microbiological criteria of animal breeding. The influence of internal and external factors on the health state and reactivity of animals: genetic determinants, sex, social and behavioral factors. The influence of physical factors of housing (temperature, humidity, light, noise, transport). Design of experiments.Alternate coursesÚBEV/EF1/99
Recommended elective courses

TitleBasic BioinformaticsCodeÚBEV/BI1/03TeacherSaxová Patrícia, ellárová EvaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo allow students to use interdisciplinary methods and approaches involving mathematics and computer science in solving selected problems in molecular biology, as, for example, the analysis of nucleotide and protein sequences, genome study, etc.ContentThe introductory lectures in Bioinformatics involve the comparison of nucleotide and protein sequences, molecular evolution, evolutionary trees, work with biological databases, use of neuron networks and HMM in Bioinformatics. Practical experience is provided by student use of concrete bioinformatic programs accessible on the Internet.Alternate coursesÚBEV/BI1/01Recommended reading Grau D. & Li W.-H.: Fundamentals of Molecular Evolutions, Sinuar Associates, 2000.
Durbin, R., Eddy, S., Krogh, A. & Mitchison, G.: Biological SequenceAnalysis: Probabilistic Models of Proteins and Nucleic Acids, CUP, 1999





























CHEMISTRY
Study programme Analytical Chemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚCHV/DPCO1a/00Diploma Work2-/-Recognition1/1ÚCHV/DPCO1b/00Diploma Work6-/-Recognition1/2ÚCHV/EMDP/03Experimental Methods
for Master’s Thesis6-/6Assessment2/3ÚCHV/DPCO1c/03Diploma Work8-/-Recognition2/3ÚCHV/SDP/03Seminar on Diploma Work2-/2Assessment2/3ÚCHV/DPCO1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚCHV/AAS1/03Atomic Spectrochemistry62/2Examination1/1ÚCHV/BACH1/03Bioanalytical Chemistry52/1Examination1/1CHV/KCHR/06Liquid Chromatography52/1Examination1/1ÚCHV/BACH1/03Bioanalytical Chemistry52/1Examination1/1ÚCHV/IAHS/06Identification of Analytes by Mass Spectrometry42/-Examination1/1ÚCHV/ACPE1/03Industrial Ecology52/1Examination1/1ÚCHV/AVZ1/02Analytical Sampling52/1Examination1/2ÚCHV/PC1/06Gas Chromatography52/1Examination1/2ÚCHV/ACM1/06Chemometrics62/2Examination1/2ÚCHV/AOL1/06Analysis of Organic Substances62/2Examination1/2ÚCHV/ANS/05Analytical Sensors52/1Examination1/2ÚCHV/GLP1a/06Quality Management and Good Laboratory Practices52/1Examination1/2ÚCHV/APO1/02Analysis of Psychotropic and Narcotic Substances42/-Examination2/3ÚCHV/AZP1/04Environmental Analytical Chemistry62/2Examination1/1, 2/3ÚCHV/FEM/03Electroanalytical Methods62/2Examination2/3ÚCHV/SVK1/00Student scientific conference 4-/-Assessment1/2, 2/4

Recommended elective courses

ÚCHV/MMU/03 Macromolecular Chemistry43/-Examination1/1ÚCHV/EMST/05Electrophoretic Methods52/1Examination1/1ÚCHV/KOC1/01Quantum Chemistry53/1Examination1/1ÚCHV/VSE1a/04Special Seminar2-/2Assessment1/1ÚCHV/JCH1/04Nuclear Chemistry42/1Examination1/2ÚCHV/TA1/03Thermal Analysis52/1Examination1/2ÚCHV/ATV1/04Water Pretreatment62/2Examination1/2ÚCHV/FKC1/03Colloid Chemistry42/1Examination1/2ÚCHV/NMR1/001D & 2D NMR Spectroscopy62/3Examination1/2ÚCHV/VSE1b/04Special Seminar2-/2 Assessment1/2ÚCHV/PBACH1/03Practical in Bioanalytical Chemistry3-/3Assessment1/2, 2/4ÚCHV/SKACH1/06Forensic and Clinical Analytical Chemistry52/1Examination1/2, 2/4
Course units

Compulsory courses

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1T/L methodObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.
ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.
Recommended reading According to the approved setting of diploma work.

TitleAnalytical Chemistry IIICodeÚCHV/ANCH2/06TeacherAndruch Vasi>, Baze> YaroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentFlow injection analysis. Kinetic analytical methods. Radiochemical analytical methods. Ultra-Violet, Visible, Infrared, Microwave spectrometry for chemical analysis. Fourier Transform infrared. Raman spectrometry. Electron Paramagnetic Resonance. Nuclear Magnetic Resonance. Mass spectrometry. Secondary Ion Mass Spectrometry. X-ray photoelectron spectrometry.
Recommended reading 1. H.H. Willard, L.L. Merritt, Jr., J.A. Dean, F.A. Settle, Jr.: Instrumental Methods of Analysis, Wadsworth Publ. Co., Belmont (CA) 1988, ISBN 0-534-08142-8

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments required for diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits8Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4ObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.


TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.
Recommended reading According to the field of diploma work.Compulsory elective courses

TitleAtomic SpectrochemistryCodeÚCHV/AAS1/03TeacherBaze> Yaroslav, Vojteková VieraECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with theoretical information and practical experience with atomic absorption and emission methods used in analytical practice (environmental analysis, material research, clinical and food analysis).ContentBasic and enhanced information about spectral (optical) methods; history of their development; practical applications: optical analytical methods, principles, classification; atomic spectra, creation, analytical use. Modern equipment for scanning for radiation. Detection of radiation in spectrochemistry. Historical development; actual trends. Photographical detection and its particularities. Methodologies for solution analysis; special methods for the direct transport of the solid samples in the DCA source. Atomic absorption spectrometry, flame and electrothermal atomisation. Methods based on the interaction of the RTG radiation and the sample: advantages, disadvantages and applications of WDXRF, EDXRF, TXRF.Alternate coursesÚCHV/AAS1/01Recommended reading D. A. Skoog, J. J. Leary: Instrumental Analytics. Springer, Berlin - Heidelberg 1996
B. Welz, M. Sperling: Atomic Absorption Spectrometry,Wiley-VCH Verlagsgesellschaft mbH, Germany 1998
Douglas A. Skoog, Donald M. West, F. James Holler, Timothy A. Nieman: Principles of Instrumental Analysis. Wandsworth, 1997

TitleBioanalytical ChemistryCodeÚCHV/BACH1/03TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students theoretical knowledge and practical experience regarding the application of analytical chemistry and analytical methods to laboratory medicine.ContentIntroduction to bioanalytical chemistry. Biological sample, classification. Sampling techniques, transport, sample storing and conservation. Selected methods of sample pre-treatment for bioanalysis. Conditions for analytical method selection. Presentation of analytical data evaluation. Optimisation of analytical procedure. Control and management of quality in a clinical laboratory. Molecules colouring and their analytical applications. Enzymes in bioanalysis. Mechanism of enzyme catalysis. Enzyme-like analytes and analytical reagents. Moderators of enzyme activity. Basic principles of enzyme analytics. Introduction to immunochemical methods: Precipitation, nephelometric, turbidimetric and agglutination methods. Immunodiffusional methods. Radioimmunoanalytic methods (RIA). Nonisotopic methods (EIA, ELISA, LIA, FIA). Microbiological methods. Analysis of biomolecules: separation methods selection. Analytical technique of miniaturisation: principle, microchips, biosensors.Recommended reading Mikkelsen, S. R., Cortón, E.: Bioanalytical Chemistry, Wiley, 2004
Wilson, I.: Bioanalytical Separations 4, (Handbook of Analytical Separations), Elsevier, 2003
Suelter, C. H., Kricka, L. J.: Methods of Biochemical Analysis, Vol.37, Bioanalytical Instrumentation, Wiley, 1994
Rodriguez-Diaz, R., Wehr, T., Tuck, S.: Analytical Techniques for Biopharmaceutical Development, Marcell Dekker, 2005 

TitleAnalytical SamplingCodeÚCHV/AVZ1/02TeacherOriHák AndrejECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentAnalytical sample; characterisation. Sampling and norms affecting sampling process. Quantity, number of samples. Sampling techniques. Sampling laboratory equipment. Sample pre-concentration. Sample storing and conservation. Matrix simplifying; specific analysis. Chromatographic sample pre-treatment.Alternate coursesÚCHV/AVZ1/00Recommended reading O. Stoeppler: Sampling and Sample Preparation Practical Guide for Analytical Chemists. Academic Press, London, 2002
E. P. Popek: Sampling and Analysis of Environmental Chemical Pollutants. Elsevier Science, San Diego, 2003

TitleIndustrial EcologyCodeÚCHV/ACPE1/03TeacherBaze> Yaroslav, Vojteková VieraECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo give chemistry, environmental ecology and teaching students the opportunity to approach problems of environmental pollution, to appraise problems of the creation and protection of the environment, and to develop ecologically enlightened thinking in their working and personal lives.ContentIntroduction to problems of the creation and protection of the environment. Selected chapters on industrial toxicology and evaluation of environmental stress. Toxic and potentially toxic matters in the living and working environment. Hydrologic, geologic and anthropogenic cycles from the environmental point of view. Environmental behaviour, education and culture in working and personal lives.Recommended reading Stanley E. Manahan: Environmental Chemistry. , New York, Boca Raton, 2007
Stanley E. Manahan: Industrial Ecology (Hardcover), Boca Raton, New York ,1999

TitleLiquid ChromatographyCodeÚCHV/KCHR/06TeacherGondová TaeánaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with advanced knowledge about liquid chromatography applications. ContentTheoretical principles of liquid chromatography. Selection and optimisation of separation process. Sample pretreatment. New trends in HPLC techniques: uLC, chiral analysis, multidimensional chromato- graphy, combined systems with LC applications.Recommended reading Skoog D.A.: Principles of Instrumental Analysis. Saunders, New York 1985
Mondello L., Lewis A.C., Bartle K.D.: Multidimensional Chromatography, Wiley, 2002

TitleIdentification of Analytes by Mass SpectrometryCodeÚCHV/IAHS/06TeacherOriHák AndrejECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentIsotopic composition and its application, identification of molecular ion, general identification steps; hydrocarbons, halogenated hydrocarbons, alcohols, ethers and phenols, aldehydes and ketones, other derivatives and their mass spectra; mass spectrometric analysers and their application, resolution and sensitivity. MS combined chromatographic methods; evaluation of MS spectra.Recommended reading Douglas A.Skoog, James J.Leary : Principles of Instrumental Analysis, 1971, Saunders Publish.
Terence A.Lee: A Beginner´s Guide to Mass Spectral Interpretation, Wiley, 1998.

TitleEnvironmental Analytical ChemistryCodeÚCHV/AZP1/04TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide and improve student knowledge about the methods of environmental analysis ContentIntroduction. Sampling techniques and sample preparation in environmental analysis. Quality assurance for environmental analysis. Good laboratory practice. Chemometrics in environmental analysis. Analysis of water, sediments, air, etc. Analysis of environmental samples by spectroscopic methods. Separation techniques in environmental analysis. Application of electrochemical methods to environmental samples. Prerequisite coursesÚCHV/ANCHU/03 orÚCHV/ANCH1b/03 orÚCHV/ANCH3/03Recommended reading Ure, A. M., Davidson, C. M.: Chemical Speciation in the Environment. Blackie, London 1995
John R. Dean: Extraction Methods for Environmental Analysis. Wiley, 1988 

TitleMolecular SpectrometryCodeÚCHV/MOL/06TeacherAndruch Vasi>, Baze> YaroslavECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalContentMolecular spectrophotometry (Ultra-Violet, Visible, Infrared) for chemical analysis. Fourier Transform infrared. Raman spectrometry. Microwave spectrometry. Electron Paramegnetic Resonance. Nuclear Magnetic Resonance. Recommended reading E.D. Olsen. Modern optical methods of analysis. McGraw-Hill, Inc. 1975
A.Skoog, J.J.Leary. Instrumentelle Analytic. Springer. Berlin-Heidelberg. 1996 

TitleChemometricsCodeÚCHV/ACM1/06TeacherBaze> Yaroslav, Vojteková VieraECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide knowledge of methods and methodologies of uncertainty and decision statistics needed to correctly evaluate and interpret analytical results. To provide knowledge about the areas of validation and accreditation of the laboratories. ContentThe principles of the mathematic-statistical methods used in analytical chemistry. Distribution of the measuring results. Classic and robust estimation of the mean value and variance. Statistical tests and their application. Accuracy, precision and reliability of the results. Uncertainity of the results. Calibration in analytical chemistry; linear and nonlinear models. Evaluation of analytical methods; chosen optimisation methods. Solving of typical problems within the framework of the practical lecture.Alternate coursesÚCHV/ACM1/03Recommended reading Richard G. Brereton: Chemometrics: Data Analysis for the Laboratory and Chemical Plant., Boca Raton, New York, 2003

TitleAnalysis of Psychotropic and Narcotic SubstancesCodeÚCHV/APO1/02TeacherGondová TaeánaECTS credits4Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureContentDrugs; drug dependence. Psychotropic and narcotic substances: classification, properties and laws. Dose and tolerance, therapy, prevention. Pharmacokinetics of the drug. Biological effects, biotransformations, receptors. The methods used in the analysis of the drugs (clinical, forensic analysis): opiates, cocaine, amphetamines and their analogues, hallucinogenics, cannabis products, etc.Alternate coursesÚCHV/APO1/99 orÚCHV/APO1/00Recommended reading  M. D. Cole: The Analysis of Controlled Substances, Wiley 2003
E. Hodgson: A Textbook of Modern Toxicology, Wiley 2004

TitleQuality Management and Good Laboratory PracticesCodeÚCHV/GLP1a/06TeacherBaze> Yaroslav, Vojteková VieraECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give information about the topics of good laboratory practices; quality assurance of the chemical measurements; tracebility and metrological security; the system of the valid state and European norms;
use and production of standard reference materials; validation of the methods used in and accreditation of the laboratories; and the ability to produce a correct evaluation of analytical results. ContentIntroduction of the structured system of the chemical measurements, under instructions of the EU commission. Validation of analytical methods. Basics of metrology in chemistry. Uncertainities of analytical measurements.Alternate coursesÚCHV/GLP1/03Recommended reading H.-M. Kuss, K. Flórián: Einfuhrung in die Chemometrik. G. Mercator Universität GH, Duisburg, 1998
Richard G. Brereton: Chemometrics: Data Analysis for the Laboratory and Chemical Plant., Boca Raton, New York, 2003 

TitleGas ChromatographyCodeÚCHV/PC1/06TeacherOriHák AndrejECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with detailed information about gas chromatography applications.ContentIntroduction to gas chromatography; basic description of chromatographic process. Chromatographic parameters. Gas chromatography, retention volume, relation between Vg and K. Mobile phase flow rate effect. Mobile phase origin effect. Sample injection in GC. Direct injection into hot injector: split and splitless injection, on-column injection, injector with programmed temperature. Injection by thermodesorption, pyrolysis injector. Valves and loops. Detailed variations in GC sampling. Chromatographic columns in GC. Stationary phase effects. SOL-GEL and FORTE columns. Detection in GC. Microdetectors and integrated systems. Multidimensional GC, tandem GC, hyphenated GC. Qualitative and quantitative analysis. Novel applications in GC. Supercritical GC. Prerequisite coursesÚCHV/CHRA1/03Recommended reading D.A. Skoog, J.J.Leary: Principles of Instrumental Analysis, Saunders, 1992
K.Grob: On-Column Injection in Capillary Gas Chromatography. Huthig, 1991

TitleElectroanalytical MethodsCodeÚCHV/FEM/03TeacherMarkušová KvetoslavaECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students a survey of the principles, theoretical background and practical applications of modern electroanalytical methods.ContentImportance of electroanalytical methods for environmental control and protection, requirements of practice, electrochemical cells, electrode potential, mass transfer by convection, migration and diffusion, Cottrell equation, direct current voltametry and polarography (principle, theoretical backround, examples of practical application). TAST polarography and voltametry, staircase voltammetry, pulse techniques: normal pulse and differential pulse voltammetry and polarography, square-wave voltammetry and polarography, AC polarography and voltammetry, anodic stripping voltammetry, adsorptive (or accumulation) voltammetry (applications in clinical and environmental analysis), working electrodes in voltammetry: stationary mercury electrode, mercury film electrode, glassy carbon electrode, carbon paste electrode, metallic electrodes, rotating disk electrode, rotating ring-disk electrode, ultramicroelectrodes, chemically modified electrodes, potentiometry, principles of ion selective electrodes, glass electrodes, ISE with solid and liquid membranes, biocatalytic membrane electrodes, chronopotentiometry, potentiometric stripping analysis, electroanalytic-al detectors in flow systems, amperometric titrations, biamperometric and bipotentiometric titrations, potentiostatic and galvanostatic coulometry.Recommended reading F. Scholtz: Electroanalytical Methods, Springer Verlag, Heidelberg 2002, ISBN 3-540-42449-3
J. Wang: Analytical Electrochemistry, VCH Publ., New York 1994, 2000
R. Kalvoda (Ed.): Electroanalytical Methods in Chemical and Environmental Analysis, Plenum Publ. Corp., New York 1987
A. J. Bard, L. R. Faulkner: Electrochemical Methods, John Wiley and Sons, New York 1980
T. Riley, A. Watson: Polarography and Other Voltametric Methods, John Wiley and Sons, Chichester 1987
J. Wang: Stripping Analysis, VCH Publ. Inc., Deerfield Beach 1985

TitleAnalytical SensorsCodeÚCHV/ANS/05TeacherAndruch Vasi>ECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give and improve student knowledge about the theoretical principles and application of optical and electrochemical analytical sensors.ContentOptical sensors. Materials for optical sensors. Optical biosensors. Chromogenic and fluorogenic reactants. Design of biosensors. Electrochemical sensors. Recommended reading  Janata J.: Principles of Chemical Sensors, Plenum Press, London, 1989
Lakowicz J. R.: Principles of Fluorescence Spectrocopy, Plenum Press, New York, 1983
Jameson D. M. Fluorescence Principles, Methodologies and Applications, CRC Press, 1984
Narayanaswamy R., Wolfbeis O.S.: Optical Sensors, Springer, 2004, 421 p.
Brinker C. J., Scherer G. W.: Sol-gel Science, Academic Press, New York, 1990 
Elective courses

TitleQuantum ChemistryCodeÚCHV/KOC1/01TeacherDanihel IvanECTS credits5Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo have students improve their knowledge in the field of valence-bond based on molecular orbital theory (MO) and individually to perform basic quantum chemical calculations (molecular geometry optimisation, transition states, vibrational analysis, etc.). ContentDevelopment of valence-bond theory. Time-independent Schrodinger equation. Basic approximations in molecular orbital valence-bond theory. Variant methods of calculation in the framework of molecular orbital valence-bond theory. Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction coordinate. Calculation of absolute and relative equilibrium and rate constants in gas phase. Solvatation energy calculation.Alternate coursesÚCHV/KOC1/99 orÚCHV/KOC1/00Recommended reading Jensen F.: Introduction to Computational Chemistry, Wiley, 000
Leach A.R: Molecular Modelling, Addison Wesley Longman Ltd. 1998
Náray-Szabó G., Surján P. R., Ángyán J. G.: Applied Quantum
Chemistry, Akadémia Kiadó, Budapest, 1987 

TitleMacromolecular ChemistryCodeÚCHV/MMU/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo make students familiar with available structures of polymers and their synthesis methods as well as with the ways that structure is reflected in their properties.ContentFundamental aspects of chemical composition of polymers-monomers; shape and the relationship between structure and properties. Primary, secondary, tertiary and quaternary structures. Thermal transition. Molecular mass distributions. Determination of molecular mass of macromolecules. Synthetic methods of functional polymers and their characterisation. Naturally occurring polymers: their properties. Degradation of polymers. Polymers and the environment.Recommended reading Elias H.-G.: Macromolecules. Volume 1 (Structure and Properties); Volume 2 (Synthesis, Materials, and Technology). Plenum Press, New York, 1984
Moore W. J.: Physical Chemistry. Longman, London,1972
Munk P.: Introduction to Macromolecular Science. John Wiley & Sons, New York, 1989
Atkins P. W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002

TitleElectrophoretic MethodsCodeÚCHV/EMST/05TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentPrinciples and classification of electrophoretic methods. Comparison of basic electorphoretic methods: Zone electrophoresis, the moving boundary method, focusing methods, capillary isotachophoresis, capillary zone electrophoresis. Selection of electrolyte system, leading electrolyte (LE), terminating electrolyte (TE), the steady state, Evaluation of the results of an isotachophoretic separation. The determination of quality of substances. Quantification.Recommended reading Handbook of Capillary Electrophoresis, 2. Ed., CRC, Boca Raton, 1997
P. Bo
ek: Basic course and Advanced course of Isotachophoresis, Institute of Analytical Chemistry, Czech Academy of Science, Brno, 1984

TitleThermal AnalysisCodeÚCHV/TA1/03TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of experimental thermoanalytical techniques, the use of thermoanalytic methods for characterisation of inorganic and organic compounds and reaction kinetics.ContentIntroduction: Experimental thermoanalytical techniques (thermogravi-metric analysis, differential thermal analysis, thermomagnetic techniques, thermodilatometric analysis, high temperature reflectance spectroscopy). The use of thermoanalytic methods for characterisation of inorganic and organic compounds, materials and pharmaceutical substances. Reaction kinetics.Recommended reading Wendlandt, W. W.: Thermal Methods of Analysis, 2. ed. New York, 1985
Schultze, D.: Differentialthermoanalyse, VEB Deutsch Verlag Wissenschaften, Berlin, 1969
Heide, K.: Dynamische thermische Analysenmethoden, VEB Deutsch Verlag Wissenschaften, Leipzig, 1979

TitleSpecial SeminarCodeÚCHV/VSE1a/04TeacherAndruch Vasi>, Reiffová Katarína, Gondová Taeána, Vojteková VieraECTS credits2Hrs/week-/2AssessmentAssessmentSemester1T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students theses.

TitleNuclear ChemistryCodeÚCHV/JCH1/04TeacherTuroHová Andrea, Markuaová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basics of radioactivity and nuclear reactions, of preparation of the radionuclides and their use in technical practice, and of the biological effects of nuclear radiation.ContentFundamentals of nuclear chemistry. Elementary particles. Nuclear core. Nuclides and isotopes. Radioactivity and radioactive disintegration kinetics. Radioactive disintegration. Decay law. Half life period. Units of radioactivity. Nuclear reactions. Sources of nuclear radiation. Detection and registration of radiation. Nuclear chemical technology. Radioactive analytical methods. Isotopic dilution method, activation analysis. Biological effects of the nuclear radiation. Nuclear medicine. Nuclear power station. Recommended reading G. R. Choppin, J. O. Liljenzin, J. Rydberg: Radiochemistry and Nuclear Chemistry, 3rd edition, Woburn, USA, Butterworth-Heinemann, 2002.
W. D. Ehmann, D. E. Vance: Radiochemistry and Nuclear Methods of Analysis, Wiley, New York, 1991
A. Vértes, I. Kiss: Nuclear Chemistry, Elsevier, 1987 

Title1D & 2D NMR SpectroscopyCodeÚCHV/NMR1/00TeacherImrich JánECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveStudents will learn how to analyse structure and properties of organic, inorganic and biomolecular compounds by 1D and 2D proton and carbon NMR spectra, quantitative NMR analysis, and practical applications in various fields of science and technology.ContentTheoretical principles of nuclear magnetic resonance (NMR), basic NMR pulse techniques and Fourier transformation, NMR spectrometers, description of NMR by vector models. Parameters of one- (1D) and two-dimensional (2D) NMR spectra, practical application of 1H and 13C NMR spectra and basic correlated 2D spectra for structure and stereochemical arrangement, elucidation of reaction mechanisms, molecular dynamics, physico-chemical properties and quantitative analysis of chemical compounds.Alternate coursesÚCHV/NMR1/99Recommended reading Friebolin H.: Basic One- and Two-Dimensional NMR Spectrocopy, Verlag Chemie, Weinheim 1993
Claridge T. D. W.: High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 1999
Atta-ur-Rahman, Choudhary M. I.: Solving Problems with NMR spectroscopy, Academic Press 1996.
Kalinowski H.-O., Berger S., Braun S.: Carbon-13 NMR Spectroscopy. Wiley, New York 1988
Derome A. E.: Modern NMR Techniques for Chemistry Research. Pergamon Press, Oxford 1987
Pretsch E., Buhlmann B., Affolter C.: Structure Determination of Organic Compounds. Tables of Spectral Data. Springer Verlag, Berlin 2000
Breitmaier E.: Vom NMR-Spektrum zur Strukturformel organischer Verbindungen. B. G. Teubner, Stuttgart 1992.
Breitmaier E.,Voelter W.: Carbon13 NMR Spectroscopy VCH Weinheim1990 

TitleWater PretreatmentCodeÚCHV/ATV1/04TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo allow students to obtain and improve their knowledge of the methods of water pretreatment.ContentPurification of waste waters from colloid substances. Purification of waste waters by chemical precipitation. Water degasing. Ion exchange purification of waste waters. Adsorption methods of waste water purification. Waste water purification via extraction. Waste water purification by membrane methods. Biological purification of water. Prerequisite coursesÚCHV/CHHS/07 orÚCHV/ANCH1b/03Recommended reading Handbook of Water and Wastewater Treatment Technologies. Ed. By Nicholas P. Cheremisinoff, BUTTERWORTH HEINEMANN, 576 p. 2001
Principles of Water Quality Control, Ed. by Thy Tebbutt, BUTTERWORTH HEINEMANN, 288 p. 1997
Water Technology. Ed. by N. F. Gray, BUTTERWORTH HEINEMANN, 600 p. 2005
TitleColloid ChemistryCodeÚCHV/FKC1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo clarify basic physicochemical principles of colloid disperse systems (sise of dispersed particles); to examine selected important problems of technology and nature.ContentClassification and characterisation of dispersed systems. Heterogeneity of colloidal systems. Optical properties of colloids. Theory of light scattering. Molecular-kinetic properties. Brownian motion, diffusion, osmosis, and sedimentation. Adsorption-basic concepts. Electrokinetic phenomena and their application. Structure, stability and coagulation of colloids. Rheology of dispersed systems. Gels. Aerosols. Solid dispersions, emulsions and foams. Application of theory during laboratory and calculation exercises.Alternate coursesÚCHV/FKC1/99ÚCHV/FKC1/00Recommended reading Moore W. J.: Physical Chemistry. Longman, London, 1972.
Hiemenz P. C.: Principles of Colloid and Surface Chemistry. M. Dekker, New York, 1986
Atkins P. W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002 

TitleSpecial SeminarCodeÚCHV/VSE1b/04TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students theses.

TitleForensic and Clinical Analytical ChemistryCodeÚCHV/SKACH1/06TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester8, 10T/L methodLecture, PracticalContentBasic principles and definition of subject. Toxicology: classification of toxic and foreign substances. Drugs of abuse, doping agents, chemical harmful agents, and their metabolisms and analyses, application of analytical methods for the before-mentioned chemicals in human matrices.Alternate coursesÚCHV/SKACH1/03Recommended reading A. Mozayani, C.Noziglia: The Forensic Laboratory Handbook. Procedures and Practice, Springer, 2006
J.H.Duffus, H.G.J.Worth: Fundamental Toxicology, Springer, 2006
R.Bertholf, R.Winecker: Chromatographic Methods in Clinical Chemistry and Toxicology, Wiley. 2007

Study programme Biochemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚCHV/BFC1a/01Biophysical Chemistry I52/2Examination1/1ÚCHV/BMB1/03Modern Trends in Biochemistry and Molecular Biology63/1Examination1/1ÚCHV/DPCO1a/00Diploma Work2-/-Recognition1/1ÚCHV/DPCO1b/00Diploma Work6-/-Recognition1/2ÚCHV/EMDP/03Experimental Methods for Master’s Thesis6-/6Assessment1/2ÚCHV/KLB1/03Clinical Biochemistry52/1Examination1/2ÚCHV/PAT1/03Patobiochemistry72/3Examination1/2ÚCHV/BFC1b/03Biophysical Chemistry II82/4Examination1/2ÚCHV/DPCO1c/03Diploma Work8-/-Recognition2/3ÚCHV/SDP/03Seminar on Diploma Work2-/2Assessment2/3ÚCHV/DPCO1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚCHV/BCM/04Biochemistry of Micro-organisms62/2Examination1/1ÚCHV/PBT1/03Biotechnology Practical6-/5Assessment1/1ÚCHV/BFP/04Biochemistry of Physiological Processes83/3Examination1/2ÚCHV/ENZ/04Enzymology53/-Examination1/1, 2/3ÚCHV/BBA1/03Bioenergetics and Bioelectronics53/-Examination2/3ÚCHV/PSF/03Proteins: Structure and Function53/-Examination2/3
Elective courses

ÚCHV/BAM1/00Biochemical Analytical Methods42/1Examination1/1ÚCHV/BOC/03Bio-organic Chemistry53/-Examination1/1, 2/3ÚCHV/XBCH/03Xenobiochemistry53/-Examination1/2ÚCHV/SVK/03Student Scientific Conference4-/2Assessment1/2, 2/4ÚCHV/VPC/01PC in Biomacromolecule Analysis42/1Examination2/3

Course units

Compulsory courses

TitleBiophysical Chemistry ICodeÚCHV/BFC1a/01TeacherPodhradský Dušan, Antalík MariánECTS credits5Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalContentMatter and its demonstration in living systems. Space and time connections in biological systems. Energy and mass connections in biological systems. Physicochemical properties of water and cell liquids. Reaction kinetics. Ligand binding. Nonequilibrium thermodynamics. Dynamics of conservative systems; chaos. Dissipative systems; attractors. Stability of biomacromolecules. Interfaces and membranes; membrane transports. Dynamics of complex biochemical process. Structuralisation of biosystems induced by diffusion.Alternate coursesÚCHV/BFC1a/00Recommended reading Cantor,C.R.,Schimmel, P.R Biophysical Chemistry, W.H. Freeman and Co., S. Francisco,1980
P.Glansdorff, I.Prigogine, Thermodynamics theory of structure, stability and fluctuations, Willey 1971
Voet,D. Voet, J.G. Biochemistry, John Willey @Sons, 1990
Kersal E. van Holde, W. Curtis Johnson, P. Shing Ho: Principles of Physical Biochemistry, Prentise Hall, 1998
Articles from Journals

TitleModern Trends in Biochemistry and Molecular BiologyCodeÚCHV/BMB1/03TeacherPodhradský Dušan, Víglaský Viktor, Pristaš Peter, Javorský PeterECTS credits6Hrs/week3/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo give students an overview of modern biochemistry and molecular biology methods and their application in practice.ContentApplication of modern biochemistry and molecular biology methods for gene analysis, quantification of gene expression, nanotechnology and biotechnology.

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1T/L methodObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.Recommended reading According to the approved setting of diploma work.

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments for experimental part of diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Automatic rerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits8Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4ObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleBiophysical Chemistry IICodeÚCHV/BFC1b/03TeacherSedlák Erik, Podhradský Dušan, Antalík MariánECTS credits8Hrs/week2/4AssessmentExaminationSemester3T/L methodLecture, PracticalContentGeneral laboratory work on problems with biological systems: Properties of materials and fields; cryoscopy, pressure, density, surface tension, osmometry; callorimetry, microgravimetry; transport and hydrodynamic analysis; conductivity, ion selective and enzyme electrodes, dielectric spectroscopy; absorption spectroscopy, circular dichroism; Raman and infrared spectroscopy,; spectrofluorescence, chemiluminescence, rapid kinetic techniques; Mossebauer spectroscopy;
NMR, EPR spectroscopy; light, x-ray scattering; atomic field force measurements, tunneling spectroscopy; microscopy (electron, light, ultrasound).Prerequisite coursesÚCHV/BFC1a/01Recommended reading Cantor,C.R.,Schimmel,P.R Biophysical Chemistry, W.H. Freeman and Co., S. Francisco,1980
Kersal E. van Holde, W. Curtis Johnson, P. Shing Ho: Principles of Physical Biochemistry, Prentise Hall, 1998
Atkins PW. Physical Chemistry, Oxford Univ. Press, Oxford, 1998
Hoppe W, Lohmann W, Markl H, Ziegler H (ed.) Biophysics, Springer- Verlag, Berlin, 1983
Articles from Journals

TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.
Recommended reading According to field of diploma work.
Compulsory elective courses

TitleBioenergetics and BioelectronicsCodeÚCHV/BBA1/03TeacherPodhradský Dušan, Antalík MariánECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureContentCell metabolism, ATP, polyphosphates. Electron transport chain, mitochondria, chloroplast, chemoautotrops
Photosynthesis, bacteriorodopsin. Oxidative phosphorylation, chemical gradient. ATPases
Membrane transport. ATP metabolism. Electron transport in biomacromolecules. Electric sources, battery. Organic electric materials. Photolysis of water. Organic a biological memories
Molecular films, nanotechnology, Integrated system between neurons and electronics.
Recommended reading Voet,D. Voet,J.G. Biochemistry,
Articles from Journals

TitleBiochemistry of Micro-organismsCodeÚCHV/BCM/04TeacherPodhradský Duaan, Ko~urková MáriaECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalContentStructure, physiology and control of micro-organisms; extremophiles; nitrogen-fixing bacteria, nitrogen cycle, nitrification; microbial genetics; medical microbiology; immunology and applied microbiology; biofilms.Recommended reading McCall D., Stock D., Achrey P., Introduction to Microbiology, Blackwell Science, USA, 2001

TitleBiochemistry of Physiological ProcessesCodeÚCHV/BFP/04TeacherPodhradský Dušan, Antalík Marián, Tomášková NatašaECTS credits8Hrs/week3/3AssessmentExaminationSemesterT/L methodLecture, PracticalContentCell cycle; regulation mechanism of embryogenesis; apoptosis and degradation of biomacromolecules; regeneration processes; biochemical specialisation of inner cell particles; specialisation of body organs; metabolic functions of the liver and the kidney; the endocrine system, hormones; second messengers; generation and conduction of action potentials; synaptic transmission; immune system; blood sedimentation rate; communication between organisms; symbiosis; ecology.Recommended reading D.Voet, J.G. Voetová, Biochemie, Viktoria Publishing, Praha, 1994
Alberts at al.., Molecular Biology of The Cell, 3rd edition, Garland Publishing, NY.1994H. Tedeshi, Cell Physiology, www.cellphysiology.com; article in science journals.

TitleEnzymologyCodeÚCHV/ENZ/04TeacherSedlák Erik, Podhradský Dušan, Györyová KatarínaECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo teach students to use the basic equations of enzyme kinetics. To have students develop the ability to determine basic kinetic and thermo-dynamic parameters of enzyme catalyzed reaction.ContentIntroduction. Chemical catalysis: theory of transition state. Enzyme catalysis: types and examples. Cofactors. Active site: lock and key; induced fit. Enzymes: classification. 3D structure of proteins. Noncovalent interactions. Secondary, tertiary and quaternary structures. Convergent and divergent evolution. Multienzyme complexes. Dynamics of proteins. Ligand binding. Thermodynamics and kinetics. Techniques. Chemical kinetics. Basic equations of enzyme kinetics.
Regulations of enzyme activity: examples. Conformational change; allosteric regulation. Regulation of metabolic pathways. Experimental determination of enzyme activity. pH and temperature dependence of enzyme catalysis. Determination of individual rate constants. Stop flow. Enzyme-substrate complementarities and the use of binding energy in enzyme catalysis. Reversible inhibition. Irreversible inhibition. Specificity and control mechanisms. „Moonlighting“ enzymes. Applic-ations of enzymes (organic solvents). Catalytic antibodies. Extremo-philes. Directed selection of enzymes. Enzymatic reactions with multiple substrates.Recommended reading Alan Fersht “Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. “ (3rd Ed. W. H. Freeman and Company, 1999)
Robert A. Copeland: Enzymes (2nd edition), Wiley-VCH, 2000.

TitleBiotechnology PracticalCodeÚCHV/PBT1/03TeacherECTS credits6Hrs/week-/5AssessmentAssessmentSemesterT/L methodPracticalContentAlcoholic fermentation. Milk fermentation. Pectin as a gellic agent: its alcalimetric determination. Preservative food additives. Paper chromato-graphy of aminoacids. Antibiotics: bacteriocines. Antioxidation effect of vitamin C. Preparation of drugstore.Recommended reading M.Feren
ík, B. `kárka, Biochemical laboratory methods, ALFA 1981
C.Fini, A.Floridi, V.N. Finelli, B.Wittman-Liebold, Laboratory Methodology in Biochemistry, CRC Press, Florida, 1990

TitleProteins: Structure and FunctionCodeÚCHV/PSF/03TeacherSedlák Erik, Podhradský DušanECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo develop students’ ability to suggest/use suitable methods for determination of structural and functional properties of proteins.ContentChemical properties of polypeptides. Detection of amino acids, peptides and proteins. Biosynthesis of proteins: procaryotes. Biosynthesis of proteins: eucaryotes. Topogenesis. Protein folding. Post-translational covalent modifications of polypeptide chains. Physical interactions determining the properties of proteins. Conformational properties of polypeptide chains. Proteins in solution and in membranes. Interactions with other molecules. Allostery. Degradation. Extremophiles.Recommended reading T.E. Creighton: Proteins - structures and molecular properties, 1993, W.H. Freeman and Company - New York.
Alan Fersht: Structure and mechanism in protein science, W.H. Freeman and Company, New York, 1999.
Robert A. Copeland: Enzymes (2nd edition), Wiley-VCH, 2000.
Elective courses

TitleBio-organic ChemistryCodeÚCHV/BOC/03TeacherGonda JozefECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo teach students the fundamental principles for the construction of bioorganic molecular models of biochemical processes using the tools of organic chemistry.ContentIntroduction: Basic considerations; proximity effects in biochemistry, Molecular adaptation. Molecular recognition at the supramolecular level. Bio-organic chemistry of amino acids and polypeptides: chemistry of the living cells, Analoguey between organic reactions and biochemical tranformations, Chemistry of the peptide bond: nonribosomal peptide formation, asymmetric synthesis of amino acids, asymmetric synthesis with chiral organometalic catalysts, Transition state analogues. Antibodies as enzymes. Chemical mutations. Molecular recognition and drug design. Bio-organic chemistry of the phosphate groups and polynucleotides:d energy storage, DNA intercalates, RNA molecules as catalysts. Enzyme chemistry: introduction to catalysis and enzymes, Multifuntional catalysis and simple models. Alpha-chymotrypsin. Other hydrolytic enzymes. Strereoelectronic control in hydrolytic reactions. Immobilised enzymes. Enzymes in synthetic organic chemistry. Enzyme-Analogue-Built polymers. Design of molecular clefts. Enzyme Models: host-guest complexation chemistry, New developments in crown ether chemistry, Membrane chemistry and micelles. Polymers. Cyclodextrins. Enzyme design using steroid template. Remote functionalisation reactions. Polyene biomimetic cyclisations. Metal Ions: in proteins and biological molecules. Carbopeptidase A. Hydrolysis of amino acid esters and peptides. Iron and oxygen transport. Cooper ion. Cobalt and vitamin B12 action. Oxidoreduction. Pyridoxal phosphate. Biotin.Recommended reading Voet J.: Biochemistry, Springer Verlag, 1998
Dugas H.: Bioorganic Chemistry, Springer Verlag, 1999.

TitlePC in Biomacromolecule AnalysisCodeÚCHV/VPC/01TeacherPristaš Peter, Podhradský DušanECTS credits4Hrs/week2/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo have students perform analysis of nucleotide and amino acid sequences with personal computers (PC) and free software (BioEdit, Prophet, GeneDoc, RasMol, VNTI-Viewer) and web-based analysis tools (blast, fasta, clustal). To introduce students to public biological databases (PubMed, GenBank, SwissProt) and data mining. To teach methods of specialised analysis: molecular taxonomy, phylogenetic analysis, prediction of biopolymer structureContentUsage of PC and WWW network for biological sequence analysis. History of the Internet, FTP, E-mail services. Freely available biological and biomedicinal databases (PubMed, GenBank, SwissProt). Nucleotide sequence analysis. Protein sequence analysis. Pairwise sequence comparisons: blast software. Multiple sequence comparisons: clustal software. Molecular taxonomy of bacteria. Evolutionary and phylogenetic analysis. Secondary and tertiary structure prediction.

TitleXenobiochemistryCodeÚCHV/XBCH/03TeacherPodhradský Dušan, Györyová Katarína, Sabolová DanicaECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureContentBasic characterisation of xenobiochemistry and xenobiotics. Toxines, pesticides and artificial agents in food. Medicines: their division and characterisation. Metabolism of strange matter in the liver. Categories of biotransformation. Oxygen and its reactive forms. Peroxizomes and the mechanism of oxidation harm. Peroxidation of lipids. Influence of hard metal ions on animal texture. Hemoproteine P 450. Recommended reading Z. ura
ková: Vo>né radikály a antioxidanty v medicíne, Slovak akademik press 1998
Z.Vodrá~ka : Biochémia, Academic Press Praha, 1992
Study programme Bioorganic Chemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚCHV/BOC/03Bio-organic Chemistry53/- Examination1/1 ÚCHV/DPCO1a/00Diploma Work2-/- Recognition1/1 ÚBEV/CYTF/03Cytology43/- Examination1/1 ÚCHV/DPCO1b/00Diploma Work6-/- Recognition1/2 ÚCHV/DPCO1c/03Diploma Work8-/- Recognition2/3 ÚCHV/SDP/03Seminar on Diploma Work2-/2 Assessment2/3 ÚCHV/DPCO1d/03Diploma Work30-/- Recognition2/4 
Compulsory elective courses

ÚCHV/KOC1/01Quantum Chemistry53/1 Examination1/1 ÚCHV/OS/03Organic Synthesis52/1 Examination1/1, 2/3 ÚCHV/FMCH/04Medicinal Chemistry63/1 Examination1/1 ÚCHV/TOXOL/03Toxicology of Organic Compounds43/- Examination1/1 ÚCHV/MM1/00Molecular Modelling41/3 Assessment1/1, 2/3 ÚCHV/ENZ/04Enzymology53/- Examination1/1, 2/3 ÚCHV/FAK1a/07Pharmacology I42/2 Assessment1/2 ÚCHV/SAL/06Synthesis and Analysis of Drugs63/1 Examination1/2 ÚCHV/ZCI/04Basic Cheminformatics Tools22/1 Examination1/2 ÚCHV/PATF/03Patobiochemistry32/- Examination1/2 ÚCHV/NCH/03Neurochemistry52/1 Examination1/2 ÚCHV/NMR1/001D & 2D NMR Spectroscopy62/3 Examination1/2 ÚBEV/MB1/01Molecular Biology43/- Examination1/2 ÚCHV/SVK1/00Student Scientific Conference 4-/- Assessment1/2, 2/4 ÚCHV/FAK1b/07Pharmacology II62/2 Examination2/3 ÚCHV/BACH1/03Bioanalytical Chemistry52/1 Examination2/3 ÚBEV/NFYZ/07Neurophysiology32/- Examination2/3 ÚCHV/HZ1/00Heterocyclic Compounds42/1 Examination2/3 ÚBEV/BTR1/06Plant Biotechnology62/3 Examination2/3 ÚCHV/STA1/03Structure Analysis62/2 Examination2/3 
Elective courses

ÚCHV/KC/03Cosmetic Chemistry42/1 Examination1/1 ÚBEV/IMUF/03Immunology32/- Assessment1/1 ÚCHV/BFP/04Biochemistry of Physiological Processes83/3 Examination1/2 ÚBEV/NAT/06Neuroanatomy41/2 Examination1/2 ÚCHV/CMG/03Chemical Management53/- Examination2/3 ÚCHV/PCH1/00Food Chemistry42/1 Examination2/3 ÚBEV/LR1/03Healing Plants32/- Examination2/3 
Course units

Compulsory courses

TitleBio-organic ChemistryCodeÚCHV/BOC/03TeacherGonda JozefECTS credits5Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo teach students the fundamental principles for the construction of bioorganic molecular models of biochemical processes using the tools of organic chemistry.
ContentIntroduction: Basic considerations; proximity effects in biochemistry, Molecular adaptation. Molecular recognition at the supramolecular level. Bio-organic chemistry of amino acids and polypeptides: chemistry of the living cells, Analoguey between organic reactions and biochemical tranformations, Chemistry of the peptide bond: nonribosomal peptide formation, asymmetric synthesis of amino acids, asymmetric synthesis with chiral organometalic catalysts, Transition state analogues. Antibodies as enzymes. Chemical mutations. Molecular recognition and drug design. Bio-organic chemistry of the phosphate groups and polynucleotides:d energy storage, DNA intercalates, RNA molecules as catalysts. Enzyme chemistry: introduction to catalysis and enzymes, Multifuntional catalysis and simple models. Alpha-chymotrypsin. Other hydrolytic enzymes. Strereoelectronic control in hydrolytic reactions. Immobilised enzymes. Enzymes in synthetic organic chemistry. Enzyme-Analogue-Built polymers. Design of molecular clefts. Enzyme Models: host-guest complexation chemistry, New developments in crown ether chemistry, Membrane chemistry and micelles. Polymers. Cyclodextrins. Enzyme design using steroid template. Remote functionalisation reactions. Polyene biomimetic cyclisations. Metal Ions: in proteins and biological molecules. Carbopeptidase A. Hydrolysis of amino acid esters and peptides. Iron and oxygen transport. Cooper ion. Cobalt and vitamin B12 action. Oxidoreduction. Pyridoxal phosphate. Biotin.
Recommended reading Voet J. : Biochemistry, Springer Verlag, 1998
Dugas H.: Bioorganic Chemistry, Springer Verlag, 1999.

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1ObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.Recommended reading According to the approved setting of diploma work.

TitleCytologyCodeÚBEV/CYTF/03TeacherMišúrová EvaECTS credits4Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students with knowledge of basic principles of microscopic and submicroscopic cell structure and function.ContentLevels of living system organisation. Characteristics and comparison of prokaryotic and eukaryotic plant and animal cells. Microscopic, submicroscopic and molecular structure and function of individual cell components. Nuclei and cell division.Alternate coursesÚBEV/CYT1/02Recommended reading Alberts, B., Bray, D., Lewis, J. et al.: Molecular Biology of the Cell. Garland Publishing Inc., New York, London, 1994

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments required for diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Automatic rerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits8Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.Recommended reading According to field of diploma work.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4ObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.
Compulsory elective courses

TitleQuantum ChemistryCodeÚCHV/KOC1/01TeacherDanihel IvanECTS credits5Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo have students improve their knowledge in the field of valence-bond based on molecular orbital theory (MO) and individually to perform basic quantum chemical calculations (molecular geometry optimisation, transition states, vibrational analysis, etc.). ContentDevelopment of valence-bond theory. Time-independent Schrodinger equation. Basic approximations in molecular orbital valence-bond theory. Variant methods of calculation in the framework of molecular orbital valence-bond theory. Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction coordinate. Calculation of absolute and relative equilibrium and rate constants in gas phase. Solvatation energy calculation.Alternate coursesÚCHV/KOC1/99 orÚCHV/KOC1/00Recommended reading Jensen F.: Introduction to Computational Chemistry, Wiley,2000
Leach A.R.: Molecular Modelling, Addison Wesley Longman Ltd. 1998
Náray-Szabó G., Surján P.R., Ángyán J.G.: Applied Quantum
Chemistry, Akadémia Kiadó, Budapest, 1987 
TitleOrganic SynthesisCodeÚCHV/OS/03TeacherKutschy PeterECTS credits5Hrs/week2/1AssessmentExaminationSemester1,3T/L methodLecture, PracticalObjectiveTo teach students the most important methods for the synthesis of organic compounds, their combination and application in the synthesis of complex molecules.ContentFormation of carbon-carbon single and double bonds. Synthesis of main groups of organic compounds (halogen derivatives, oxygen, nitrogen and sulphur containing compounds). Transformation and protection of functional groups. Retrosynthetic analysis.Recommended reading Carruthers W., Coldham I.: Modern Methods of Organic Synthesis, Fourth Edition, Cambridge University Press, 2005
Comprehensive Organic Synthesis Trost B. M., Fleming I., Eds., Vol. 1-9, Pergamon Press, Oxford, 1991

TitleMedicinal ChemistryCodeÚCHV/FMCH/04TeacherKutschy PeterECTS credits6Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students the basic principles involved in the research and development of chemical drugs. To develop student understanding of structure-activity relationships including space structure and chirality and their consequences on chemical and physico-chemical properties influencing biological activity. To familiarise students with the present state in the field of selected important groups of drugs, such as antibacterial, antiviral or antitumor drugs.ContentIntroduction. Classification of drugs. Factors influencing design and activity of drugs of the third generation. Drug chirality. Search for new drugs. Structure-activity relationships. Chemotherapeutics of central, peripheral and vegetative nervous system. Antibacterial compounds, antibiotics, antitumor compounds, antiviral compounds. Recommended reading Medicinal Chemistry: Principles and Practice, King F. D., Ed., The Royal Society of Chemistry, Thomas Graham House, Cambridge, 1994.
Advances in Drug Discovery Techniques: Harvey A. L., Ed., Wiley & Sons, Chichester, 1998
Thomas G.: Medicinal Chemistry: An introduction. John Willey & Sons, 2000

TitleToxicology of Organic CompoundsCodeÚCHV/TOXOL/03TeacherMartinková MiroslavaECTS credits4Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo examine the interaction between chemicals and biological systems in order for students to quantitatively determine the potential for chemicals to produce harmful effects in living organisms.ContentGeneral principles of toxicology. Absorption, distribution and excretion of toxicants. Biotransformation of xenobiotics: phase-1 reactions (oxidation, reduction, hydrolysis), phase-2 reactions (conjugation reactions). Toxication versus detoxication. Toxic effects of organic solvents. Toxicology of chemical warfare agents. Neurotoxicology. Toxic effects of plants and animal poisons. Toxic effects of drugs (barbiturates, benzodiazepines, tricyclic antidepressants). Drug dependence. Recommended reading C. D. Klaassen: Casaret and Doull`s Toxicology: The basic science of poisons, McGraw-Hill Companies, Inc., 2001

TitleMolecular ModellingCodeÚCHV/MM1/00TeacherTörök MarcelECTS credits4Hrs/week1/3AssessmentAssessmentSemester1, 3T/L methodLecture, PracticalObjectiveTo teach students the basic skills and theory necessary for the realisation of computational experiments in chemistry using specialised software packages. Students will be able to perform theoretical studies of the structure and electronic properties of small and middle-sised molecules and study the thermodynamical and structural aspects of chemical reactions. ContentBasic concepts. Reality vs. model: quantum mechanical models I, quantum mechanical models II, quantum mechanical models III, empirical force field models I, empirical force field models II, solvation models. Methods for exploring the energy surface: conformational analysis of molecules I, conformational analysis of molecules II. Exploring of the reaction pathways. Molecular dynamics and computer simulations. Overview of the software tools for molecular modelling., Presentation of the seminar project.Recommended reading LEACH, Andrew R.: Molecular Modelling: Principles and Applications.
JENSEN, Frank: An Introduction to Computational Chemistry.
Manuals for MOPAC, HYPERCHEM, GAMESS, GAUSSIAN.

TitleEnzymologyCodeÚCHV/ENZ/04TeacherSedlák ErikECTS credits5Hrs/week3/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo teach students to use the basic equations of enzyme kinetics. To have students develop the ability to determine basic kinetic and thermo-dynamic parameters of enzyme catalyzed reaction.ContentIntroduction. Chemical catalysis: theory of transition state. Enzyme catalysis: types and examples. Cofactors. Active site: lock and key; induced fit. Enzymes: classification. 3D structure of proteins. Noncovalent interactions. Secondary, tertiary and quaternary structures. Convergent and divergent evolution. Multienzyme complexes. Dynamics of proteins. Ligand binding. Thermodynamics and kinetics. Techniques. Chemical kinetics. Basic equations of enzyme kinetics.
Regulations of enzyme activity: examples. Conformational change; allosteric regulation. Regulation of metabolic pathways. Experimental determination of enzyme activity. pH and temperature dependence of enzyme catalysis. Determination of individual rate constants. Stop flow. Enzyme-substrate complementarities and the use of binding energy in enzyme catalysis. Reversible inhibition. Irreversible inhibition. Specificity and control mechanisms. „Moonlighting“ enzymes. Applic-ations of enzymes (organic solvents). Catalytic antibodies. Extremo-philes. Directed selection of enzymes. Enzymatic reactions with multiple substrates.Recommended reading Alan Fersht: “Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. “ (3rd Ed. W. H. Freeman and Company, 1999)
Robert A. Copeland: Enzymes (2nd edition), Wiley-VCH, 2000

TitleSynthesis and Analysis of DrugsCodeÚCHV/SAL/06TeacherGondová Taeána, Kutschy PeterECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the most important methods used in drug synthesis and the application of physico-chemical methods for analysis, control and purity determination of drugs.ContentApproaches used in the drug synthesis: chiral drug synthesis, disconnection approach, combinatorial synthesis. Methods for analysis, control and purity determination of drugs.Recommended reading Advances in Drug Discovery Techniques: Harvey A. L., Ed., Wiley & Sons, Chichester, 1998
Thomas G.: Medicinal Chemistry: An introduction. John Willey & Sons, 2000
Ahuja S., Scypinski S., Eds.: Separation Science and Technology, Vol. 3, Handbook of Modern Pharmaceutical Analysis, Academic Press, 2001

TitleBasic Cheminformatics ToolsCodeÚCHV/ZCI/04TeacherTörök MarcelECTS credits2Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo introduce students to the fundamental informatics techniques for chemistry-related disciplines: representation and use of chemical structure information, computer-aided drug design, 3D visualisation and computation, and handling of large volumes of chemical information.ContentRepresenting 2D structures. 2D chemical database applications. Advanced 2D descriptors. Representing 3D structures. 3D visualisation and computation. Laboratory information management systems. Electronic laboratory notebooks. Chemical informatics software development. Emerging web service technologies for chemical informatics.Recommended reading Johann Gasteiger & Thomas Engel (eds.), Chemoinformatics: A Textbook. Wiley-VCH, Weinheim, 2003
Andrew Leach & Valerie Gillet, An Introduction to Chemoinformatics. Kluwer Academic Publishers, Dordrecht, NL, 2003

TitleNeurochemistryCodeÚCHV/NCH/03TeacherMartinková MiroslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the fundamental principles of chemical transmission between nerve cells; to have students understand the necessary link between neuroanatomy and neurochemistry.ContentNeurocellular anatomy - characteristics of the neuron. Cell membrane structures: phospholipid bilayer, membrane proteins, brain lipids, brain lipids biosynthesis. Membrane transport and ion channels. Synaptic transmission and cellular signaling. Neurotransmitters: acetylcholine, catecholamines, serotonin, amino acids (glutamate, aspartate, GABA, glycine). Neuropeptides: neuropeptide functions and regulation. G-proteins; the second-messenger hypothesis (cAMP, IP3, DAG, Ca2+). Neurotransmitters and disorders of the basal ganglia. Endocrine effects on the brain and their relationship to behaviour. Recommended reading G. J. Siegel, B. W. Agranoff, R. W. Albers, S. K. Fisher, M. D. Uhler: Basic neurochemistry, Lippincott Williams and Wilkins, Philadelphia 1999.

Title1D & 2D NMR SpectroscopyCodeÚCHV/NMR1/00TeacherImrich JánECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students how to analyse the structure and properties of organic, inorganic and biomolecular compounds by 1D and 2D proton and carbon NMR spectra, quantitative NMR analysis, and practical applications in various fields of science and technology.ContentTheoretical principles of nuclear magnetic resonance (NMR), basic NMR pulse techniques and Fourier transformation, NMR spectrometers, description of NMR by vector models. Parameters of one- (1D) and two-dimensional (2D) NMR spectra, practical application of 1H and 13C NMR spectra and basic correlated 2D spectra for structure and stereo chemical arrangement, elucidation of reaction mechanisms, molecular dynamics, physico-chemical properties and quantitative analysis of chemical compounds.Alternate coursesÚCHV/NMR1/99Recommended reading Friebolin H.: Basic One- and Two-Dimensional NMR Spectrocopy, Verlag Chemie, Weintheim 1993
T.D.W. Claridge: High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 1999
Atta-ur-Rahman, M. I. Choudhary: Solving Problems with NMR spectroscopy, Academic Press 1996
H.-O. Kalinowski, S. Berger, S. Braun: Carbon-13 NMR Spectroscopy. Wiley New York, 1988
A. E. Derome: Modern NMR Techniques for Chemistry Research. Pergamon Press Oxford, 1987
E. Pretsch, B. Buhlmann, C. Affolter: Structure Determination of Organic Compounds. Tables of Spectral Data. Springer Verlag Berlin, 2000
E. Breitmaier: Vom NMR-Spektrum zur Strukturformel organischer Verbindungen. B. G. Teubner Stuttgart 1992.
E.Breitmaier, W.Voelter:Carbon13 NMR Spectroscopy. VCH Weinheim 1990 

TitleMolecular BiologyCodeÚBEV/MB1/01TeacherSolár PeterECTS credits4Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide the students with knowledge of molecular basis of inheritance and control of gene expression and development.ContentStructure and properties of information macromolecules. Molecular mechanisms of DNA replication and repair, transcription and translation. Prokaryotic and eukaryotic genome. Control of gene expression in prokaryotes and eukaryotes. Control of cell cycle.Recommended reading Lodish, H., Baltimore, D., Berk, A. et al.: Molecular Cell Biology. Sci. Amer. Books Inc., W.H. Freeman and Company, New York, 1995
Myers, R.A.: Molecular Biology and Biotechnology. VCH Publishers Inc., New York, 1995

TitleBioanalytical ChemistryCodeÚCHV/BACH1/03TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo impart theoretical knowledge and to give practical experience to students about the application of analytical chemistry and analytical methods to clinical chemistry, clinical biochemistry, haematology, microbiology and immunology.ContentIntroduction to bioanalytical chemistry. Biological sample; classification. Sampling techniques, transport, sample storing and conservation. Selected methods of sample pre-treatment for bio- analysis. Conditions for analytical method selection. Presentation of analytical data evaluation. Optimisation of analytical procedure. Control and management of quality in clinical laboratory. Molecules colouring and their analytical applications. Enzymes in bioanalysis. Immunochemical methods. Microbiological methods. Analysis
of biomolecules separation methods selection. Analytical technique of miniaturisation: principle, microchips, biosensors.Recommended reading Mikkelsen S.R, Cortón E.: Bioanalytical Chemistry, Wiley, 2004
Wilson I., Bioanalytical Separations 4, (Handbook of Analytical Separations), Elsevier, 2003

TitleHeterocyclic CompoundsCodeÚCHV/HZ1/00TeacherKutschy PeterECTS credits4Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students basic information about the occurrence, practical significance, synthesis, and chemical and biological properties of heterocyclic compounds.ContentPreparation and properties of various types of heterocycles. Attention will be paid to aromatic and non-aromatic compounds, including their biological properties and application in organic synthesis. Recommended reading Gilchrist T.L.: Heterocyclic Chemistry, Longman Harlow 1992
Eichler T., Hauptmann S.: The Chemistry of Heterocycles. Structure, Reactions, Synthesis and Application. Second Edition, WILEY-VCH, Weinheim, 2003

TitleStructure AnalysisCodeÚCHV/STA1/03Teacher ernák JurajECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo teach students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal structure determination and how to use the results of the crystal structure analysis in their own work.ContentHistorical introduction: importance of diffraction methods. Origin and properties of x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations. Reciprocal space; Ewald construction. Single crystal diffraction methods; automatic diffractometers. Powder diffraction: Debye-Scherrer and diffractometric methods, their theory and use. Atomic factor, structure factor, electronic density and their relationship. The phase problem: overview of the methods for solving the phase problems. Refinement of the structure; geometric parameters. Crystallisation processes; methods of preparation of single crystals. Density. Basic inorganic structure types.Recommended reading Clegg W.: Crystal Structure Determination, Oxford University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals. Walter de Gruyter, Berlin, 1980

TitlePlant BiotechnologyCodeÚBEV/BTR1/06Teacher ellárová EvaECTS credits6Hrs/week2/3AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo give students theoretical and practical knowledge of plant tissue culture in vitro.ContentGenetics and physiology of plant cell and tissue culture, protoplasts, embryoids and organs cultured in vitro under sterile conditions. Use of tissue culture in research and praxis. Cryopreservation of plant cells and tissues. Immobilised plant systems. Genetic transformation of plants and expression of foreign genes.Recommended reading Dodds, J. H. and Roberts, L. W.: Experiments in Plant Tissue Culture. Cambridge University Press, 1985
Periodicals and Internet sources
Elective courses

TitleCosmetic ChemistryCodeÚCHV/KC/03TeacherMartinková MiroslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students the chemical ingredients in cosmetic products.ContentThe basic ingredients in the cosmetic products. Cosmetic lipids. Proteins, amino acids, AHA, tensides, antioxidants, dyes, preservatives. The chemistry of fragrances.
Recommended reading D. H. Pybus, Ch. S. Sell: The chemistry of fragrances, Royal Society of Chemistry, UK 1999
G. Ohloff: Scent and fragrances, Springer-Verlag 1990

TitleBiochemistry of Physiological ProcessesCodeÚCHV/BFP/04TeacherPodhradský Dušan, Antalík Marián, Tomášková NatašaECTS credits8Hrs/week3/3AssessmentExaminationSemester2T/L methodLecture, PracticalContentCell cycle; regulation mechanism of embryogenesis; apoptosis and degradation of biomacromolecules; regeneration processes; biochemical specialisation of inner cell particles; specialisation of body organs; metabolic functions of the liver and the kidney; the endocrine system, hormones; second messengers; generation and conduction of action potentials; synaptic transmission; immune system; blood sedimentation rate; communication between organisms; symbiosis; ecology.Recommended reading Literature:
D.Voet, J.G. Voetová, Biochemie, Viktoria Publishing, Praha, 1994
Alberts et al. Molecular Biology of The Cell, 3rd edition, Garland Publishing, NY.1994H. Tedeshi, Cell Physiology, www.cellphysiology.com; article in science journals.

TitleHealing PlantsCodeÚBEV/LR1/03TeacherRep
ák MiroslavECTS credits3Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo provide students knowledge of the principles of using healing plants and of the production of drugs.ContentHistory and present state. Pharmacotherapeutical and toxic effects of drugs. Active substances. Inheritance, chemotypes and breeding. Cultivation and post-harvest technology. Essential oil and extracts production. Special focus: claviceps, angelica, valeriana, drosera, levandula. digitalis, hypericum, althaea, calendula, silybum, chamomilla, arctostaphylos, melissa, mentha, hyssopus, thymus, salvia, agrimonia, rosa, tilia, achillea, plantago, panax and other tonic plants.Alternate coursesÚBEV/LR1/00Recommended reading Pahlow M.: Healing plants. New York 1993 







Study programme Chemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester


Compulsory courses

ÚCHV/DPCO1a/00Diploma Work2-/-Recognition1/1ÚCHV/DPCO1b/00Diploma Work6-/-Recognition1/2ÚCHV/EMDP/03Experimental Methods for Master’s Thesis6-/6Assessment2/3ÚCHV/DPCO1c/03Diploma Work8-/-Recognition2/3ÚCHV/SDP/03Seminar on Diploma Work2-/2Assessment2/4ÚCHV/DPCO1d/03Diploma Work30-/-Recognition2/4

Compulsory elective courses

Block – Bioinorganic Chemistry

ÚCHV/BAC1/04Bioinorganic Chemistry I52/1Examination1/1ÚCHV/STA1/03Structure Analysis62/2Examination1/1ÚCHV/KCH1/00Coordination Chemistry52/1Examination1/1ÚCHV/SAZ1/03Stereochemistry of Inorganic Compounds4-/3Assessment1/1ÚCHV/CTF1/00Solid State Chemistry52/1Examination1/1ÚCHV/ZTOX/04Basic Toxicology52/1Examination1/1ÚCHV/CMG1/04Chemical Management32/-Assessment1/2ÚCHV/NPC2/02Seminar on Advanced Inorganic Chemistry1-/1Assessment1/2ÚCHV/BAC2/05Bioinorganic Chemistry II52/1Examination1/2ÚCHV/MCV1/03Methods of Chemical Research42/1Examination1/2ÚCHV/NCH/03Neurochemistry52/1Examination1/2ÚBEV/MB1/01Molecular Biology43/-Examination1/2ÚCHV/TA1/03Thermal Analysis52/1Examination1/2ÚCHV/MAR1/04Mechanisms of Inorganic Reactions31/1Assessment1/2ÚCHV/OKKU/03Chemistry Organometals and Clusters42/1Examination1/2ÚCHV/SVK1/00Student Scientific Conference 4-/-Assessment1/2, 2/4ÚCHV/BAC3/04Bioinorganic Chemistry III52/1Examination2/3



Block – Physical and Analytical Chemistry

ÚCHV/ELD1/03Electrode Processes and Technology42/1Examination1/1ÚCHV/MMU/03Macromolecular Chemistry43/-Examination1/1ÚCHV/FKK1/03Kinetics and Catalysis42/1Examination1/1ÚCHV/KOC1/01Quantum Chemistry53/1Examination1/1ÚCHV/VSE1a/04Special Seminar2-/2Assessment1/1ÚCHV/CTF1/00Solid State Chemistry52/1Examination1/1ÚCHV/AAS1/03Atomic Spectrochemistry62/2Examination1/1ÚCHV/APO1/02Analysis of Psychotropic and Narcotic Substances42/-Examination 4 7ÚCHV/CHRA1/03Chromatographic Analysis62/2Examination1/1ÚCHV/PFCU/03Practical in Physical Chemistry4-/3Assessment1/1ÚCHV/BACH1/03Bioanalytical Chemistry52/1Examination1/1, 2/3ÚCHV/FEM/03Electroanalytical Methods62/2Examination1/1, 2/3ÚCHV/FEM1/03Electroanalytical Methods52/1Examination1/1, 2/3ÚCHV/STA1/03Structure Analysis62/2Examination1/1, 2/3ÚCHV/FKC1/03Colloid Chemistry42/1Examination1/2ÚCHV/FKC/00Colloid Chemistry Practical3-/3Assessment1/2ÚCHV/MCV1/03Methods of Chemical Research42/1Examination1/2ÚCHV/VSE1b/04Special Seminar2-/2Assessment1/2ÚCHV/ACM1/03Chemometrics52/2Examination1/2ÚCHV/FMP1/03Modelling of Physicochemical Processes42/1Examination1/2ÚCHV/APC1/03Practical Chromatography52/2Examination1/2ÚCHV/ATV1/04Water Pretreatment62/2Examination1/2ÚCHV/AVZ1/02Analytical Sampling 52/1Examination1/2ÚCHV/SVK1/00Student Scientific Conference 4-/-Assessment1/2, 2/4ÚCHV/AZP1/04Environmental Analytical Chemistry62/2Examination2/3ÚCHV/FOCHP1/04Corrosion and Surface Protection52/1Examination2/3ÚCHV/FVE1/04Selected Chapters on Electrochemistry62/2
Examination2/3

Elective courses

Block – Bioinorganic Chemistry

ÚCHV/BACH1/03Bioanalytical Chemistry52/1Examination1/1ÚCHV/FUMCH1/03Introduction to Material Chemistry52/1 Examination1/1,2/3ÚCHV/CHE2/03Chemical Excursion4-/1tAssessment1/2ÚCHV/PCH1/00Food Chemistry42/1Examination2/3
Block – Physical and Analytical Chemistry

ÚCHV/FUMCH1/03Introduction to Material Chemistry52/1Examination1/1, 2/3ÚCHV/AOL1/03Analysis of Organic Substances52/2Examination1/2ÚCHV/JCH1/04Nuclear Chemistry42/1Examination1/2ÚCHV/NMR1/001D & 2D NMR Spectroscopy62/3Examination1/2ÚCHV/TA1/03Thermal Analysis52/1Examination1/2ÚCHV/CMG/03Chemical Management53/-Examination2/3

Course units

Compulsory courses

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1ObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.Recommended reading According to the approved setting of diploma work.

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments required for diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Automatic rerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits8Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester4T/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.Recommended reading According to the field of diploma work.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4T/L methodObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.
Compulsory elective courses

TitleBioinorganic Chemistry ICodeÚCHV/BAC1/04TeacherReháková MáriaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentMetalic and non-metalic elements and their roles in biological systems (biometals, bulk biological elements, essential trace elements). Biocoordination compounds, bioligands. Biocatalyzers. Oxygen carriers and oxygen transport proteins. Photochemical process. Catalysis and regulation of bioenergetic processes by the alkaline earth metal ions. Calcium biominerals and biomineralisation. Toxic metals. Application of knowledge of bioinorganic chemistry in pharmacy, chemotherapy (e.g. platinum complexes in cancer therapy) radiodiagnostics, mineral biotechnology, and in other branches of life. Recommended reading Kaim W., Schwederski B.: Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life. Wiley, Chichester 1998.
Wilkins P. C., Wilkins R. G.: Inorganic Chemistry in Biology. OCP, Oxford 1997
Hay R. W.: Bio-inorganic Chemistry. John Wiley and Sons, New York 1989

TitleStructure AnalysisCodeÚCHV/STA1/03Teacher ernák JurajECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal structure determination and how to use the results of the crystal structure analysis in their own work.ContentHistorical introduction: importance of diffraction methods. Origin and properties of x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations. Reciprocal space; Ewald construction. Single crystal diffraction methods; automatic diffractometers. Powder diffraction: Debye-Scherrer and diffractometric methods, their theory and use. Atomic factor, structure factor, electronic density and their relationship. The phase problem: overview of the methods for solving the phase problems. Refinement of the structure; geometric parameters. Crystallisation processes; methods of preparation of single crystals. Density. Basic inorganic structure types.Recommended reading Clegg W.: Crystal Structure Determination, Oxford University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals. Walter de Gruyter, Berlin, 1980

TitleStereochemistry of Inorganic CompoundsCodeÚCHV/SAZ1/03Teacher ernák JurajECTS credits4Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalContentSymmetry, elements of symmetry, point groups, symmetrical properties of orbitals and bonds. Principles of stereochemistry, VSEPR, configuration of molecules, polyhedra, regular and semiregular polyhedra. Valence shells with 4 to 12 electron pairs, geometry of molecules and periodic system.Recommended reading Kepert, D. L.: Inorganic Stereochemistry. Springer-Verlag, Berlin, 1982.
Kettle, S. F. A.: Symmetry and Structure. John Wiley & Sons, New York, 1985.

TitleSolid State ChemistryCodeÚCHV/CTF1/00Teacher ernák Juraj, Tká
ová KláraECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge on the fundamentals and significance of solid state chemistry and of reaction in the solid state.ContentHistorical development of solid state chemistry and its significance for technological progress. General fundamentals and important properties of solids: ideal and real crystals, deformation of crystals, diffusion in solids. Non-catalysed reactions involving solids: thermal decomposition, surface oxidation, reaction between solids, chemical dissolution. The influence of non-equilibrium defects on the reactivity of solids. Generation of defects by various methods of treatment: rapid quenching, doping, irradiation, mechanical activation and low temperature decomposition.Alternate coursesÚCHV/CTF1/99Recommended reading West A.R.: Basic Solid State Chemistry, J. Wiley, Chichester, 1999.
Tká
ová, K.: Mechanical Activation of Minerals. Elsevier, Amsterdam, 1989. 

TitleBasic ToxicologyCodeÚCHV/ZTOX/04TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with knowledge of types of toxic substances and their metabolism and of the safe handling of toxic substances.ContentHistorical aspects. Types of toxic substances, types of exposure, dose-response relationship. Disposition of toxic compounds (absorption, distribution, excretion of toxic compounds). Metabolism of toxic compounds. Drugs as toxic substances, food additives and contaminants, environmental pollutants. Statement of chemistry laboratory policy. Safe handling of toxic substances.Recommended reading G. F.Fuhrman: Allgemeine Toxikologie fuer Chemiker, Teubner Verlag, Stutgart 1984
V. E. Forbes, T. L. Forbe: Ecotoxicology in Theory and Practice, Chapman&Hall, London 1994.
J. A. Timbrell: Introduction to Toxicology, Taylor&Francis, London 1994


TitleSeminar on Advanced Inorganic ChemistryCodeÚCHV/NPC2/02TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo acquaint students with the current state of research in inorganic chemistry.ContentSelected topics in inorganic and coordination chemistry. Study of the scientific literature and publications. Elaboration of the chemical information.Recommended reading Actual scientific papers and literature concerning the actual research topics in inorganic chemistry.
Shriver D. F. Shriver, Atkins P. W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

TitleBioinorganic Chemistry IICodeÚCHV/BAC2/05TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide the students with knowledge of biocoordination compounds and their physicochemical properties, e.g., the biological efficiency of some coordination compounds with transition elements (Zn, Fe, Co, Mn, Cu).ContentBiocoordination compounds and their physicochemical properties. Metal centers in biosystems. Biological efficiency of some coordination compounds with transition elements (Zn, Fe, Co, Mn, Cu) and their utilisation in human and veterinary medicine. Toxicity of biometals.Prerequisite coursesÚCHV/BAC1/04Recommended reading Kaim, W., Schwederski, B.: Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, John Wiley and Sons, Chichester 1994

TitleMethods of Chemical ResearchCodeÚCHV/MCV1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo familiarise students with physicochemical parameters as a means of measurement, evaluation, and interpretation in the study of a process. ContentOverview of basic principles of the determination of physicochemical quantities (dissociation constant, activity coefficient, solubility product, stability constant of complex, diffusion coefficient). Calorimetry and its utilisation. Experimental methods in kinetics. The Butler-Volmer equation. Survey of selected key topics in colloid chemistry. Adsorption-BET equation. A discussion of topics selected from active research fields. Recommended reading Moore,W. J. : Physical Chemistry. Longman Group Limited, London, 1972
Willard, H. H. et al.: Instrumental Methods of Analysis. Wadsworth, Belmont, 1988
Koryta, J., DvoYák, J., Kavan, L.: Principles of Electrochemistry. John Wiley & Sons, New York, 1993

TitleNeurochemistryCodeÚCHV/NCH/03TeacherMartinková MiroslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the fundamental principles of chemical transmission between nerve cells; to have students understand the necessary link between neuroanatomy and neurochemistry.ContentNeurocellular anatomy - characteristics of the neuron. Cell membrane structures: phospholipid bilayer, membrane proteins, brain lipids, brain lipids biosynthesis. Membrane transport and ion channels. Synaptic transmission and cellular signaling. Neurotransmitters: acetylcholine, catecholamines, serotonin, amino acids (glutamate, aspartate, GABA, glycine). Neuropeptides: neuropeptide functions and regulation. G-proteins; the second-messenger hypothesis (cAMP, IP3, DAG, Ca2+). Neurotransmitters and disorders of the basal ganglia. Endocrine effects on the brain and their relationship to behaviour.
Recommended reading G. J. Siegel, B. W. Agranoff, R. W. Albers, S. K. Fisher, M. D. Uhler: Basic Neurochemistry, Lippincott Williams and Wilkins, Philadelphia 1999

TitleMolecular BiologyCodeÚBEV/MB1/01TeacherMišúrová EvaECTS credits4Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide the students with knowledge of molecular basis of inheritance and control of gene expression and development.ContentStructure and properties of information macromolecules. Molecular mechanisms of DNA replication and repair, transcription and translation. Prokaryotic and eukaryotic genome. Control of gene expression in prokaryotes and eukaryotes. Control of cell cycle.Recommended reading Lodish, H., Baltimore, D., Berk, A. et al.: Molecular Cell Biology. Sci. Amer. Books Inc., W.H. Freeman and Company, New York, 1995.
Myers, R. A.: Molecular Biology and Biotechnology. VCH Publishers Inc., New York, 1995

TitleThermal AnalysisCodeÚCHV/TA1/03TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of experimental thermoanalytical techniques, the use of thermoanalytic methods for characterisation of inorganic and organic compounds and reaction kinetics.ContentIntroduction: Experimental thermoanalytical techniques (thermogravi-metric analysis, differential thermal analysis, thermomagnetic techniques, thermodilatometric analysis, high temperature reflectance spectroscopy). The use of thermoanalytic methods for characterisation of inorganic and organic compounds, materials and pharmaceutical substances. Reaction kinetics.Recommended reading Heide K.: Dynamische thermische Analysenmethoden, VEB Deutsch Verlag Wissenschaften, Leipzig, 1979 

TitleBioinorganic Chemistry IIICodeÚCHV/BAC3/04TeacherZeleHák VladimírECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo acquant students with the current state of selected topics of the research in bioinorganic chemistry.ContentSinglet and triplet dioxygen and organisms. Oxygen atom transfer reactions. Dioxygen radical generating systems. Inorganic compounds as the analogues of the active sites of the metalloproteins. Construction of small molecule enzyme mimics as drugs (SOD mimics). Metals in medical applications (the use of chelating agents, metal based chemotherapeutic drugs, metallodrugs as diagnostic agents, metals as biomaterials). Physical methods.Prerequisite coursesÚCHV/BAC1/04Recommended reading W. Kaim, B. Schwederski: Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Wiley, Chichester, England, 1994
J. A Helsen, H. J. Breme: Metals as Biomaterials, Wiley, Chichester, England, 1998
P. C. Wilkins, R. G. Wilkins: Inorganic Chemistry in Biology. Oxford University Press, Oxford 1997.
R.W. Hay: Bio-inorganic chemistry. Ellis Horwood Ltd., Chichester, England, 1987

TitleSpecial ToxicologyCodeÚCHV/STOX/04TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the toxicology of organic and inorganic compounds, drugs, food additives, e.g., safety of substances, designation of substances in accordance with norms of the European Union and the laws of the Slovak Republic.ContentHistorical aspects, types of toxic substances, dosage (LD50, ED50, TD50, tolerance), absorption and distribution of toxic compounds. Metabolism of toxic compounds (oxidation reactions, reduction, glucuronidation, glutathione conjugation, acetylation); excretion of toxic compounds; toxicology of metals (alkali, alkali earth and transition metals), radioactive substances, drugs, food additives, industrial chemicals, household poisons, environmental pollutants and organic compounds, animal toxins, fungal and microbial toxins. Risk and safety practices with chemical substances, designation of substances in accordance with the norms of the European Union and the laws of the Slovak Republic.Recommended reading J. A. Timbrell: Introduction to Toxicology, Taylor and Francis, London 1989
H. Kenneth Dillon, Mat H. Ho: Biological Monitoring of Exposure to
Chemicals: Metals, John Wiley & Sons, New York 1991
V. E. Forbes, T. L. Forbes: Toxicology in Theory and Practice, Chapmane Hall, London 1994
H. M. Stahr: Analytical Methods in Toxicology, John Wiley & Sons, New York 1991

TitleElectrode Processes and TechnologyCodeÚCHV/ELD1/03TeacherTuroHová Andrea, ECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students the various electrochemical processes and their applications in practical technology.ContentTheory of the electrode processes. Electrolyser construction. Electrolysis of H2O. Electrolysis of NaCl. Electrolytical deposition and refining of metal from aqueous solutions, non-aqueous solutions, from melts. Electrolysis of Al. Electrolytic deposition of metal coatings on substrates. Electrolytic coating of varnish for car industry. Principles of corrosion and surface protection. 

TitleMacromolecular ChemistryCodeÚCHV/MMU/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo make students familiar with available structures of polymers and their synthesis methods as well as with the ways that structure is reflected in their properties.ContentFundamental aspects of chemical composition of polymers-monomers; shape and the relationship between structure and properties. Primary, secondary, tertiary and quaternary structures. Thermal transition. Molecular mass distributions. Determination of molecular mass of macromolecules. Synthetic methods of functional polymers and their characterisation. Naturally occurring polymers: their properties. Degradation of polymers. Polymers and the environment.Recommended reading Elias H.-G.: Macromolecules. Volume 1 (Structure and Properties); Volume 2 (Synthesis, Materials, and Technology). Plenum Press, New York, 1984
Moore W. J.: Physical Chemistry. Longman, London,1972
Munk P.: Introduction to Macromolecular Science. John Wiley & Sons, New York, 1989
Atkins P. W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002

TitleKinetics and CatalysisCodeÚCHV/FKK1/03TeacherOriHáková Renáta, Markuaová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo develop student understanding of the kinetics of different types of reactions, e.g., homogeneous and heterogeneous catalysis. ContentClassification of chemical reactions. Reaction rates. Rate laws. Reaction order. Elementary reactions. Complicated reactions. Theory of chemical kinetics. Experimental methods of chemical kinetics. Complex reactions mechanism. Explosions. Photochemical reactions. Essence of adsorption, types of adsorption, adsorption isotherms. Essence of catalytic processes. Catalysis influenced phenomena. Homogeneous and heterogeneous catalysis. Enzymatic catalysis. Alternate coursesÚCHV/FKK1/99 orÚCHV/FKK1/02

TitleQuantum ChemistryCodeÚCHV/KOC1/01TeacherDanihel IvanECTS credits5Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo have students improve their knowledge in the field of valence-bond based on molecular orbital theory (MO) and individually to perform basic quantum chemical calculations (molecular geometry optimisation, transition states, vibrational analysis, etc.). ContentDevelopment of valence-bond theory. Time-independent Schrodinger equation. Basic approximations in molecular orbital valence-bond theory. Variant methods of calculation in the framework of molecular orbital valence-bond theory. Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction coordinate. Calculation of absolute and relative equilibrium and rate constants in gas phase. Solvatation energy calculation.Alternate coursesÚCHV/KOC1/99 orÚCHV/KOC1/00Recommended reading Jensen F.: Introduction to Computational Chemistry, Wiley, 2000
Leach A.R.: Molecular Modelling, Addison Wesley Longman Ltd. 1998
Náray-Szabó G., Surján P.R., Ángyán J.G.: Applied Quantum
Chemistry, Akadémia Kiadó, Budapest, 1987 

TitleSpecial SeminarCodeÚCHV/VSE1a/04TeacherAndruch Vasi>, Reiffová Katarína, Gondová Taeána, Vojteková VieraECTS credits2Hrs/week-/2AssessmentAssessmentSemester1T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students theses.

TitleSolid State ChemistryCodeÚCHV/CTF1/00Teacher ernák Juraj, Tká
ová KláraECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge on the fundamentals and significance of solid state chemistry and of reaction in the solid state.ContentHistorical development of solid state chemistry and its significance for technological progress. General fundamentals and important properties of solids: ideal and real crystals, deformation of crystals, diffusion in solids. Non-catalysed reactions involving solids: thermal decomposition, surface oxidation, reaction between solids, chemical dissolution. The influence of non-equilibrium defects on the reactivity of solids. Generation of defects by various methods of treatment: rapid quenching, doping, irradiation, mechanical activation and low temperature decomposition.Alternate coursesÚCHV/CTF1/99Recommended reading West A.R.: Basic Solid State Chemistry, J. Wiley, Chichester, 1999
Tká
ová, K.: Mechanical Activation of Minerals. Elsevier, Amsterdam, 1989.

TitleAtomic SpectrochemistryCodeÚCHV/AAS1/03TeacherBaze> Yaroslav, Vojteková VieraECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with theoretical information and practical experience with atomic absorption and emission methods used in analytical practice (environmental analysis, material research, clinical and food analysis).ContentBasic and enhanced information about spectral (optical) methods; history of their development; practical applications: optical analytical methods, principles, classification; atomic spectra, creation, analytical use. Modern equipment for scanning for radiation. Detection of radiation in spectrochemistry. Historical development; actual trends. Photographical detection and its particularities. Methodologies for solution analysis; special methods for the direct transport of the solid samples in the DCA source. Atomic absorption spectrometry, flame and electrothermal atomisation. Methods based on the interaction of the RTG radiation and the sample: advantages, disadvantages and applications of WDXRF, EDXRF, TXRF.Alternate coursesÚCHV/AAS1/01Recommended reading D. A. Skoog, J. J. Leary: Instrumental Analytics. Springer, Berlin - Heidelberg 1996
B. Welz, M. Sperling: Atomic Absorption Spectrometry, Wiley-VCH Verlagsgesellschaft mbH, Germany 1998
2. Douglas A. Skoog, Donald M. West, F. James Holler, Timothy A. Nieman: Principles of Instrumental Analysis, Wandsworth, 1997

TitleAnalysis of Psychotropic and Narcotic SubstancesCodeÚCHV/APO1/02TeacherGondová TaeánaECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentDrugs; drug dependence. Psychotropic and narcotic substances: classification, properties and laws. Dose and tolerance, therapy, prevention. Pharmacokinetics of the drug. Biological effects, biotransformations, receptors. The methods used in the analysis of the drugs (clinical, forensic analysis): opiates, cocaine, amphetamines and their analogues, hallucinogenics, cannabis products, etc.Alternate coursesÚCHV/APO1/99 orÚCHV/APO1/00

TitleChromatographic AnalysisCodeÚCHV/CHRA1/03TeacherOriHák AndrejECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentGeneral characteristics of chromatographic system and chromatographic separation. Analyte retention in chromatography; retention indices. Models used for chromatographic system description. Parameters affecting quality of chromatographic separation. Sensitivity, separated analytes, separation time, optimisation of chromatographic process. General equation of chromatography. Evaluation of retention and selectivity of chromatographic process. Stationary phase. Qualitative chromatographic analysis. Quantitative analysis methods; sample preparation. System of analyte separation. Identification in chromatographic analysis.

TitlePractical in Physical ChemistryCodeÚCHV/PFCU/03TeacherMarkušová KvetoslavaECTS credits4Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo allow students to verify theoretical principles and to learn to describe each technique involved in appropriate physical chemistry experiments.ContentExperimental verification of theoretical knowledge involving thermodynamics, thermochemistry, chemical equilibria (determination of enthalpy, phase diagrams), colligative properties (cryoscopy, ebulioscopy), adsorption. Experimental verification of theoretical knowledge involving electrochemistry (conductivity, dissociation constants, potentials, electromotoric potentials of cells, activity coefficients, polarography) and chemical kinetics (determination of rate constants).Recommended reading Levitt B. P.: Findlay´s Practical Physical Chemistry. Longman, London, 1973
Moore W. J.: Physical Chemistry. Longman, London, 1972
Atkins P. W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002

TitleBioanalytical ChemistryCodeÚCHV/BACH1/03TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo impart theoretical knowledge and to give practical experience to students about the application of analytical chemistry and analytical methods to clinical chemistry, clinical biochemistry, haematology, microbiology and immunology.ContentIntroduction to bioanalytical chemistry. Biological sample; classification. Sampling techniques, transport, sample storing and conservation. Selected methods of sample pre-treatment for bio- analysis. Conditions for analytical method selection. Presentation of analytical data evaluation. Optimisation of analytical procedure. Control and management of quality in clinical laboratory. Molecules colouring and their analytical applications. Enzymes in bioanalysis. Immunochemical methods. Microbiological methods. Analysis
of biomolecules separation methods selection. Analytical technique of miniaturisation: principle, microchips, biosensors.Recommended reading Mikkelsen S.R, Cortón E.: Bioanalytical Chemistry, Wiley, 2004
Wilson I.: Bioanalytical Separations 4, (Handbook of Analytical Separations), Elsevier, 2003

TitleElectroanalytical MethodsCodeÚCHV/FEM/03TeacherMarkušová KvetoslavaECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students a survey of the principles, theoretical background and practical applications of modern electroanalytical methods.ContentImportance of electroanalytical methods for environmental control and protection, requirements of practice, electrochemical cells, electrode potential, mass transfer by convection, migration and diffusion, Cottrell equation, direct current voltametry and polarography (principle, theoretical backround, examples of practical application). TAST polarography and voltametry, staircase voltammetry, pulse techniques: normal pulse and differential pulse voltammetry and polarography, square-wave voltammetry and polarography, AC polarography and voltammetry, anodic stripping voltammetry, adsorptive (or accumulation) voltammetry (applications in clinical and environmental analysis), working electrodes in voltammetry: stationary mercury electrode, mercury film electrode, glassy carbon electrode, carbon paste electrode, metallic electrodes, rotating disk electrode, rotating ring-disk electrode, ultramicroelectrodes, chemically modified electrodes, potentiometry, principles of ion selective electrodes, glass electrodes, ISE with solid and liquid membranes, biocatalytic membrane electrodes, chronopotentiometry, potentiometric stripping analysis, electroanalytic-al detectors in flow systems, amperometric titrations, biamperometric and bipotentiometric titrations, potentiostatic and galvanostatic coulometry.Recommended reading F. Scholtz: Electroanalytical Methods, Springer Verlsag, Heidelberg 2002, ISBN 3-540-42449-3
J. Wang: Analytical Electrochemistry, VCH Publ., New York 1994, 2000
R. Kalvoda (Ed.): Electroanalytical Methods in Chemical and Environmental Analysis, Plenum Publ. Corp., New York 1987.
A. J. Bard, L. R. Faulkner: Electrochemical Methods, John Wiley and Sons, New York 1980
T. Riley, A. Watson: Polarography and Other Voltametric Methods, John Wiley and Sons, Chichester 1987
J. Wang: Stripping Analysis, VCH Publ. Inc., Deerfield Beach 1985

TitleStructure AnalysisCodeÚCHV/STA1/03Teacher ernák JurajECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo teach students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal structure determination and how to use the results of the crystal structure analysis in their own work.ContentHistorical introduction: importance of diffraction methods. Origin and properties of x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations. Reciprocal space; Ewald construction. Single crystal diffraction methods; automatic diffractometers. Powder diffraction: Debye-Scherrer and diffractometric methods, their theory and use. Atomic factor, structure factor, electronic density and their relationship. The phase problem: overview of the methods for solving the phase problems. Refinement of the structure; geometric parameters. Crystallisation processes; methods of preparation of single crystals. Density. Basic inorganic structure types.Recommended reading Clegg W.: Crystal Structure Determination, Oxford University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals. Walter de Gruyter, Berlin, 1980

TitleColloid ChemistryCodeÚCHV/FKC1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo clarify basic physicochemical principles of colloid disperse systems (sise of dispersed particles); to examine selected important problems of technology and nature.ContentClassification and characterisation of dispersed systems. Heterogeneity of colloidal systems. Optical properties of colloids. Theory of light scattering. Molecular-kinetic properties. Brownian motion, diffusion, osmosis, and sedimentation. Adsorption-basic concepts. Electrokinetic phenomena and their application. Structure, stability and coagulation of colloids. Rheology of dispersed systems. Gels. Aerosols. Solid dispersions, emulsions and foams. Application of theory during laboratory and calculation exercises.Alternate coursesÚCHV/FKC1/99ÚCHV/FKC1/00Recommended reading Moore W. J.: Physical Chemistry. Longman, London 1972
Hiemenz P. C.: Principles of Colloid and Surface Chemistry. M.Dekker, New York, 1986
Atkins P. W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002 

TitleColloid Chemistry PracticalsCodeÚCHV/FKC/00TeacherMarkušová KvetoslavaECTS credits3Hrs/week-/3AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo give an introduction to technically important applications of colloid and surface chemistry.ContentSurface effects. Adsorption at interface of solid and liquid phases, determination of surface nature. Electrical properties. Stability and coagulation of colloids. Structure-mechanical properties of colloids. Properties and aggregation of surfactants and micelles. Rheological properties. Alternate coursesÚCHV/FKC/99Recommended reading Internal textbooks

TitleMethods of Chemical ResearchCodeÚCHV/MCV1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo familiarise students with physicochemical parameters as a means of measurement, evaluation, and interpretation in the study of a process. ContentOverview of basic principles of the determination of physicochemical quantities (dissociation constant, activity coefficient, solubility product, stability constant of complex, diffusion coefficient). Calorimetry and its utilisation. Experimental methods in kinetics. The Butler-Volmer equation. Survey of selected key topics in colloid chemistry. Adsorption-BET equation. A discussion of topics selected from active research fields. Recommended reading Moore, W.J.: Physical Chemistry. Longman Group Limited, London, 1972
Willard, H.H. et al.: Instrumental Methods of Analysis. Wadsworth, Belmont, 1988
Koryta, J., DvoYák, J., Kavan, L.: Principles of Electrochemistry. John Wiley & Sons, New York, 1993

TitleSpecial SeminarCodeÚCHV/VSE1b/04TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students theses. 

TitleModelling of Physicochemical ProcessesCodeÚCHV/FMP1/03TeacherOriHáková Renáta, Markuaová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students general principles of modelling and how to report the examples of mathematic models of basic physicochemical processes. ContentModelling and processes control. General principles of modelling. Examples of mathematical models of processes dynamics. Dynamic properties of processes. Dynamic characteristics of processes. Computational models. Alternate coursesÚCHV/FMP1/99 orÚCHV/FMP1/00 orÚCHV/FMP1/02

TitlePractical ChromatographyCodeÚCHV/APC1/03TeacherOriHák AndrejECTS credits5Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalContentPractical aspects of chromatographic instrumentation. Characterisation of HPLC functional composition, injector, column, detectors, data evaluation, errors. Instrumentation in GC, injector, columns, detectors, data evaluation. Recommended reading Dean, R.: A Practical Guide to the Care, Maintenance, and Troubleshooting of Capillary Gas Chromatographic Systems. Huthig, Heidelberg, 1991
Grob, K.: On-Line Coupled LC-GC. Huthig, Heidelberg 1991

TitleWater PretreatmentCodeÚCHV/ATV1/04TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo allow students to obtain and improve their knowledge of the methods of water pretreatment.ContentPurification of waste waters from colloid substances. Purification of waste waters by chemical precipitation. Water degasing. Ion exchange purification of waste waters. Adsorption methods of waste water purification. Waste water purification via extraction. Waste water purification by membrane methods. Biological purification of water. Prerequisite coursesÚCHV/CHHS/07 or ÚCHV/ANCH1b/03Recommended reading Handbook of Water and Wastewater Treatment Technologies. Ed. By Nicholas P. Cheremisinoff, BUTTERWORTH HEINEMANN, 2001
Principles of Water Quality Control, Ed. by Thy Tebbutt, BUTTERWORTH HEINEMANN, 1997
Water Technology. Ed. by N. F. Gray, BUTTERWORTH HEINEMANN, 2005
TitleAnalytical SamplingCodeÚCHV/AVZ1/02TeacherOriHák AndrejECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentAnalytical sample; characterisation. Sampling and norms affecting sampling process. Quantity, number of samples. Sampling techniques. Sampling laboratory equipment. Sample pre-concentration. Sample storing and conservation. Matrix simplifying; specific analysis. Chromatographic sample pre-treatment.Alternate coursesÚCHV/AVZ1/00Recommended reading O. Stoeppler: Sampling and Sample Preparation Practical Guide for Analytical Chemists

TitleEnvironmental Analytical ChemistryCodeÚCHV/AZP1/04TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo gain and improve student knowledge about the methods of environmental analysis ContentIntroduction. Sampling techniques and sample preparation in environmental analysis. Quality assurance for environmental analysis. Good laboratory practice. Chemometrics in environmental analysis. Analysis of water, sediments, air, etc. Analysis of environmental samples by spectroscopic methods. Separation techniques in environmental analysis. Application of electrochemical methods to environmental samples. Prerequisite coursesÚCHV/ANCHU/03 orÚCHV/ANCH1b/03 orÚCHV/ANCH3/03Recommended reading Ure A. M., Davidson C. M. Chemical Speciation in the Environment. Blackie, London 1995
John R. Dean: Extraction Methods for Environmental Analysis. Wiley, 1988
Environmental Analysis. Elsevier, 1993 

TitleCorrosion and Surface ProtectionCodeÚCHV/FOCHP1/04TeacherTuroHová Andrea, Markuaová KvetoslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo present the fundamentals of chemical and electrochemical degradation processes of metals, including specific types of corrosion and surface protection.ContentChemical corrosion of metals. Chemical and electrochemical degradation processes; specific forms of corrosion. Oxidic layers. Vanadic corrosion. Hydrogen corrosion. Chemical corrosion in nonelectrolytes. Electrochemical corrosion. Electrode potentials. Thermodynamics and kinetics of electrochemical corrosion. Corrosion influence on the quality and properties of the materials. Contact corrosion. Soil corrosion. Surface protection. Electrochemical protection. Corrosion properties of Cu, Al, Ti, Zn, Mg, Sn and Pb.
Ecological aspects of corrosion and metal protection.

TitleSelected Chapters on ElectrochemistryCodeÚCHV/FVE1/04TeacherKladeková Daniela, Markušová KvetoslavaECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge of electric double layer theory and of the fundamentals of electrochemical kinetics.ContentEquilibrium at electrified interfaces; classification of electric potentials. Electric double layer, electrocapillaric phenomena, capacity of the electric double layer, adsorption phenomena at the electrode/solution interface. Structure of the electrical double layer according to Helmholtz model, Gouy-Chapman model, Stern model, and jellium model. Colloid chemistry: interaction of double layers and stability of colloids. Fundamentals of electrochemical kinetic: the Butler-Volmer equation, charge transfer coefficient, heterogeneous rate constant, exchange current, transport processes and their influence on electrode kinetics. Galvanic cells (chemical and concentration). Electromotoric potential of the galvanic cell. Thermodynamics of the galvanic cell. Primary and secondary cells, examples of modern electric energy sources. Electrolytic deposites, their preparation and characteristic, adhesion. Electrolytic deposition of metals and semiconductors. Electrochemical preparation of non-conductive deposites. Conductive organic polymers: preparation and properties.Recommended reading A. J. Bard, L. R. Faulkner : Electrochemical Methods. Fundamentals and Applications, J. Wiley and Sons, New York 1980
J. O. M. Bockris, A. K. N. Reddy: Modern Electrochemistry, Macdonald, London 2002
B. B. Damaskin, O. A. Petrij : Vvedenie v elektrokhimicheskuyu kinetiku, Izd. Vysshaya škola, Moskva 1975
E. Scholz (Ed.), Electroanalytical Methods. Guide to Experiments and Applications, Springer Verlag, Berlin 2002
Elective courses

TitleBioanalytical ChemistryCodeÚCHV/BACH1/03TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo impart theoretical knowledge and to give practical experience to students about the application of analytical chemistry and analytical methods to clinical chemistry, clinical biochemistry, haematology, microbiology and immunology.ContentIntroduction to bioanalytical chemistry. Biological sample; classification. Sampling techniques, transport, sample storing and conservation. Selected methods of sample pre-treatment for bio- analysis. Conditions for analytical method selection. Presentation of analytical data evaluation. Optimisation of analytical procedure. Control and management of quality in clinical laboratory. Molecules colouring and their analytical applications. Enzymes in bioanalysis. Immunochemical methods. Microbiological methods. Analysis
of biomolecules separation methods selection. Analytical technique of miniaturisation: principle, microchips, biosensors.Recommended reading Mikkelsen S. R, Cortón E.: Bioanalytical Chemistry, Wiley, 2004.
Wilson I., Bioanalytical Separations 4, (Handbook of Analytical Separations), Elsevier, 2003

TitleIntroduction to Material ChemistryCodeÚCHV/FUMCH1/03TeacherOriHáková Renáta, Markuaová KvetoslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo present the different types of functional materials, their atomic structure and mechanical properties.ContentHistorical perspectives. Materials and human being. Participation of natural science in material engineering. Material revolutions. Classification of materials. Atomic structure and interatomic bonding. Amorphous and crystalline materials. Mechanics of materials. Imperfections in solids. Crystal lattice defects. Point defects. Line defects. Dislocations. Diffusion. Diffusion mechanisms. Deformations and failures, re-crystallisation. Deformations. Plastic deformations. Solid solutions. Intermediary phases. Phases in ceramic systems. Phase transformations. Crystallisation of metals. Phase identification methods. Stress and strain. Structure of metallic and ceramic materials. Alloys. Steel. Light metals. Metallic glasses. Gold. Inorganic non-metallic materials. Ceramic construction materials. Ceramic tools. Bio-ceramics. Ceramics in cosmos. High-temperature superconductors. Glass. Building binders. Polymers. Essence of polymers. Thermoplastics. Reactoplastics. Polymer structure. Mechanical properties of polymers. Natural materials. Wood. Bones. Teeth. Conchs and shells. Tectrices.Recommended reading W.D. Callister, Jr.: Fundamentals of Materials Science and Engineering, John Wiley & Sons, 2001

TitleChemical ExcursionCodeÚCHV/CHE2/03TeacherGyöryová KatarínaECTS credits4Hrs/week-/1tAssessmentAssessmentSemester2T/L methodPracticalContentVisit to chemical factories in East Slovakia (Kerko, a.s. Košice - manufactury Michalovce, U.S. Steel s.r.o. - Košice, Vsl. stavebné hmoty, a.s. - TurHa nad Bodvou, Chemko, a.s. - Strá~ske, Kovohuty, a.s. Krompachy).

TitleNuclear ChemistryCodeÚCHV/JCH1/04TeacherTuroHová Andrea, Markuaová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basics of radioactivity and nuclear reactions, of preparation of the radionuclides and their use in technical practice, and of the biological effects of nuclear radiation.ContentFundamentals of nuclear chemistry. Elementary particles. Nuclear core. Nuclides and isotopes. Radioactivity and radioactive disintegration kinetics. Radioactive disintegration. Decay law. Half life period. Units of radioactivity. Nuclear reactions. Sources of nuclear radiation. Detection and registration of radiation. Nuclear chemical technology. Radioactive analytical methods. Isotopic dilution method, activation analysis. Biological effects of the nuclear radiation. Nuclear medicine. Nuclear power station. 

Title1D & 2D NMR SpectroscopyCodeÚCHV/NMR1/00TeacherImrich JánECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students how to analyse the structure and properties of organic, inorganic and biomolecular compounds by 1D and 2D proton and carbon NMR spectra, quantitative NMR analysis, and practical applications in various fields of science and technology.ContentTheoretical principles of nuclear magnetic resonance (NMR), basic NMR pulse techniques and Fourier transformation, NMR spectrometers, description of NMR by vector models. Parameters of one- (1D) and two-dimensional (2D) NMR spectra, practical application of 1H and 13C NMR spectra and basic correlated 2D spectra for structure and stereo chemical arrangement, elucidation of reaction mechanisms, molecular dynamics, physico-chemical properties and quantitative analysis of chemical compounds.Alternate coursesÚCHV/NMR1/99Recommended reading Friebolin H.: Basic One- and Two-Dimensional NMR Spectrocopy, Verlag Chemie, Weinheim 1993
T. D.W. Claridge: High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 1999
Atta-ur-Rahman, M. I. Choudhary: Solving Problems with NMR spectroscopy, Academic Press 1996
H.-O. Kalinowski, S. Berger, S. Braun: Carbon-13 NMR Spectroscopy. Wiley, New York 1988
A. E. Derome: Modern NMR Techniques for Chemistry Research. Pergamon Press, Oxford 1987
E. Pretsch, B. Buhlmann, C. Affolter: Structure Determination of Organic Compounds. Tables of Spectral Data. Springer Verlag, Berlin 2000
E. Breitmaier: Vom NMR-Spektrum zur Strukturformel organischer Verbindungen. B. G. Teubner, Stuttgart 1992
E. Breitmaier, W. Voelter: Carbon-13 NMR Spectroscopy. VCH Weinheim, 1990 

TitleThermal AnalysisCodeÚCHV/TA1/03TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of experimental thermoanalytical techniques, the use of thermoanalytic methods for characterisation of inorganic and organic compounds and reaction kinetics.ContentIntroduction: Experimental thermoanalytical techniques (thermogravi-metric analysis, differential thermal analysis, thermomagnetic techniques, thermodilatometric analysis, high temperature reflectance spectroscopy). The use of thermoanalytic methods for characterisation of inorganic and organic compounds, materials and pharmaceutical substances. Reaction kinetics.Recommended reading Wendlandt W. W.: Thermal Methods of Analysis, 2. vydanie, New York, 1985
Heide K.: Dynamische thermische Analysenmethoden, VEB Deutsch Verlag Wissenschaften, Leipzig, 1979 

Study programme Inorganic Chemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚCHV/DPCO1a/00Diploma Work2-/-Recognition1/1ÚCHV/KCH1/00Coordination Chemistry52/1Examination1/1ÚCHV/DPCO1b/00Diploma Work6-/-Recognition1/2ÚCHV/DPCO1c/03Diploma Work8-/-Recognition2/3ÚCHV/DPCO1d/03Diploma Work30-/-Recognition2/4ÚCHV/SDP/03Seminar on Diploma Work2-/2Assessment2/4ÚCHV/VKA/04Selected Topics in Inorganic Chemistry52/1Examination2/3
Compulsory elective courses

ÚCHV/STA1/03Structure analysis62/2Examination1/1ÚCHV/HGS/03Host-Guest and Supramolecular systems42/-Assessment1/1ÚCHV/KOC1/01Quantum chemistry53/1Examination1/1, 2/3ÚCHV/SAZ1/03Stereochemistry of Inorganic Compounds4-/3Assessment1/1, 2/3ÚCHV/NPC1a/00Seminar on Advanced Inorganic Chemistry1-/1Assessment1/1ÚCHV/NPC2/02Seminar on Advanced Inorganic Chemistry1-/1Assessment1/2ÚCHV/JCH1/04Nuclear chemistry42/1Examination1/2ÚCHV/AKO/03Inorganic Polymers, Clusters and Organometallics63/1Examination1/2ÚCHV/TA1/03Thermal Analysis52/1ExaminationÚCHV/ADP/03Adsorption and Porosity of Solids 52/1Assessment1/2ÚCHV/VMS1/03Computing Methods in X-ray Structure Analysis2-/2Assessment1/2ÚCHV/MAR1/04Mechanisms of Inorganic Reactions31/1Assessment1/2ÚCHV/TOX1/03Chemical Toxicology52/1Examination2/3ÚCHV/CTF1/00Solid State Chemistry52/1Examination2/3ÚCHV/EMDP/03Experimental Methods for Master’s Thesis6-/6 Assessment 2/3
Recommended elective courses

ÚCHV/SVK1/00Student Scientific Conference 4-/-Assessment1/2ÚCHV/DPV1/03History of Natural Sciences 52/1Examination1/1, 2/3ÚCHV/CHE2/03Chemical Excursion4-/1 wAssessment1/2, 2/4ÚCHV/CMG/03Chemical Management3/-Examination1/1

Course units

Compulsory courses

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1ObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.Recommended reading According to the approved setting of diploma work.

TitleCoordination ChemistryCodeÚCHV/KCH1/00Teacher ernák Juraj, Chomi
 JozefECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentCentral atoms and ligands. Bonding and electronic structure, crystal-field theory, weak-field and strong-field of ligands, ligand-field stabilisation energy, molecular orbital theory, sigma-bonding, pi-bonding, structures and symmetries of complexes. Classification of coordination compounds, coordination numbers, tetragonal and trigonal distorsion, Jahn-Teller effect, isomerism, spectral and magnetic properties of complexes.Alternate coursesÚCHV/KCH1/99Recommended reading S.F.A. Keetle: Physical Inorganic Chemistry. A Coordination Chemistry Approach. Oxford University Press, Oxford, 1998
D.F. Shriver, P. W. Atkins: Inorganic Chemistry, 4th Edition,Oxford University Press, Oxford, 2006 

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments required for diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Automatic prerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits8Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4ObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester4T/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.Recommended reading According to field of diploma work.
TitleSelected Topics in Inorganic ChemistryCodeÚCHV/VKA/04TeacherKuchár Juraj, Poto
Hák Ivan, ZeleHák Vladimír, Györyová Katarína, ernák Juraj, Reháková Mária, Chomi
 Jozef, Vargová ZuzanaECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo acquaint students with the current state of research in inorganic chemistry.ContentCu-Zn heterobimetallic compounds: preparation, structure and properties. Biological and physicochemical properties of some zinc complex compounds with bioactive ligands. Pentacoordinated Copper (II) compounds: a trigonal bipyramid or a tetragonal pyramid? Structure, spectral and thermal properties of cyanoargentates. Hydrothermal synthesis in inorganic chemistry. Materials on the basis of inclusion compounds, their structure, properties and application.Recommended reading Greenwood, N.N., Earnshaw, A.: Chemistry of the elements I and II, Pergamon Press N.Y., 1993
J. E. Huheey, E.A. Keiter, R.L. Keiter: Inorganic Chemistry: Principles of Structure and Reactivity (4th Edition, Addison-Wesley Pub Co, 4th edition, 1997 
Compulsory elective courses

TitleStructure AnalysisCodeÚCHV/STA1/03Teacher ernák JurajECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal structure determination and how to use the results of the crystal structure analysis in their own work.ContentHistorical introduction: importance of diffraction methods. Origin and properties of x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations. Reciprocal space; Ewald construction. Single crystal diffraction methods; automatic diffractometers. Powder diffraction: Debye-Scherrer and diffractometric methods, their theory and use. Atomic factor, structure factor, electronic density and their relationship. The phase problem: overview of the methods for solving the phase problems. Refinement of the structure; geometric parameters. Crystallisation processes; methods of preparation of single crystals. Density. Basic inorganic structure types.Recommended reading Clegg W.: Crystal Structure Determination, Oxford University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals. Walter de Gruyter, Berlin, 1980

TitleHost-Guest and Supramolecular SystemsCodeÚCHV/HGS/03Teacher ernák JurajECTS credits4Hrs/week2/-AssessmentAssessmentSemester1T/L methodLectureContentClathate, inclusion compound, supramolecular systems. Water clathates, clathrates of urea and thiourea, Hofmann type clathates and their analogues, Werner-type clathates, calixarenes, crown-ethers, cryptates, possibilities for their practical use. From molecular to supramolecular chemistry, types and importance of weak interactions in supramolecular chemistry, crystal engineering.Recommended reading Beer P.D., Gale P.A., Smith D.K.: Supramolecular Chemistry, Oxford University Press, Oxford, 2003

TitleQuantum ChemistryCodeÚCHV/KOC1/01TeacherDanihel IvanECTS credits5Hrs/week3/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo have students improve their knowledge in the field of valence-bond based on molecular orbital theory (MO) and individually to perform basic quantum chemical calculations (molecular geometry optimisation, transition states, vibrational analysis, etc.). ContentDevelopment of valence-bond theory. Time-independent Schrodinger equation. Basic approximations in molecular orbital valence-bond theory. Variant methods of calculation in the framework of molecular orbital valence-bond theory. Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction coordinate. Calculation of absolute and relative equilibrium and rate constants in gas phase. Solvatation energy calculation.Alternate coursesÚCHV/KOC1/99 orÚCHV/KOC1/00Recommended reading Jensen F.: Introduction to Computational Chemistry, Wiley,2000
Leach A.R.: Molecular Modelling, Addison Wesley Longman Ltd. 1998
Náray-Szabó G., Surján P.R., Ángyán J.G.: Applied Quantum
Chemistry, Akadémia Kiadó, Budapest, 1987 

TitleStereochemistry of Inorganic CompoundsCodeÚCHV/SAZ1/03Teacher ernák JurajECTS credits4Hrs/week-/3AssessmentAssessmentSemester1, 3T/L methodPracticalContentSymmetry, elements of symmetry, point groups, symmetrical properties of orbitals and bonds. Principles of stereochemistry, VSEPR, configuration of molecules, polyhedra, regular and semiregular polyhedra. Valence shells with 4 to 12 electron pairs, geometry of molecules and periodic system.Recommended reading Kepert, D. L.: Inorganic Stereochemistry. Spribger-Verlag, Berlin, 1982
Kettle, S. F. A.: Symmetry and Structure. John Wiley & Sons, New York, 1985

TitleSeminar on Advanced Inorganic ChemistryCodeÚCHV/NPC1a/00TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo acquaint students with the current state of research in inorganic chemistry.ContentSelected topics in inorganic and coordination chemistry. Study of the scientific literature and publications. Elaboration of the chemical information.Recommended reading Actual scientific papers and literature concerning the actual research topics in inorganic chemistry
Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

TitleSeminar on Advanced Inorganic ChemistryCodeÚCHV/NPC2/02TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo acquaint students with the current state of research in inorganic chemistry.ContentSelected topics in inorganic and coordination chemistry. Study of the scientific literature and publications. Elaboration of the chemical information.Recommended reading Actual scientific papers and literature concerning the actual research topics in inorganic chemistry
Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

TitleNuclear ChemistryCodeÚCHV/JCH1/04TeacherTuroHová Andrea, Markuaová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basics of radioactivity and nuclear reactions, of preparation of the radionuclides and their use in technical practice, and of the biological effects of nuclear radiation.ContentFundamentals of nuclear chemistry. Elementary particles. Nuclear core. Nuclides and isotopes. Radioactivity and radioactive disintegration kinetics. Radioactive disintegration. Decay law. Half life period. Units of radioactivity. Nuclear reactions. Sources of nuclear radiation. Detection and registration of radiation. Nuclear chemical technology. Radioactive analytical methods. Isotopic dilution method, activation analysis. Biological effects of the nuclear radiation. Nuclear medicine. Nuclear power station. Recommended reading G.R. Choppin, J. Rydberg: Nuclear Chemistry, Theory and Applications
Pergamon Press,1980
G.R. Choppin, J.O. Liljenzin, J. Rydberg: Radiochemistry and nuclear chemistry, 3rd edition, Woburn, USA, Butterworth-Heinemann, 2002
W.D. Ehmann, D.E. Vance: Radiochemistry and nuclear methods of analysis, Wiley, New York, 1991
A. Vértes, I. Kiss: Nuclear chemistry, Elsevier,1987

TitleInorganic Polymers, Clusters and OrganometallicsCodeÚCHV/AKO/03Teacher ernák Juraj, Chomi
 JozefECTS credits6Hrs/week3/1AssessmentExaminationSemesterT/L methodLecture, PracticalContentDefinition and classification of inorganic polymers. Linear polymers S, Se, Te, (SN)x. Chalkogenic glasses, BN, borate glasses. Quartz and silicate glasses. Crystalline silicates and aluminosilicates. Boranes and heteroboranes, polyoxovanadium compounds. Hetero- and isopolyanions. Polymeric cyanocomplexes. Cluster compounds, metal-metal bonding in clusters, intersticial atoms. Organometallic compounds, bondings M-C; types of ligands, their preparation and their propereties. Prerequisite coursesÚCHV/ACH2/03 orRecommended reading Ray, N.H.: Inorganic Polymers, Academic Press, New York, 1978.
Haiduc I., Zuckerman J.J.: Basic Organometallic Chemistry, W. de Gruyter, Berlin, N.Y. 1985.

TitleThermal AnalysisCodeÚCHV/TA1/03TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge of experimental thermoanalytical techniques, the use of thermoanalytic methods for characterisation of inorganic and organic compounds and reaction kinetics.ContentIntroduction: Experimental thermoanalytical techniques (thermogravi-metric analysis, differential thermal analysis, thermomagnetic techniques, thermodilatometric analysis, high temperature reflectance spectroscopy). The use of thermoanalytic methods for characterisation of inorganic and organic compounds, materials and pharmaceutical substances. Reaction kinetics.Recommended reading Wendlandt W. W.: Thermal Methods of Analysis, 2nd ed., New York, 1985 

TitleAdsorption and Porosity of Solids CodeÚCHV/ADP/03TeacherZeleHák VladimírECTS credits5Hrs/week2/1AssessmentAssessmentSemester2T/L methodLecture, PracticalObjectiveTo familiarise students with various types of porous solids and basic methods for their investigation.ContentTerminology associated with powders, porous solids and adsorption. Methodology of adsorption at the gas-solid interface and at the liquid-solid interface. Assessment of surface area and porosity. Inorganic materials (active carbon, metal oxides, zeolites, clay minerals, new advanced materials) and the phenomenon of adsorption. Application in industry and everyday life.Recommended reading F. Rouquerol, J. Rouquerol, K. Sing: Adsorption by powders and porous solids, Academic press, London, UK, 1999
S. J. Gregg, K.S.W. Sing: Adsorption, surface area and porosity, Academic Press, London,, UK, 1982 

TitleComputing Methods in X-Ray Structure AnalysisCodeÚCHV/VMS1/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo provide students with basic knowledge on the use of crystallographic and crystal structure visualisation programs on personal computersContentCambridge Crystal Structure Database: the use of the data from CCSD and published papers. Calculation of geometric parameters including hydrogen bonds (program PARST). Graphic visualisation of crystal structures (program DIAMOND. Use of the Internet for transfer of crystallographic data; interesting crystallographic web sites. The programs for crystal structure analysis: SHELX. Prerequisite coursesÚCHV/STA1/03 orÚCHV/USA/03 orÚCHV/MIN1/00

TitleMechanisms of Inorganic ReactionsCodeÚCHV/MAR1/04TeacherReháková MáriaECTS credits3Hrs/week1/1AssessmentAssessmentSemester2T/L methodLecture, PracticalContentClassification of chemical reactions according to mechanisms found in specific aspects of the reactions of coordination compounds. Kinetic and thermodynamic properties of chemical reactions. SN1, SN2, SE1 and SE2 types of reaction mechanisms. Mechanisms in coordination and inclusion compounds. Practical application of knowledge of reaction mechanisms.Recommended reading Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

TitleChemical ToxicologyCodeÚCHV/TOX1/03TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with knowledge of toxic substances and their toxic effect and of interactions between chemicals and biological systems. ContentHistorical aspects, types of toxic substances, dose-response relationship. Disposition of toxic compounds (absorption, distribution, excretion, metabolism of toxic compounds, factors affecting toxic responses). Types of exposure and response. Drugs as toxic substances. Industrial toxicology. Food additives and contaminants. Pesticides. Environmental pollutants. Natural products. Risk and safety practices with chemical substances, designation of substances in accordance with the norms of the European Union and the laws of the Slovak Republic.Recommended reading J. A. Timbrell: Introduction to Toxicology, Taylor and Francis, London 1989
V. E. Forbes, T. L. Forbes: Toxicology in Theory and Practice, Chapmane Hall, London 1994
H. M. Stahr: Analytical Methods in Toxicology, John Wiley & Sons, New York 1991

TitleSolid State ChemistryCodeÚCHV/CTF1/00Teacher ernák Juraj, Tká
ová KláraECTS credits5Hrs/week2/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge on the fundamentals and significance of solid state chemistry and of reaction in the solid state.ContentHistorical development of solid state chemistry and its significance for technological progress. General fundamentals and important properties of solids: ideal and real crystals, deformation of crystals, diffusion in solids. Non-catalysed reactions involving solids: thermal decomposition, surface oxidation, reaction between solids, chemical dissolution. The influence of non-equilibrium defects on the reactivity of solids. Generation of defects by various methods of treatment: rapid quenching, doping, irradiation, mechanical activation and low temperature decomposition.Alternate coursesÚCHV/CTF1/99Recommended reading West A.R.: Basic Solid State Chemistry, J. Wiley, Chichester, 1999.
Tká
ová, K.: Mechanical Activation of minerals. Elsevier, Amsterdam, 1989 
Elective courses

TitleHistory of Natural Science CodeÚCHV/DPV1/03TeacherGanajová MáriaECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalContentBasic patterns of the emergence of chemistry in relation to the rest of the natural sciences. Stages in the emergence of chemistry. Matter and the meaning of alchemy. Chemistry of air. Discoveries of basic quantitative laws. Ideas of evolution. The structure of substances; models of atoms. Classification of elements: Periodic Table. The current state of chemistry. 

TitleChemical managementCodeÚCHV/CMG/03TeacherKoa
ík DuaanECTS credits5Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo expose students to the basic principles of production management, marketing, and strategy building in the chemical and pharmaceutical industries through lectures by top managers from Slovak chemical companies. ContentBasic processes connected to manufacturing and management of chemical production in Slovakia.Recommended reading Internal sources

TitleChemical ExcursionCodeÚCHV/CHE2/03TeacherVargová ZuzanaECTS credits4Hrs/week-/1tAssessmentAssessmentSemester2, 4T/L methodPracticalContentVisit to chemical factories in East Slovakia (Kerko, a.s. Košice - manufactury Michalovce, U.S. Steel s.r.o. - Košice, Vsl. stavebné hmoty, a.s. - TurHa nad Bodvou, Chemko, a.s. - Strá~ske, Kovohuty, a.s. Krompachy).


Study programme Organic Chemistry
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester


Compulsory courses

ÚCHV/BOC/03Bio-organic Chemistry53/-Examination1/1ÚCHV/PRL/04Chemistry of Natural Compounds42/1Examination1/1,2,3ÚCHV/OS/03Organic Synthesis52/1Examination1/1ÚCHV/DPCO1a/00Diploma Work2-/-Recognition1/1ÚCHV/AS1/03Asymmetric Synthesis52/1Examination1/2ÚCHV/NMR1/001D & 2D NMR Spectroscopy62/3Examination1/2ÚCHV/MSM1/00Modern Synthetic Methods63/1Examination1/2ÚCHV/DPCO1b/00Diploma Work6-/-Recognition1/2ÚCHV/DPCO1c/03Diploma Work2-/-Recognition2/3ÚCHV/SEM1a/00Seminar on Diploma Work 2-/2Assessment2/3ÚCHV/DPCO1d/03Diploma Work30-/-Recognition2/4ÚCHV/SEM1b/00Seminar on Diploma Work 2-/2Assessment2/4
Compulsory elective courses

ÚCHV/SMCH/03Supramolecular Chemistry42/1Examination1/1, 2/3ÚCHV/TOXOL/03Toxicology of Organic Compounds43/-Examination1/1ÚCHV/MM1/00Molecular Modelling41/3Assessment1/1ÚCHV/NCH/03Neurochemistry52/1Examination1/2ÚCHV/ZCI/04Basic Cheminformatics Tools22/1Examination1/2ÚCHV/HZ1/00Heterocyclic Compounds42/1Examination1/1, 2/3ÚCHV/CHOZ/03Organometallic Compounds42/1Examination2/3ÚCHV/KOC1/01Quantum Chemistry53/1Examination2/3ÚCHV/KC/03Cosmetic Chemistry42/1Examination1/1, 2/3

Elective courses

ÚCHV/FMCH/04Medicinal Chemistry63/1Examination1/1,2/3ÚCHV/KOR1/00Organic Reaction Kinetics42/1Examination1/1ÚCHV/NSM/04New Spectroscopic Methods22/1Examination1/2ÚCHV/SVK1/00Student Scientific Conference 4-/-Assessment1/2, 2/4ÚCHV/CMG/03Chemical Management53/-Examination2/3ÚCHV/PCH1/00Food Chemistry42/1Examination2/3ÚCHV/EMDP/03Experimental Methods for Master’s Thesis6-/6Assessment2/3
Course units

Compulsory courses

TitleBioorganic ChemistryCodeÚCHV/BOC/03TeacherGonda JozefECTS credits5Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo teach students the fundamental principles for the construction of bioorganic molecular models of biochemical processes using the tools of organic chemistry.
ContentIntroduction: Basic considerations; proximity effects in biochemistry, Molecular adaptation. Molecular recognition at the supramolecular level. Bio-organic chemistry of amino acids and polypeptides: chemistry of the living cells, Analoguey between organic reactions and biochemical tranformations, Chemistry of the peptide bond: nonribosomal peptide formation, asymmetric synthesis of amino acids, asymmetric synthesis with chiral organometalic catalysts, Transition state analogues. Antibodies as enzymes. Chemical mutations. Molecular recognition and drug design. Bio-organic chemistry of the phosphate groups and polynucleotides:d energy storage, DNA intercalates, RNA molecules as catalysts. Enzyme chemistry: introduction to catalysis and enzymes, Multifuntional catalysis and simple models. Alpha-chymotrypsin. Other hydrolytic enzymes. Strereoelectronic control in hydrolytic reactions. Immobilised enzymes. Enzymes in synthetic organic chemistry. Enzyme-Analogue-Built polymers. Design of molecular clefts. Enzyme Models: host-guest complexation chemistry, New developments in crown ether chemistry, Membrane chemistry and micelles. Polymers. Cyclodextrins. Enzyme design using steroid template. Remote functionalisation reactions. Polyene biomimetic cyclisations. Metal Ions: in proteins and biological molecules. Carbopeptidase A. Hydrolysis of amino acid esters and peptides. Iron and oxygen transport. Cooper ion. Cobalt and vitamin B12 action. Oxidoreduction. Pyridoxal phosphate. Biotin.
Recommended reading Voet J. : Biochemistry, Springer Verlag, 1992
Dugas H.: Bioorganic Chemistry, Springer Verlag, 1999


TitleChemistry of Natural CompoundsCodeÚCHV/PRL/04TeacherMartinková MiroslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students with general information about atractive natural products from various living organisms.ContentGeneral introduction, nomenclature, occurrence, isolation, detection, structure elucidation, biosynthesis, synthesis, biological activity and comercial aplications of natural compounds, such as: saccharides, lipids, amino acids, alkaloids, terpenoids, steroids, vitamins.Recommended reading S. V. Bhat, B. A. Nagasampagi, M. Sivakumar: Chemistry of natural compounds, Springer Narosa 2005

TitleOrganic SynthesisCodeÚCHV/OS/03TeacherKutschy PeterECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students the most important methods for the synthesis of organic compounds, their combination and application in the synthesis of complex molecules.ContentFormation of carbon-carbon single and double bonds. Synthesis of main groups of organic compounds (halogen derivatives, oxygen, nitrogen and sulphur containing compounds). Transformation and protection of functional groups. Retrosynthetic analysis.Recommended reading Carruthers W., Coldham I.: Modern Methods of Organic Synthesis, Fourth Edition, Cambridge University Press, 2005
Comprehensive Organic Synthesis Trost B. M., Fleming I., Eds., Vol. 1-9, Pergamon Press, Oxford, 1991

TitleDiploma WorkCodeÚCHV/DPCO1a/00TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester1ObjectiveTo allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.ContentStudy of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.
Recommended reading According to the approved setting of diploma work.

Title1D & 2D NMR SpectroscopyCodeÚCHV/NMR1/00TeacherImrich JánECTS credits6Hrs/week2/3AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students how to analyse the structure and properties of organic, inorganic and biomolecular compounds by 1D and 2D proton and carbon NMR spectra, quantitative NMR analysis, and practical applications in various fields of science and technology.ContentTheoretical principles of nuclear magnetic resonance (NMR), basic NMR pulse techniques and Fourier transformation, NMR spectrometers, description of NMR by vector models. Parameters of one- (1D) and two-dimensional (2D) NMR spectra, practical application of 1H and 13C NMR spectra and basic correlated 2D spectra for structure and stereo chemical arrangement, elucidation of reaction mechanisms, molecular dynamics, physico-chemical properties and quantitative analysis of chemical compounds.Alternate coursesÚCHV/NMR1/99Recommended reading Friebolin H.: Basic One- and Two-Dimensional NMR Spectrocopy, Verlag Chemie, Weintheim 1993
T.D.W. Claridge: High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 1999
Atta-ur-Rahman, M. I. Choudhary: Solving Problems with NMR spectroscopy, Academic Press 1996
H.-O. Kalinowski, S. Berger, S. Braun: Carbon-13 NMR Spectroscopy. Wiley New York, 1922
A. E. Derome: Modern NMR Techniques for Chemistry Research. Pergamon Press Oxford, 1927
E. Pretsch, B. Buhlmann, C. Affolter: Structure Determination of Organic Compounds. Tables of Spectral Data. Springer Verlag Berlin, 2000
E. Breitmaier: Vom NMR-Spektrum zur Strukturformel organischer Verbindungen. B. G. Teubner Stuttgart 1992
E. Breitmaier, W. Voelter: Carbon-13 NMR Spectroscopy. VCH Weinheim, 1990 

TitleModern Synthetic MethodsCodeÚCHV/MSM1/00TeacherMartinková Miroslava, Kutschy Peter, Gonda JozefECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students to understand modern methods in the synthesis of organic compounds.ContentConcepts, methods, starting materials, and target molecules that play important roles in modern organic synthesis. The concept of synthons, retrosynthetic analysis of simple organic molecules, asymmetric synthesis, nucleophilic addition, oxidation, reduction, protection of functional groups.Alternate coursesÚCHV/MSM1/99Recommended reading Comprehensive organic synthesis. Trost B. M., Fleming I., Eds. Vol. 1-9. Pergamon Press, Oxford 1991
J. Fuhrhop, G. Penzlin: Organic synthesis, VCH Weinheim, 1994

TitleDiploma WorkCodeÚCHV/DPCO1b/00TeacherECTS credits6Hrs/week-/-AssessmentRecognitionSemester2ObjectiveTo have students perform the experiments required for diploma work.ContentIndividual experimental work of student and study of required literature.Prerequisite coursesÚCHV/DPCO1a/00Automatic rerequisite coursesÚCHV/DPCO1a/00Recommended reading According to the approved setting of diploma work and literature search.

TitleDiploma WorkCodeÚCHV/DPCO1c/03TeacherECTS credits2Hrs/week-/-AssessmentRecognitionSemester3ObjectiveTo have students perform the experiments required for diploma work and to process their results.ContentIndividual experimental work of student and continuous processing of the obtained results.Prerequisite coursesÚCHV/DPCO1b/00Recommended reading According to the approved setting of diploma work and student’s own literature search.

TitleDiploma WorkCodeÚCHV/DPCO1d/03TeacherECTS credits30Hrs/week-/-AssessmentRecognitionSemester4ObjectiveTo have students finish their experiments, process their results, and learn how to write a thesis.ContentFinishing the student’s experimental work, processing of the obtained results and writing the diploma work.Prerequisite coursesÚCHV/DPCO1c/03Recommended reading According to the approved setting of diploma work and student’s own literature search.
Compulsory elective courses

TitleToxicology of Organic CompoundsCodeÚCHV/TOXOL/03TeacherMartinková MiroslavaECTS credits4Hrs/week3/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo examine the interaction between chemicals and biological systems in order for students to quantitatively determine the potential for chemicals to produce harmful effects in living organisms.ContentGeneral principles of toxicology. Absorption, distribution and excretion of toxicants. Biotransformation of xenobiotics: phase-1 reactions (oxidation, reduction, hydrolysis), phase-2 reactions (conjugation reactions). Toxication versus detoxication. Toxic effects of organic solvents. Toxicology of chemical warfare agents. Neurotoxicology. Toxic effects of plants and animal poisons. Toxic effects of drugs (barbiturates, benzodiazepines, tricyclic antidepressants). Drug dependence.
Recommended reading C. D. Klaassen: Casaret and Doull`s Toxicology: The basic science of poisons, McGraw-Hill Companies, Inc., 2001

TitleMolecular ModellingCodeÚCHV/MM1/00TeacherTörök MarcelECTS credits4Hrs/week1/3AssessmentAssessmentSemester3T/L methodLecture, PracticalObjectiveTo teach students the basic skills and theory necessary for the realisation of computational experiments in chemistry using specialised software packages. Students will be able to perform theoretical studies of the structure and electronic properties of small and middle-sised molecules and study the thermodynamical and structural aspects of chemical reactions. ContentBasic concepts. Reality vs. model: quantum mechanical models I, quantum mechanical models II, quantum mechanical models III, empirical force field models I, empirical force field models II, solvation models. Methods for exploring the energy surface: conformational analysis of molecules I, conformational analysis of molecules II. Exploring of the reaction pathways. Molecular dynamics and computer simulations. Overview of the software tools for molecular modelling., Presentation of the seminar project.Recommended reading LEACH, Andrew R.: Molecular Modelling: Principles and Applications
JENSEN, Frank: An Introduction to Computational Chemistry
Manuals for MOPAC, HYPERCHEM, GAMESS, GAUSSIAN

TitleNeurochemistryCodeÚCHV/NCH/03TeacherMartinková MiroslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the fundamental principles of chemical transmission between nerve cells; to have students understand the necessary link between neuroanatomy and neurochemistry.ContentNeurocellular anatomy - characteristics of the neuron. Cell membrane structures: phospholipid bilayer, membrane proteins, brain lipids, brain lipids biosynthesis. Membrane transport and ion channels. Synaptic transmission and cellular signaling. Neurotransmitters: acetylcholine, catecholamines, serotonin, amino acids (glutamate, aspartate, GABA, glycine). Neuropeptides: neuropeptide functions and regulation. G-proteins; the second-messenger hypothesis (cAMP, IP3, DAG, Ca2+). Neurotransmitters and disorders of the basal ganglia. Endocrine effects on the brain and their relationship to behaviour. Recommended reading G. J. Siegel, B. W. Agranoff, R. W. Albers, S. K. Fisher, M. D. Uhler: Basic neurochemistry, Lippincott Williams and Wilkins, Philadelphia 1999

TitleBasic Cheminformatics ToolsCodeÚCHV/ZCI/04TeacherTörök MarcelECTS credits2Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo introduce students to the fundamental informatics techniques for chemistry-related disciplines: representation and use of chemical structure information, computer-aided drug design, 3D visualisation and computation, and handling of large volumes of chemical information.ContentRepresenting 2D structures. 2D chemical database applications. Advanced 2D descriptors. Representing 3D structures. 3D visualisation and computation. Laboratory information management systems. Electronic laboratory notebooks. Chemical informatics software development. Emerging web service technologies for chemical informatics.Recommended reading Johann Gasteiger & Thomas Engel (eds.), Chemoinformatics: A Textbook. Wiley-VCH, Weinheim, 2003
Andrew Leach & Valerie Gillet, An Introduction to Chemoinformatics. Kluwer Academic Publishers, Dordrecht, NL, 2003.

TitleHeterocyclic CompoundsCodeÚCHV/HZ1/00TeacherKutschy PeterECTS credits4Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students basic information about the occurrence, practical significance, synthesis, and chemical and biological properties of heterocyclic compounds.ContentPreparation and properties of various types of heterocycles. Attention will be paid to aromatic and non-aromatic compounds, including their biological properties and application in organic synthesis. Recommended reading Gilchrist T.L.: Heterocyclic Chemistry, Longman Harlow 1992
Eichler T., Hauptmann S.: The Chemistry of Heterocycles. Structure, Reactions, Synthesis and Application. Second Edition, WILEY-VCH, Weinheim, 2003

TitleQuantum ChemistryCodeÚCHV/KOC1/01TeacherDanihel IvanECTS credits5Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo have students improve their knowledge in the field of valence-bond based on molecular orbital theory (MO) and individually to perform basic quantum chemical calculations (molecular geometry optimisation, transition states, vibrational analysis, etc.). ContentDevelopment of valence-bond theory. Time-independent Schrodinger equation. Basic approximations in molecular orbital valence-bond theory. Variant methods of calculation in the framework of molecular orbital valence-bond theory. Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction coordinate. Calculation of absolute and relative equilibrium and rate constants in gas phase. Solvatation energy calculation.Alternate coursesÚCHV/KOC1/99 orÚCHV/KOC1/00Recommended reading Jensen F.: Introduction to Computational Chemistry, Wiley,2000
Leach A.R.: Molecular Modelling, Addison Wesley Longman Ltd. 1992
Náray-Szabó G., Surján P.R., Ángyán J.G.: Applied Quantum
Chemistry, Akadémia Kiadó, Budapest, 1927 

TitleCosmetic ChemistryCodeÚCHV/KC/03TeacherMartinková MiroslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo teach students the chemical ingredients in cosmetic products.ContentThe basic ingredients in the cosmetic products. Cosmetic lipids. Proteins, amino acids, AHA, tensides, antioxidants, dyes, preservatives. The chemistry of fragrances.
Recommended reading D. H. Pybus, Ch. S. Sell: The chemistry of fragrances, Royal Society of Chemistry, UK 1999
G. Ohloff: Scent and fragrances, Springer-Verlag 1990
Elective courses

TitleMedicinal ChemistryCodeÚCHV/FMCH/04TeacherKutschy PeterECTS credits6Hrs/week3/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo teach students the basic principles involved in the research and development of chemical drugs. To develop student understanding of structure-activity relationships including space structure and chirality and their consequences on chemical and physico-chemical properties influencing biological activity. To familiarise students with the present state in the field of selected important groups of drugs, such as antibacterial, antiviral or antitumor drugs.ContentIntroduction. Classification of drugs. Factors influencing design and activity of drugs of the third generation. Drug chirality. Search for new drugs. Structure-activity relationships. Chemotherapeutics of central, peripheral and vegetative nervous system. Antibacterial compounds, antibiotics, antitumor compounds, antiviral compounds.
Recommended reading Medicinal Chemistry: Principles and Practice, King F. D., Ed., The Royal Society of Chemistry, Thomas Graham House, Cambridge, 1994
Advances in Drug Discovery Techniques: Harvey A. L., Ed., Wiley & Sons, Chichester, 1992
Thomas G.: Medicinal Chemistry: An introduction. John Willey & Sons, 2000

TitleNew Spectroscopic MethodsCodeÚCHV/NSM/04TeacherHritzová O>gaECTS credits2Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentEmission methods. Chiroptical methods. Special applications of infrared and Raman spectroscopy. Microwave spectroscopy. Utilisation of methods for structure determination in chemistry and biology.


TitleComputational Statistics and Simulation MethodsCodeÚMV/VP1/04Teacher}e~ula IvanECTS credits5Hrs/week1/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo familiarise students with modern software and computational and simulation methods in statistics.ContentSystems of statistical software. Computation of distribution functions. Matrix computations. Random numbers generation. General and specific methods for generating random numbers with a given distribution. Monte Carlo methods. Resampling. Exploratory data analysis.Alternate coursesÚMV/VP1/99Recommended reading Abramowitz, Stegun: Handbook of mathematical functions,
Dover Publications, 1972
Deák: Random number generators and simulation, Akadémiai
kiadó, 1990
Fishman: Monte Carlo. Concepts, Algorithms, and Applications., Springer, 1996























GENERAL ECOLOGY
Study programme General Ecology and Ecology of Individuals and Populations
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚBEV/DP1a/03Diploma Work2-/-Recognition1/1ÚBEV/DP1b/03Diploma Work6-/-Recognition1/2ÚBEV/DP1c/03Diploma Work8-/-Recognition2/3ÚBEV/DP1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚGE/FYG1/03Physical Geography 153/1Examination1/1 ÚCHV/CHRA1/03Chromatographic Analysis62/2Examination1/1 ÚCHV/MMU/03Macromolecular Chemistry13/-Examination1/1 ÚGE/GEP2/05Geology and Petrography63/2ExaminationÚCHV/MSO1/03Wastes Treatment Methods12/1Examination1/1 ÚCHV/PFCU/03Practical in Physical Chemistry1-/3Assessment1/1 ÚCHV/CHHS/07Hydrochemistry62/2Examination1/1 ÚGE/VYM2/03Selected Chapters on Meteorology and Climatology2-/2Assessment ÚCHV/ACM1/06Chemometrics62/2Examination1/2 ÚCHV/EECH/03Environmental Chemistry52/1Examination1/2 ÚBEV/GB1/03Geobotany12/1Examination1/1 ÚCHV/FKC1/03Colloid Chemistry12/1Examination1/2 ÚCHV/FKC/00Colloid Chemistry Practical3-/3Assessment1/2 ÚBEV/CRO1/03Chronophysiology52/1Examination1/1 ÚBEV/EFZ1/03Animal and Human Ecophysiology62/2Examination1/1 ÚBEV/ETO1/03Ethology62/2Examination1/1 ÚCHV/MCV1/03Methods of Chemical Research12/1Examination1/2 ÚCHV/AOL1/06Analysis of Organic substances62/2Examination1/2, 2/4ÚCHV/SKACH1/06Forensic and Clinical Analytical Chemistry52/1Examination1/2, 2/4ÚBEV/EET1/03Ecological Ethology6 2/2Examination1/2ÚBEV/BFA1/03Biopharmacology52/2Examination1/2 ÚBEV/VKH1/03Selected Topics in Herpetology12/1Examination1/2 ÚCHV/VSE1b/01Special Seminar2-/2Assessment1/2 ÚBEV/EKR1/03Plant Ecology62/2Examination1/2 ÚCHV/SDP/03Seminar on Diploma Work2-/2Assessment2/4ÚBEV/DNR/06Dendrology52/2Examination1/2 ÚCHV/AAS1/03Atomic Spectrochemistry62/2Examination1/2, 1/3ÚCHV/BACH1/03Bioanalytical Chemistry52/1Examination1/2, 1/3 ÚBEV/PG1/03Population Genetics52/1Examination1/2 ÚCHV/AVZ1/02Analytical Sampling52/1Examination1/2 ÚCHV/ATV1/01Water Pre-treatment62/2Examination1/2 ÚBEV/REK1/01Radiation ecology32/-Examination2/3 ÚCHV/FEM1/03Electroanalytical Methods52/1Examination1/2, 1/3 ÚCHV/VSE1a/01Special Seminar2 -/2Assessment1/1ÚCHV/ZTOX/01Basic Toxicology52/1Examination1/2, 1/3ÚCHV/ACPE1/03Industrial Ecology52/1Examination1/2, 1/3
Elective courses

ÚCHV/BOC/03Bio-organic Chemistry53/-Examination ÚCHV/TOXOL/03Toxicology of Organic Compounds13/-Examination ÚCHV/PCH1/00Food Chemistry12/1Examination ÚCHV/CMG/03Chemical Management53/-Examination ÚCHV/APO1/02Analysis of Psychotropic and Narcotic Substances12/-ExaminationÚCHV/STOX/01Special Toxicology52/1Examination

Course units

Compulsory elective courses

TitlePhysical Geography 1CodeÚGE/FYG1/03TeacherBarabas DušanECTS credits5Hrs/week3/1AssessmentExaminationSemester7T/L methodLecture, PracticalContentHydrology of running water, genesis and development of river basins, measuring of water and its flow. Genesis of the main types of lakes, temperatures, water movements. Movements of sea and ocean waters, their chemical make-up, relief of the sea-floor. Underground waters; glaciers. Soil science and soil geography: the physical and chemical nature of soils; presently used systems of the soil classification. Distribution of different soil types in the world and Slovakia. Principles of the soil zonality.Prerequisite coursesÚGE/GEM2/05Exclusive coursesÚGE/HYD/07,ÚGE/PED/07Alternate coursesÚGE/MEH1/99,ÚGE/PEB1/99 or ÚGE/FYG1/00 or ÚGE/FYG1/01

TitleGeology and PetrographyCodeÚGE/GEP2/05TeacherBónová Katarína, Hochmuth ZdenkoECTS credits6Hrs/week3/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo introduce students to current theories about processes occurring in the Earth and to familiarise them with rock formation and the geology of Slovakia.ContentCurrent theories about processes which occur in the Earth (global tectonics, species of magmatism). Rock-forming minerals, taxology of intrusive rocks, taxology of sedimentary rocks and rocks which overcame metamorphosis. Basics of the regional geology of Slovakia; basics of historical geology and paleontology. Alternate coursesÚGE/GEP1/99 or ÚGE/GEP2/01

TitleChosen Chapters of Meteorology and ClimatologyCodeÚGE/VYM2/03TeacherHochmuth ZdenkoECTS credits2Hrs/week-/2AssessmentAssessmentSemesterT/L methodPracticalContentThe condition of the atmosphere at a given time: physical characteristics of individual layers and zones. Weather elements: temperature, atmospheric heating, measurement of temperature, moisture, clouds, precipitation. Climatic influences, controls and classifications.
Prerequisite coursesÚGE/FYG2/05 or ÚGE/MEK/07Alternate coursesÚGE/VYM2/01 or ÚGE/VYM1/99

TitleZoogeographyCodeÚBEV/ZOG1/03TeacherKová
 =ubomírECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students knowledge of the basic reasons for the recent distribution of animals on Earth, zoogeographic regionalisation of the Earth´s surface and human influence on the historical distribution of fauna. ContentCurrent understanding of the patterns of animal distribution and the processes that influence distributions of species and their attributes. Historical and current ecology; genetics; physiology of animals and their interaction with environmental processes (continental drift, climate) in regulating geographic distributions. Descriptive and analytical approaches useful in hypothesis testing in zoogeography. Illustration of applied aspects of zoogeography (e.g., refuge design in conservation).
Alternate coursesÚBEV/ZOG1/99Recommended reading Darlington, P.J., 1998: Zoogeography: The geographical distribution of animals. Krieger, USA
Lomolino M.V., Brown J.H., Riddle B. R., 2005: Biogeography. Sinauer Associates, 1-845

TitlePhytogeographyCodeÚBEV/FG1/03TeacherMártonfi PavolECTS credits5Hrs/week2/1AssessmentExaminationSemester7T/L methodLecture, PracticalObjectiveTo provide students theoretical and practical knowledge of phytogeography.ContentHistory of phytogeography. Plants and environment. Chorology, area, area disjunctions, relics, endemites, vicariancy, floral elements. Main course of florogenesis from paleozoic to quaternary ages. Postglacial evolution of Slovak vegetation. Regional phytogeography of Earth. Vegetation geography: from tropical rainforests to tundra. Changes of earth vegetation and their study. Geographical origin of cultivated plants. Practices: Fieldwork. Preparing maps. Phytogeographical division of Slovakia. Student seminar works on phytogeography.Alternate coursesÚBEV/FG1/00 orÚBEV/FG1/99Recommended reading Hendrych R.: Fytogeografie. - SPN, Praha 1984
Brown J. H., Lomolino M. V.: Biogeography. - Sinauer Associates, Sunderland, 1998

TitleHydrobiologyCodeÚBEV/HDR1/99TeacherHudec IgorECTS credits3Hrs/week1/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentAbiotic and biotic factors of a water environment; typology and characteristics of freshwater habitats; eutrophycation, pollution saprobity and evaluation of habitats with relation to abiotic factors.Recommended reading Horn, A., Goldman, C.: Limnology. Mc Graw Hill. 2nd Edition, 1994
Wetzel, R.G.: Limnological analyses. Springer Verl., 3rd Edition, 2000

TitleAnimal and Human EcophysiologyCodeÚBEV/EFZ1/03TeacherAhlersová Eva, Bojková BiankaECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with basic mechanisms and principles of the action of the environmental condition on the internal physiological processes. To show the possible mechanisms of adaptation of animals to extremal values of environmental factors.ContentThe influence of environmental factors in phylogenesis and ontogenesis. The course of the stress reaction, kinds of adaptation. Pathology of adaptation processes: general symptoms of pathological processes. Adaptations on vital factors of the environment: adaptations to changes in food intake (starvation and overfeeding), the effects of hypo- and hyperbary, adaptation to increased water salinity, the influence of gravitation, the effects of high and low temperatures, effects of electricity, electromagnetic field and laser beam of noise, non-ionizing and ionizing radiation, ultrasound and vibrations on living organisms. Alternate coursesÚBEV/EFZ1a/99

TitleEthologyCodeÚBEV/ETO1/03TeacherMajláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students to know and to be aware of the importance of the behavioural aspect in biological sciences.ContentHistory and development of ethology. Ethological methods. The innate forms of behaviour. The simplest forms of learning: conditioning and instrumental learning. Higher forms of learning. Social behaviour. Sexual behaviour. Play behaviour. Biological rhythms. Orientation in space and animal migrations. Communication systems of animals. Emotions. Aggression in animal and human behaviour. Abnormal forms of behaviourAlternate coursesÚBEV/ETO1/99Recommended reading Franck, D.: Verhaltensbiologie. Einfuhrung in die Ethologie. Georg Thieme-Verlag, 1993
Manning, A., Dawkins, M. S.: An introduction to animal behaviour. Cambridge University Press, 1992

TitleSoil EcologyCodeÚBEV/EKP1/04TeacherKová
 =ubomírECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo give students knowledge of soil as a heterogenous substrate and environment for organisms with special emphasis on the mineral and organic components of the soil essential for existence and development of populations of the living biota. ContentComponents of the soil environment, microclimate, nutrient cycling and energy flow. Soil-forming factors and processes, soil organisms microbial communities, plant roots, invertebrate communities and functioning of the soil system (decomposition, litter system, rhizosphere, drillosphere, termitosphere). Recommended reading Coleman D. C., Crossley D. A. jr.: Fundamentals of soil ecology. Academic Press, 1995
Dunger W., Fiedler H. J.: Methoden in Bodenbiologie. VEB Gustav Fischer Verlag, Jena, 1989
Lavelle P. Spain A. V.: Soil ecology. Kluwer Academic Publishers. Dordrecht-Boston-London, 2001 

TitleEcology of Soil AnimalsCodeÚBEV/EPZ1/03TeacherKostúrová NatáliaECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give students basic knowledge on the functioning of the soil system with special reference to dominant systematic groups of soil fauna, their ecology and taxonomic identification.ContentThe soil as an ecological system and type of environment Ecological factors ruling life in soil, soil-dwelling animals and their adaptations to this specific habitat. Functioning of the soil system and understanding of the principal interactions of soil fauna with the plant rhizosphere and soil microflora. Prerequisite coursesÚBEV/EKP1/04Alternate coursesÚBEV/EPZ1/99Recommended reading Coleman, D.C., Crossley, D. A., 1996: Fundamentals of Soil Ecology. Academic Press, London, 1-205
Eisenbeis, G., Wichard, W., 1987: Atlas on the Biology of Soil Arthropods. Springer- Verlag Berlin, Germany, 1-437
Schaller, F. 1968: Soil Animals. The University of Michigan Press, United States of America, 1-144
Wallwork, J. A., 1970: Ecology of Soil Animals. McGraw- Hill, England, 1-283
Wallwork, J. A., 1976: The distribution and Diversity of Soil Fauna. Academis Press, London, 1-355

TitleEcology of Water AnimalsCodeÚBEV/EVZ1/03TeacherHudec IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the ecological characteristics of freshwater groups and prevalent species of invertebrates.ContentBiology of the most common representatives and groups of freshwater animals of the Central Europe temperate region. Mohological adaptations, taxanomical characters, water communities.
Alternate coursesÚBEV/EVZ1/99Recommended reading Fryer, G., Murphy, S.: A natural history of the lakes, tarns and streams of the English Lake District. Freshw. Biol. Association Cumbria, 1991
Bronsmark, Ch., Hannsson, L. A.: The biology of Lakes and ponds. Biol. Of Habitats Ser, 1998


TitleEcological EthologyCodeÚBEV/EET1/03TeacherAhlers Ivan, Majláth IgorECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo give students the means to analyse and comprehend the principles of behavioral strategies in a given ecosystem from the point of view of sociobiology.ContentThe topic of sociobiology and its relations to other disciplines. The evolution of social behavior in animals and in man. Strategies of social interactions and formation of groups in relation to the ecosystem. The choice of appropriate social arrangement, sexual partner, reproductive and parental strategy. Competition among individuals and sexes.
Prerequisite coursesÚBEV/ETO1/03

TitleBiopharmacologyCodeÚBEV/BFA1/03TeacherGálik JánECTS credits5Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide the students with basic knowledge on the classification and mechanism of action of the most important pharmaceuticalsContentPharmaceutical principles. Classification of drugs. Absorption, biotransformation and excretion of drugs from the organism. Pharmacogenetics. Molecular mechanisms of drug effects. Drug-receptor interactions. Chronic administration of drugs. Teratogenity and cancerogenity of drugs. Development and introduction of drugs for clinical use. Principle of chronopharmacologyAlternate coursesÚBEV/BFA1/99Recommended reading Clark, W. G., Braber, D.C., Johnen, A.R.: Goth‘s medical pharmacology. Mosby Year Book, 1992


TitleBiology of Plant SymbiosesCodeÚBEV/BRS1/03TeacherBa
kor MartinECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo familiarise students with the most typical examples of plant symbioses.ContentMorphological, cytological, physiological and biochemical aspects of the most typical examples of plant symbioses (lichens, mycorrhiza, nitrogen fixing bacteria, coral reefs, endosymbiosis). Alternate coursesÚBEV/BRS1/99Recommended reading Van den Hoek, C. a kol. 1995: Algae, an introduction to phycology,
Deacon, J.W. 1997: Modern Mycology


TitlePopulation GeneticsCodeÚBEV/PG1/03Teacher ellárová Eva, Brezáni PeterECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo understand genetic relations at the population level, importance of population equilibrium and consequences of its changes.ContentGenofond and genotype composition of a population. Genetic equilibrium of the population - Hardy-Weinberg law, linkage disequilibrium. Random mating and inbreeding, consequences of inbreeding in population - Bernstein-Wright law, consanguinity, homogamy, Wahlund effect. Mutations a mutation pressure, selection and selection pressure, fitness. Random effects: genetic drift, migration. Genetic isolates and their consequences, genetic polymorphism. Evolutionary significance of genofond changes.
Recommended reading Griffiths, A.J.F. et al.: Modern Genetic Analysis, W.H.Freeman and Co., New York, 1999

TitleBiospeleologyCodeÚBEV/BSP/04TeacherKová
 =ubomírECTS credits4Hrs/week1/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo give students basic knowledge on the diversity of the cave biota, relationships between and adaptations of biota to the specific environment, human influence and protection of the cave biota. ContentMorphology and systematics of the cave fauna and microflora, their adaptations to this specific habitat type, geographic distribution, functioning of the cave system and interactions between its components, human influence and protection of the cave biota. Prerequisite coursesÚBEV/EPZ1/03Recommended reading Culver D. C., 1982: Cave life – evolution and ecology. Harvard University Press, Cambridge, Massachusetts and London
Culver D.C., White W.B., 2005: Encyclopedia of caves. Elsevier, 1-654
Vandel A., 1965: Biospeleology - the biology of cavernicolous animals. Pergamon Press, Oxford
Wilkens H., Culver D.C., Humphreys W.F., 2000: Subterranean Ecosystems. Ecosystems of the World, vol. 30. Elsevier, 1-791

TitleRadiation EcologyCodeÚBEV/REK1/01Teacher`majda BeHadikECTS credits3Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo provide students with a basic knowledge about the effects of ionizing radiation on living systems.ContentBiologically important radionuclides. Natural sources of ionizing radiation. Artificial radioisotopes and the paths of their entrance into the biosphere. Radioactive compounds in the food chains. Entrance, acummulation and excretion of radioactive substances in animals. Biological effects of ionizing radiation.Alternate coursesÚBEV/REK1/99Recommended reading Coggle, J.E.: Biological Effects of Radiation. Taylor and Francis LTD, London, 1983
Hall, E.J.: Radiobiology for the Radiologist. J.B. Lippincott Company, Philadelphia, 1988

TitleChromatographic AnalysisCodeÚCHV/CHRA1/03TeacherOriHák AndrejECTS credits6Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalContentGeneral characteristics of chromatographic system and chromatographic separation. Analyte retention in chromatography; retention indices. Models used for chromatographic system description. Parameters affecting quality of chromatographic separation. Sensitivity, separated analytes, separation time, optimisation of chromatographic process. General equation of chromatography. Evaluation of retention and selectivity of chromatographic process. Stationary phase. Qualitative chromatographic analysis. Quantitative analysis methods; sample preparation. System of analyte separation. Identification in chromatographic analysis.Recommended reading D.A. Skoog, J.J. Leary: Principles of Instrumental Analysis, Saunders, 1992

TitleMacromolecular ChemistryCodeÚCHV/MMU/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week3/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo make students familiar with available structures of polymers and their synthesis methods as well as with the ways that structure is reflected in their properties.ContentFundamental aspects of chemical composition of polymers-monomers; shape and the relationship between structure and properties. Primary, secondary, tertiary and quaternary structures. Thermal transition. Molecular mass distributions. Determination of molecular mass of macromolecules. Synthetic methods of functional polymers and their characterisation. Naturally occurring polymers: their properties. Degradation of polymers. Polymers and the environment.Recommended reading Elias H.-G.: Macromolecules. Volume 1(Structure and Properties); Volume 2 (Synthesis, Materials, and Technology). Plenum Press, New York, 1984
Moore W.J.: Physical Chemistry. Longman, London,1972
Munk P.: Introduction to Macromolecular Science. John Wiley & Sons, New York, 1989
Atkins P.W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002

TitleWastes Treatment MethodsCodeÚCHV/MSO1/03TeacherOriHák AndrejECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentWastes classification; wastes separation. Re-cycling of wastes; methods of wastes elimination and re-finishing. Pyrolysis, degradation of wastes by pyrolysis, process optimisation. Analytical methods for wastes analysis. Monitoring of wastes degradation pollutants, toxicity of wastes and degradation products.

TitlePractical in Physical ChemistryCodeÚCHV/PFCU/03TeacherMarkušová KvetoslavaECTS credits4Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo allow students to verify theoretical principles and to learn to describe each technique involved in appropriate physical chemistry experiments.ContentExperimental verification of theoretical knowledge involving thermodynamics, thermochemistry, chemical equilibria (determination of enthalpy, phase diagrams), colligative properties (cryoscopy, ebulioscopy), adsorption. Experimental verification of theoretical knowledge involving electrochemistry (conductivity, dissociation constants, potentials, electromotoric potentials of cells, activity coefficients, polarography) and chemical kinetics (determination of rate constants).Recommended reading B.P. Levitt: Findlay´s practical physical chemistry. Longman, London, 1973
W.J. Moore: Physical Chemistry. Longman, London, 1972
P.W. Atkins: Physical Chemistry. Oxford University Press, Oxford, New York, 2002


TitleHydrochemistryCodeÚCHV/CHHS/07TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo improve student knowledge of hydrochemistry ContentProperties of water. Types of water, their characteristics. Chemical content and properties of natural waters. Surface waters. Chemical content and properties of surface waters. Fundamentals of aquatic chemistry. The hydrologic cycle. Mineral waters, their classification. Chemical content and properties of mineral waters. Underground water. Processes influencing the content of underground water. Sea water. Problems of sea water purification. Waste water. Content and properties of waste water. Basic strategies of water analysis. Sampling. Features of opening-up samples in water analysis. Conservation of samples. Methods of investigation of integral characteristics of water. Important physical indexes of quantity of water: temperature, density, transparency, color, turbidity, taste, smell. Content of soluble and insoluble compounds. Important methods of analysis of water chemical content. Chemical, physic-chemical, physical, biological methods of analysis. Total nitrogen. Organic nitrogen. Total phosphorus. Organic carbon. Chemical consumption of oxygen. Biochemical consumption of oxygen. Dissolved oxygen. Hydrogen sulfide and sulfides. Acidity, basicity, components of carbonate system, aggressive carbon dioxide. Distributing diagrams. Interaction of content of water and sediments. Features of organic substances analysis. Separation and concentration of organic substances. Lignosulfonic acides and tannin. Oils. Organic acids. Synthetic detergents. Pesticides. Test-methods in water analysis. Automatic monitoring stations. Sensor systems. Requirements for water quality.
Prerequisite coursesÚCHV/ANCHU/03 or ÚCHV/ANCH1b/03 or ÚCHV/ANCH3/03Alternate coursesÚCHV/EACHH/04Recommended reading Handbook of Water and Wastewater Treatment Technologies. Ed. By Nicholas P Cheremisinoff, BUTTERWORTH HEINEMANN, 576 p. 2001
Principles of Water Quality Control, Ed. by Thy Tebbutt, BUTTERWORTH HEINEMANN, 288 p. 1997.
Water Technology. Ed. by N. F. Gray, BUTTERWORTH HEINEMANN, 600 p. 2005


TitleChemometricsCodeÚCHV/ACM1/06TeacherBaze> Yaroslav, Vojteková VieraECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide knowledge of methods and methodologies of uncertainty and decision statistics needed to correctly evaluate and interpret analytical results. To provide knowledge about the areas of validation and accreditation of the laboratories. ContentThe principles of the mathematic-statistical methods used in analytical chemistry. Distribution of the measuring results. Classic and robust estimation of the mean value and variance. Statistical tests and their application. Accuracy, precision and reliability of the results. Uncertainity of the results. Calibration in analytical chemistry; linear and nonlinear models. Evaluation of analytical methods; chosen optimisation methods. Solving of typical problems within the framework of the practical lecture.Alternate coursesÚCHV/ACM1/03Recommended reading Richard G. Brereton: Chemometrics: Data Analysis for the Laboratory and Chemical Plant., Boca Raton, New York, 2003

TitleEnvironmental ChemistryCodeÚCHV/EECH/03TeacherOriHák AndrejECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentMatter cycles on Earth. Geochemical cycles. Carbon, nitrogen, sulphur, phosphorous cycles. Metals and environment. Special cycles. Earth atmosphere composition; functions of atmosphere. Physical and chemical processes in atmosphere. Atmospheric photochemistry. Pollutants in atmosphere and the greenhouse effect. Models of greenhouse effects. Principles of air quality control. Energetic Earth balance. Water environment and pollutants monitoring. Classification of pollutants and ways of elimination. Waste water cleaning processes. Analytical methods in environmental chemistry, applications. Soil analysis, biogeochemical processes. Acid rain; metal ions in soil. Environmental analysis, strategy and concepts.Recommended reading G. Schwedt: The Essential Guide to Environmental Chemistry, Wiley and Sons, London 2001
R.N. Reeve, J.D. Barnes: General Environmental Chemistry, Wiley, London 1994 

TitleColloid ChemistryCodeÚCHV/FKC1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo clarify basic physicochemical principles of colloid disperse systems (sise of dispersed particles); to examine selected important problems of technology and nature.ContentClassification and characterisation of dispersed systems. Heterogeneity of colloidal systems. Optical properties of colloids. Theory of light scattering. Molecular-kinetic properties. Brownian motion, diffusion, osmosis, and sedimentation. Adsorption-basic concepts. Electrokinetic phenomena and their application. Structure, stability and coagulation of colloids. Rheology of dispersed systems. Gels. Aerosols. Solid dispersions, emulsions and foams. Application of theory during laboratory and calculation exercises.Alternate coursesÚCHV/FKC1/99ÚCHV/FKC1/00Recommended reading Moore W.J.: Physical Chemistry. Longman, London,1972
Hiemenz P.C.: Principles of Colloid and Surface Chemistry. M.Dekker, New York, 1986
Atkins P.W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002 

TitleColloid Chemistry PracticalsCodeÚCHV/FKC/00TeacherMarkušová KvetoslavaECTS credits3Hrs/week-/3AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo give an introduction to technically important applications of colloid and surface chemistry.ContentSurface effects. Adsorption at interface of solid and liquid phases, determination of surface nature. Electrical properties. Stability and coagulation of colloids. Structure-mechanical properties of colloids. Properties and aggregation of surfactants and micelles. Rheological properties. Alternate coursesÚCHV/FKC/99Recommended reading Internal textbooks

TitleMethods of Chemical ResearchCodeÚCHV/MCV1/03TeacherKladeková Daniela, Markušová KvetoslavaECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo familiarise students with physicochemical parameters as a means of measurement, evaluation, and interpretation in the study of a process. ContentOverview of basic principles of the determination of physicochemical quantities (dissociation constant, activity coefficient, solubility product, stability constant of complex, diffusion coefficient). Calorimetry and its utilisation. Experimental methods in kinetics. The Butler-Volmer equation. Survey of selected key topics in colloid chemistry. Adsorption-BET equation. A discussion of topics selected from active research fields. Recommended reading Moore W.J.: Physical Chemistry. Longman Group Limited, London, 1972
Willard H.H. et al.: Instrumental Methods of Analysis. Wadsworth, Belmont, 1988
Koryta J., DvoYák J., Kavan L.: Principles of Electrochemistry. John Wiley & Sons, New York, 1993
Atkins P.W.: Physical Chemistry. Oxford University Press, Oxford, New York, 2002

TitleForensic and Clinical Analytical ChemistryCodeÚCHV/SKACH1/06TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester2, 4T/L methodLecture, PracticalContentBasic principles and definition of subject. Toxicology: classification of toxic and foreign substances. Drugs of abuse, doping agents, chemical harmful agents, and their metabolisms and analyses, application of analytical methods for the before-mentioned chemicals in human matrices.Alternate coursesÚCHV/SKACH1/03Recommended reading A. Mozayani, C.Noziglia: The Forensic Laboratory Handbook. Procedures and Practice, Springer, 2006
J.H.Duffus, H.G.J.Worth: Fundamental Toxicology, Springer, 2006
R.Bertholf, R.Winecker: Chromatographic Methods in Clinical Chemistry and Toxicology, Wiley. 2007

TitleSpecial SeminarCodeÚCHV/VSE1b/04TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students’ theses.

TitleSeminar on Diploma WorkCodeÚCHV/SDP/03TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester4T/L methodPracticalObjectiveTo teach the student to prepare a presentation of his/her own results, to respond to criticism, to participate in scientific discussion, and to fulfil formal requirements of written diploma work.ContentPresentation of researched information and own experimental results; scientific discussions and writing of scientific text.Recommended reading According to field of diploma work.

TitleAtomic SpectrochemistryCodeÚCHV/AAS1/03TeacherBaze> Yaroslav, Vojteková VieraECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3 T/L methodLecture, PracticalObjectiveTo provide students with theoretical information and practical experience with atomic absorption and emission methods used in analytical practice (environmental analysis, material research, clinical and food analysis).ContentBasic and enhanced information about spectral (optical) methods; history of their development; practical applications: optical analytical methods, principles, classification; atomic spectra, creation, analytical use. Modern equipment for scanning for radiation. Detection of radiation in spectrochemistry. Historical development; actual trends. Photographical detection and its particularities. Methodologies for solution analysis; special methods for the direct transport of the solid samples in the DCA source. Atomic absorption spectrometry, flame and electrothermal atomisation. Methods based on the interaction of the RTG radiation and the sample: advantages, disadvantages and applications of WDXRF, EDXRF, TXRF.Alternate coursesÚCHV/AAS1/01Recommended reading D. A. Skoog, J.J.Leary: Instrumental Analytics. Springer, Berlin - Heidelberg 1996
B. Welz, M. Sperling: Atomic Absorption Spectrometry,Wiley-VCH Verlagsgesellschaft mbH Germany 1998
Douglas A. Skoog, Donald M. West, F.James Holler, Timothy A. Nieman: Principles of Instrumental Analysis. , Wandsworth, 1997

TitleBioanalytical ChemistryCodeÚCHV/BACH1/03TeacherReiffová Katarína, Baze> YaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester7, 9T/L methodLecture, PracticalObjectiveTo convey theoretical knowledge and to give practical experience to students concerning the application of analytical chemistry and analytical methods to laboratory medicine.ContentIntroduction to bioanalytical chemistry. Biological sample; classification. Sampling techniques, transport, sample storing and conservation. Selected methods of sample pre-treatment for bioanalysis. Conditions for analytical method selection. Presentation of analytical data evaluation. Optimisation of analytical procedure. Control and management of quality in clinical laboratory. Molecules colouring and their analytical applications. Enzymes in bioanalysis. Mechanism of enzyme catalysis. Enzymes like analytes and analytical reagents. Moderators of enzyme activity. Basic principles of enzyme analytics. Introduction to Immunochemical methods: precipitation, nephelometric, turbidimetric and agglutination methods. Immunodiffusional methods. Radioimmunoanalytic methods (RIA). Nonisotopic methods (EIA, ELISA, LIA, FIA). Microbiological methods. Analysis of biomolecules: separation methods selection. Analytical technique of miniaturisation: principle, microchips, biosensors.Recommended reading Mikkelsen S.R, Cortón E.: Bioanalytical Chemistry, Wiley, 2004
Wilson I.: Bioanalytical Separations 4, (Handbook of Analytical Separations), Elsevier, 2003
Suelter C.H.,Kricka L.J.: Methods of Biochemical Analysis, Vol.37, Bioanalytical Instrumentation, Wiley, 1994
Rodriguez-Diaz R., Wehr T., Tuck S.: Analytical Techniques for Biopharmaceutical Development, Marcell Dekker, 2005

TitleAnalytical SamplingCodeÚCHV/AVZ1/02TeacherOriHák AndrejECTS credits5Hrs/week2/1AssessmentExaminationSemester8T/L methodLecture, PracticalContentAnalytical sample; characterisation. Sampling and norms affecting sampling process. Quantity, number of samples. Sampling techniques. Sampling laboratory equipment. Sample pre-concentration. Sample storing and conservation. Matrix simplifying; specific analysis. Chromatographic sample pre-treatment.
Alternate coursesÚCHV/AVZ1/00Recommended reading O. Stoeppler: Sampling And Sample Preparation Practical Guide for Analytical Chemists. Academic Press, London, 2002
E.P.Popek: Sampling and Analysis of Environmental Chemical Pollutants.Elsevier Science, San Diego, 2003

TitleWater PretreatmentCodeÚCHV/ATV1/04TeacherAndruch Vasi>ECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo allow students to obtain and improve their knowledge of the methods of water pretreatment.ContentPurification of waste waters from colloid substances. Purification of waste waters by chemical precipitation. Water degasing. Ion exchange purification of waste waters. Adsorption methods of waste water purification. Waste water purification via extraction. Waste water purification by membrane methods. Biological purification of water. Prerequisite coursesÚCHV/CHHS/07 orÚCHV/ANCH1b/03Recommended reading 1Handbook of Water and Wastewater Treatment Technologies. Ed. By Nicholas P Cheremisinoff, BUTTERWORTH HEINEMANN, 576 p. 2001
Principles of Water Quality Control, Ed. by Thy Tebbutt, BUTTERWORTH HEINEMANN, 288 p. 1997.
Water Technology. Ed. by N. F. Gray, BUTTERWORTH HEINEMANN, 600 p. 2005

TitleElectroanalytical MethodsCodeÚCHV/FEM1/03TeacherMarkušová KvetoslavaECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students a survey of the principles, theoretical background and practical applications of modern electroanalytical methods.ContentImportance of electroanalytical methods for environmental control and protection, requirements of practice, electrochemical cells, electrode potential, mass transfer by convection, migration and diffusion, Cottrell equation, direct current voltametry and polarography (principle, theoretical backround, examples of practical application). TAST polarography and voltametry, staircase voltammetry, pulse techniques: normal pulse and differential pulse voltammetry and polarography, square-wave voltammetry and polarography, AC polarography and voltammetry, anodic stripping voltammetry, adsorptive (or accumulation) voltammetry (applications in clinical and environmental analysis), working electrodes in voltammetry: stationary mercury electrode, mercury film electrode, glassy carbon electrode, carbon paste electrode, metallic electrodes, rotating disk electrode, rotating ring-disk electrode, ultramicroelectrodes, chemically modified electrodes, potentiometry, principles of ion selective electrodes, glass electrodes, ISE with solid and liquid membranes, biocatalytic membrane electrodes, chronopotentiometry, potentiometric stripping analysis, electroanalytic-al detectors in flow systems, amperometric titrations, biamperometric and bipotentiometric titrations, potentiostatic and galvanostatic coulometry.Alternate coursesÚCHV/FEM1/02Recommended reading F. Scholtz: Electroanalytical Methods, Springer Vrlg., Heidelberg 2002, ISBN 3-540-42449-3
J. Wang: Analytical Electrochemistry, VCH Publ., New York 1994,2000 R. Kalvoda (Ed.): Electroanalytical Methods in Chemical and Environmental Analysis, Plenum Publ. Corp., New York 1987
A.J. Bard, L.R. Faulkner: Electrochemical Methods, Jofn Wiley and Sons, New York 1980
T. Riley, A. Watson: Polarography and Other Voltametric methods, John Wiley and Sons, Chichester 1987
J. Wang: Stripping Analysis, VCH Publ. Inc., Deerfield Beach 1985

TitleSpecial SeminarCodeÚCHV/VSE1a/04TeacherAndruch Vasi>, Reiffová Katarína, Gondová Taeána, Vojteková VieraECTS credits2Hrs/week-/2AssessmentAssessmentSemester1T/L methodPracticalContentActual problems of physical and analytical chemistry which are connected with the solution of the students’ theses.

TitleBasic ToxicologyCodeÚCHV/ZTOX/04TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemester7, 9T/L methodLecture, PracticalObjectiveTo provide students with knowledge of types of toxic substances and their metabolism and of the safe handling of toxic substances.ContentHistorical aspects. Types of toxic substances, types of exposure, dose-response relationship. Disposition of toxic compounds (absorption, distribution, excretion of toxic compounds). Metabolism of toxic compounds. Drugs as toxic substances, food additives and contaminants, environmental pollutants. Statement of chemistry laboratory policy. Safe handling of toxic substances.Recommended reading G.F.Fuhrman: Allgemeine Toxikologie fur Chemoker, Teubner Verlag, Stutgart 1984
V.E.Forbes, T.L.Forbe: Ecotoxikology in Theory and Practice, Chapman&Hall, London 1994
J.A.Timbrell: Introduction to Toxicology, Taylor&Francis, London 1994

TitleIndustrial EcologyCodeÚCHV/ACPE1/03TeacherBaze> Yaroslav, Vojteková VieraECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo give chemistry, environmental ecology and teaching students the opportunity to approach problems of environmental pollution, to appraise problems of the creation and protection of the environment, and to develop ecologically enlightened thinking in their working and personal lives.ContentIntroduction to problems of the creation and protection of the environment. Selected chapters on industrial toxicology and evaluation of environmental stress. Toxic and potentially toxic matters in the living and working environment. Hydrologic, geologic and anthropogenic cycles from the environmental point of view. Environmental behaviour, education and culture in working and personal lives.Recommended reading Stanley E. Manahan: Environmental Chemistry. , New York, Boca Raton, 2007
Stanley E. Manahan: Industrial Ecology (Hardcover), Boca Raton, New York ,1999
Elective courses

TitleField Course of EcologyCodeÚBEV/TCE/02TeacherKová
 =ubomírECTS credits3Hrs/week-/5dAssessmentRecognitionSemester2T/L methodPracticalObjectiveTo teach students fundamental methods of ecological research in field and to familiarise them with the influence of abiotic factors on zoocenoses, with practical demecology and with quantitative characteristics of zoocenoses. ContentVerification through field study of theoretical knowledge concerning animal ecology. Prerequisite coursesÚBEV/EVZ1/03,ÚBEV/EFZ1/03,ÚBEV/ETS1/03Recommended reading Begon M., Harper J.L., Townsend C.R., 1990: Ecology - individuals, populations and communities. Blackwell, New York, 1-945

TitleBio-organic ChemistryCodeÚCHV/BOC/03TeacherGonda JozefECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo teach students the fundamental principles for the construction of bioorganic molecular models of biochemical processes using the tools of organic chemistry.ContentIntroduction: Basic considerations; proximity effects in biochemistry, Molecular adaptation. Molecular recognition at the supramolecular level. Bio-organic chemistry of amino acids and polypeptides: chemistry of the living cells, Analoguey between organic reactions and biochemical tranformations, Chemistry of the peptide bond: nonribosomal peptide formation, asymmetric synthesis of amino acids, asymmetric synthesis with chiral organometalic catalysts, Transition state analogues. Antibodies as enzymes. Chemical mutations. Molecular recognition and drug design. Bio-organic chemistry of the phosphate groups and polynucleotides:d energy storage, DNA intercalates, RNA molecules as catalysts. Enzyme chemistry: introduction to catalysis and enzymes, Multifuntional catalysis and simple models. Alpha-chymotrypsin. Other hydrolytic enzymes. Strereoelectronic control in hydrolytic reactions. Immobilised enzymes. Enzymes in synthetic organic chemistry. Enzyme-Analogue-Built polymers. Design of molecular clefts. Enzyme Models: host-guest complexation chemistry, New developments in crown ether chemistry, Membrane chemistry and micelles. Polymers. Cyclodextrins. Enzyme design using steroid template. Remote functionalisation reactions. Polyene biomimetic cyclisations. Metal Ions: in proteins and biological molecules. Carbopeptidase A. Hydrolysis of amino acid esters and peptides. Iron and oxygen transport. Cooper ion. Cobalt and vitamin B12 action. Oxidoreduction. Pyridoxal phosphate. Biotin.Recommended reading Voet J. : Biochemistry, Springer Verlag, 1998
Dugas H.: Bioorganic Chemistry, Springer Verlag, 1999

TitleToxicology of Organic CompoundsCodeÚCHV/TOXOL/03TeacherMartinková MiroslavaECTS credits4Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo examine the interaction between chemicals and biological systems in order for students to quantitatively determine the potential for chemicals to produce harmful effects in living organisms.ContentGeneral principles of toxicology. Absorption, distribution and excretion of toxicants. Biotransformation of xenobiotics: phase-1 reactions (oxidation, reduction, hydrolysis), phase-2 reactions (conjugation reactions). Toxication versus detoxication. Toxic effects of organic solvents. Toxicology of chemical warfare agents. Neurotoxicology. Toxic effects of plants and animal poisons. Toxic effects of drugs (barbiturates, benzodiazepines, tricyclic antidepressants). Drug dependence. Recommended reading C. D. Klaassen: Casaret and Doull`s Toxicology: The basic science of poisons, McGraw-Hill Companies, Inc., 2001

TitleFood ChemistryCodeÚCHV/PCH1/00TeacherKoa
ík DuaanECTS credits4Hrs/week2/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students, through excursions to food plants and to laboratories specializing in food analysis and through their own food preparation projects, a general overview of food chemistry, additives, and basic legal documents related to food production and analysis. ContentThe main categories of substances in the most important groups of food. Contamination of food. Physical and chemical properties of food. chemical reactions related to obtaining, storing and preparing of food. Analytical methods for determining the quality of food.Alternate coursesÚCHV/PCH1/99

TitleChemical ManagementCodeÚCHV/CMG/03TeacherKoa
ík DuaanECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo expose students to the basic principles of production management, marketing, and strategy building in the chemical and pharmaceutical industries through lectures by top managers from Slovak chemical companies. ContentBasic processes connected to manufacturing and management of chemical production in Slovakia.
Recommended reading Internal sources

TitleAnalysis of Psychotropic and Narcotic SubstancesCodeÚCHV/APO1/02TeacherGondová TaeánaECTS credits4Hrs/week2/-AssessmentExaminationSemesterT/L methodLectureContentDrugs; drug dependence. Psychotropic and narcotic substances: classification, properties and laws. Dose and tolerance, therapy, prevention. Pharmacokinetics of the drug. Biological effects, biotransformations, receptors. The methods used in the analysis of the drugs (clinical, forensic analysis): opiates, cocaine, amphetamines and their analogues, hallucinogenics, cannabis products, etc.Alternate coursesÚCHV/APO1/99 or ÚCHV/APO1/00

TitleSpecial ToxicologyCodeÚCHV/STOX/04TeacherGyöryová KatarínaECTS credits5Hrs/week2/1AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo provide students with knowledge of the toxicology of organic and inorganic compounds, drugs, food additives, e.g., safety of substances, designation of substances in accordance with norms of the European Union and the laws of the Slovak Republic.ContentHistorical aspects, types of toxic substances, dosage (LD50, ED50, TD50, tolerance), absorption and distribution of toxic compounds. Metabolism of toxic compounds (oxidation reactions, reduction, glucuronidation, glutathione conjugation, acetylation); excretion of toxic compounds; toxicology of metals (alkali, alkali earth and transition metals), radioactive substances, drugs, food additives, industrial chemicals, household poisons, environmental pollutants and organic compounds, animal toxins, fungal and microbial toxins. Risk and safety practices with chemical substances, designation of substances in accordance with the norms of the European Union and the laws of the Slovak Republic.Recommended reading J. A. Timbrell: Introduction to Toxicology, Taylor and Francis, London 1989
H. Kenneth Dillon, Mat H. Ho: Biological Monitoring of Exposure to
Chemicals: Metals, John Wiley & Sons, New York 1991
V. E. Forbes, T. L. Forbes: Toxicology in Theory and Practice, Chapmane Hall, London 1994
H. M. Stahr: Analytical Methods in Toxicology, John Wiley & Sons, New York 1991

INFORMATICS
Study programme Informatics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚINF/VYZ1/04Computational Complexity42/-Examination1/1 ÚINF/PDSI1/04Diploma Thesis in Informatics Pro-seminar 2 -/2Recognition1/1ÚMV/MMA2a/01Mathematical Analysis52/2Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚMV/PST2a/03Probability and Statistics53/1Examination1/2 ÚINF/SDI1a/03Diploma Theses in Informatics Seminar2-/2Recognition1/2 ÚINF/PPU1a/04Running Practice2-/2Recognition1/2 ÚINF/DPITa/06Diploma Thesis in Informatics4-/4Recognition1/2 ÚINF/SPA1/05Probabilistic Algorithms4-/3Assessment2/3 ÚINF/SDI1b/00Diploma Theses in Informatics Seminar2-/2Recognition2/3 ÚINF/PPU1b/04Running Practice3-/3Recognition2/3 ÚINF/DPITb/06Diploma Thesis in Informatics6-/6Recognition2/3 ÚINF/SDI1c/00Diploma Theses in Informatics Seminar2-/2Recognition2/4 ÚINF/DPITc/06Diploma Thesis in Informatics28-/- Recognition2/4 
Compulsory elective courses

ÚINF/DSB1a/01Security of Computer Networks Seminar2-/2Assessment1/2 ÚINF/NEU1/03Neural Networks52/1Examination1/1 ÚINF/DSL1a/01Logic of Information Systems Seminar2-/2Assessment1 2 ÚINF/DSN1a/04Neural Networks and Stringology Seminar2-/2Assessment1/2 ÚINF/KPI1/01Encoding and Transfer of Information42/1Examination1/1,2/3ÚINF/DST1a/01Theoretical Informatics Seminar2-/2Assessment1/2 ÚINF/ZNA1/06Foundations of Knowledge Systems42/-Examination1/1,2/3ÚINF/DSA1a/06Applied Infromatics Seminar2-/2Assessment1/2 ÚINF/KRP1/06Cryptographic Protocols42/1 Examination1/1ÚINF/MZK/06Mathematical Foundations of Cryptography63/2Examination1/1,2/3ÚINF/LAD1/06Logical Aspects of Databases42/-Examination1/2 ÚINF/DSB1b/01Security of Computer Networks Seminar2-/2Assessment2/3 ÚINF/SPS1/00Network Programming Seminar3-/3Assessment1/1 ÚINF/DSL1b/01of Information Systems Seminar2-/2Assessment2/3 ÚMV/TIN1/03Theory of Information42/- Examination1/1,2/3ÚINF/DSN1b/04Neural Networks and Stringology Seminar2-/2Assessment2/3 ÚINF/DST1b/01Theoretical Informatics Seminar2-/2Assessment2/3 ÚINF/DSA1b/06Applied Informatics Seminar2-/2Assessment2/3 ÚINF/KKV1/06Classical and Quantum Computations63/1Examination1/1,2/3ÚFV/NOT1a/03Nontraditional Optimisation Techniques I52/2Examination1/1,2/3ÚFV/NOT1b/03Nontraditional Optimisation Techniques II52/2Examination1/2 ÚFV/BSIM1/03Biomolecular Simulations62/2Examination1/2 ÚINF/SZS1/06Semantics of Knowledge Systems42/-Examination1/1,2/3ÚMV/KOA1/04Combinatorial Algorithms53/-Examination1/2 ÚINF/AIS1/01Architecture of Information Systems42/1Examination1/2 ÚMV/ANP/03Algorithmically Unsolvable Problems42/-Examination1/2 ÚINF/VYU1/03Computational Learning52/1Examination1/2 ÚINF/SPG1/05Computer Graphics Seminar3-/2Assessment1/2 ÚINF/OPS1/06Security of Computer Networks52/2Examination1/1,2/3ÚINF/PDS1/03Parallel and Distributed Systems42/1Examination1/1,2/4ÚINF/ARP1/05Architecture of Computers42/1Examination1/1,2/3ÚMV/VP1/04Computational Statistics and Simulation Methods51/2Examination2 /3
Recommended elective courses

ÚMV/DIS/04Taxes and Information Systems53/2Examination1/1,2/3ÚMV/UM/05Introduction to Maple2-/2Assessment1/1,2/3ÚINF/OOP1/04Object-oriented Programming4-/4Assessment1/2ÚFV/ZKM1/01Introductory Course in Quantum Mechanics for Informatics42/1Examination1/1,2/3ÚFV/KVP/02Introductory Course in Quantum Computers32/-Examination1/1,2/3ÚINF/SVK1/00Student Scientific Conference4-/-Assessment1/1,2/4ÚINF/MIN1/06Informatics for Medicine2-/2Assessment1/1,2/3ÚMV/NM1/04Numerical Mathematics34/3Examination1/1,2/3ÚINF/TDB1/06Development of Web-oriented Database Applications2-/2Assessment1/1,2/4ÚINF/BPM1/06Business Process Management2-/2Assessment1/1,2/4ÚINF/UUI1/06Introduction to Artificial Intelligence32/-Examination1/1,2/3ÚINF/SAP1a/06Introduction to mySAP Technology2-/2Assessment1/1,2/3ÚINF/SAP1b/06Administration of mySAP System2-/2Assessment1/1,2/4ÚINF/MSW1/07Modern Methods of Sofware System Development4-/2Assessment1/1,2/3UMV/VP1/99 Computational Statistics and Simulation Methods51/2Examination2/3

Course units

Compulsory courses

TitleComputational ComplexityCodeÚINF/VYZ1/04TeacherGeffert ViliamECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo give students background in the computational complexity and theory of NP-completeness.ContentDeterministic and nondeterministic algorithms with polynomial time; NP-completeness. Deterministic simulation of a nondeterministic Turing machine. Satisfiability of Boolean formulae. Other NP-complete problems: satisfiability of a formula in a conjunctive normal form, 3-satisfiability, 3-colorability of a graph, 3-colorability of a planar graph, knapsack problem, balancing, etc. Space bounded computations, classes LOG-space and P-space. Deterministic simulation: Savitch’s theorem. Closure under complement. Classification of computational complexity of problems.
Alternate coursesÚINF/VYZ1/03 or ÚINF/VYZ1/00Recommended reading A.V.Aho and J.D.Ullman. The design and analysis of computer algorithms. Addison-Wesley, 19741
P.van Emde Boas. Machine models and simulations. In J.van Leeuwen (ed.): Handbook of theoretical computer science. North-Holland, 1990
Ch.K.Yap. Introduction to the theory of complexity classes. To be published by Oxford Univ. Press. (Electronic version available via anonymous ftp://cs.nyu.edu/pub/local/yap/complexity-bk).
TitleDiploma Thesis in Informatics Pro-seminarCodeÚINF/PDSI1/04TeacherGeffert ViliamECTS credits2Hrs/week-/2AssessmentRecognitionSemester1T/L methodPracticalObjectiveTo inform students about areas of informatics suitable for their diploma thesis work and to have them prepare, by the end of the semester, a prospectus for their thesis that includes the theme(s) of the thesis, goals and recommended study literature.ContentSeminar is oriented to problems pertinent to preparations of diploma theses.Alternate coursesÚBEV/DP2a/03 orÚCHV/DPCUa/04 orÚFV/DPF2a/03 orÚGE/DPGa/03 orÚMV/DPMUa/03Recommended reading ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents. 

TitleProbability and StatisticsCodeÚMV/PST2a/03TeacherSkYivánková ValériaECTS credits5Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentProbability space; properties of probability. Conditional probability and independence. Random variables, their distributions and characteristics. Distribution, quantile and characteristic functions, their properties. Special types of distributions. Central limit theorem. Descriptive statistics.Prerequisite coursesÚMV/MMA2a/01Recommended reading Pfeiffer P.E.: Probability for applications, Springer, New York, 199O.
Viniotis Y.: Probability and random processes, Mc.Graw-Hill, Singapure, 1998

TitleDiploma Thesis in Informatics SeminarCodeÚINF/SDI1a/03TeacherGeffert Viliam, Andrejková GabrielaECTS credits2Hrs/week-/2AssessmentRecognitionSemester2T/L methodPracticalObjectiveTo provide students with monitoring and assessment of the work done to this point on thesis preparation and to give them the opportunity for public presentation of their work.ContentEvery thesis has a compulsory theoretical part and may also contain a software part. To gain recognition, the following is necessary: a detailed compilation of studied literature (a minimum of thirty pages) and at least twenty pages of text containing the candidate's own views of the problem area, possible research goals, own results are welcome (if the thesis is purely theoretical, this will be judged more strictly). For the software part: a tested implementation (must conform to user requirements, help and user friendly user interface not necessary at this stage) and access to source texts. For both parts there will be an oral presentation and discussion.Alternate coursesÚINF/SDI1a/00
TitleProbabilistic Algorithms SeminarCodeÚINF/SPA1/05TeacherSemanišin Gabriel, Lacko VladimírECTS credits4Hrs/week-/3AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo teach basic concepts of probabilistic algorithms and to classify them according to the probability of error point of view.ContentIntroduction to probabilistic algorithms. Classification and development of probabilistic algorithms; methods of development (Las Vegas, Monte Carlo). Applications of the methods in some problems Methods of transforming probabilistic algorithms to deterministic ones.Exclusive coursesÚINF/PAL1/01

TitleDiploma Thesis in Informatics SeminarCodeÚINF/SDI1b/00TeacherGeffert ViliamECTS credits2Hrs/week-/2AssessmentRecognitionSemester3T/L methodPracticalObjectiveTo provide students with monitoring and assessment of the work done to this point on thesis preparation and to give them the opportunity for public presentation of their work.ContentEvery thesis has a compulsory theoretical part and may also contain a software part. To gain recognition, the following is necessary: a detailed compilation of studied literature (a minimum of thirty pages) and at least twenty pages of text containing the candidate's own views of the problem area, possible research goals, own results are welcome (if the thesis is purely theoretical, this will be judged more strictly). For the software part: a tested implementation (must conform to user requirements, help and user friendly user interface not necessary at this stage) and access to source texts. For both parts there will be an oral presentation and discussion.Automatic prerequisite coursesÚINF/SDI1a/03

TitleDiploma Theses in Informatics SeminarCodeÚINF/SDI1c/00TeacherGeffert ViliamECTS credits2Hrs/week-/2AssessmentRecognitionSemester4T/L methodPracticalObjectiveTo provide students with monitoring and assessment of the work done to this point on thesis preparation and to give them the opportunity for public presentation of their work.ContentEvery thesis has a compulsory theoretical part and may also contain a software part. To gain recognition, the following is necessary: a detailed compilation of studied literature (a minimum of thirty pages) and at least twenty pages of text containing the candidate's own views of the problem area, possible research goals, own results are welcome (if the thesis is purely theoretical, this will be judged more strictly). For the software part: a tested implementation (must conform to user requirements, help and user friendly user interface not necessary at this stage) and access to source texts. For both parts there will be an oral presentation and discussion.Automatic prerequisite coursesÚINF/SDI1b/00
Compulsory elective courses

TitleMathematical Foundations of CryptographyCodeÚINF/MZK/06TeacherGeffert Viliam, Lacko VladimírECTS credits6Hrs/week3/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalContentClassical cryptography. Steganography. Conventional symmetric cryptography. Feistel networks. Encryption modes: ECB, CBC, CFB, OFB. Security definitions. Models of an adversary. Cryptoanalysis. Asymmetric cryptosystems. One-way functions with trapdoors. RSA cryptosystem. El-Gamal cryptosystem. Generating large prime numbers. Elliptic curves cryptography. Keyed Hash functions. Collision resistant functions. Birthday paradox. SHA-1. Message authentication codes. Password security. Digital signatures. Blind signatures. Key management. X509. Certificates. Certification authorities. Electronic payments. Electronic cash.Exclusive coursesÚINF/UKR1/03

TitleNeural NetworksCodeÚINF/NEU1/03TeacherAndrejková GabrielaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo establish student understanding and knowledge for using basic paradigms of neural networks.ContentFeed-forward and recurrent neural networks; back propagation algorithm to adaptation of neural networks; capability of neural networks to be universal approximators. Hopfield neural networks and solving optimisation problems. Kohonen neural networks. Neural networks in connections to computational models. Theoretical problems of neural networks.Alternate coursesÚINF/NEU1/00 orÚINF/NEU1/99Recommended reading J. Hertz, A. Krogh, R.G. Palmer: Introduction to the theory of neural computation, Addison Wesley, 1991

TitleNontraditional Optimisation Techniques ICodeÚFV/NOT1a/03TeacherHorváth Denis, Uli
ný Jozef, Brutovský BranislavECTS credits5Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo allow students to learn major optimisation methods.ContentThe classification of optimisation methods. Optimisation function. Multifunction-optimisation. The penalty function. The Barier function. The stochastic and deterministic methods. Gradient methods. The physical picture of gradient optimisation. Blind search and hill climbing methods. Multi-agent evolutionary strategy and meta-optimisation. Genetic algorithms. Quantum mechanical applications of genetic algorithms. Genetic algorithms in variable environments. The training of neural nets as optimisation. Principal component analysis. The prediction of time series. Monte Carlo techniques and simulated annealing. Optimisation and self-organisation attractor. The self-organised Kohonen nets; neural gas model. Cellular automata models. Agent-based systems. Strategies and demographic games on the lattice. Swarm optimisation. Recommended reading J.C.Principe, N.R.Euliano, Neural and Adaptive Systems, John Wiley & Sons. INC., New York, 2000
K.Binder, D.W.Heermann, Monte Carlo Simulation in Statistical Physics, Springer-Verlag, Berlin, 2002

TitleTheory of InformationCodeÚMV/TIN1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo introduce students to mathematical attempts at solving selected problems of computer science.ContentMeasurement of information. Entropy and its properties. Shanon’s theorems. Coding and basic types of codes. Using of algebraic structures in construction of codes. Kolmogorov complexity. Basic properties and relation to the notion of entropy. Complexity and randomness. Recommended reading J. H. van Lint, Introduction to Coding Theory, Springer 1992
M. Li and P. Vitanyi, Kolmogorov Complexity and its Applications, Handbook of Theoretical Computer Science, Elsevier, 1990, p. 188-252

TitleFoundations of Knowledge SystemsCodeÚINF/ZNA1/06TeacherVojtᚠPeterECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureContentRelations of formal models: DBMS, SQL, and logic programming. Summary of different formal models of computational processes, connections among them and translations. Gentzenov systems, semantics and verification of programs. Formal specifications, temporal logics: formulas, models, tableaux.Recommended reading M. Ben-Ari. Mathematical logic for Computer Science 2ed. Springer Verlag London 2001
J. Ullman. Principles of database and knowledge based systems. Comp. Sci. Press 1988
J. W. Lloyd. Foundations of logic programming. Springer Berlin 1987

TitleEncoding and Transfer of InformationCodeÚINF/KPI1/01TeacherGeffert Viliam, Jirásek JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students knowledge of basic principles of information theory, coding and data compression.ContentIntroduction to information theory: entropy, Markov models. Huffman coding, adaptive Huffman coding, applications. Arithmetic coding, dictionary techniques, applications. Lossless image compression. Scalar and vector quantisations. Differential encoding, delta modulation, subband coding, wavelets. Transform coding, DFT, DCT, application to JPEG. Analysis/synthesis schemes; fractal compression. Video compression.Alternate coursesÚINF/KPI1/00Recommended reading D. Hankersson, G. Harris, P. Johnson: Introduction to Information Theory and Data Compression, CRC Pr.,1998
K. Sayood: Introduction to Data Compression, Morgan Kaufmann, 1996

TitleAlgorithmically Unsolvable ProblemsCodeÚMV/ANP/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the most important results about the non-existence of an algorithm for solving a given problem.ContentAxiomatic theories of natural numbers. Definability of recursive functions. Tarski’s theorem on undefinability of truth in formalised arithmethic. Godel incompleteness theorem. Algorithmic unsolvability of particular mathematical problems. Non-existence of an algorithm for finding a solution to Diophantine equations. Reduction of problems and degrees of unsolvability. Recommended reading J. Barwise ed., Handbook of Mathematical Logic, North Holland 1977S. C. Kleene, Introduction to the Metamathematics, Van Nostrand 1952, ruský preklad Moskva 1957
E. Mendelson, Introduction to Mathematical Logic, Van Nostrand 1963.
M. Davis, Hilbert's Tenth Problem is Unsolvable, Amer. Math. Monthly, 1973, 233--269

TitleClassical and Quantum ComputationsCodeÚINF/KKV1/06TeacherSemanišin GabrielECTS credits6Hrs/week3/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide students information on quantum computers and quantum computations. To allow students to compare classical and quantum models and methods.ContentThe basics of classical theory of computation: Turing machines, Boolean circuits, parallel algorithms, probabilistic computation, NP-complete problems, and the idea of complexity of an algorithm. Introduction of general quantum formalism (pure states, density matrices, and superoperators), universal gate sets and approximation theorems. Grover's algorithm, Shor's factoring algorithm, and the Abelian hidden subgroup problem. Parallel quantum computation, a quantum analogue of NP-completeness, and quantum error-correcting codes.Recommended reading A. Yu. Kitaev, Classical and Quantum Computation, American Mathematical Society, Graduate Studies in Mathematics 47 (2002), ISBN 0-8218-3229-8
Gruska, J: Quantum Computing. McGraw-Hill London 1999 

TitleCombinatorial AlgorithmsCodeÚMV/KOA1/04TeacherJendro> Stanislav, Lacko VladimírECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureContentIntroduction to graphs. Introduction to algorithms and complexity. Sorting algorithms. Search algorithms. Greedy algorithms. NP-completeness. Trees and rooted trees. Generating all spanning trees of a graph. Minimum spanning tree problem. Distance in graphs. Shortest path problem and its analogues. Location centres. Networks. Eulerian gaphs and Chinese Postman's Problem. Hamiltonian graphs. Travelling Salesman Problem. Matchings. Transportation and assignment problems.Exclusive coursesÚMV/KOO/04Recommended reading N. Christophides, Graph Theory: An Algorithmic Approach, Academic Press, New York 1975
G. Chartrand, O. R. Oellermann, Applied and Algorithmic Graph Theory, McGraw-Hill, Inc., New York 1993


TitleCryptographic ProtocolsCodeÚINF/KRP1/06TeacherJirásek JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students about the design and verification of cryptographic protocolsContentAuthentication and key establishment using shared and public key cryptography, key agreement protocols, conference key agreement, zero-knowledge protocols.Recommended reading 1. Colin Boyd, Anish Mathuria: Protocols for Authentication and Key Establishment, Springer, 2003
2. Douglas R. Stinson: Cryptography: Theory and Practice, Third Edition, Chapman & Hall/CRC, 2006
3. Bruce Schneier: Applied Cryptography, Second Edition,
John Wiley & Sons Inc., 1996
4. Peter Ryan, Steve Schneider: Modelling and Analysis of Security Protocols, Addison-Wesley, 2001


TitleLogical Aspects of DatabasesCodeÚINF/LAD1/06TeacherKraj
i StanislavECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo have students understand and be able to formalise relationships between databases, first order logic and logic programming.ContentRelationships between databases, logic and logic programming.Recommended reading Serge Abiteboul, Richard Hull, Victor Vianu: Foundations of Databases. Addison-Wesley 1995, ISBN 0-201-53771-0

TitleNontraditional Optimisation Techniques IICodeÚFV/NOT1b/03TeacherHorváth Denis, Uli
ný Jozef, Brutovský BranislavECTS credits5Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students applications of optimisation techniques on thestudy and interpretation of complex systems using examples from biology. To introduce students to new paradigms in the area of systems biology.ContentComplex systems; emergent behavior. Evolutionary theory and memetics. Application of optimisation techniques on complex systems. Application of methods (genetic algorithms, simulated annealing, taboo search) on selected problems of biomolecular simulations. Molecular dynamics; protein folding. Population dynamics, metabolic networks and complexity in bioinformatics.Recommended reading The actual scientific papers.

TitleNetwork Programming SeminarCodeÚINF/SPS1/00TeacherAndrejková GabrielaECTS credits3Hrs/week-/3AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo teach students current technologies of programming in a network distributed environment. ContentBasics of programming client-server applications, iterative and concurrent servers, Remote Procedure Calls. Server-side programming, CGI, PHP, basics of Perl and Python. Script languages, ASP, JSP, Component Object Model, Corba, database connection's interfaces. Document Object Model, XML, XSL, dynamic extensions of HTML.
Advanced level of programming is expected.Recommended reading Internet sources and specifications.

TitleBiomolecular SimulationsCodeÚFV/BSIM1/03TeacherUli
ný JozefECTS credits6Hrs/week2/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo introduce students to actual problems of biomolecular simulations. ContentStructural characteristics of biological polymers. Foldamers. Central dogma of molecular biology as flow of biological information. 3D-structure and function of foldamers. Recent view on enzyme mechanisms. Experimental methods of structure determination and their limitations. Empirical force fields and methods of classical molecular dynamics. Molecular dynamics and Monte Carlo methods: algorithms and parallelisation. Ab initio molecular dynamics and hybrid approaches. Computational challenges in biomolecular simulations: simulations of chemical reactions, free energy evaluation, protein folding. Computational complexity, nontraditional approaches and heuristic approaches.


TitleSeminar on Principles of Database DevelopmentCodeÚINF/SPD1a/07TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester1, 3T/L methodPracticalObjectiveTo have students understand common database system concepts and to be able to use their knowledge of database principles to solve commom optimalisation problems with very large data.ContentData storing, file organisation, tree indexing methods, B-trees, R-trees, hash methods, prefect and partial hashing, hash indices, external sort, relational operators processing, top-k join, query optimisation, transactions, parallel and distributed databases, security, recovery system, performance measurement, data reduction, objekct databases, XML databases.Prerequisite coursesÚINF/DBS1b/03Recommended reading R. Ramakrishnan,J. Gehrke: Database Management Systems, McGraw Hill Higher Education, 2003
A. Silberschatz, H. F. Korth, S. Sudarshan: Database system concepts, McGraw Hill Higher Education, 2006

TitleComputational Statistics and Simulation MethodsCodeÚMV/VP1/04Teacher}e~ula IvanECTS credits5Hrs/week1/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo familiarise students with modern software and computational and simulation methods in statistics.ContentSystems of statistical software. Computation of distribution functions. Matrix computations. Random numbers generation. General and specific methods for generating random numbers with a given distribution. Monte Carlo methods. Resampling. Exploratory data analysis.Alternate coursesÚMV/VP1/99Recommended reading Abramowitz, Stegun: Handbook of mathematical functions,
Dover Publications, 1972
Deák: Random number generators and simulation, Akadémiai
kiadó, 1990
Fishman: Monte Carlo. Concepts, Algorithms, and Applications., Springer, 1996

TitleArchitecture of Information SystemsCodeÚINF/AIS1/01TeacherSemanišin GabrielECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide an overview of an older and of the newest information system development techniques. ContentInformation system, subsystem; information system development life cycle. Visual modelling; overview of modelling techniques. Structured methodologies. Verification and validation. Testing. Identification of critical systems. Quality control. Planning. MDA life cycle. MDA models. Transformations. OMG standards for languages.Recommended reading http://www.omg.org
Sommerville, I.: Software Engineering, Addison-Wesley 2005
Kleppe, A., Bast, W.,Warmer, J. B.: MDA Explained, the Model Driven Architecture, Addison-Wesley 2003
Berkun, S.: The Art Of Project Management, O Reilly 2005 

TitleComputational LearningCodeÚINF/VYU1/03TeacherAndrejková GabrielaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo provide students with basic knowledge about computational learning algorithms.ContentConcepts, hypotheses, learning algorithms. Boolean formulae and representation, learning algorithms for disjunctions. Probabilistic learning, consistent algorithms and learnability, efficient learning, probably approximately correct (PAC) learning, Occam algorithms, Vapnik-Cervonenkis (VC) dimension and learning algorithms. Alternate coursesÚINF/VYU1/00Recommended reading M. Anthony, N. Biggs: Computational Learning Theory, Cambridge University Press, 1991
M. J. Kearns, U. V. Vazirani: An Introduction to Computational Learning Theory, MIT Press London, 1994 

TitleComputer Graphics SeminarCodeÚINF/SPG1/05TeacherJirásek JozefECTS credits3Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalContentSeminar is connected to the lecture course Introduction to Computer Graphics (UGR). Students will present actual theoretical and implementation problems involving quick algorithms for computer graphics, geometric modelling and realistic drawing of scenes. Knowledge from UGR and good programming experience are expected. 

TitleParallel and Distributed SystemsCodeÚINF/PDS1/03TeacherGeffert Viliam, Jirásek JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester2, 4T/L methodLecture, PracticalObjectiveTo introduce students to the fundamentals of parallel and distributed programmingContentCurrent parallel and distributed architectures; basic issues in parallel and distributed applications development; data structures and programming methodologiesAlternate coursesÚINF/PDS1/00Recommended reading Kenneth A. Berman and Jerome L. Paul: Algorithms: Sequential, Parallel, and Distributed, Thomson, 2005, ISBN 0-534-42057-5
Gregory R. Andrews: Foundations of Multithreaded, Parallel, and Distributed Programming, Addison-Wesley, 2000, ISBN 0-201-35752-6
Joseph JáJá: An Introduction to Parallel Algorithms, Addison-Wesley, 1992, ISBN 0-201-54856-9
Gerard Tel: Introduction to Distributed Algorithms, Cambridge University Press, 1994, ISBN 0-521-47069-2


TitleArchitecture of ComputersCodeÚINF/ARP1/05TeacherJirásek JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester2, 4T/L methodLecture, PracticalObjectiveTo provide students with knowledge of the basic principles of computer architecture.ContentMilestones in computer organisation; fundamental limitations. The representation of numbers and the implementation of floating point arithmetic. Combinatorial and sequential circuits, memory organisation, RAMs and ROMs. Digital logic level architecture, data path timing, machine cycle. The microarchitecture level: microinstructions and microinstrucion control. The instruction set architecture level: data types, addressing modes, instruction types. Instruction execution, pipelining, cache memory. I/O controllers, ports, interrupts, direct memory access. Device drivers, operating system kernel, device-independent software.Recommended reading A. S. Tanenbaum: Structured Computer Organisation, 4.ed., Prentice-Hall, 1999
W. Stallings: Computer Organisation and Architecture, 4.ed., Prentice-Hall, 1996
J. Blieberger, G. H. Schildt, U. Schmid, S. Stoeckler: Informatik, Springer-Verlag, 1990


TitleData Mining SeminarCodeÚINF/SDM1a/07TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2, 4T/L methodPracticalObjectiveTo teach students the basic process of knowledge discovery in databases, its methods and principles. To familiarise students with data mining methods and with multi-relational learning and its use in complex-data structures.ContentPre-processing and data preparation (data cleaning, noise handling, data transformation), data mining, use and verification of result. Types of data mining methods: descriptive (regression, clustering, association rules) and predictive (classification and regression trees). Multi-relational learning (inductive logic programming) and its use in complex-data structuresRecommended reading Saao D~eroski, Nada Lavra
: Relational Data Mining. Springer-Verlag, 2001, ISBN 3-540-42289-7
David Hand, Heikki Mannila, Phadraic Smyth: Principles of Data mining. The MIT Press, 2001, ISBN 0-262-08290-X.
Jiawei Han, Micheline Kamber: Data Mining:Concepts and Techniques. Morgan Kaufmann Publishers, 2001, ISBN 1-55860-489-8
Dorian Pyle: Data Preparation for Data Mining. Morgan Kaufmann Publishers, 1999, ISBN 1-55860-529-0

TitleSecurity of Computer Networks SeminarCodeÚINF/DSB1a/01TeacherJirásek JozefECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo present new knowledge in the area of cryptology and the security of computer networks in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of computer network security. Exclusive coursesÚINF/DSL1a/01,ÚINF/DSN1a/01,ÚINF/DST1a/01Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleLogic of Information Systems SeminarCodeÚINF/DSL1a/01TeacherKraj
i StanislavECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo present new knowledge in the area of logic of information and knowledge systems in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of logic of information systems.Exclusive coursesÚINF/DSB1a/01,ÚINF/DSN1a/01,ÚINF/DST1a/01Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleNeural Networks and Stringology SeminarCodeÚINF/DSN1a/04TeacherAndrejková GabrielaECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo present new knowledge in the area of neural networks and stringology in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of neural networks and stringology.Alternate coursesÚINF/DSN1a/01Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleTheoretical Informatics SeminarCodeÚINF/DST1a/01TeacherGeffert ViliamECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo present new knowledge in the area of theoretical informatics in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of theoretical foundations of informatics.Exclusive coursesÚINF/DSB1a/01,ÚINF/DSL1a/01,ÚINF/DSN1a/01Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleApplied Informatics SeminarCodeÚINF/DSA1a/06TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo present new knowledge in the area of applied informatics in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of information system development, the application of combinatorial algorithms, etc.Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleSecurity of Computer Networks SeminarCodeÚINF/DSB1b/01TeacherJirásek JozefECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo present new knowledge in the area of cryptology and security of computer networks in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of the security of computer networks.Automatic prerequisite coursesÚINF/DSB1a/01Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleLogic of Information Systems SeminarCodeÚINF/DSL1b/01TeacherKraj
i StanislavECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo present new knowledge in the area of logic of information and knowledge systems in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of logic of information systems.Prerequisite coursesÚINF/DSL1a/01Automatic prerequisite coursesÚINF/DSL1a/01Recommended reading Special and research literature connected to Diplomaa theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleNeural Networks and Stringology SeminarCodeÚINF/DSN1b/04TeacherAndrejková GabrielaECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo present new knowledge in the area of neural networks and stringology in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of neural networks and stringology.Prerequisite coursesÚINF/DSN1a/04Alternate coursesÚINF/DSN1b/01
Automatic rerequisite coursesÚINF/DSN1a/04Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleTheoretical Informatics SeminarCodeÚINF/DST1b/01TeacherGeffert ViliamECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo present new knowledge in the area of theoretical informatics in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of the theoretical foundations of informatics.Prerequisite coursesÚINF/DST1a/01Automatic prerequisite coursesÚINF/DST1a/01Recommended reading Special and research literature connected to Diplomaa theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.

TitleApplied Informatics SeminarCodeÚINF/DSA1b/06TeacherECTS credits2Hrs/week-/2AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo present new knowledge in the area of applied informatics in seminar form. To examine the current state of research in the area using conference proceedings and specialised journals.ContentSeminar is oriented to the individual work of students who are pursuing diploma theses in the area of information system development, application of combinatorial algorithms, etc.Recommended reading Special and research literature connected to Diploma theses according to recommendations of supervisor.
ISO 690: 1987 Documentation - Bibliographic references. Content, form and structure.
ISO 2145: 1978 Documentation - Numbering of divisions and subdivisions in written documents.
Elective courses

TitleTaxes and Information SystemsCodeÚMV/DIS/04TeacherCechlárová Katarína, Semanišin Gabriel, Soták RomanECTS credits5Hrs/week3/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalContentInformation system, subsystem, information system development life cycle. Visual modelling, overview of modelling techniques. Structured methodologies. Algorithms in taxes.Exclusive coursesÚMV/DIS/00Alternate coursesÚMV/DIS/00Recommended reading Booch G., Jacobson I., Rumbaugh J.: The Unified Modelling Language user Guide, Addison-Wesley Pub. Co. 1998, ISBN 0-20157168-4

TitleIntroductory Course in Quantum ComputersCodeÚFV/KVP/02TeacherMockov
iak SamuelECTS credits3Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureContentReasons to study quantum computers (QC): microtechnology, dissipation of energy, "classical PC" is time-demanding. Quantum mechanics for QC. Hilbert space of quantum states. Operators of observables. EPR paradox. Reversible gates. Qubits as quantum states, their evolution. Quantum memory registers. Logic circuits. Quantum algorithms. Superposition of states and parallelism of computations. Entaglement of quantum states. Teleportation. Quantum information.Recommended reading J. Gruska: Quantum Computing, McGraw Hill, Maidenhead, 1999
C.PWilliams, S.H. Clearwater: Explorations in Quantum Computing,
Springer Verlag, New York, 1998
G.Birkhoff, T.C.Bartee: Aplikovaná Algebra, Alfa, Bratislava, 1981 

TitleObject-oriented ProgrammingCodeÚINF/OOP1/04TeacherGeffert ViliamECTS credits4Hrs/week-/4AssessmentAssessmentSemester2T/L methodPracticalContentClasses and objects; subclasses and inheritance. Instance and class variables and methods. Redefinition of methods, overfitting and encapsulation of data. Abstract classes. Polymorfism and its use in programming. Exceptions. Applets and aplications. Programming in concrete object oriented language.

TitleInformatics for MedicineCodeÚINF/MIN1/06TeacherSemanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester1, 3T/L methodPracticalObjectiveTo acquaint students with the application of computer science to medicine with emphasis on the specific conditions for the so-called safety-relevant domain.ContentSoftware development in the medical domain (radiotherapy and ultrasound). Syngo platform, MS .NET, C#, C++. Development based on so-called "V" development model. An overview of used software tools: RationalRose, RequisitePro, UITA, Caliber, ClearCase. Quality and process management and software company management according to CMMI methodology.
Recommended reading http://www.syngo.com
http://www.siemens.com

TitleNumerical MathematicsCodeÚMV/NM1/04TeacherHorváth DenisECTS credits9Hrs/week4/3AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo acquaint students with basic numerical methods, with conditions of their use and with errors accompanying approximations by numerical methods. To lead the students to test their own computer programs corresponding to some numerical methods.ContentInterpolation (ordinary, generalised). Numerical differentiation. Numerical integration (rules, errors). Gaussian quadrature. Interval-halving method. Regula falsi method. Newton's method. Method of successive iterations. Sturm's theorem. Bernoulli's method. Matrix inversion. LU-decomposition. Iterative methods for solving systems of linear equations. Least squares method. Approximating eigenvalues of a symmetric matrix via Jacobi's method.Exclusive coursesÚMV/NM1/03Alternate coursesÚMV/NM1/03Recommended reading A. Ralston: A First Course in Numerical Analysis, McGraw-Hill, New York 1965
A. Björck and G. Dahlquist: Numerical Methods, Prentice-Hall, Englewood Cliffs 1974; reprint Dover Publications, Mineola 2003

TitleDevelopment of Web-oriented Database ApplicationsCodeÚINF/TDB1/06TeacherSemanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester8, 10T/L methodPracticalObjectiveTo teach students modern methods for the development of web-oriented applications with emphasis on database server ORACLE and programming techniques in JAVA.ContentOracle SQL Data Manipulation Language. Oracle SQL Data Definition Language. Oracle PL/SQL. Java JDBC API Java Database Connectivity. Java JDBC API. Java JSP. JSTL.Recommended reading  http://www.oracle.com 

TitleBusiness Process ManagementCodeÚINF/BPM1/06TeacherSemanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester2, 4T/L methodPracticalObjectiveTo teach students the fundamental modelling techniques for and methods used in Business Process Management.ContentAn application of Model Driven Architecture (MDA) for problems belonging to the area of Business Process Management (BPM). Process modelling. Integration of applications in term of WebServices. Development of Enterprise Service Bus. Generating of algorithms, documentations and test plans. Work with specific software packages.Recommended reading Patterns: SOA with an Enterprise Service Bus in WebSphere Application Server V6, SG24-
6494-00, Redbook, published 26 May 2005, last updated 6 June 2005,
Managing Information Access to an Enterprise Information System Using J2EE and Services
Oriented Architecture, SG24-6371-00, Redbook, published 3 February 2005
BPEL4WS Business Processes with WebSphere Business Integration: Understanding,
Modelling, Migrating, SG24-6381-00, Redbook, published 17 December 2004, last updated 22, December 2004

TitleIntroduction to Artificial IntelligenceCodeÚINF/UUI1/06TeacherGeffert Viliam, Schmotzer MilanECTS credits3Hrs/week2/-AssessmentExaminationSemester4T/L methodLectureObjectiveTo familiarise students with basic information about artificial intelligence techniques. To give students the opportunity to study the literature of the field more deeply as required. ContentGoal of artificial intelligence, natural intelligence, edges of agent machine intelligence. Knowledge representation in AI (semantic networks, frames), reasoning. Problem solving in status space: non-informed versus informed deep and wide search, A*, solving of problems described as the game, iterative enhancement algorithms, problem solving by decomposition. Planning and scheduling, constraint logic programming, machine learning; computer vision: image recognition (flag described objects recognition, structural scene analysis), image preprocessing, image representation and description, object recognition. Natural language processing, artificial neural networks, knowledge systems (structure, characteristics, direct and backward reasoning, working with vague information), genetic algorithms, distributed artificial intelligence and multi-agent systems.Recommended reading Russell S.J., Norvig P: Artificial Intelligence: A Modern Approach (2nd Edition), Prentice Hall, 2002, ISBN: 0137903952
Negnevitsky Michael: Artificial Intelligence: A Guide to Intelligent Systems (2nd Edition), Addison Wesley, 2004, ISBN: 0321204662
Luger George: Artificial Intelligence: Structures and Strategies for Complex Problem Solving (5th Edition), Addison Wesley, 2004, ISBN: 0321263189

TitleIntroduction to mySAP TechnologyCodeÚINF/SAP1a/06TeacherSemanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester1, 3T/L methodPracticalObjectiveTo provide an introduction to mySAP technology.ContentDefining mySAP technology (products, innovations provided by SAP);
navigation (logon, screen design, calling functions); system kernel (client/server architecture, structure of an SAP system, processing in SAP); communication and integration technologies (remote function calls, internet technologies).Recommended reading http://www.sap.com/


TitleAdministration of mySAP SystemCodeÚINF/SAP1b/06TeacherSemanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester2, 4T/L methodPracticalObjectiveTo provide an introduction to the administration techniques of mySAP system.ContentFundamentals (system logon, configuring SAP logon); starting and stopping (starting SAP/Database, stopping SAP/Database); system configuration (parameters in SAP, parameters in Database); background tasks (scheduling background jobs, monitoring background jobs); database administration (extend tablespaces).Automatic rerequisite coursesÚINF/SAP1a/06Recommended reading http://www.sap.com/

TitleModern Methods of Sofware System DevelopmentCodeÚINF/MSW1/07TeacherGeffert Viliam, Chladný Vladimír, Semanišin GabrielECTS credits2Hrs/week-/2AssessmentAssessmentSemester1, 3T/L methodPracticalObjectiveTo provide information on the development of software products and the management of large software projects.ContentSoftware development life cycle. Initialisation and analyses of a project. Technical specification and implementation. Testing and acceptation procedures. Data transformation and testing. Pilot and parallel operation; support organisation. Modern technologies supporting development of software products. Organisational structure of IT companies.Recommended reading http://murphy2.hab.sk/upjs
http://www.ness-europe.com/
http://www.omg.org
http://www.rational.com
http://www.w3c.org







MATHEMATICS
Study programme Economical and Financial Mathematics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚMV/PST1b/04Probability and Statistics62/2Examination1/1 ÚMV/VKP1/01Selected Topics in Probability53/-Examination1/1ÚMV/DPM1a/03Diploma Work2-/- Recognition1/1 ÚMV/TH1/01Game Theory63/1Examination1/1 ÚMV/MMF1/01Mathematical Methods in Finance62/2Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚMV/NPR1a/01Stochastic Processes 163/2Examination1/2 ÚMV/APS1/99Applied Statistics63/2Examination1/2 ÚMV/DPM1b/01Diploma Work2-/-Recognition1/2 ÚMV/MAE1/01Mathematical Economics53/-Examination1/2 ÚMV/ZIP1/99Life Insurance12/1Examination1/2 ÚMV/NPR1b/01Stochastic Processes 263/2Examination2/3 ÚMV/VP1/01Computational Statistics and Simulation Methods51/2Examination2/3ÚMV/TS1/01Control Theory63/1Examination2/3 ÚMV/DIS/01Taxes and Information Systems53/2Examination2/3 ÚMV/DPM1c/01Diploma Work5-/-Recognition2/3 ÚMV/DPM1d/01Diploma Work12-/- Recognition2/4
Compulsory elective courses

ÚMV/THO1/01Queueing Theory61/- Examination1/1, 2/3 ÚMV/DBS/01Databases Systems63/1 Examination1/2, 2/4 ÚMV/KOA1/01Combinatorial Algorithms23/- Examination1/2 ÚMV/TKO1/01Theory of Codes61/- Examination2/3 ÚMV/FAN/06Functional Analysis63/1 Examination1/2
Recommended elective courses

ÚMV/POI1/01Insurance33/- Examination1/1, 2/3ÚMV/PRA1/01Law32/- Examination1/1, 2/3ÚINF/OPS1/06Security of Computer Networks22/2 Examination2/4ÚINF/PSO1/03Presentation Software2-/2 Assessment1/2 ÚMV/OIM1/00Evaluation of Investment Possibilities12/- Examination1/2 Course units

Compulsory courses

TitleProbability and StatisticsCodeÚMV/PST1b/04TeacherSkYivánková Valéria, Ohriska JánECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentRandom vectors, their distributions and characteristics. Correlation and regression. Random sample, sampling distributions and characteristics. Point estimates and their properties. Maximum likelihood method. Interval estimates; confidence interval construction. Testing of statistical hypothesis; critical region and level of significance. Parametric and nonparametric tests.Recommended reading Mason-Lind.: Statistical Techniques in Business and Economics, Irwin, Inc., 1990

TitleSelected Topics in ProbabilityCodeÚMV/VKP1/04Teacher}e~ula IvanECTS credits5Hrs/week3/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo present the perspective of probability from the standpoint of measure theory and to have students understand the most important results of probability theory.ContentGeneral definition of probability. Distribution function and its properties. Basic types of multivariate distributions. Conditional distributions and means. Convolutions. Types of convergence of random variables. Strong law of large numbers. Central limit theorems.Alternate coursesÚMV/VKP1/99Recommended reading }e~ula, I.: Lecture notes in AIS


TitleGame TheoryCodeÚMV/TH1/04TeacherCechlárová Katarína, Hajduková JanaECTS credits6Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach the basic methods of game theory and to have students model situations from everyday life as simple games.ContentExamples of games. Extensive form of a game, value of the game. Von Neumann Morgenstern theory of utility. Matrix games and their solution. Bimatrix games.Theory of negotiations. n-person games: core, Shapley value. Economic applications of game theory.Alternate coursesÚMV/TH1/99Recommended reading Binmore, K.: Fun and games, D.C. Heath, 1992
M. Chobot, F. Turnovec, V. Ulašin, Teória hier a rozhodovania, Alfa, Bratislava, 1991
Owen, G.: Game Theory, Academic Press.
Thomas, L.C.: Games, Theory and Applications, Wiley, New York.
Bierman H.S, Fernandez L.,: Game Theory with Economic
Applications, Addison-Wesley, 1998
K. Cechlárová: Lecture notes in AIS 

TitleApplied StatisticsCodeÚMV/APS1/99Teacher}e~ula IvanECTS credits6Hrs/week3/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the most frequently applied statistical methods.ContentMatrices and geometry of linear space. One- and multidimensional normal distribution and related distributions. General linear model. Regression. Analysis of variance. Analysis of covariance.Prerequisite coursesÚMV/PST1b/04Recommended reading Seber: Linear regression analysis, Wiley, 1977


TitleLife InsuranceCodeÚMV/ZIP1/99Teacher}e~ula IvanECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the basics of insurance mathematics for life insurance.ContentLife tables. Computation of premiums; various types of life insurance. Reserve of insurance.Prerequisite coursesÚMV/APS1/99Recommended reading Gerber: Life insurance mathematics, Springer, 1997
Bowers et al.: Actuarial mathematics, The Society of Actuaries, 1986

TitleComputational Statistics and Simulation MethodsCodeÚMV/VP1/04Teacher}e~ula IvanECTS credits5Hrs/week1/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo familiarise students with modern software and computational and simulation methods in statistics.ContentSystems of statistical software. Computation of distribution functions. Matrix computations. Random numbers generation. General and specific methods for generating random numbers with a given distribution. Monte Carlo methods. Resampling. Exploratory data analysis.
Alternate coursesÚMV/VP1/99Recommended reading Abramowitz, Stegun: Handbook of mathematical functions,
Dover Publications, 1972
Deák: Random number generators and simulation, Akadémiai
kiadó, 1990
Fishman: Monte Carlo. Concepts, Algorithms, and Applications., Springer, 1996
Compulsory elective courses

TitleTheory of CodesCodeÚMV/TKO1/04TeacherHorHák MirkoECTS credits6Hrs/week4/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo acquaint students with the basic principles and theoretical bases of text coding and possibilities for their application.ContentMonoids. Basic notions of theory of codes. Examples of codes. Important classes of codes. Maximal codes. Submonoids generated by codes. Stable submonoids. Group codes. Free hull of a set of words. Test for recognising codes. Measure of a code. Bernoulli distribution. Dyck code. Complete sets in monoids. Thin codes. Composition of codes. Indecomposable codes.Recommended reading J. Berstel and D. Perrin, Theory of Codes, Academic Press 1985. 

TitleFunctional AnalysisCodeÚMV/FAN/06TeacherDoboš JozefECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentMetric spaces and their fundamental properties. Complete metric space and the contrary mapping principle. Normed linear spaces. Hilbert's space. Linear operators. The spectrum of the operator.Recommended reading N. Dunford, J.T. Schwartz, Linear operators, Part I, Generaly theory, New York, 1963
N. Dunford, J.T. Schwartz, Linear operators, Part II, Spectral theory, New York, 1963

Study programme Informatic Mathematics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚMV/DPM1a/03Diploma Work2-/-Recognition1/1 ÚMV/TIN1/03Theory of Information42/-Examination1/1 ÚINF/MZK/06Mathematical Foundations of Cryptography63/2Examination1/1 KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚMV/TKO1/04Theory of Codes64/-Examination1/1, 2 /3 ÚMV/TMT/04Matroid Theory53/-Examination1/1,2/3 ÚINF/VYZ1/04Computational Complexity42/-Examination2/3 ÚINF/KKV1/06Classical and Quantum Computations63/1Examination2/3 ÚMV/KOA1/04Combinatorial Algorithms53/-Examination1/2 ÚMV/SKA1/99Combinatorial Algorithms Seminar2-/2Assessment1/2 ÚMV/TZ1/04Lattice Theory52/1Examination1/2, 2/4 ÚMV/DSMIa/04Seminar on Diploma Work 2-/2Recognition1/2 ÚMV/DPM1b/04Diploma Work2-/-Recognition1/2 ÚMV/DSMIb/04Seminar on Diploma Work2-/2Recognition2/3 ÚMV/DPM1c/04Diploma Work5-/-Recognition2/3 ÚMV/ANP/03Algorithmically Unsolvable Problems42/-Examination2/4 ÚMV/DBS/04Databases Systems63/1Examination2/4 ÚMV/DSMIc/04Seminar on Diploma Work 2-/2Recognition2/4 ÚMV/DPM1d/04Diploma Work15-/-Recognition2/4 
Compulsory elective courses

ÚMV/DIS/04Taxes and Information Systems53/2Examination1/1ÚMV/PMTG/04Probabilistic Method in Graph Theory42/-Examination1/2ÚMV/GZ/04Geometric Transformations52/1Examination1/1, 2/3ÚMV/TS1/04Control Theory63/1Examination1/1ÚMV/TGT/04Graph Theory42/-Examination1/1, 2/3ÚFV/KVP/02Introductory Course in Quantum Computers32/-Examination1/1, 2/3ÚFV/ZKM1/01Introductory Course in Quantum Mechanics for Informatics42/1Examination1/1, 2/3ÚINF/ZNA1/06Foundations of Knowledge Systems42/-Examination1/1, 2/3ÚMV/ALA1/04Applied Linear Algebra52/1Examination1/2ÚMV/FRG1/03Fractal Geometry42/-Examination1/2ÚINF/KPI1/01Encoding and Transfer of Information42/1Examination1/1ÚMV/TGR1/04Theory of Groups52/1Examination1/2, 2/4ÚMV/TH1/04Game Theory63/1Examination2/3
Elective courses

ÚMV/THO1/04Queueing Theory64/-Examination1/1, 2/3ÚMV/PST1b/04Probability and Statistics62/2Examination1/1ÚMV/MAE1/04Mathematical Economics53/-Examination1/2ÚMV/POT1/04Polyhedral Theory42/-Examination1/2ÚMV/SVK1/01Student Scientific Conference4-/-Assessment1/2ÚMV/TCI/04Number Theory42/-Examination1/2ÚMV/UAL/04Universal Algebra53/-Examination1/2ÚMV/SVK1/01Student scientific conference4-/-Assessment1/2


Course units

Compulsory courses

TitleTheory of InformationCodeÚMV/TIN1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo introduce students to mathematical attempts at solving selected problems of computer science.ContentMeasurement of information. Entropy and its properties. Shanon’s theorems. Coding and basic types of codes. Using of algebraic structures in construction of codes. Kolmogorov complexity. Basic properties and relation to the notion of entropy. Complexity and randomness. Recommended reading J. H. van Lint, Introduction to Coding Theory, Springer 1992
M. Li and P. Vitanyi, Kolmogorov Complexity and its Applications, Handbook of Theoretical Computer Science, Elsevier, 1990, p. 188-252

TitleMathematical Foundations of CryptographyCodeÚINF/MZK/06TeacherGeffert Viliam, Lacko VladimírECTS credits6Hrs/week3/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentClassical cryptography. Steganography. Conventional symmetric cryptography. Feistel networks. Encryption modes: ECB, CBC, CFB, OFB. Security definitions. Models of an adversary. Cryptoanalysis. Asymmetric cryptosystems. One-way functions with trapdoors. RSA cryptosystem. El-Gamal cryptosystem. Generating large prime numbers. Elliptic curves cryptography. Keyed Hash functions. Collision resistant functions. Birthday paradox. SHA-1. Message authentication codes. Password security. Digital signatures. Blind signatures. Key management. X509. Certificates. Certification authorities. Electronic payments. Electronic cash.Exclusive coursesÚINF/UKR1/03

TitleTheory of CodesCodeÚMV/TKO1/04TeacherHorHák MirkoECTS credits6Hrs/week4/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with the basic principles and theoretical bases of text coding and possibilities for their application.ContentMonoids. Basic notions of theory of codes. Examples of codes. Important classes of codes. Maximal codes. Submonoids generated by codes. Stable submonoids. Group codes. Free hull of a set of words. Test for recognising codes. Measure of a code. Bernoulli distribution. Dyck code. Complete sets in monoids. Thin codes. Composition of codes. Indecomposable codes.Recommended reading J. Berstel and D. Perrin, Theory of Codes, Academic Press 1985


TitleMatroid TheoryCodeÚMV/TMT/04TeacherHorHák MirkoECTS credits5Hrs/week3/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with basic notions of matroid theory and possibilities of using matroids in various disciplines of discrete mathematics.ContentIndependent sets and bases. Properties of rank function. Closure operator. Circuits. Duality in matroids. Hyperplanes. Submatroids. Restriction, contraction, minor of a matroid. Transversals. Radó-Hall's Theorem and its generalisations. Greedy algorithm versus matroids.Recommended reading D. J. A. Welsh, Matroid Theory, Academic Press, 1976 

TitleComputational ComplexityCodeÚINF/VYZ1/04TeacherGeffert ViliamECTS credits4Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo give students background in the computational complexity and theory of NP-completeness.ContentDeterministic and nondeterministic algorithms with polynomial time; NP-completeness. Deterministic simulation of a nondeterministic Turing machine. Satisfiability of Boolean formulae. Other NP-complete problems: satisfiability of a formula in a conjunctive normal form, 3-satisfiability, 3-colorability of a graph, 3-colorability of a planar graph, knapsack problem, balancing, etc. Space bounded computations, classes LOG-space and P-space. Deterministic simulation: Savitch’s theorem. Closure under complement. Classification of computational complexity of problems.Alternate coursesÚINF/VYZ1/03 orÚINF/VYZ1/00Recommended reading A.V.Aho and J.D.Ullman. The design and analysis of computer algorithms. Addison-Wesley, 1974.
P.van Emde Boas. Machine models and simulations. In J.van Leeuwen (ed.): Handbook of theoretical computer science. North-Holland, 1990.
Ch.K.Yap. Introduction to the theory of complexity classes. To be published by Oxford Univ. Press. (Electronic version available via anonymous ftp://cs.nyu.edu/pub/local/yap/complexity-bk).

TitleClassical and Quantum ComputationsCodeÚINF/KKV1/06TeacherSemanišin GabrielECTS credits6Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students information on quantum computers and quantum computations. To allow students to compare classical and quantum models and methods.ContentThe basics of classical theory of computation: Turing machines, Boolean circuits, parallel algorithms, probabilistic computation, NP-complete problems, and the idea of complexity of an algorithm. Introduction of general quantum formalism (pure states, density matrices, and superoperators), universal gate sets and approximation theorems. Grover's algorithm, Shor's factoring algorithm, and the Abelian hidden subgroup problem. Parallel quantum computation, a quantum analogue of NP-completeness, and quantum error-correcting codes.Recommended reading 1. A. Yu. Kitaev, Classical and Quantum Computation, American Mathematical Society, Graduate Studies in Mathematics 47 (2002), ISBN 0-8218-3229-8
2. Gruska, J: Quantum Computing. McGraw-Hill Londýn 1999 

TitleCombinatorial AlgorithmsCodeÚMV/KOA1/04TeacherJendro> Stanislav, Lacko VladimírECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureContentIntroduction to graphs. Introduction to algorithms and complexity. Sorting algorithms. Search algorithms. Greedy algorithms. NP-completeness. Trees and rooted trees. Generating all spanning trees of a graph. Minimum spanning tree problem. Distance in graphs. Shortest path problem and its analogues. Location centres. Networks. Eulerian gaphs and Chinese Postman's Problem. Hamiltonian graphs. Travelling Salesman Problem. Matchings. Transportation and assignment problems.Exclusive coursesÚMV/KOO/04Recommended reading 1. N. Christophides, Graph Theory: An Algorithmic Approach, Academic Press, New York 1975
2. G. Chartrand, O. R. Oellermann, Applied and Algorithmic Graph Theory, McGraw-Hill, Inc., New York 1993

TitleLattice TheoryCodeÚMV/TZ1/04TeacherLihová JuditaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentDistributive and modular lattices, Boolean algebras. Ideals, representation of distributive lattices and Boolean algebras. Metric lattices. Congruence relations of lattices. Recommended reading G.Grätzer: General Lattice Theory, Birkhäuser, 1998


TitleAlgorithmically Unsolvable ProblemsCodeÚMV/ANP/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester4T/L methodLectureObjectiveTo introduce students to the most important results about the non-existence of an algorithm for solving a given problem.ContentAxiomatic theories of natural numbers. Definability of recursive functions. Tarski’s theorem on undefinability of truth in formalised arithmethic. Godel incompleteness theorem. Algorithmic unsolvability of particular mathematical problems. Non-existence of an algorithm for finding a solution to Diophantine equations. Reduction of problems and degrees of unsolvability. Recommended reading J. Barwise ed., Handbook of Mathematical Logic, North Holland 1977S. C. Kleene, Introduction to the Metamathematics, Van Nostrand 1952, ruský preklad Moskva 1957.
E. Mendelson, Introduction to Mathematical Logic, Van Nostrand 1963.
M. Davis, Hilbert's Tenth Problem is Unsolvable, Amer. Math. Monthly,1973, 233--269.

TitleDatabases SystemsCodeÚMV/DBS/04TeacherSoták Roman, HorHák MirkoECTS credits6Hrs/week3/1AssessmentExaminationSemester4T/L methodLecture, PracticalObjectiveTo teach students to use and understand the principles of database modelling and the theory of databases through work with a selected concrete database system.ContentFormal foundations of database systems: logic of database systems, relation algebra. Functional dependencies, decompositions. Normal forms. SQL: aggregate functions, nested queries, modification of data, integrity constraints, modification of the table structure, transitive closure, next aspects of SQL.Recommended reading J. Ullman: Principles of database and knowledge – base systems, Comp. Sci. Press., 1988
Compulsory elective courses

TitleTaxes and Information SystemsCodeÚMV/DIS/04TeacherCechlárová Katarína, Semanišin Gabriel, Soták RomanECTS credits5Hrs/week3/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentInformation system, subsystem, information system development life cycle. Visual modelling, overview of modelling techniques. Structured methodologies. Algorithms in taxes.Exclusive coursesÚMV/DIS/00Alternate coursesÚMV/DIS/00Recommended reading Booch G., Jacobson I., Rumbaugh J.: The Unified Modelling Language user Guide, Addison-Wesley Pub. Co. 1998, ISBN 0-20157168-4

TitleGeometric TransformationsCodeÚMV/GZ/04TeacherIvan
o JaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide deeper knowledge of projective spaces and transformation groups. ContentProjective spaces, Projective transformations, collineations. Fixed elements of a collineation. A clasification of collineations. Recommended reading S. V. Duzhin, B. D. Chebotarevsky: Transformation Groups for Beginers, AMS 2004 

TitleControl TheoryCodeÚMV/TS1/04TeacherCechlárová KatarínaECTS credits6Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students the basic concepts of controllable systems.ContentControllable systems. Pontrjagin maximum principle. Linear systems, bang-bang controls, singular controls.. Discrete systems, dynamic programming, Bellmann’s optimality principle. Practical applications of theoretical results. Alternate coursesÚMV/TS1/99 or ÚMV/TS1/00Recommended reading K. Macki, A. Strauss: Introduction to Optimal Control Theory, Springer, 1980
G. Feichtinger, R.F. Hartl: Optimale Kontrolle okonomischer Prozesse, Berlin, 1986

TitleGraph TheoryCodeÚMV/TGT/04TeacherJendro> Stanislav, Madaras TomáaECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo provide students deeper knowledge of graph theory.ContentConnectivity of graphs. Hamiltonian graphs. Colouring of graphs. Planar graphs. Oriented graphs. Automorphism of graphs. Snarks. Minors of graphs.Recommended reading J. Bang-Jensen and G. Gutin, Digraphs: Theory, Algorithms and Applications. Springer-Verlag London 2001
J. A. Bondy and U.S.R. Murty, Graph Theory with Applications. North Holland, Amsterdam 1976.
R. Diestel, Graph Theory, Springer-Verlag. New York 2000, 2nd edition. 

TitleIntroductory Course in Quantum ComputersCodeÚFV/KVP/02TeacherMockov
iak SamuelECTS credits3Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureContentReasons to study quantum computers (QC): microtechnology, dissipation of energy, "classical PC" is time-demanding. Quantum mechanics for QC. Hilbert space of quantum states. Operators of observables. EPR paradox. Reversible gates. Qubits as quantum states, their evolution. Quantum memory registers. Logic circuits. Quantum algorithms. Superposition of states and parallelism of computations. Entaglement of quantum states. Teleportation. Quantum information..Recommended reading J. Gruska: Quantum Computing, McGraw Hill, Maidenhead, 1999
C.PWilliams, S.H. Clearwater: Explorations in Quantum Computing,
Springer Verlag, New York, 1998
G.Birkhoff, T.C.Bartee: Aplikovaná Algebra, Alfa, Bratislava, 1981

TitleFoundations of Knowledge SystemsCodeÚINF/ZNA1/06TeacherVojtᚠPeterECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureContentRelations of formal models: DBMS, SQL, and logic programming. Summary of different formal models of computational processes, connections among them and translations. Gentzenov systems, semantics and verification of programs. Formal specifications, temporal logics: formulas, models, tableaux.Recommended reading M. Ben-Ari. Mathematical logic for Computer Science 2ed. Springer Verlag London 2001
J. Ullman. Principles of database and knowledge based systems. Comp. Sci. Press 1988
J. W. Lloyd. Foundations of logic programming. Springer Berlin 1987

TitleApplied Linear AlgebraCodeÚMV/ALA1/04TeacherStudenovská DanicaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students basic knowledge about linear algebra; to make students able to apply the theory in concrete excercises.ContentMatrices over Euclidean rings, canonical forms. Polynomial matrices. Similar matrices. Jordan normal form. Functions of matrices, sequences, series. Inversion of singular matrices, pseudoinverse matrices and their application.Alternate coursesÚMV/ALA1/99Recommended reading H.E.Rose: Linear algebra, A pure mathematical approach, Birkhäuser Verlag, 2002
D.Serre: Matrices, Theory and applications, Springer Verlag, 2002.
http://www.cs.ut.ee/~toomas_l/linalg/

TitleFractal GeometryCodeÚMV/FRG1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the mathematical approach to analysing the concept of a fractal with the possibility of using the results for the construction of fractals.ContentConcept of a fractal. Basic topology of metric spaces. Self-similarity of a fractal. Fractal as fixpoint of a mapping. Construction of a fractal by iteration. Topological dimension and basic properties. Hausdorff measure and Hausdorff dimension. Topological and Hausdorff dimension of particular fractals. Some methods of construction of a fractal (topological dynamics).Recommended reading G. A. Edgar: Measure, Topology and Fractal Geometry, Springer 1990
K. Falconer, Fractal Geometry, John Willey 1992
H. O. Peitgen, H. Jurgens and D. Saupe, Fractals for Classroom, I, II, Springer Verlag, Berlin 1991 

TitleEncoding and Transfer of InformationCodeÚINF/KPI1/01TeacherGeffert Viliam, Jirásek JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students knowledge of basic principles of information theory, coding and data compression.ContentIntroduction to information theory: entropy, Markov models. Huffman coding, adaptive Huffman coding, applications. Arithmetic coding, dictionary techniques, applications. Lossless image compression. Scalar and vector quantisations. Differential encoding, delta modulation, subband coding, wavelets. Transform coding, DFT, DCT, application to JPEG. Analysis/synthesis schemes; fractal compression. Video compression.
Alternate coursesÚINF/KPI1/00Recommended reading D. Hankersson, G. Harris, P. Johnson: Introduction to Information Theory and Data Compression, CRC Pr.,1998
K. Sayood: Introduction to Data Compression, Morgan Kaufmann, 1996
J. Adámek: Coding and Inormation Theory, VUT, 1994 (Czech)

TitleTheory of GroupsCodeÚMV/TGR1/04TeacherLihová JuditaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentCyclic groups; quotient groups. Finitely generated Abelian groups. Groups of permutations and their applications.
Recommended reading M.Hall: The Theory of Groups, New York, 1959
L.Fuchs: Abelian groups, Akadémiai Kiadó,Budapest, 1966

TitleGame TheoryCodeÚMV/TH1/04TeacherCechlárová Katarína, Hajduková JanaECTS credits6Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo teach the basic methods of game theory and to have students model situations from everyday life as simple games.ContentExamples of games. Extensive form of a game, value of the game. Von Neumann Morgenstern theory of utility. Matrix games and their solution. Bimatrix games.Theory of negotiations. n-person games: core, Shapley value. Economic applications of game theory.
Alternate coursesÚMV/TH1/99Recommended reading K. Binmore, Fun and games, D.C. Heath, 1992
G. Owen: Game Theory, Academic Press.
L.C. Thomas: Games, Theory and Applications, Wiley, New York.
H.S. Bierman, L.Fernandez, Game Theory with Economic
Applications, Addison-Wesley, 1998
Elective courses

TitleQueueing TheoryCodeÚMV/THO1/04TeacherHorHák MirkoECTS credits6Hrs/week4/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with functioning of simple queuing systems and with the analysis of corresponding stochastic processes and Markov chains.ContentQueuing system. Input request stream. Intensity and parameter of input request stream. Stationarity. Memoryless stochastic process. Markov's theorem. Ergodic theorem. Markov chain.Recommended reading B.V. Gnedenko and I.N. Kovalenko, Introduction to Queueing Theory, Second Edition, Birkhauser Boston, Cambridge MA 1989

TitleProbability and StatisticsCodeÚMV/PST1b/04TeacherSkYivánková Valéria, Ohriska JánECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentRandom vectors, their distributions and characteristics. Correlation and regression. Random sample, sampling distributions and characteristics. Point estimates and their properties. Maximum likelihood method. Interval estimates; confidence interval construction. Testing of statistical hypothesis; critical region and level of significance. Parametric and nonparametric tests.Recommended reading Mandenhall W.: Introduction to probability and statistics,PWS Publishers, Boston, 1987
Sincich T.: Statistics by example, Dellen Publishing Company, New Jersey, 1990

TitleMathematical EconomicsCodeÚMV/MAE1/04TeacherCechlárová KatarínaECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach the basic concepts and methods of modern mathematical economics.ContentThe notion of exchange economy. Edgeworth box. Preferences and utility functions. Optimality in exchange economies. Existence of core. Walrasian equilibrium. Optimality and decentralisation. Production economies.Alternate coursesÚMV/MAE1/99Recommended reading C.D. Aliprantis, D.J. Brown, O. Burkinshaw: Existence and optimality of competitive equilibria, Springer 1989
W. Hildenbrand, A.P. Kirman: Equilibrium analysis, North Holland,
A. Takayama: Mathematical economics, Cambridge University Press, 1985

TitlePolyhedral TheoryCodeÚMV/POT1/04TeacherJendro> StanislavECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students basic knowledge of the theory of convex polyhedra and polyhedral maps.ContentCombinatorial and geometric properties of three-dimensional convex polyhedra and their analogues: polyhedral maps. Euler’s theorem; Steinitz’s theorem. Light subgraphs. Face and vertex vectors. Groups of symmetries of polyhedra. Applications in optimisation and chemistry.Recommended reading B. Grunbaum: Convex polytopes (2nd edition), Springer New York 2003
G.M. Ziegler: Lectures on Polytopes, Springer-Verlag, New York, 1996

TitleNumber TheoryCodeÚMV/TCI/04TeacherHarminc MatúšECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo familiarise students with the divisibility and congruences of integers, linear and quadratic congruences and arithmetic functions. ContentEuclidean algorithm. Fundamental theorem of arithmetic. Primes, composites, canonical form and its applications. Congruences, criteria of divisibility. Arithmetic functions. Euler’s theorem. Fermat’s theorem. Wilson’s theorem. Linear and quadratic congruences. Recommended reading M. B. Nathanson: Elementary Methods in Number Theory. Springer, 2000
H. E. Rose: A Course in Number Theory. Clarendon Press, Oxford, 1994

TitleUniversal AlgebraCodeÚMV/UAL/04TeacherStudenovská DanicaECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide basic knowledge of universal algebra and to make students able to apply this knowledge in concrete situations.ContentAlgebraic structures. Homomorphisms and congruences. Direct and subdirect products. Terms. Free algebras. Birkhoff’s theorems about varieties.Exclusive coursesÚMV/KAL1/04Recommended reading S.Burris, H.P.Sankappanavar: A Course in Universal Algebra. Springer-Verlag, 1981
B. Jónsson: Topics in universal algebra, Springer-Verlag 1972
G. Grätzer: Universal Algebra, 2nd edition, Springer Verlag, 1979
Study programme Manager Mathematics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚMV/DPM1a/03Diploma Work2-/-Recognition1/1ÚMV/PST1b/04Probability and Statistics62/2Examination1/1ÚMV/TH1/04Game Theory63/1Examination1/1ÚMV/TS1/04Control Theory63/1Examination1/1KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚMV/DPM1b/04Diploma Work2-/-Recognition1/2ÚMV/KOO/04Combinatorial Optimisation63/1Examination1/2ÚMV/DBS/04Databases Systems63/1Examination1/2ÚMV/MAE1/04Mathematical Economics53/-Examination1/2ÚINF/KKV1/06Classical and quantum Computations63/1Examination2/3ÚMV/THO1/04Queueing Theory64/-Examination2/3ÚMV/DPM1c/04Diploma Work5-/-Recognition2/3ÚMV/DPM1d/04Diploma Work15-/-Recognition2/4ÚMV/FAN/06Functional Analysis63/1Examination1/2
Compulsory elective courses

ÚINF/ZNA1/06Foundations of Knowledge Systems42/-Examination1/1ÚINF/MZK/06Mathematical Foundations of Cryptography63/2Examination1/1ÚMV/PRA1/04Law32/-Examination1/1, 2/3ÚMV/TGT/04Graph Theory42/-Examination1/1, 2/3ÚMV/TIN1/03Theory of Information42/-Examination1/1, 2/3ÚMV/TKO1/04Theory of Codes64/-Examination1/1, 2/3ÚMV/TMT/04Matroid Theory53/-Examination1/1, 2/3ÚINF/VYZ1/04Computational Complexity42/-Examination1/1, 2/3ÚMV/GZ/04Geometric Transformations52/1Examination1/1, 2/3ÚMV/FRG1/03Fractal Geometry42/-Examination1/2ÚMV/TGR1/04Theory of Groups52/1Examination1/2ÚMV/SKA1/99Seminar on Combinatorial Algorithms2-/2Assessment1/2ÚMV/APS1/99Applied Statistics63/2Examination1/2ÚMV/ALA1/04Applied Linear Algebra52/1Examination1/2, 2/4ÚMV/POT1/04Polyhedral Theory42/-Examination1/2, 2/4ÚMV/UAL/04Universal Algebra53/-Examination1/2, 2/4
Recommended elective courses

ÚMV/SVK1/01Student scientific conference4-/-Assessment1/2
Course units

Compulsory courses

TitleProbability and StatisticsCodeÚMV/PST1b/04TeacherSkYivánková Valéria, Ohriska JánECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentRandom vectors, their distributions and characteristics. Correlation and regression. Random sample, sampling distributions and characteristics. Point estimates and their properties. Maximum likelihood method. Interval estimates; confidence interval construction. Testing of statistical hypothesis; critical region and level of significance. Parametric and nonparametric tests.Recommended reading Mason-Lind.:Statistical Techniques in Business and Economics, Irwin, Inc., 1990
SkYivánková, V:Pravdepodobnose v príkladoch, UPJ`, Koaice, 2006
SkYivánková, V.-Han
ová, M.:`tatistika v príkladoch, UPJ`, Koaice, 2005

TitleGame TheoryCodeÚMV/TH1/04TeacherCechlárová Katarína, Hajduková JanaECTS credits6Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach the basic methods of game theory and to have students model situations from everyday life as simple games.ContentExamples of games. Extensive form of a game, value of the game. Von Neumann Morgenstern theory of utility. Matrix games and their solution. Bimatrix games.Theory of negotiations. N-person games: core, Shapley value. Economic applications of game theory.Alternate coursesÚMV/TH1/99Recommended reading K. Binmore, Fun and games, D.C. Heath, 1992.
M. Chobot, F. Turnovec, V. Ulašin, Teória hier a rozhodovania, Alfa, Bratislava, 1991.
G. Owen, Game Theory, Academic Press.
L.C. Thomas, Games, Theory and Applications, Wiley, New York.
H.S. Bierman, L.Fernandez, Game Theory with Economic
Applications, Addison-Wesley, 1998.
K. Cechlárová: Lecture notes in AIS 

TitleCombinatorial OptimisationCodeÚMV/KOO/04TeacherJendro> Stanislav, Lacko VladimírECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students basic knowledge about the methods of modelling and controlling and how to apply them to typical problems using methods of discrete mathematics.ContentComplexity of combinatorial algorithms. Sorting problems. Searching algorithms. Greedy algorithm. Trees and spanning trees: rooted trees. Minimal spanning tree problem. Optimal path problems. Introduction to network analysis. Distribution problems. Flows. Assignment problem. The Chinese Postman problem. The Travelling Salesman problem. Transportation problems.Exclusive coursesÚMV/KOA1/04Recommended reading N. Christofides: Graph Theory - An Algorithmic approach, Academic Press, New York 1975 (ruský preklad z r. 1978)
G. Chartrand, O.R. Vellermann: Applied and Algorithmic Graph Theory, McGraw-Hill, Inc. New York 1993

TitleClassical and Quantum ComputationsCodeÚINF/KKV1/06TeacherSemanišin GabrielECTS credits6Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo provide students information on quantum computers and quantum computations. To allow students to compare classical and quantum models and methods.ContentThe basics of classical theory of computation: Turing machines, Boolean circuits, parallel algorithms, probabilistic computation, NP-complete problems, and the idea of complexity of an algorithm. Introduction of general quantum formalism (pure states, density matrices, and superoperators), universal gate sets and approximation theorems. Grover's algorithm, Shor's factoring algorithm, and the Abelian hidden subgroup problem. Parallel quantum computation, a quantum analogue of NP-completeness, and quantum error-correcting codes.Recommended reading 1 A. Yu. Kitaev, Classical and Quantum Computation, American Mathematical Society, Graduate Studies in Mathematics 47 (2002), ISBN 0-8218-3229-8
1 Gruska, J: Quantum Computing. McGraw-Hill Londýn 1999 

TitleFunctional AnalysisCodeÚMV/FAN/06TeacherDoboš JozefECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentMetric spaces and their fundamental properties. Complete metric space and the contrary mapping principle. Normed linear spaces. Hilbert's space. Linear operators. The spectrum of the operator.Recommended reading N. Dunford, J.T. Schwartz, Linear operators, Part I, Generaly theory, New York, 1963
N. Dunford, J.T. Schwartz, Linear operators, Part II, Spectral theory, New York, 1963
Compulsory elective courses

TitleFoundations of Knowledge SystemsCodeÚINF/ZNA1/06TeacherVojtᚠPeterECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentRelations of formal models: DBMS, SQL, and logic programming. Summary of different formal models of computational processes, connections among them and translations. Gentzenov systems, semantics and verification of programs. Formal specifications, temporal logics: formulas, models, tableaux.Recommended reading M. Ben-Ari. Mathematical logic for Computer Science 2ed. Springer Verlag London 2001
J. Ullman. Principles of database and knowledge based systems. Comp. Sci. Press 1988
J. W. Lloyd. Foundations of logic programming. Springer Berlin 1987

TitleMathematical Foundations of CryptographyCodeÚINF/MZK/06TeacherGeffert Viliam, Lacko VladimírECTS credits6Hrs/week3/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentClassical cryptography. Steganography. Conventional symmetric cryptography. Feistel networks. Encryption modes: ECB, CBC, CFB, OFB. Security definitions. Models of an adversary. Cryptoanalysis. Asymmetric cryptosystems. One-way functions with trapdoors. RSA cryptosystem. El-Gamal cryptosystem. Generating large prime numbers. Elliptic curves cryptography. Keyed Hash functions. Collision resistant functions. Birthday paradox. SHA-1. Message authentication codes. Password security. Digital signatures. Blind signatures. Key management. X509. Certificates. Certification authorities. Electronic payments. Electronic cash.Exclusive coursesÚINF/UKR1/03

TitleGraph TheoryCodeÚMV/TGT/04TeacherJendro> Stanislav, Madaras TomáaECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo provide students deeper knowledge of graph theory.ContentConnectivity of graphs. Hamiltonian graphs. Colouring of graphs. Planar graphs. Oriented graphs. Automorphism of graphs. Snarks. Minors of graphs.Recommended reading J. Bang-Jensen and G. Gutin, Digraphs: Theory, Algorithms and Applications. Springer-Verlag London 2001
J. A. Bondy and U.S.R. Murty, Graph theory with applications. North Holland, Amsterdam 1976.
R. Diestel, Graph Theory, Springer-Verlag. New York 2000, 2nd edition. 

TitleTheory of InformationCodeÚMV/TIN1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo introduce students to mathematical attempts at solving selected problems of computer science.ContentMeasurement of information. Entropy and its properties. Shanon’s theorems. Coding and basic types of codes. Using of algebraic structures in construction of codes. Kolmogorov complexity. Basic properties and relation to the notion of entropy. Complexity and randomness. Recommended reading J.Adámek, Kódovaní a teorie informace, Vydavatelství VUT, Praha 1994
J. erný, Entrópia a informácia v kybernetike, Alfa 1981
M. Li and P. Vitanyi, Kolmogorov Complexity and its Applications, Handbook of Theoretical Computer Science, Elsevier, 1990, p. 188-252.

TitleTheory of CodesCodeÚMV/TKO1/04TeacherHorHák MirkoECTS credits6Hrs/week4/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with the basic principles and theoretical bases of text coding and possibilities for their application.ContentMonoids. Basic notions of theory of codes. Examples of codes. Important classes of codes. Maximal codes. Submonoids generated by codes. Stable submonoids. Group codes. Free hull of a set of words. Test for recognising codes. Measure of a code. Bernoulli distribution. Dyck code. Complete sets in monoids. Thin codes. Composition of codes. Indecomposable codes.Recommended reading J. Berstel and D. Perrin, Theory of Codes, Academic Press 1985 

TitleMatroid theoryCodeÚMV/TMT/04TeacherHorHák MirkoECTS credits5Hrs/week3/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with basic notions of matroid theory and possibilities of using matroids in various disciplines of discrete mathematics.ContentIndependent sets and bases. Properties of rank function. Closure operator. Circuits. Duality in matroids. Hyperplanes. Submatroids. Restriction, contraction, minor of a matroid. Transversals. Radó-Hall's Theorem and its generalisations. Greedy algorithm versus matroids.Recommended reading D. J. A. Welsh, Matroid Theory, Academic Press, 1976. 

TitleComputational complexityCodeÚINF/VYZ1/04TeacherGeffert ViliamECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo give students background in the computational complexity and theory of NP-completeness.ContentDeterministic and nondeterministic algorithms with polynomial time; NP-completeness. Deterministic simulation of a nondeterministic Turing machine. Satisfiability of Boolean formulae. Other NP-complete problems: satisfiability of a formula in a conjunctive normal form, 3-satisfiability, 3-colorability of a graph, 3-colorability of a planar graph, knapsack problem, balancing, etc. Space bounded computations, classes LOG-space and P-space. Deterministic simulation: Savitch’s theorem. Closure under complement. Classification of computational complexity of problems.
Alternate coursesÚINF/VYZ1/03 orÚINF/VYZ1/00Recommended reading A.V.Aho and J.D.Ullman. The design and analysis of computer algorithms. Addison-Wesley, 1974.
P.van Emde Boas. Machine models and simulations. In J.van Leeuwen (ed.): Handbook of theoretical computer science. North-Holland, 1990.
Ch.K.Yap. Introduction to the theory of complexity classes. To be published by Oxford Univ. Press. (Electronic version available via anonymous ftp://cs.nyu.edu/pub/local/yap/complexity-bk).

TitleFractal GeometryCodeÚMV/FRG1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the mathematical approach to analysing the concept of a fractal with the possibility of using the results for the construction of fractals.ContentConcept of a fractal. Basic topology of metric spaces. Self-similarity of a fractal. Fractal as fixpoint of a mapping. Construction of a fractal by iteration. Topological dimension and basic properties. Hausdorff measure and Hausdorff dimension. Topological and Hausdorff dimension of particular fractals. Some methods of construction of a fractal (topological dynamics).

TitleTheory of GroupsCodeÚMV/TGR1/04TeacherLihová JuditaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentCyclic groups; quotient groups. Finitely generated Abelian groups. Groups of permutations and their applications.Recommended reading M.Hall: The Theory of Groups, New York, 1959

TitleApplied StatisticsCodeÚMV/APS1/99Teacher}e~ula IvanECTS credits6Hrs/week3/2AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the most frequently applied statistical methods.ContentMatrices and geometry of linear space. One- and multidimensional normal distribution and related distributions. General linear model. Regression. Analysis of variance. Analysis of covariance.Prerequisite coursesÚMV/PST1b/04Recommended reading Seber: Linear regression analysis, Wiley, 1977

TitleApplied Linear AlgebraCodeÚMV/ALA1/04TeacherStudenovská DanicaECTS credits5Hrs/week2/1AssessmentExaminationSemester2, 4T/L methodLecture, PracticalObjectiveTo teach students basic knowledge about linear algebra; to make students able to apply the theory in concrete excercises.ContentMatrices over Euclidean rings, canonical forms. Polynomial matrices. Similar matrices. Jordan normal form. Functions of matrices, sequences, series. Inversion of singular matrices, pseudoinverse matrices and their application.Alternate coursesÚMV/ALA1/99Recommended reading M. Fiedler: Speciálni matice a jejich pou~ití v numerické matematice, 

TitleUniversal AlgebraCodeÚMV/UAL/04TeacherStudenovská DanicaECTS credits5Hrs/week3/-AssessmentExaminationSemester8, 10T/L methodLectureObjectiveTo provide basic knowledge of universal algebra and to make students able to apply this knowledge in concrete situations. ContentAlgebraic structures. Homomorphisms and congruences. Direct and subdirect products. Terms. Free algebras. Birkhoff’s theorems about varieties.Exclusive coursesÚMV/KAL1/04Recommended reading M.Kolibiar a kol.: Algebra a príbuzné disciplíny. Bratislava, 1991.
S.Burris, H.P.Sankappanavar: A Course in Universal Algebra. Springer-Verlag, 1981. 
Study programme Mathematics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚMV/DPM1a/03Diploma Work2-/-Recognition1/3KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚMV/TGT/01Graph Theory42/-Examination1/3ÚMV/UAS/01Ordered Algebraic Structures52/1Examination1/3ÚMV/TOP/03Topology42/-Examination1/3ÚMV/UAL/01Universal Algebra53/-Examination1/2ÚMV/POT1/01Polyhedral Theory42/-Examination1/2ÚMV/TGR1/01Theory of Groups52/1Examination1/2ÚMV/DPM1b/01Diploma Work2-/-Recognition1/2ÚMV/DSMa/04Seminar on Diploma Work 2-/2Recognition1/2ÚMV/TMT/01Matroid Theory53/-Examination2/3ÚMV/DPM1c/01Diploma Work2-/-Recognition2/3ÚMV/DSMb/04Seminar on Diploma Work2-/2Recognition2/1ÚMV/VKP1/01Selected Topics in Probability53/-Examination2/3ÚMV/DIR/06Differential and Integral Equations63/1Examination2/3ÚMV/KOO/01Combinatorial Optimisation63/1Examination2/4ÚMV/DPM1d/01Diploma Work15-/-Recognition2/4ÚMV/DSMc/04Seminar on Diploma Work 2-/2Recognition2/2ÚMV/FAN/06Functional Analysis63/1Examination1/2
Compulsory elective courses

ÚINF/MZK/06Mathematical Foundations of Cryptography63/2Examination1/3ÚMV/GZ/01Geometric Transformations52/1Examination1/1, 2/3ÚMV/PST1b/01Probability and Statistics62/2Examination1/1, 2/3ÚMV/TH1/01Game Theory63/1Examination1/1, 2/3ÚMV/TKO1/01Theory of Codes61/-Examination1/1, 2/3ÚMV/PMTG/01Probability Method in Graph Theory42/-Examination1/2ÚMV/ALA1/01Applied Linear Algebra52/1Examination1/2, 2/4ÚMV/FRG1/03Fractal Geometry42/-Examination1/2ÚMV/TCI/01Number Theory42/-Examination1/2ÚMV/SKA1/99Combinatorial Algorithms Seminar2-/2Assessment2/4ÚMV/TK/07Theory of Categories52/1Examination1/2ÚMV/TRF/07Real Functions Theory 52/1Examination1/1
Recommended elective courses

ÚINF/ZNA1/06Foundations of Knowledge Systems42/-Examination2/3ÚMV/TIN1/03Theory of Information42/-Examination1/1, 2/3ÚMV/TS1/01Control Theory63/1Examination1/1, 2/3ÚINF/VYZ1/01Computational Complexity42/-Examination1/1, 2/3ÚMV/ANP/03Algorithmically Unsolvable Problems42/-Examination1/2ÚMV/PME/04Matching Models in Economics52/1Examination1/2ÚMV/SVK1/01Student scientific conference4-/-Assessment1/2

Course units

Compulsory courses

TitleGraph TheoryCodeÚMV/TGT/04TeacherJendro> Stanislav, Madaras TomáaECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide students deeper knowledge of graph theory.ContentConnectivity of graphs. Hamiltonian graphs. Colouring of graphs. Planar graphs. Oriented graphs. Automorphism of graphs. Snarks. Minors of graphs.Recommended reading J. Bang-Jensen and G. Gutin, Digraphs: Theory, Algorithms and Applications. Springer-Verlag London 2001
J. A. Bondy and U.S.R. Murty, Graph Theory with Applications. North Holland, Amsterdam 1976
R. Diestel, Graph Theory, Springer-Verlag. New York 2000, 2nd edition. 

TitleOrdered Algebraic StructuresCodeÚMV/UAS/04TeacherLihová JuditaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentPartially ordered, linearly ordered, lattice ordered groups. Partially ordered and linearly ordered rings, fields; lattice ordered rings. Recommended reading L.Fuchs: Partially ordered algebraic systems, Pergamon Press, 1963 

TitleTopologyCodeÚMV/TOP/07TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentBasic notions and results of set-theoretical topology. Connected and arcwise connected space. Compactness. ech-Stone compactification. Uniform space, basic properties. The notion of a manifold and examples of manifolds. Homotopy, homotopy group. Homotopy group of a simple manifold. Fix point theorem proved by using properties of homotopy groups.Recommended reading I.M.Singer and J.A.Thorpe, Lecture Notes on Elementary Topology and Geometry, Springer 1967
R. Engelking, General Topology, Heldermann 1999

TitleUniversal AlgebraCodeÚMV/UAL/04TeacherStudenovská DanicaECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo provide basic knowledge of universal algebra and to make students able to apply this knowledge in concrete situations. ContentAlgebraic structures. Homomorphisms and congruences. Direct and subdirect products. Terms. Free algebras. Birkhoff’s theorems about varieties.Exclusive coursesÚMV/KAL1/04Recommended reading S.Burris, H.P.Sankappanavar: A Course in Universal Algebra. Springer-Verlag, 1981
B. Jónsson: Topics in universal algebra, Springer-Verlag 1972
G. Grätzer: Universal Algebra, 2nd edition, Springer Verlag, 1979

TitlePolyhedral TheoryCodeÚMV/POT1/04TeacherJendro> StanislavECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students basic knowledge of the theory of convex polyhedra and polyhedral maps.ContentCombinatorial and geometric properties of three-dimensional convex polyhedra and their analogues: polyhedral maps. Euler’s theorem; Steinitz’s theorem. Light subgraphs. Face and vertex vectors. Groups of symmetries of polyhedra. Applications in optimisation and chemistry.Recommended reading B. Grunbaum: Convex polytopes (2nd edition), Springer New York 2003
G.M. Ziegler: Lectures on Polytopes, Springer-Verlag, New York, 1996


TitleTheory of GroupsCodeÚMV/TGR1/04TeacherLihová JuditaECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentCyclic groups; quotient groups. Finitely generated Abelian groups. Groups of permutations and their applications. Recommended reading M.Hall: The Theory of Groups, New York, 1959
L.Fuchs: Abelian groups, Akadémiai Kiadó,Budapest, 1966


TitleMatroid theoryCodeÚMV/TMT/04TeacherHorHák MirkoECTS credits5Hrs/week3/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo acquaint students with basic notions of matroid theory and possibilities of using matroids in various disciplines of discrete mathematics.ContentIndependent sets and bases. Properties of rank function. Closure operator. Circuits. Duality in matroids. Hyperplanes. Submatroids. Restriction, contraction, minor of a matroid. Transversals. Radó-Hall's Theorem and its generalisations. Greedy algorithm versus matroids.Recommended reading D. J. A. Welsh, Matroid Theory, Academic Press, 1976 

TitleSelected Topics in ProbabilityCodeÚMV/VKP1/04Teacher}e~ula IvanECTS credits5Hrs/week3/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo present the perspective of probability from the standpoint of measure theory and to have students understand the most important results of probability theory.ContentGeneral definition of probability. Distribution function and its properties. Basic types of multivariate distributions. Conditional distributions and means. Convolutions. Types of convergence of random variables. Strong law of large numbers. Central limit theorems.Alternate coursesÚMV/VKP1/99Recommended reading Loeve: Probability theory, Van Nostrand, 1960
Rényi: Foundations of Probability, Holden-Day, 1970

TitleDifferential and Integral EquationsCodeÚMV/DIR/06TeacherMihalíková Bo~enaECTS credits6Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalContentBoundary value problems. Asymptotic properties and the stability of linear differential systems. Fredholm's integral equations with degenerate and nondegenerate kernel. Integral equations with symmetric kernel.
Prerequisite coursesÚMV/FAN/06 orÚMV/FAN/04Recommended reading P. Hartman, Ordinary differential equations, New York, 1964
G.F.Trikomi, Integral equations, New York, 1967

TitleCombinatorial OptimisationCodeÚMV/KOO/04TeacherJendro> Stanislav, Lacko VladimírECTS credits6Hrs/week3/1AssessmentExaminationSemester4T/L methodLecture, PracticalObjectiveTo teach students basic knowledge about the methods of modelling and controlling and how to apply them to typical problems using methods of discrete mathematics.ContentComplexity of combinatorial algorithms. Sorting problems. Searching algorithms. Greedy algorithm. Trees and spanning trees: rooted trees. Minimal spanning tree problem. Optimal path problems. Introduction to network analysis. Distribution problems. Flows. Assignment problem. The Chinese Postman problem. The Travelling Salesman problem. Transportation problems.
Exclusive coursesÚMV/KOA1/04Recommended reading N. Christofides: Graph Theory - An Algorithmic approach, Academic Press, New York 1975 (ruský preklad z r. 1978).
J. Plesník: Grafové algoritmy, Veda Bratislava 1983.
G. Chartrand, O.R. Vellermann: Applied and Algorithmic Graph Theory, McGraw-Hill, Inc. New York 1993.

TitleFunctional AnalysisCodeÚMV/FAN/06TeacherDoboš JozefECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalContentMetric spaces and their fundamental properties. Complete metric space and the contrary mapping principle. Normed linear spaces. Hilbert's space. Linear operators. The spectrum of the operator.
Recommended reading N. Dunford, J.T. Schwartz, Linear operators, Part I, Generaly theory, New York, 1963
N. Dunford, J.T. Schwartz, Linear operators, Part II, Spectral theory, New York, 1963

Compulsory elective courses

TitleMathematical Foundations of CryptographyCodeÚINF/MZK/06TeacherGeffert Viliam, Lacko VladimírECTS credits6Hrs/week3/2AssessmentExaminationSemester1T/L methodLecture, PracticalContentClassical cryptography. Steganography. Conventional symmetric cryptography. Feistel networks. Encryption modes: ECB, CBC, CFB, OFB. Security definitions. Models of an adversary. Cryptoanalysis. Asymmetric cryptosystems. One-way functions with trapdoors. RSA cryptosystem. El-Gamal cryptosystem. Generating large prime numbers. Elliptic curves cryptography. Keyed Hash functions. Collision resistant functions. Birthday paradox. SHA-1. Message authentication codes. Password security. Digital signatures. Blind signatures. Key management. X509. Certificates. Certification authorities. Electronic payments. Electronic cash.Exclusive coursesÚINF/UKR1/03

TitleReal Functions TheoryCodeÚMV/TRF/07TeacherDoboš JozefECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentContinuity properties of real functions, generalisations of continuity, quasi-uniform convergence, sets of discontinuity points, stationary sets, determining sets, metric preserving functions.

TitleGeometric TransformationsCodeÚMV/GZ/04TeacherIvan
o JaroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo provide deeper knowledge of projective spaces and transformation groups. ContentProjective spaces, Projective transformations, collineations. Fixed elements of a collineation. A clasification of collineations. Recommended reading S. V. Duzhin, B. D. Chebotarevsky: Transformation Groups for Beginers, AMS 2004 

TitleProbability and StatisticsCodeÚMV/PST1b/04TeacherSkYivánková Valéria, Ohriska JánECTS credits6Hrs/week2/2AssessmentExaminationSemester1, 3T/L methodLecture, PracticalContentRandom vectors, their distributions and characteristics. Correlation and regression. Random sample, sampling distributions and characteristics. Point estimates and their properties. Maximum likelihood method. Interval estimates; confidence interval construction. Testing of statistical hypothesis; critical region and level of significance. Parametric and nonparametric tests.Recommended reading Mandenhall W.: Introduction to probability and statistics, PWS Publishers, Boston, 1987
Sincich T.: Statistics by example, Dellen Publishing Company, New Jersey, 1990

TitleGame TheoryCodeÚMV/TH1/04TeacherCechlárová Katarína, Hajduková JanaECTS credits6Hrs/week3/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo teach the basic methods of game theory and to have students model situations from everyday life as simple games.ContentExamples of games. Extensive form of a game, value of the game. Von Neumann Morgenstern theory of utility. Matrix games and their solution. Bimatrix games.Theory of negotiations. n-person games: core, Shapley value. Economic applications of game theory.Alternate coursesÚMV/TH1/99Recommended reading 1. K. Binmore, Fun and games, D.C. Heath, 1992.
2. G. Owen, Game Theory, Academic Press.
3. L.C. Thomas, Games, Theory and Applications, Wiley, New York.
4. H.S. Bierman, L.Fernandez, Game Theory with Economic
Applications, Addison-Wesley, 1998.

TitleTheory of CodesCodeÚMV/TKO1/04TeacherHorHák MirkoECTS credits6Hrs/week4/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo acquaint students with the basic principles and theoretical bases of text coding and possibilities for their application.ContentMonoids. Basic notions of theory of codes. Examples of codes. Important classes of codes. Maximal codes. Submonoids generated by codes. Stable submonoids. Group codes. Free hull of a set of words. Test for recognising codes. Measure of a code. Bernoulli distribution. Dyck code. Complete sets in monoids. Thin codes. Composition of codes. Indecomposable codes.Recommended reading J. Berstel and D. Perrin, Theory of Codes, Academic Press 1985

TitleTheory of CategoriesCodeÚMV/TK/07TeacherPloa
ica MiroslavECTS credits5Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students a categorical approach to various mathematical objects and constructions. To provide basic knowledge about categories, functors and natural transformations. ContentAbstract and concrete categories. Morphisms, monomorphisms, epimorphisms and isomorphisms. Subobjects, quotient objects, free objects. Products and copoducts. Limits and colimits, completeness.
Functors. Natural transformations. Adjoint functors.Recommended reading Adámek J. : Theory of Mathematical Structures, Reidel Publications, Dordrecht-Boston 1983
Mac Lane S., Birkhoff G.: Algebra, The Macmillan Company, 1967
Lawvere F. W., Schanuel S. H.: Conceptual Mathematics (A first introduction to categories), Cambridge University Press 1997
Adámek J., Herrlich H., Strecker G.: Abstract and concrete categories: The joy of cats, John Wiley and Sons, New York 1990

TitleApplied Linear AlgebraCodeÚMV/ALA1/04TeacherStudenovská DanicaECTS credits5Hrs/week2/1AssessmentExaminationSemester2, 4T/L methodLecture, PracticalObjectiveTo teach students basic knowledge about linear algebra; to make students able to apply the theory in concrete excercises.ContentMatrices over Euclidean rings, canonical forms. Polynomial matrices. Similar matrices. Jordan normal form. Functions of matrices, sequences, series. Inversion of singular matrices, pseudoinverse matrices and their application.Alternate coursesÚMV/ALA1/99Recommended reading H.E.Rose: Linear algebra, A pure mathematical approach, Birkhäuser Verlag, 2002
D.Serre: Matrices, Theory and applications, Springer Verlag, 2002.
http://www.cs.ut.ee/~toomas_l/linalg/

TitleFractal GeometryCodeÚMV/FRG1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the mathematical approach to analysing the concept of a fractal with the possibility of using the results for the construction of fractals.ContentConcept of a fractal. Basic topology of metric spaces. Self-similarity of a fractal. Fractal as fixpoint of a mapping. Construction of a fractal by iteration. Topological dimension and basic properties. Hausdorff measure and Hausdorff dimension. Topological and Hausdorff dimension of particular fractals. Some methods of construction of a fractal (topological dynamics).Recommended reading G. A. Edgar: Measure, Topology and Fractal Geometry, Springer 1990.
K. Falconer, Fractal Geometry, John Willey 1992
H. O. Peitgen, H. Jurgens and D. Saupe, Fractals for Classroom, I, II, Springer Verlag, Berlin 1991 


TitleNumber TheoryCodeÚMV/TCI/04TeacherHarminc MatúšECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo familiarise students with the divisibility and congruences of integers, linear and quadratic congruences and arithmetic functions. ContentEuclidean algorithm. Fundamental theorem of arithmetic. Primes, composites, canonical form and its applications. Congruences, criteria of divisibility. Arithmetic functions. Euler’s theorem. Fermat’s theorem. Wilson’s theorem. Linear and quadratic congruences. Recommended reading M. B. Nathanson: Elementary Methods in Number Theory. Springer, 2000
H. E. Rose: A Course in Number Theory. Clarendon Press, Oxford, 1994
Elective courses

TitleFoundations of Knowledge SystemsCodeÚINF/ZNA1/06TeacherVojtᚠPeterECTS credits4Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureContentRelations of formal models: DBMS, SQL, and logic programming. Summary of different formal models of computational processes, connections among them and translations. Gentzenov systems, semantics and verification of programs. Formal specifications, temporal logics: formulas, models, tableaux.Recommended reading M. Ben-Ari. Mathematical logic for Computer Science 2ed. Springer Verlag London 2001
J. Ullman. Principles of database and knowledge based systems. Comp. Sci. Press 1988
J. W. Lloyd. Foundations of logic programming. Springer Berlin 1987

TitleTheory of InformationCodeÚMV/TIN1/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo introduce students to mathematical attempts at solving selected problems of computer science.ContentMeasurement of information. Entropy and its properties. Shanon’s theorems. Coding and basic types of codes. Using of algebraic structures in construction of codes. Kolmogorov complexity. Basic properties and relation to the notion of entropy. Complexity and randomness. Recommended reading J. H. van Lint, Introduction to Coding Theory, Springer 1992
M. Li and P. Vitanyi, Kolmogorov Complexity and its Applications, Handbook of Theoretical Computer Science, Elsevier, 1990, p. 188-252

TitleControl TheoryCodeÚMV/TS1/04TeacherCechlárová KatarínaECTS credits6Hrs/week3/1AssessmentExaminationSemester1, 3T/L methodLecture, PracticalObjectiveTo teach students the basic concepts of controllable systems.ContentControllable systems. Pontrjagin maximum principle. Linear systems, bang-bang controls, singular controls.. Discrete systems, dynamic programming, Bellmann’s optimality principle. Practical applications of theoretical results. Alternate coursesÚMV/TS1/99 orÚMV/TS1/00Recommended reading K. Macki, A. Strauss: Introduction to Optimal Control Theory, Springer, 1980
G. Feichtinger, R.F. Hartl: Optimale Kontrolle okonomischer Prozesse, Berlin, 1986

TitleComputational ComplexityCodeÚINF/VYZ1/04TeacherGeffert ViliamECTS credits4Hrs/week2/-AssessmentExaminationSemester1, 3T/L methodLectureObjectiveTo give students background in the computational complexity and theory of NP-completeness.ContentDeterministic and nondeterministic algorithms with polynomial time; NP-completeness. Deterministic simulation of a nondeterministic Turing machine. Satisfiability of Boolean formulae. Other NP-complete problems: satisfiability of a formula in a conjunctive normal form, 3-satisfiability, 3-colorability of a graph, 3-colorability of a planar graph, knapsack problem, balancing, etc. Space bounded computations, classes LOG-space and P-space. Deterministic simulation: Savitch’s theorem. Closure under complement. Classification of computational complexity of problems.Alternate coursesÚINF/VYZ1/03 orÚINF/VYZ1/00Recommended reading A.V.Aho and J.D.Ullman. The design and analysis of computer algorithms. Addison-Wesley, 1974
P.van Emde Boas. Machine models and simulations. In J.van Leeuwen (ed.): Handbook of theoretical computer science. North-Holland, 1990
Ch.K.Yap. Introduction to the theory of complexity classes. To be published by Oxford Univ. Press. (Electronic version available via anonymous ftp://cs.nyu.edu/pub/local/yap/complexity-bk).

TitleAlgorithmically Unsolvable ProblemsCodeÚMV/ANP/03TeacherBukovský LevECTS credits4Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the most important results about the non-existence of an algorithm for solving a given problem.ContentAxiomatic theories of natural numbers. Definability of recursive functions. Tarski’s theorem on undefinability of truth in formalised arithmethic. Godel incompleteness theorem. Algorithmic unsolvability of particular mathematical problems. Non-existence of an algorithm for finding a solution to Diophantine equations. Reduction of problems and degrees of unsolvability. Recommended reading J. Barwise ed., Handbook of Mathematical Logic, North Holland 1977S. C. Kleene, Introduction to the Metamathematics, Van Nostrand 1952, ruský preklad Moskva 1957.
E. Mendelson, Introduction to Mathematical Logic, Van Nostrand 1963.
M. Davis, Hilbert's Tenth Problem is Unsolvable, Amer. Math. Monthly, 1973, 233--269. PHYSICS

Study programme Biophysics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚFV/CHV1/03Molecular Structure and Chemical Bonding62/2Examination1/1ÚFV/SP1/04Semester Project4-/4Assessment1/1ÚCHV/STA1/03Structure Analysis62/2Examination1/1ÚFV/FCH1/02Physical Chemistry for Biological Sciences63/2Examination1/1ÚCHV/BCH1a/03Biochemistry I32/-Examination1/1KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚFV/BME1/00Introduction to Physics of Biological Membranes32/-Examination1/2ÚFV/EMB1b/04Optical Spectroscopy64/-Examination1/2ÚCHV/BCH1b/03Biochemistry II53/-Examination1/2ÚFV/EMB1d/04Nuclear Magnetic Resonance53/-Examination1/1ÚFV/RP1/04Annual Project6-/6Assessment1/2ÚFV/SP2/04Semester Project6-/6Assessment2/3
Compulsory elective courses

ÚFV/NOT1a/03Nontraditional Optimisation Techniques I52/2ExaminationÚFV/ZSY1/03Complex Systems52/2ExaminationÚFV/MBB1/03Fundamentals of Cellular and Molecular Biology53/-ExaminationÚFV/EMB1c/04Modern Trends in Biophysical Methods53/-ExaminationÚFV/SBFc/03Biophysical Seminar1-/1AssessmentÚFV/SBFe/03Biophysical Seminar1-/1AssessmentÚCHV/ENZ/04Enzymology53/-ExaminationÚFV/BSIM1/03Biomolecular Simulations62/2ExaminationÚFV/BIOE1/02Bioenergetics32/-ExaminationÚFV/PRb/04Laboratory Training II: Optical Spectroscopy Methods3-/3AssessmentÚFV/PRd/04Laboratory Training III: NMR3-/3Zápo
etÚFV/SBFd/03Biophysical Seminar1-/1AssessmentÚFV/NOT1b/03Nontraditional Optimisation Techniques II52/2ExaminationÚFV/NANO1/02Nanotechnologies32/-ExaminationÚFV/MSA1/03Methods of Structural Analysis73/2ExaminationÚFV/SBFf/03Biophysical Seminar1-/1AssessmentÚFV/BMM1/05Introduction to Physics of Biomacromolecules32/-ExaminationÚFV/ZBF1/05Fundamentals of Biophotonics32/-Examination
Course units

Compulsory courses

TitleMolecular Structure and Chemical BondingCodeÚFV/CHV1/03TeacherUli
ný JozefECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach actual methods used for computer simulations of molecules and to give students hands-on experience with standard methods. ContentBorn-Oppenheimer approximation. Methods and approaches of classical molecular mechanics. Force fields and force constants for polyatomic simulations. Force fields for biomolecular simulations (CHARMM, AMBER, MM2-4, MMFF, CVFF, etc.). Independent electron approximation. Hartree-Fock self-consistent field method. Post Hartee-Fock methods. Density functional theory (DFT): basic principles and implementation. LSDA approximation and gradient corrected methods. Hybrid methods. Wavefunction and electron density analysis. Limits and perspectives of classical and quantum molecular mechanics. Alternative methods. Ab initio computations and experimental observables. Experimental and computational observables. Molecular dynamic and stochastic methods. Integration algorithms. Car-Parinello dynamics.
Recommended reading Leech: Molecular Modelling: Principles and Applications, Longmann,
1996
M.P. Allen, D.J. Tildesley: Computer Simulation of Liquids,
Oxford, University Press, 1989
P. W. Atkins, R. S. Friedman: Molecular Quantum Mechanics.Oxford
University Press, 1997 (3. edition)


TitleSemester ProjectCodeÚFV/SP1/04TeacherMiškovský PavolECTS credits4Hrs/week-/4AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo realise experimental and/or theoretical works within the frame of a chosen theme and to present the results of this work in a consistent way.ContentWork on a chosen theme for the semester project in the Department of Biophysics.Recommended reading The literature will be recommended by supervisors of individual works.



TitleStructure AnalysisCodeÚCHV/STA1/03Teacher ernák JurajECTS credits6Hrs/week2/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo teach students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal structure determination and how to use the results of the crystal structure analysis in their own work.ContentHistorical introduction: importance of diffraction methods. Origin and properties of x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations. Reciprocal space; Ewald construction. Single crystal diffraction methods; automatic diffractometers. Powder diffraction: Debye-Scherrer and diffractometric methods, their theory and use. Atomic factor, structure factor, electronic density and their relationship. The phase problem: overview of the methods for solving the phase problems. Refinement of the structure; geometric parameters. Crystallisation processes; methods of preparation of single crystals. Density. Basic inorganic structure types.Recommended reading Clegg W.: Crystal Structure Determination, Oxford University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals. Walter de Gruyter, Berlin, 1980


TitlePhysical Chemistry for Biological SciencesCodeÚFV/FCH1/02TeacherJancura Daniel, Miškovský PavolECTS credits6Hrs/week3/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo introduce students to fundamental knowledge of physical chemistry emphasizing the physico-chemical properties of biomacromolecules and biological systems.ContentDescription of macroscopic systems, energy and 1st law of thermodynamics, entropy and 2nd law of thermodynamics, Gibbs energy and equilibrium state, chemical potential, binding constants of ligand-macromolecule interactions, biophysical applications of the thermodynamics. Solutions, electrolytic solutions, electrochemical equilibrium, electrodes, electrochemical potential. Statistical thermodynamics: the interpretation of energy, heat, entropy and information; the partition functions, biological applications of statistical thermodynamics, the conformational transitions in proteins and nucleic acids. Chemical reactions, chemical and biochemical kinetics, dynamics of the chemical reactions, kinetics of enzymatic reactions, inhibition of enzymes. Transport processes, molecular diffusion, membrane transport and its significance for biological organisms. Recommended reading P. Atkins and J. de Paula: Physical chemistry (7th Edition),
Oxford University Press, 2002
D. Eisenberg and D. Crothers: Physical chemistry with applications to the life sciences, Benjamin/Cummings, 1979
K. van Holde, W. Johnson and P. Ho, Principles of physical biochemistry, Prentice Hall, 1988


TitleBiochemistry ICodeÚCHV/BCH1a/03TeacherPoto
Hák Ivan, Podhradský DuaanECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureObjectiveTo provide understanding of life’s processes in molecular terms.ContentBasic structures of biomolecules. Structures and functions of saccharides and lipids. Amino Acids and nucleic acids. Techniques of protein and nucleic acid purification. Three-dimensional structures of proteins. Protein folding, Dynamics and structural evolution. Hemoglobin: protein function in a microcosm. Flow of genetic information. Proteosynthesis. Biosynthesis of nucleic acids, replication, transcription and translation. Enzymes: structure and function. Rates of enzymatic reactions Mechanisms of enzyme action and control of enzymatic activity.Recommended reading Lubert Stryer and col.: Biochemistry 5th edition, W.H.Freeman and Company, New York, 2003
Voet, Voet: Biochemistry 3rd edition, John Wiley & sons, England, 2004

TitleIntroduction to Physics of Biological MembranesCodeÚFV/BME1/00TeacherFabriciová Gabriela, Miškovský PavolECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach the fundamental processes that occur in biological membranes. ContentStructure and models of membranes. Physico-chemical properties of biological membranes. Functions of membranes. Propagation of nerve impulse and the process of vision. Physical methods for the study of membranes.Recommended reading C.Hidalgo: Physical Properties of Biological Membranes,Plenum Press, New York 1988
van Winkle I. J.: Biomembrane transport, Academic Press, San Diego 1999
Stein W. D.: Channels, carriers, and pumps, Academic Press, San Diego 1990
Glaser R.: Biophysics, Springer-Verlag, Heidelberg 1999
Pollard T. D., Earnshaw W. C.: Cell biology, Saunders, Philadelphia 2004
Alberts: Molecular biology of the cell, Garland Science, New York 2002 

TitleBiochemistry IICodeÚCHV/BCH1b/03TeacherPoto
Hák Ivan, Podhradský DuaanECTS credits5Hrs/week3/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students about living organisms on the basis of their molecular structure and metabolism.ContentIntroduction to Metabolism; regulation of metabolic pathways. Basic metabolic processes: oxidative phosphorylation, glycolysis, phentose phosphate pathway, citric acid cycle, gluconeogenesis, oxidation of fatty acids, amino acids degradation and the urea cycle. Photosynthesis. Transport through membranes. Lipid metabolism. Amino acid metabolism. Energy metabolism: Integration and Organ specialisation. Nucleotide metabolism. Principle of bioenergetic. Hormones and vitamins.Prerequisite coursesÚCHV/BCH1a/03Recommended reading Lubert Stryer and col.: Biochemistry 5th edition, W.H.Freeman and Company, New York, 2003
Voet, Voet: Biochemistry 3rd edition, John Wiley & sons, England, 2004

TitleSemester projectCodeÚFV/SP2/04TeacherMiškovský PavolECTS credits6Hrs/week-/6AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo realise experimental and/or theoretical works within the frame of a chosen theme and to present the results of this work in a consistent way.ContentWork on a chosen theme for the semester project in the Department of Biophysics.Recommended reading The literature will be recommended by supervisors of individual works.
Compulsory elective courses

TitleNontraditional Optimisation Techniques ICodeÚFV/NOT1a/03TeacherHorváth Denis, Uli
ný Jozef, Brutovský BranislavECTS credits5Hrs/week2/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo allow students to learn major optimisation methods.ContentThe classification of optimisation methods. Optimisation function. Multifunction-optimisation. The penalty function. The Barier function. The stochastic and deterministic methods. Gradient methods. The physical picture of gradient optimisation. Blind search and hill climbing methods. Multi-agent evolutionary strategy and meta-optimisation. Genetic algorithms. Quantum mechanical applications of genetic algorithms. Genetic algorithms in variable environments. The training of neural nets as optimisation. Principal component analysis. The prediction of time series. Monte Carlo techniques and simulated annealing. Optimisation and self-organisation attractor. The self-organised Kohonen nets; neural gas model. Cellular automata models. Agent-based systems. Strategies and demographic games on the lattice. Swarm optimisation. Recommended reading J.C.Principe, N.R.Euliano, Neural and Adaptive Systems, John Wiley & Sons. INC., New York, 2000.
K.Binder, D.W.Heermann, Monte Carlo Simulation in Statistical Physics, Springer-Verlag, Berlin, 2002.

TitleFundamentals of Cellular and Molecular BiologyCodeÚFV/MBB1/03TeacherFabriciová Gabriela, Miškovský PavolECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo provide students basic information about the structure and function of cells and genetics processes. ContentCharacteristics of cells, the surface of the cell, biological membranes, cell's organelles, the cell cycle. Macromolecules of information, genome of prokaryotes, eukaryotes and viruses, the mechanisms of DNA replication, mechanisms of transcription and transduction, the regulation of gene expression, mutations and mutagenes, experimental methods in molecular biology. Prerequisite coursesÚCHV/BCH1b/03Recommended reading G. M. Cooper, The cell a molecular approach, ASM Press,
Washington 2000
J. D. Watson, molekulární biologie genu, Acadenie, Praha 1982
J. Darnell, H. Lodish, D. Baltimore: Molecular Cell Biology, W.
H. Freeman and Co., New York 1990 

TitleModern Trends in Biophysical MethodsCodeÚFV/EMB1c/04TeacherMiakovský Pavol, Uli
ný JozefECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo inform students about state-of the art experimental and theoretical methods in biophysics (different types of microscopy, nanotechnology, methods of genomics, proteomics, etc.). The content of the course will be determined each year. ContentAFM, SNOM, microspectroscopic methods, modern methods in time-resolved spectroscopy, microcalorimetry, modern methods in the simulation of biological processes.Prerequisite coursesÚFV/EMB1b/04

TitleBiophysical SeminarCodeÚFV/SBFc/03TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo teach students about individual scientific work within the frame of the year's diploma theses and lead them to the intelligible presentation of their scientific results. ContentBiophysics Department seminar oriented to the themes of the year's diploma works.Recommended reading The literature will be recommended by supervisors of individual works.

TitleBiophysical SeminarCodeÚFV/SBFe/03TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo teach students about individual scientific work within the frame of the year's diploma theses and lead them to the intelligible presentation of their scientific results. ContentBiophysics Department seminar oriented to the themes of the year's diploma works.Recommended reading The literature will be recommended by supervisors of individual works.

TitleEnzymologyCodeÚCHV/ENZ/04TeacherSedlák Erik, Podhradský Dušan, Györyová KatarínaECTS credits5Hrs/week3/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo teach students to use the basic equations of enzyme kinetics. To have students develop the ability to determine basic kinetic and thermo-dynamic parameters of enzyme catalyzed reaction.ContentIntroduction. Chemical catalysis: theory of transition state. Enzyme catalysis: types and examples. Cofactors. Active site: lock and key; induced fit. Enzymes: classification. 3D structure of proteins. Noncovalent interactions. Secondary, tertiary and quaternary structures. Convergent and divergent evolution. Multienzyme complexes. Dynamics of proteins. Ligand binding. Thermodynamics and kinetics. Techniques. Chemical kinetics. Basic equations of enzyme kinetics.
Regulations of enzyme activity: examples. Conformational change; allosteric regulation. Regulation of metabolic pathways. Experimental determination of enzyme activity. pH and temperature dependence of enzyme catalysis. Determination of individual rate constants. Stop flow. Enzyme-substrate complementarities and the use of binding energy in enzyme catalysis. Reversible inhibition. Irreversible inhibition. Specificity and control mechanisms. „Moonlighting“ enzymes. Applic-ations of enzymes (organic solvents). Catalytic antibodies. Extremo-philes. Directed selection of enzymes. Enzymatic reactions with multiple substrates.Recommended reading Alan Fersht “Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. “ (3rd Ed. W. H. Freeman and Company, 1999)
Robert A. Copeland: Enzymes (2nd edition), Wiley-VCH, 2000


TitleBiomolecular SimulationsCodeÚFV/BSIM1/03TeacherUli
ný JozefECTS credits6Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo introduce students to actual problems of biomolecular simulations. ContentStructural characteristics of biological polymers. Foldamers. Central dogma of molecular biology as flow of biological information. 3D-structure and function of foldamers. Recent view on enzyme mechanisms. Experimental methods of structure determination and their limitations. Empirical force fields and methods of classical molecular dynamics. Molecular dynamics and Monte Carlo methods: algorithms and parallelisation. Ab initio molecular dynamics and hybrid approaches. Computational challenges in biomolecular simulations: simulations of chemical reactions, free energy evaluation, protein folding. Computational complexity, nontraditional approaches and heuristic approaches.


TitleBioenergeticsCodeÚFV/BIOE1/02TeacherJancura Daniel, Miškovský PavolECTS credits3Hrs/week2/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo provide students an introduction to the principles of membrane transport in biological systems and to the fundamental bioenergetic processes in biological organisms with emphasis on the description of the structure and function of the biomacromolecules involving in the processes of the oxidative phosphorylation. ContentEnergy in the biosphere. Phenomenology of bioenergetical processes. Control and regulation in bioenergetics. Chemiosmotic theory. Structure and function of the respiratory chain. Oxidative phosphorylation. The enzymes of the respiratory chain. Structure and function of NADH dehydrogenase (complex I), succinate dehydrogenase (complex II), cytochrome bc1 (complex III) and cytochrome c oxidase (complex IV). Formation of the mitochondrial proton gradient. Photosynthesis-basic informations and mechanisms. Thermodynamics and kinetics of membrane transport. Carriers, pumps and channels in the biological membranes. Recommended reading I. Scheffer, Mitochondria, John Wiley & Sons, Inc., 1999
D. Harris, Bioenergetics at a glance, Blackwell Science Ltd., 1995
D. Nicholls, S. Ferguson, Bioenergetics 3, Academic Press,
Elsevier Science Ltd., 2002
S. Papa, F. Guerrieri, J. Tager (Eds.), Frontiers of cellular bioenergetics, Kluwer Academic, 1999
Selected scientific publications.

TitleLaboratory Training II: Optical Spectroscopy MethodsCodeÚFV/PRb/04TeacherMiškovský PavolECTS credits3Hrs/week-/3AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo provide students with basic skills for manipulations with the instruments utilised in optical spectroscopy. ContentPractical training in the frame of the subject "Methods of Optical Spectroscopy". The training includes a practical intoduction to the following experimental techniques: UV-VIS spectroscopy, fluorescence spectroscopy, Raman and IR spectroscopy and CD spectroscopy. Recommended reading The actual scientific papers.

TitleBiophysical SeminarCodeÚFV/SBFd/03TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo teach students about individual scientific work within the frame of the year's diploma theses and lead them to the intelligible presentation of their scientific results.
ContentBiophysics Department seminar oriented to the themes of the year's diploma works.Recommended reading The literature will be recommended by supervisors of individual works.

TitleNontraditional Optimisation Techniques IICodeÚFV/NOT1b/03TeacherHorváth Denis, Uli
ný Jozef, Brutovský BranislavECTS credits5Hrs/week2/2AssessmentExaminationSemesterT/L methodLecture, PracticalObjectiveTo teach students applications of optimisation techniques on thestudy and interpretation of complex systems using examples from biology. To introduce students to new paradigms in the area of systems biology.ContentComplex systems; emergent behavior. Evolutionary theory and memetics. Application of optimisation techniques on complex systems. Application of methods (genetic algorithms, simulated annealing, taboo search) on selected problems of biomolecular simulations. Molecular dynamics; protein folding. Population dynamics, metabolic networks and complexity in bioinformatics.Recommended reading The actual scientific papers.

TitleMethods of Structural AnalysisCodeÚFV/MSA1/03TeacherSovák PavolECTS credits7Hrs/week3/2AssessmentExaminationSemesterT/L methodLecture, PracticalContentOptic microscopy. Electron microscopy: Electron beam instruments, electron optics, electron lenses and deflection systems, transmission electron microscopy (principle and construction). Electron–specimen interactions. Electron diffraction. Kikuchy lines. Scanning electron microscopy (principle and construcion). Scanning transmission electron microscopy. High Voltage electron microscopy. Electron microprobe analysis: WDX spectrometer, EDX spectrometer, Auger electron spectrometer. self-emission microscopy. Convergent beam diffraction. X-ray diffractometry: Scattering of x-rays, neutrons and neutron scattering, CW-diffractometer, Ewald´s sphere, diffraction on powder samples, The main characteristics of powder diffraction pattern, structure factor, occupation factor, Atomic displacement factor, Peak intensity, shape and symmetry, Sherrer equation. Peak profile, Rietweld method.
Alternate coursesÚFV/SAK1/99,ÚFV/SAK1/00,ÚFV/RTG1/01Recommended reading S. Amelincks, D.van Dyck, J. van Landyut: Electron Microscopy – Principles and Fundamentals, VCH, 1997
M.H. Loretto: Electrom beam analysis of materials. Springer, 2002
Fundamentals of Powder Diffraction and Structural Characterisation of Materials, Vitalij K. Pecharsky & Peter Y. Zavalij , Kluwer Academic Publishers, 2003
Structure Determination from Powder Diffraction Data, Edited by W.I.F. David, K. Shankland, L.B. McCusker, C. Bärlocher, Oxford University Press, 2006

TitleBiophysical SeminarCodeÚFV/SBFf/03TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemesterT/L methodPracticalObjectiveTo teach students about individual scientific work within the frame of the year's diploma theses and lead them to the intelligible presentation of their scientific results. ContentBiophysics Department seminar oriented to the themes of the year's diploma works.Recommended reading The literature will be recommended by supervisors of individual works.

TitleIntroduction to Physics of BiomacromoleculesCodeÚFV/BMM1/05TeacherFabriciová Gabriela, Miškovský PavolECTS credits3Hrs/week2/-AssessmentExaminationSemesterT/L methodLectureObjectiveTo provide information about the structure and principles of organisation of the biological macromolecules.ContentConformations of biological macromolecules. Dynamics of the biopolymers. Hydratation of the biopolymers. Biopolymers as polyelectrolytes.Alternate coursesÚFV/BPM1/99,ÚFV/DNA1/99Recommended reading C.R.Cantor, P.R. Schimmel: Biophysical Chemistry Part I-III,
Freeman and Co., San Francisco, 1980.
H.Frauenfelder, J.Disenhofer, P.G.Wolyns: Simplicity and
Complexity in Proteins and Nucleic Acids, Dahlem University
Press, 1999.
M. Daune: Molecular biophysics, Oxford University press, 2004.


Study programme Nuclear and Subnuclear Physics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚFV/DPF1a/00Diploma Work2-/-Recognition1/1KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚFV/FJA1/99Physics of the Nucleus32/- Examination1/1ÚFV/FEC1/04Elementary Particle Physics84/2Examination1/1ÚFV/KTP1a/03Quantum Field Theory I63/1Examination1/1FFKF/DF/07History of Philosophy42/1Examination1/1ÚFV/DPF1b/00Diploma Thesis6-/-Recognition1/2ÚFV/KTP1b/03Quantum Field Theory II63/1Examination1/2 ÚFV/RJF1/99Relativistic Nuclear Physics32/-Examination1/2 ÚFV/EJF1a/04Experimental Methods of Nuclear Physics84/1Examination2/3ÚFV/DPF1c/03Diploma Work8-/-Recognition2/3ÚFV/DPF1d/03Diploma Work30-/-Recognition2/4
Compulsory elective courses

ÚFV/TGC1/03Group Theory, Classification and Structure of Elementary Particles32/-Examination1/1ÚFV/DJB1/07Programming and Data Processing in HEP42/1Examination1/1ÚFV/SEB1/04Nuclear Physics Seminar1-/1Assessment1/1ÚFV/UMJF/06Introduction to Experimental Methods in Nuclear Physics42/1Examination1/1ÚFV/JRE1/03Nuclear Reactions32/-Examination1/2 ÚFV/ZMSE/07Introduction to Simulations and Modelling of Experiments42/1Examination1/2ÚFV/SPJ1/99Special Practice in Nuclear Physics3-/3Assessment1/2 ÚFV/SEC1/04Nuclear Physics Seminar1-/1Assessment1/2 ÚFV/FPL/03Plasma Physics32/-Examination1/2 ÚFV/KDO1/99Methods of Clinical Dosimetry32/-Examination1/2 ÚFV/AJF1/03Applied Nuclear Physics43/-Examination2/3ÚFV/KZI1/03Cosmic Rays42/-Examination2/3ÚFV/SPE1/03Solid State Spectroscopy53/1Examination2/3ÚFV/SED1/04Nuclear Physics Seminar1-/1Assessment2/3ÚFV/PFC1/03Selected topics in Elementary Particle Physics42/-Examination2/3
Recommended elective courses

ÚINF/NEU1/03Neural networks52/1Examination1/1 ÚFV/TRV1/00General Theory of Relativity32/-Examination1/2 ÚFV/SVKJ/99Student Scientific Conference4-/-Assessment1/2 ÚFV/RPJ/03Term Project2-/-Assessment1/2 ÚFV/IKTN/03New Information and Communication Technologies41/2Examination2/3


Course units

Compulsory courses

TitleQuantum Field Theory ICodeÚFV/KTP1a/03TeacherHnati
 MichalECTS credits6Hrs/week3/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo introduce students to quantum field theory.ContentRelativistic quantum field conception. Particles as quantum fluctuations of the field. Lagrange formalism. Symmetries and conservation laws. Euler-Lagrange equation. The basic fields: scalar, spinor, electro-magnetic and vector. Equations for the classical fields: Klein-Gordon and Dirac, Maxwell, Lagrange and Hamilton operators. The quantisation of the free fields. Basic quantum field commutation and anti-commutation relations.Alternate coursesÚFV/KTP1a/99

TitlePhysics of the NucleusCodeÚFV/FJA1/99TeacherChalupka SlavkoECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentBasic properties of nucleus. Nuclear masses, binding energy, nuclear stability. Nuclear radius, density distribution of nuclear matter. Nuclear momentum and parity. Spin and magnetic momentum of nuclei. Quadrupole electric momentum. Theory of deuteron. Theory of scattering. Nuclear spin and isospin. Nuclear forces. Tensor character of nuclear forces. Models of atomic nucleus.

TitleElementary Particle PhysicsCodeÚFV/FEC1/04TeacherMartinská GabrielaECTS credits8Hrs/week4/2AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide basic knowledge of particle physics necessary for quantum field theory and quantum chromodynamics.ContentThe basic characteristics of elementary particles and conservation laws. Fundamental interactions (gravitational, weak, electromagnetic and strong forces). Classification of the particles. Determination of the mass, time of life, spin and parity of particles. Dalitz diagram. Leptons, baryons, pseudoscalar mesons. Resonances. Quark model. Symmetries and conservation laws. C-, P- and CP-parity violation. Helicity of the leptons. Neutral K mesons and CP-violation. Weak interaction and its classification. Neutral and charged currents. Cabbibo theory. The Glashow-Weinberg-Salam model. Intermediate W±, Z0 bosons.Alternate coursesÚFV/FEC1/03

TitleQuantum Field Theory IICodeÚFV/KTP1b/03TeacherHnati
 MichalECTS credits6Hrs/week3/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo have students examine selected topics in quantum field theory.ContentInteracting fields. The principle of symmetry and the form of interactions of quantum fields. Lagrange operator in QED. S–matrix. Wick’s theorems and Feynman diagrams. Perturbative calculation of S - matrix. S-matrix and cross section of the processes. Compton scattering of the proton on electron cross section calculation in QCD frame. Radiation corrections and the divergences of the Feynman graphs. Running coupling constant.Prerequisite coursesÚFV/KTP1a/03Alternate coursesÚFV/KTP1b/99

TitleRelativistic Nuclear PhysicsCodeÚFV/RJF1/99TeacherUrbán JozefECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo introduce students to the study of nuclear interactions at relativistic energies.ContentBasic parameters and quantities of particle collisions at high energies. Relativistic kinematics, invariants, rapidity and light cone variables. Basic parameters of high energy nuclear collisions, energy thresholds, the velocity or sound, cross sections, spectators and participants, temperature, thermal and transverse spectra, collision volume. Glauber model for hadron-nucleus and nuclear collisions. The equation of state for nuclear matter. Quark-gluon plasma.

TitleExperimental Methods of Nuclear PhysicsCodeÚFV/EJF1a/04TeacherVokál Stanislav, Krav
áková AdelaECTS credits8Hrs/week4/1AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo teach students the priniciples and methods of the experimental techniques of nuclear physics.ContentPrinciples and construction of particle detectors: quantities characterising detectors. proportional chambers, MWPC. Drift chambers, TPC. Special types of gas detectors, MSGC. Silicon detectors (pixels/strips). Scintillators and photodetectors. Methods of physical quantities measurement: vertex detectors. track detectors (measurement of coordinates, paths, angles, momenta). Charged particle identification (ionisation losses, time of flight, etc.). Calorimetry; electromagnetic and hadron calorimeters. Large detector systems, fixed target and collider experiments. Basis of electronics used in subnuclear physics (fundamental concepts, principles, requirements, specialness). Analogue and digital processing of signal (front-end). Electronic and physical calibration of measurement (calibration system). Selection systems (trigger), principles (physical characteristics of interesting events, electronical realisation), levels. Data readout from track detectors, calorimeters and particle identifing detectors. Data acquisition systems (DAQ).Alternate coursesÚFV/EJF1a/03,ÚFV/EJF1b/99
Compulsory elective courses

TitleGroup Theory, Classification and Structure of Elementary ParticlesCodeÚFV/TGC1/03TeacherTóth =ubomírECTS credits3Hrs/week2/-AssessmentExaminationSemester1T/L methodLectureContentPhenomenology of elementary particles and interactions, conservation laws. Lie groups and Lie algebras, representations. Unitary groups SU(2), SU(3), SU(4), SU(6), SU(n), irreducible representations, Young tableaux. Classification of elementary particles, eightfold way, quark model. New particles, new quarks and higher symmetries. Subquark models, strings, theory of everything.

TitleApplied Nuclear PhysicsCodeÚFV/AJF1/03TeacherMartinská GabrielaECTS credits4Hrs/week3/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo show students the basic applications of nuclear physics.ContentBasic characteristics of radioactive radiation. Biological effects of radiation. Dosimetry units. Activation analysis. Radioactive indicators. Radioactive dating. Applications of radioactivity in medicine.

TitleNuclear Physics SeminarCodeÚFV/SEB1/04TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester1T/L methodPracticalObjectiveTo bring the topical problems, methods and tools of high energy physics to the students.ContentSelected topical problems of nuclear and subnuclear physics.

TitleProgramming and Data Processing in HEPCodeÚFV/DJB1/07TeacherDirner AlexanderECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo provide students with theoretical and working knowledge of defined topics in this field.ContentThe CERN program libraries: CERNLIB, the maintenance and development of extensive programs using PATCHY and CMZ. Statistical processing of experimental data and their presentation with HBOOK. Physics Analysis Workstation (PAW). Utilisation of GEANT. Publication and presentation of results with LaTeX. WWW, CSS for creating HTML documents.Recommended reading Microsoft Fortran Version 5.0 Reference;
Convex Fortran Language Reference;
Goossens M: Using LaTeX at CERN;
CERN Program Library Long Writeup Y250;
HBOOK Reference Manual;
CERN PAW User's Guide Ref. Manual;

TitleNuclear ReactionsCodeÚFV/JRE1/03TeacherTóth =ubomírECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students the physics of nuclear reactions.ContentClassification of nuclear reactions. Conservation laws, kinematics. Elastic and inelastic scattering. Diffraction and optical theorem. Resonance reactions. Bohr model of nuclear reactions, compound nucleus. Density of energy states. Partial statistical model. Optical model. Direct reactions. Plane-wave Born approximation. Distorted- wave Born approximation. Pre-compound model of nuclear reactions. Exciton model. Heavy ion reactions. Nuclear synthesis.

TitleSpecial Practice in Nuclear PhysicsCodeÚFV/SPJ1/99TeacherECTS credits3Hrs/week-/3AssessmentAssessmentSemester2T/L methodPracticalObjectivePractice in nuclear physics - methods of identification of unknown beta radiators (alpha, beta, gamma) using selected detectors.ContentIntroduction to practice. Gamma radiator identification using ethalon. Gamma radiator activity determination. Identification of unknown beta radiators from their maximal energy. Statistical processing of the data measurements. Emulsion detector - geometrical measurements and their evaluation. Determination of short lived radioisotop halftimes.
Semiconductor detectors.

TitleNuclear Physics SeminarCodeÚFV/SEC1/04TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester2T/L methodPracticalObjectiveTo bring the topical problems, methods and tools of high energy physics to the students.ContentSelected topical problems of nuclear and subnuclear physics.

TitlePlasma PhysicsCodeÚFV/FPL/03TeacherKudela KarelECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students the characteristics of plasma objects in space.ContentMatter in space, distribution function, equation of continuity in phase space. Earth magnetosphere. Radiation belts. Ionosphere and upper atmosphere. Solar wind. Solar eruptions. Heliosphere. Space weather.

TitleMethods of Clinical DosimetryCodeÚFV/KDO1/99TeacherMatula PavelECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureObjectiveTo teach students the basic methods of clinical dosimetry.ContentThe basic concepts of clinical dosimetry and its radiotherapy applications. The sources of ionising radiation. Dose measurement methods. New trends in clinical dosimetry. PC supported topometry and dosimetry of beams ”in phantoms” and ”in vivo” dosimetry. 3D-figures (based on tomograph slices) in simulation methods and their use in radiotherapy.

TitleIntroduction to Simulations and Modelling of ExperimentsCodeÚFV/ZMSE/07TeacherKrav
áková Adela, Urbán JozefECTS credits4Hrs/week2/1AssessmentExaminationSemester2T/L methodLecture, PracticalObjectiveTo teach students the basics of Monte-Carlo methods and their applications in the simulation of high energy physics processes.ContentMathematical foundations of Monte-Carlo methods. Buffon`s needle and basic MC methods. Comparisons of Monte-Carlo integrations with numerical quadrature. Random number generators (random numbers, random numbers generation, tests of random number generators). Monte-Carlo simulations of high energy physics processes.Recommended reading James F.: Monte-Carlo theory and practice, Rep. Prog. Phys. 43, 1980, s. 1145-1189; Cern preprint DD/80/6, February 1980.
http://placzek.home.cern.ch/placzek/lectures,
http://en.wikipedia.org/wiki/Monte_Carlo_method


TitleIntroduction to Experimental Methods in Nuclear PhysicsCodeÚFV/UMJF/06TeacherVokál Stanislav, Krav
áková AdelaECTS credits4Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalContentAccelerators of charged particles: linear and circular, colliding beams. Particle passage through the matter. Energy loss of charged particles. Multiple scattering. Interactions of electrons and gamma radiation with matter. Transition radiation. Particle detection. Gaseous ionisation detectors. Scintillation detectors. Cherenkov detectors. Semiconductor detectors. Spectrometry of charged particles. Tracking detectors.


TitleSolid State SpectroscopyCodeÚFV/SPE1/03TeacherOrendá
ová Al~beta, Petrovi
 Pavol, Imrich JánECTS credits5Hrs/week3/1AssessmentExaminationSemester3T/L methodLecture, PracticalContentMethods of condensed matter spectroscopy:
1. Mössbauer spectroscopy. The physical bases of Mössbauer effect. Probability of recoil-free nuclear resonance absorption of gamma-radiation in solids. Analysis of hyperfine interactions of nuclei with their surroundings: electric monopole, electric quadrupole, and magnetic dipole interactions. Mössbauer spectroscopy, processing of experimental data, physical interpretation of hyperfine structure of Mössbauer spectra: intensity and width of lines, isomer shift, quadrupole splitting and magnetic splitting.
2. NMR/EPR spectroscopy. Basic properties of nuclei. Interactions of nuclei with magnetic and electric fields. Nuclear paramagnetism. Continual wave and pulse nuclear magnetic resonance techniques. Relaxation processes in nuclear spin system. Electron spin resonance. Spin-orbital interaction and interaction with crystal field. Detection of electron paramagnetic and ferromagnetic resonances.Alternate coursesÚFV/SPE1/99Recommended reading Dickson P.E., Berry F.J.: Mössbauer spectroscopy. Cambridge University Press, London 1986
Hennel J. W., Kolinowski J.: Fundamentals of Nuclear Magnetic Resonance. Longman Scientific and Technical, Essex 1993
Maddock A.G.: Mössbauer spectroscopy. Principles and Applications of the Techniques. Horwood Publishing, Chichester, 1997
Slichter C. P.: Principles of Magnetic Resonance, Springer-Verlag, London, 1990

TitleCosmic RaysCodeÚFV/KZI1/03TeacherKudela KarelECTS credits4Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo teach students about cosmic rays and the physical processes forming their fluxes and detection methods.ContentEnergetic particles in space. Origin of cosmic rays. Interaction of cosmic rays with matter. Detectors of cosmic rays, X- and gamma rays. Cosmic rays in the upper atmosphere. Geomagnetic effects on cosmic rays. Solar wind and its influence on cosmic rays. Acceleration mechanism of cosmic rays.

TitleNuclear Physics SeminarCodeÚFV/SED1/04TeacherECTS credits1Hrs/week-/1AssessmentAssessmentSemester3T/L methodPracticalObjectiveTo bring the topical problems, methods and tools of high energy physics to the students.ContentSelected topical problems of nuclear and subnuclear physics.

TitleSelected Topics in Elementary Particle PhysicsCodeÚFV/PFC1/03TeacherKrav
áková Adela, Urbán JozefECTS credits4Hrs/week2/-AssessmentExaminationSemester3T/L methodLectureObjectiveTo provide students a unified description of processes in nuclear and particle physics and to make them aware of selected experiments that demonstrate nuclear and nucleon substructures, quarks.ContentNucleon-nucleon interactions at high and relativistic energies. Geometric shape of nuclei, nuclear form factor. Elastic scattering of electrons on nucleons, form factor of nucleons. Deep inelastic scattering and the structure of particles. Scaling and the parton model. Charge independence and strangeness. G-parity. Classification of particles according to their strangeness. Quark model, coloured quarks and gluons and strong interaction. Resonances. Baryon and boson resonances.Prerequisite coursesÚFV/FEC1/03 orÚFV/FEC1/04Recommended reading Perkins D.H.: Introduction to high energy physics, Oxford, 1987
Povh, Rith, Scholz, Zetsche: Particles and Nuclei, An Introduction to the Physical Concepts, Berlin, 1993
Ryder L.: Elementary particles and symetries
Close F.: Quarks and Partons 
Elective courses

TitleNeural networksCodeÚINF/NEU1/03TeacherAndrejková GabrielaECTS credits5Hrs/week2/1AssessmentExaminationSemester1T/L methodLecture, PracticalObjectiveTo establish student understanding and knowledge for using basic paradigms of neural networks.ContentFeed-forward and recurrent neural networks; back propagation algorithm to adaptation of neural networks; capability of neural networks to be universal approximators. Hopfield neural networks and solving optimisation problems. Kohonen neural networks. Neural networks in connections to computational models. Theoretical problems of neural networks.Alternate coursesÚINF/NEU1/00 orÚINF/NEU1/99Recommended reading J. Hertz, A.Krogh, R.G. Palmer: Introduction to the theory of neural computation, Addison Wesley, 1991.

TitleGeneral Theory of RelativityCodeÚFV/TRV1/00TeacherMockov
iak SamuelECTS credits3Hrs/week2/-AssessmentExaminationSemester2T/L methodLectureContentOverview of the special theory of relativity (STR). Uniformly accelerated motion in STR. Local principle of equivalence: Eotvos experiment. Tensor calculus in pseudo-Riemann metric. Einstein’s equations of gravitational field. Schwarzschild's solution for spherically symetric field. Experimental tests of the general theory of relativity. Black holes. Solutions for homogeneous and isotropic distribution of mass. Cosmological applications. Prerequisite coursesÚFV/TRS1/99 or ÚFV/TRS/03Alternate coursesÚFV/TRV1/99Recommended reading Landau L.D., Lifshitz E.M.: The classical theory of fields. Addison- Wesley, Reading, Mass., USA, 1977 

TitleNew Information and Communication TechnologiesCodeÚFV/IKTN/03TeacherMurín Pavel, ernák Jozef, Dirner AlexanderECTS credits4Hrs/week1/2AssessmentExaminationSemester3T/L methodLecture, PracticalObjectiveTo introduce students to new information and communication technologies and their practical application in education, research activities and the popularisation of science.ContentIntroduction to new trends in internet communications with voice and video (videoconferencing, webcasting, videostreaming, video on demand, distance learning etc.). Presentation and individual training.

Study programme Physics
(Full-time master)

Code Title ECTS Credit Hours/week Assessment Recommended Year/Semester

Compulsory courses

ÚFV/TKL1/99Theory of Condensed Matter84/2Examination1/1ÚFV/POF1b/99Computational Physics II12/1Examination1/1ÚFV/ARE1a/99Automation of Physical Experiments32/-Examination1/1ÚFV/KTP1a/03Quantum Field Theory I63/1Examination1/1ÚFV/ARE1a/99Automation of Physical Experiments32/-Examination1/1ÚFV/FMT/03Physics of Materials II32/-Examination1/1ÚFV/TKL1/99Theory of Condensed Matter21/2Examination1/1ÚINF/PAZ1a/03Programming, Algorithms, and Complexity93/1Examination1/1ÚFV/EMT1/03Experimental Methods in Solid State Physics I32/-Examination1/1ÚINF/OSY1/03Operational Systems22/2Examination1/1ÚFV/KEM1/99Ceramics Materials32/-Examination1/1ÚINF/FUN1/01Functional Programming62/2Examination1/1ÚFV/PHP/02Variable Stars32/-Examination1/1ÚFV/OSA1/99Solid State Physics Seminar1-/1Assessment1/1ÚFV/TSA1/99Theoretical Physics I Seminar2-/2Assessment1/1ÚFV/NOT1a/03Nontraditional Optimisation techniques I22/2Examination1/1KFaDF/DF2p/07History of Philosophy42/1Examination1/1ÚFV/MKL/03Magnetic Properties of Solids61/-Examination1/2ÚFV/KVP/02Introductory Course in Quantum Computers32/-Examination1/1ÚINF/NEU1/03Neural networks22/1Examination1/1ÚFV/TGC1/03Group Theory, Classification and Structure of Elementary Particles32/-Examination1/1ÚFV/ARE1b/99Automation of Physical Experiments3-/3Assessment1/2ÚFV/NOT1b/03Nontraditional Optimisation Techniques II22/2Examination1/2ÚFV/NME1b/01Celestial Mechanics II23/1Zápo
et1/1ÚFV/FPK1/01Phase Transitions and Critical Phenomena32/-Examination1/2ÚINF/PAZ1b/03Programming, Algorithms, and Complexity12/1Examination1/2ÚFV/ARE1b/99Automation of Physical Experiments3-/3Assessment1/2ÚFV/PAF1b/01Practice in Astrophysics II1-/1Assessment1/1ÚFV/UMV1/99Special Practical Exercises II3-/3Assessment1/2ÚFV/KTP1b/03Quantum Field Theory II63/1Examination1/2ÚFV/BSIM1/03Biomolecular Simulations62/2Examination1/2ÚFV/NKM1/99Non-conventional Metallic Materials32/-Examination1/2ÚFV/POF1b/99Computational Physics II12/1Examination1/1ÚFV/TRV1/00General Theory of Relativity32/-Examination1/2ÚFV/FJA1/99Physics of the Nucleus32/-Examination1/1ÚFV/OSB1/99Solid State Physics Seminar1-/1Assessment1/2ÚFV/POL1/99Physics of Polymers32/-Examination2/3ÚFV/NMA/02Numerical Methods in Linear Algebra31/1Examination2/3ÚFV/SPE1/03Solid State Spectroscopy23/1Examination2/3ÚFV/POF1a/99Computational Physics I12/1Examination1/2ÚFV/PP1/99Physics of Semiconductor Elements32/-Examination2/3ÚFV/TPJ1/99Transport and Surface Phenomena13/-Examination1/2ÚFV/KVP/02Introductory Course in Quantum Computers32/-Examination2/3
 ;PQklmtu€§ôéÛɵ§–‰r–`–S7µ6hr5ph¦
—CJKHOJQJ\^JaJmHnHsH uh¦
—5mHnHsH u"hLSËh¦
—0J5mHnHsH u-jhLSËhLSË5UmHnHsH uhLSË5mHnHsH u!jhLSË5UmHnHsH uh¤Vùh¦
—mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH u#h¤Vùh¦
—CJ(aJ(mHnHsH uhìyLhìyLmHnHsH uhìyLmHnHsH uh¦
—mHnHsH u 
 ):;?@ABCDEFGún#¼õn#¬õn#¬õn#¬õn#¬õn#¬õn#¬ún#¼ðn#¬ðn#¬ðn#¬èn#ëtèn#¥èn#¥èn#¥ún#¼ún#¼ún#¼õn#¬õn#¬õn#¬õn#¬õn#¬õn#¬õn#¬õn#¬õn#¬$a$gd¦
—gdìyLgd¦
—gd¦
—•&2þGHIJKLMNOP€³Þ ; ^ z  · Ù ù /
q
Ÿ
º
ç
 : [ ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬õn#¼ún#¥ún#¥ún#¥õn#¼ún#¥ún#¥ún#¥ún#¥ún#¥ún#¥õn#¼ún#¥õn#¼ún#¥õn#¼ún#¥ún#¥ún#¥gd¦
—gd¦
—§­²ÒÝû   $ % & / 0 : ; O \ ] j y Ž œ ¦ ¶ Ê Ó Ø ê ø ù ú 
ïÞÊÞÊÞʹ¬•¹ƒ¹vfÊÞïÊÞÊÞÊÞÊïÞÊÞʹ¬h¤Vùh¦
—5mHnHsH uh¦
—5mHnHsH u"hLSËh¦
—0J5mHnHsH u-jshLSËhLSË5UmHnHsH uhLSË5mHnHsH u!jhLSË5UmHnHsH u&h¤Vùh¦
—5CJaJmHnHsH u hìyL5CJaJmHnHsH u h¦
—5CJaJmHnHsH u 


-
.
/
i
k
p
q
r

‘
’

ž
Ÿ
ª

¹
º
»
Ù
è×Å×µ¡¡×r[×Å×µ¡J¡×r hœ6o5CJaJmHnHsH u-jmhLSËhLSË5UmHnHsH uhLSË5mHnHsH u hìyL5CJaJmHnHsH u h¦
—5CJaJmHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uh¤Vùh¦
—5mHnHsH u"hLSËh¦
—0J5mHnHsH u!jhLSË5UmHnHsH u-jêhLSËhLSË5UmHnHsH uÙ
Ú
Û
ç
è
 - 9 M Z f t u v  ‘ ’ ™ š › ¥ ´ Ó Þ æ õ  è×Ũ”ƒ”ƒ”ƒ”ƒ”×v_×Å×O”ƒ”ƒ”ƒ”h¤Vùh¦
—5mHnHsH u-jchLSËhLSË5UmHnHsH uhLSË5mHnHsH u hœ6o5CJaJmHnHsH u&h¤Vùh¦
—5CJaJmHnHsH u9jhLSËCJ KH OJQJU\^JaJ mHnHsH u"hLSËh¦
—0J5mHnHsH u!jhLSË5UmHnHsH u-jèhLSËhLSË5UmHnHsH u[ u › µ ß ö   ! " # $ % & / j } ~ Ï Ð ã ä ñ ü þ 
ún#¥õn#¼ún#¥ún#¥ún#¥ún#¥ún#¥ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬ún#¬õõn#¥ún#¥ún#¥ún#¬ún#¬ín#¬ín#¬ä¬äÚ ¬äø¬äø¬ $Ifgd¦
—$a$gd¦
—gd¦
—gd¦
—    " ' / j ~ ä d
f
n
¹×BPQekw|ïÞʼ±¼¡Ê‘¼±ƒ¼‘¼¡¼r]H])h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u!h¤Vùh¦
—5\mHnHsH uheA’h¦
—mHnHsH uh¤Vùh¦
—5mHnHsH uh¤Vùh¦
—CJmHnHsH uh¦
—mHnHsH uh¤Vùh¦
—mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH u h´i45CJaJmHnHsH u h¦
—5CJaJmHnHsH u



!
L
ö|¬ö`¬/¬ö¬öÚ ¬ÆkdÖ$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—L
N
R
^
c
d
öø¬öø¬ö|¬ö`¬/YÆkd²$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—d
r
ˆ
Š
Ž
š
ž
ö¬öÚ ¬öø¬öø¬ö|¬ö`¬ $Ifgd¦
—ž
Ÿ
«
¾
À
Ä
8¬/¬/Ú ¬/ø¬/ø¬ $Ifgd¦
—ÆkdŽ$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÄ
Ð
Õ
Ö
ã
ñ
ö|¬ö`¬/¬ö¬öÚ ¬Ækdj$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ñ
ó
÷
 öø¬öø¬ö|¬ö`¬/¬ÆkdF$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
— 026BGö¬öÚ ¬öø¬öø¬ö|¬ö`¬ $Ifgd¦
—GHTprv8¬/¬/Ú ¬/ø¬/ø¬ $Ifgd¦
—Ækd"$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöv‚†‡“¢ö|¬ö`¬/¬ö¬öÚ ¬Ækdþ$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—¢¤¨´¹ºöø¬öø¬ö|¬ö`¬/¬ÆkdÚ$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ºÆÛÝâîóö¬öÚ ¬öø¬öø¬ö|¬ö`¬ $Ifgd¦
—óô8¬/¬/Ú ¬/ø¬/ø¬ $Ifgd¦
—Ækd¶ $$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $%2?ö|¬ö`¬/¬ö¬öÚ ¬Ækd’
$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—?AEQUVöø¬öø¬ö|¬ö`¬/¬Ækdn $$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—Vcprv‚†ö¬öÚ ¬öø¬öø¬ö|¬ö`¬ $Ifgd¦
—†‡”¡¤¨8¬/¬/Ú ¬/ø¬/ø¬ $Ifgd¦
—ÆkdJ $$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¨´¸¹ºö|¬ö`¬/¬'n#¬$a$gd¦
—Ækd&
$$If–FÖֈ”ÿü®~N¢Ú#h´ ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ºÖ×ãøúþ
÷n#¬÷n#¬î›¬îÓ ¬îù¬îù¬î{¬î[¬ $Ifgd¦
—$a$gd¦
—&(,:¬1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö,8=>K_ö{¬ö[¬1¬ö›¬öÓ ¬ÅkdÛ$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—_aeqvwöù¬öù¬ö{¬ö[¬1¬Åkd´$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—w„šœ ¬±ö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—±²¿×ÙÝ:¬1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÝèíîúö{¬ö[¬1¬ö›¬öÓ ¬Åkdf$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—#/45öù¬öù¬ö{¬ö[¬1YÅkd?$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—5Bacgsxö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—xy†’–:Y1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö–¢§¨´Çö{¬ö[¬1¬ö›¬öÓ ¬Åkdñ$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÇÉÍÙÞßöù¬öù¬ö{¬ö[¬1¬ÅkdÊ$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ßì
ö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—)DFR:¬1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd£$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöR]bcp“ö{¬ö[¬1§ö›¬öÓ ¬Åkd|$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—“•™¤©ªöù¬öù¬ö{¬ö[¬1YÅkdU$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ª¶ÊÌÐÜáö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—áâî":¬1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd.$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö".34AQö{¬ö[¬1Yö›¬öÓ ¬Åkd$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—QSWcijöù¬öù¬ö{¬ö[¬1¬Åkdà$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—jvŸ¡¥°¶ö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—¶·ÃÜÞã:1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—Åkd¹$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöãïøù"ö{¬ö[¬1¬ö›¬öÓ ¬Åkd’$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—"$(49:öù¬öù¬ö{¬ö[¬1¬Åkdk$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—:Grtx„ˆö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—ˆ‰•¦¨­:Y1›¬1Ó ¬1ù¬1ù¬ $Ifgd¦
—ÅkdD$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö­¹ÂÃÏâö{¬ö[¬1¬ö›¬öÓ ¬Åkd$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—âäéõùúöù¬öù¬ö{¬ö[¬1¬Åkdö$$If–FÖֈ”ÿ²ƒT§Ú#Ò„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ú&(,7@ö›¬öÓ ¬öù¬öù¬ö{¬ö[¬ $Ifgd¦
—@ABPQd:¬5n#¬0n#¥5n#¬5n#¬gd¦
—gd¦
—ÅkdÏ$$If–FÖֈ”ÿ²ƒT§Ú#Ñ„„hC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laödekvw|‰‘¡ún#¬ñ[sñ;sxsñ[sñUsñsñ
sykd¨ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
—|‰‘¡¢¯±º¾¿ÊÖßáâíõö\]e%23ERSi»¼¾Äðõ
%'045@LUWXcklvýþÿ$BD^`ŒTVnpíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØí´íÃØí´íÃØí´íÃh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uG¡¢¯±º¾`sW[sWUsWsW
s $Ifgd¦
—Ÿkd}!$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¾¿ÊÖßá`sW[sWUsWsW
s $Ifgd¦
—Ÿkdp"$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöáâíõ`sW[sW;s $Ifgd¦
—ŸkdU#$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöõö\†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd:$$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö\]e†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd%$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö%2†‰(}[s};s $Ifgd¦
—ykdÈ%$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö23ER†s}[s};s $Ifgd¦
—ykd&$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöRSi»†s}[s};s $Ifgd¦
—ykdV'$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö»¼½¾Äï†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd($$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöïðõ
†s}[s}Us}s}
s $Ifgd¦
—ykdò($$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö%'04`sW[sWUsWsW
s $Ifgd¦
—ŸkdÇ)$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö45@LUW`sW[sWUsWsW
s $Ifgd¦
—Ÿkdº*$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöWXck`sW[sW;s $Ifgd¦
—ŸkdŸ+$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöklv†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd„,$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöþÿ†„Z}[sq;sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdK-$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÿ$^†
œ}[s};s $Ifgd¦
—ykd.$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö^`Œn†s}[s};s $Ifgd¦
—ykdÙ.$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laönprt€œ†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd /$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöpt€ž¨ÂÒòô ".79:EMNX³´¼< = S ?!@!B!H!d!i!u!"""8"¸P¸X¸`sW[sWUsWsW
s $Ifgd¦
—Ÿkdì2$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöX¸Z¸p¸ˆ¸š¸œ¸`sW[sWUsWsW
s $Ifgd¦
—Ÿkdß3$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöœ¸ž¸´¸Ú¸`sW[sW;s $Ifgd¦
—ŸkdÄ4$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöڸܸð¸ü¹†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd©5$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöü¹þ¹º®»†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdp6$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö®»¯»Á»Ü»†µ}[s};s $Ifgd¦
—ykd77$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöܻݻó»6¼¼†s}[s};s};s $Ifgd¦
—ykdþ7$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¼¼‘¼’¼Â¼Õ¼Ö¼(½)½Y>Z>n>t>‚>‡>–>ž>Ÿ> >­>¯>¸>¼>½>È>Ô>Ý>ß>à>ë>ì>í>÷>±?²?³?´?¼?x@ðâðâÒâÒâðâÂⱜ‡œuœu‡œuœu‡œuœu‡œu‡œufu‡œuh¦
—CJaJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u!h¤Vùh¦
—5\mHnHsH uh¤Vùh¦
—CJmHnHsH uh¤Vùh¦
—\mHnHsH uh¤Vùh¦
—mHnHsH uh¤Vùh¦
—5mHnHsH u(è5õ5÷5û56 6ög
¬öù¬ö÷¬ö}¬ö_¬ $Ifgd¦
— 6 66(6*6.68¬/¬/g
¬/ù¬/÷¬ $Ifgd¦
—Ækd”$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö.6:6>6?6L6b6ö}¬ö_¬/¬ö¬ög
¬Ækd~$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—b6v6x6|6‡6‹6ög
¬öù¬ö÷¬ö}¬ö_¬ $Ifgd¦
—‹6Œ6›6¨6ª6®68Y/¬/g
¬/ù¬/÷¬ $Ifgd¦
—Ækdh$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö®6º6¾6¿6Ë6ã6ö}¬ö_¬/¬ö¬ög
¬ÆkdR$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ã6å6é6ô6ø6ù6öù¬ö÷¬ö}¬ö_¬/¬Ækdd?dUdŸdîd†µ}[s};s};s $Ifgd¦
—ykd„r$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöîdïdðdñd÷d
e†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdKs$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
eee e(ef†s}[s}Us}s}
s $Ifgd¦
—ykd t$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöf f:f>fPfXf`sW[sWUsWsW
s $Ifgd¦
—Ÿkdõt$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöXfZfpfˆfšfžf`sW[sWUsWsW
s $Ifgd¦
—Ÿkdèu$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöžf f¶fÜf`sW[sW;s $Ifgd¦
—ŸkdÍv$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÜfÞfòf¢g†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd²w$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¢g¤g´gÑh†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdyx$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÑhÒhèh1i„i†Î }[s};s};s $Ifgd¦
—ykd@y$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö„i…i†i‡ii½i†„Zn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdz$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö½i¾iÃiÐiØij†s}[s}Us}s}
s $Ifgd¦
—ykdÜz$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöjj8j§b§l§„§”§¸§º§Ô§اê§ò§ô§¨¨¨¨¨(¨;¨÷$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö£Å¤Å¯ÅºÅÃÅÅÅ`sW[sWUsWsW
s $Ifgd¦
—Ÿkd1ø$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÅÅÆÅÑÅÛÅ`sW[sW;s $Ifgd¦
—Ÿkdù$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÛÅÜÅäŰƆs}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdûù$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö°Æ²Æ´Æ¶ÆÂÆdžçn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdÂú$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÇÇ$ÇBÇRǖdžs}[s}Us}s}
s $Ifgd¦
—ykd—û$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö–ǘDzǶÇÈÇÐÇ`sW[sWUsWsW
s $Ifgd¦
—Ÿkdlü$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÈÇÐÇÒÇèÇÈ ÈÈÈÈ.È/È7ÈSÉTÉfÉuÉvɌɒʓʕʳÊÇÊ-ËÃÍàÍfÏwϸÐÆÐÇÐÛÐáÐíØÃíÃíØÃíØÃíØÃíØÃíظ¨”„v„v„vdvSÃ!h¤Vùh¦
—5\mHnHsH u#h¤Vùh¦
—CJaJmHnHsH uh¤Vùh¦
—mHnHsH uh¤Vùh¦
—5mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uh¤Vùh¦
—CJmHnHsH uh¦
—mHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u ÐÇÒÇèÇÈ ÈÈ`sW[sWUsWsW
s $Ifgd¦
—Ÿkd_ý$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÈÈÈ.È`sW[sW;s $Ifgd¦
—ŸkdDþ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö.È/È7ÈSɆs}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd)ÿ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöSÉTÉfÉuɆΠ}[s};s $Ifgd¦
—ykdðÿ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöuÉvÉŒÉðÉ0ʒʆs}[s};s};s};s $Ifgd¦
—ykd·$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö’ʓʔʕʳÊÆÊÇÊËË,Ë-Ë;ËSˆ†A n#¬n#¬|n#¥n#¥n#¥n#¬n#¬tn#¬tn#¬k¬kÜ
¬ $Ifgd¦
—$a$gd¦
—gd¦
—gd¦
—ykd~$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö SËUËYËeËiËjËöD¬ö«¬ö}¬ö_¬/¬ÆkdS$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—jËw˫˭˱˽ËÁËö¬öÜ
¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
—ÁËÂËÑËÞËàËäË8ž/¬/Ü
¬/D¬/«¬ $Ifgd¦
—Ækd=$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöäËðËôËõËÌÌö}¬ö_¬/¬ö¬öÜ
¬Ækd'$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÌÌÌ#Ì'Ì(ÌöD¬ö«¬ö}¬ö_¬/¬Ækd$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—(Ì5Ì^Ì`ÌdÌoÌsÌö¬öÜ
¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
—sÌt̗̙̝́Ì8Y/¬/Ü
¬/D¬/«¬ $Ifgd¦
—Ækdû$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÌ©Ì­Ì®Ì»ÌÌÌö}¬ö_¬/¬ö¬öÜ
¬Ækdå$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÌÌÎÌÒÌÞÌâÌãÌöD¬ö«¬ö}¬ö_¬/¬ÆkdÏ$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ãÌñÌ
Í ÍÍÍ Íö¬öÜ
¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
— Í!Í0Í=Í?ÍCÍ8¬/¬/Ü
¬/D¬/«¬ $Ifgd¦
—Ækd¹$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöCÍOÍSÍTÍ`ÍxÍö}¬ö_¬/¬ö¬öÜ
¬Ækd£ $$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—xÍzÍ~͉͍͎ÍöD¬ö«¬ö}¬ö_¬/¬Ækd
$$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ŽÍÍªÍ­Í±Í½ÍÁÍö¬öÜ
¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
—ÁÍÂÍÃÍßÍàÍ8¬3n#¬+n#¬3n#¬$a$gd¦
—gd¦
—Ækdw $$If–FÖֈ”ÿû¯ËN£Ú#†M#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöàÍìÍ ÎÎÎÎ"ÎöP¬ö ¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
—"Î#Î0ÎHÎJÎNÎ8Y/P¬/ ¬/D¬/«¬ $Ifgd¦
—Ækda $$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöNÎYÎ]Î^ÎjÎ’Îö}¬ö_¬/¬öP¬ö ¬ÆkdK
$$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—’ΔΘΤΨΩÎöD¬ö«¬ö}¬ö_¬/YÆkd5$$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—©ÎµÎÀÎÂÎÆÎÒÎÛÎöP¬ö ¬öD¬ö«¬ö}¬ö_¬ $Ifgd¦
—ÛÎÜÎéÎ
Ï ÏÏ8¬/P¬/ ¬/D¬/«¬ $Ifgd¦
—Ækd$$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÏÏ Ï!Ï-ÏNÏö}¬ö_¬/YöP¬ö ¬Ækd $$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—NÏPÏTÏ`ÏdÏeÏöD¬ö«¬ö}¬ö_¬/YÆkdó$$If–FÖֈ”ÿ¼¯ËN£Ú#do#äiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—eÏfÏwÏxυϤϦϪ϶ϺÏún#¬òn#¬ún#¬éO¬é ¬éC¬é«¬é{¬é_¬ $Ifgd¦
—$a$gd¦
—gd¦
— ºÏ»ÏÇÏÝÏßÏãÏ8Y/O¬/ ¬/C¬/«¬ $Ifgd¦
—ÆkdÝ$$If–FÖֈ”ÿ»²ÍP£Ú#dq"ähE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöãÏïÏøÏùÏÐÐö{¬ö_¬/¬öO¬ö ¬ÆkdÇ$$If–FÖֈ”ÿ»²ÍP£Ú#dq"ähE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÐÐÐ)Ð-Ð.ÐöC¬ö«¬ö{¬ö_¬/¬Ækd±$$If–FÖֈ”ÿ»²ÍP£Ú#dq"ähE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—.Ð:ÐXÐZÐ^ÐiÐrÐöO¬ö ¬öC¬ö«¬ö{¬ö_¬ $Ifgd¦
—rÐsÐПСХÐ8Y/O¬/ ¬/C¬/«¬ $Ifgd¦
—Ækd›$$If–FÖֈ”ÿ»²ÍP£Ú#dq"ähE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¥Ð±ÐµÐ¶Ð·Ðö{¬ö_¬/Y*n#¬gd¦
—Ækd…$$If–FÖֈ”ÿ»²ÍP£Ú#dq"ähE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—·Ð¸ÐÆÐÇÐÚÐÛÐáÐùÐúÐÿÐ
ÑÑ6Ñún#¬õn#¥ún#¬ún#¬ún#¬ì[sì;sssì[sìUsìsì
sykdo$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
—gd¦
— áÐúÐÿÐ
ÑÑ6Ñ7ÑDÑFÑOÑSÑTÑ_ÑkÑtÑuÑvсєѕѝѢӣӵÓÃÓÄÓÚÓXÕZÕ[ÕaÕ–Õ›Õ¨Õ°ÕñÕòÕÿÕÖ
ÖÖÖÖ&Ö/Ö0Ö1Ögßgàgèg±h²hÈh˜i™i›i¡iµiºiÇijjj6j:jLjTjVjlj„j–jšjœj²jØjÚjîjUlVl^lCoDoZoøoùoûop,p6pPp`p|p~p˜pœp®p¶p¸pÎpæpøpüpþpq:qgßg†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdü)$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laößgàgèg±h†„Z}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdÃ*$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö±h²hÈhi˜i†„Z}[s};s};s $Ifgd¦
—ykdŠ+$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö˜i™iši›i¡i´i†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdQ,$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö´iµiºiÇiÏij†s}[s}Us}s}
s $Ifgd¦
—ykd&-$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöjj6j:jLjTj`sW[sWUsWsW
s $Ifgd¦
—Ÿkdû-$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöTjVjlj„j–jšj`sW[sWUsWsW
s $Ifgd¦
—Ÿkdî.$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöšjœj²jØj`sW[sW;s $Ifgd¦
—ŸkdÓ/$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöØjÚjîjUl†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd¸0$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöUlVl^lCo†„Z}[sq
;s $$Ifa$gd¦
— $Ifgd¦
—ykd1$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöCoDoZo£oøo†
ƒ}[s};s};s $Ifgd¦
—ykdF2$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöøoùoúoûop*p†„Zn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd
3$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö*p,p6pPp`p|p†s}[s}Us}s}
s $Ifgd¦
—ykdâ3$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö|p~p˜pœp®p¶p`sW[sWUsWsW
s $Ifgd¦
—Ÿkd·4$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¶p¸pÎpæpøpüp`sW[sWUsWsW
s $Ifgd¦
—Ÿkdª5$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöüpþpq:q`sW[sW;s $Ifgd¦
—Ÿkd6$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö:q$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö u¡u·uvHv†Î }[s};s};s $Ifgd¦
—ykd¾?$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöHvIvJvKvQvyv†„Zn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd…@$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöyvzvv‹v“vÆv†s}[s}Us}s}
s $Ifgd¦
—ykdZA$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÆvÇvÔvÖvßvãv`çW[sWUsWsW
s $Ifgd¦
—Ÿkd/B$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöãvävïvûvww`sW[sWUsWsW
s $Ifgd¦
—Ÿkd"C$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöwww%w`sW[sW;s $Ifgd¦
—ŸkdD$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö%w&w.wy†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdìD$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöyyy)yly(z†‰(}[s};s};s};s $Ifgd¦
—ykd³E$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö(z*z,z.z:zXz††A n#sn#sxOsxGs $Ifgd¦
—gd¦
—ykdzF$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöXzZzdz|zŒz¬z†s}Os}as}s}
s $Ifgd¦
—ykdOG$$If–FÖ    Ö0”ÿ»Ú#d   $   
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¬z®zÈzÌzÞzæz`sWOsWasWsW
s $Ifgd¦
—Ÿkd$H$$If–FÖ    Ö\”ÿ»ôçÚ#d  ÷ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöæzèzþz{({,{`sWOsWasWsW
s $Ifgd¦
—ŸkdI$$If–FÖ    Ö\”ÿ»ôçÚ#d ÷ªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöæzèzþz{({,{.{D{T{V{j{||&|~~~"~#~9~c~d~f~i~l~ˆ~œ~ì~í~[€\€]€š€±„ä„’‹ċºŒêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÕÃ굪µš†vivµªµvµvµvµh¦
—5mHnHsH uh¤Vùh¦
—5mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uh¤Vùh¦
—CJmHnHsH uh¦
—mHnHsH uh¤Vùh¦
—mHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u&,{.{D{T{`sWOsWGs $Ifgd¦
—ŸkdüI$$If–FÖ    Ö\”ÿ»ôçÚ#d ÷ªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöT{V{j{|†s}OsqGs $$Ifa$gd¦
— $Ifgd¦
—ykdáJ$$If–FÖ    Ö0”ÿ»Ú#d $ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö||&|~†ç}OsqGs $$Ifa$gd¦
— $Ifgd¦
—ykd¨K$$If–FÖ    Ö0”ÿ»Ú#d $ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö~~~"~†‰(}Os}Gs $Ifgd¦
—ykdoL$$If–FÖ    Ö0”ÿ»Ú#d $ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö"~#~9~c~†s{Os{Gs ¤x$Ifgd¦
—ykd6M$$If–FÖ    Ö0”ÿ»Ú#d $ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöc~d~e~f~g~h~i~j~k~l~ˆ~›~œ~ì~†ªn#¬n#¬n#¬n#¬n#¬n#¬n#¬n#¬xn#¥qn#¥n#¥n#¬¤xgd¦
—¤¤xgd¦
—gd¦
—ykdýM$$If–FÖ    Ö0”ÿ»Ú#d  $  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
ì~í~î~$&*6:ún#¬ún#¬òn#¬ún#¬éŽ¬é·
¬é­¬é«¬éǍ¬éҍ¬ $Ifgd¦
—$a$gd¦
—gd¦
—
:;JWY]8¬/Ž¬/·
¬/­¬/«¬ $Ifgd¦
—ÆkdÒN$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö&]imn{¤öǍ¬öҍ¬/¬öŽ¬ö·
¬ÆkdÁO$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö& $Ifgd¦
—¤¦ªµ¹ºö­¬ö«¬öǍ¬öҍ¬/YÆkd°P$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö& $Ifgd¦
—ºÉÖØÜèìöŽ¬ö·
¬ö­¬ö«¬öǍ¬öҍ¬ $Ifgd¦
—ìíù€€€8¬/Ž¬/·
¬/­¬/«¬ $Ifgd¦
—ÆkdŸQ$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö&€"€&€'€6€C€öǍ¬öҍ¬/¬öŽ¬ö·
¬ÆkdŽR$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö& $Ifgd¦
—C€F€J€V€Z€[€ö­¬ö«¬öǍ¬öҍ¬/¬Ækd}S$$If–FÖֈºÿ ¯4·V $…9åäù
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö& $Ifgd¦
—[€\€]€y€z€™€š€§€À€€ƀҀրún#¬ún#¬òn#¬òn#¬ún#¬ún#¬é›¬éÏ
¬éù¬é÷¬é¬é]¬ $Ifgd¦
—$a$gd¦
—gd¦
— ր׀ä€÷€ù€ý€8¬/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—ÆkdlT$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöý€ 
2ö¬ö]¬/¬ö›¬öÏ
¬ÆkdVU$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—248DHIöù¬ö÷¬ö¬ö]¬/¬Ækd@V$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—IV}ƒŽ’ö›¬öÏ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—’“ ¶¸¼8Y/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—Ækd*W$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¼ȁ́́ځëö¬ö]¬/¬ö›¬öÏ
¬ÆkdX$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ëíñý‚‚öù¬ö÷¬ö¬ö]¬/¬ÆkdþX$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—‚‚#‚%‚)‚4‚8‚ö›¬öÏ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—8‚9‚F‚n‚p‚t‚8¬/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—ÆkdèY$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöt‚‚ƒ‚„‚‘‚«‚ö¬ö]¬/Yö›¬öÏ
¬ÆkdÒZ$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—«‚­‚±‚½‚Á‚‚öù¬ö÷¬ö¬ö]¬/¬Ækd¼[$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—‚ςì‚î‚ò‚þ‚ƒö›¬öÏ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—ƒƒƒƒ ƒ$ƒ8Y/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—Ækd¦\$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö$ƒ0ƒ4ƒ5ƒAƒSƒö¬ö]¬/¬ö›¬öÏ
¬Ækd]$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—SƒUƒYƒeƒiƒjƒöù¬ö÷¬ö¬ö]¬/¬Ækdz^$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—jƒvƒ‡ƒ‰ƒƒ™ƒƒö›¬öÏ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—ƒžƒ«ƒ̓σӃ8¬/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—Ækdd_$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöӃރâƒãƒðƒ„ö¬ö]¬/Yö›¬öÏ
¬ÆkdN`$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—„„„&„*„+„öù¬ö÷¬ö¬ö]¬/YÆkd8a$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—+„8„W„Y„]„h„q„ö›¬öÏ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—q„r„„š„œ„ „8Y/›¬/Ï
¬/ù¬/÷¬ $Ifgd¦
—Ækd"b$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö „¬„°„±„²„ö¬ö]¬/¬*n#¬gd¦
—Ækd c$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—²„³„´„µ„ä„æ„ó„………(…,…ún#¬ún#¬ún#¬ún#¬ún#¬ñœ¬ñÎ
¬ñù¬ñ÷¬ñ¬ñ]¬ $Ifgd¦
—gd¦
— ,…-…9…R…T…X…8Y/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækdöc$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöX…d…h…i…v……ö¬ö]¬/¬öœ¬öÎ
¬Ækdàd$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—……“…Ÿ…£…¤…öù¬ö÷¬ö¬ö]¬/¬ÆkdÊe$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—¤…±…ÅŅɅՅمöœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—مڅè…ø…ú…þ…8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækd´f$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöþ… †
†††1†ö¬ö]¬/¬öœ¬öÎ
¬Ækdžg$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—1†3†7†C†G†H†öù¬ö÷¬ö¬ö]¬/¬Ækdˆh$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—H†U†m†o†s††ƒ†öœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—ƒ†„†‘††ĆȆ8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækdri$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöȆՆنچ膇ö¬ö]¬/Yöœ¬öÎ
¬Ækd\j$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—‡‡‡‡‡‡öù¬ö÷¬ö¬ö]¬/¬ÆkdFk$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—‡%‡E‡G‡K‡V‡Z‡öœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—Z‡[‡i‡‡ƒ‡‡‡8Y/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækd0l$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö‡‡“‡œ‡‡©‡Çö¬ö]¬/¬öœ¬öÎ
¬Ækdm$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÇŇɇՇއ߇öù¬ö÷¬ö¬ö]¬/¬Ækdn$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—߇쇈ˆ ˆˆ!ˆöœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—!ˆ"ˆ/ˆBˆDˆHˆ8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækdîn$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöHˆTˆ]ˆ^ˆkˆ}ˆö¬ö]¬/¬öœ¬öÎ
¬ÆkdØo$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—}ˆˆƒˆˆ“ˆ”ˆöù¬ö÷¬ö¬ö]¬/¬ÆkdÂp$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—”ˆ ˆ¼ˆ¾ˆˆ͈шöœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—ш҈߈üˆþˆ‰8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækd¬q$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö‰‰‰‰!‰1‰ö¬ö]¬/Yöœ¬öÎ
¬Ækd–r$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—1‰3‰7‰B‰F‰G‰öù¬ö÷¬ö¬ö]¬/¬Ækd€s$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—G‰T‰a‰c‰g‰s‰w‰öœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—w‰x‰…‰¬‰®‰²‰8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækdjt$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö²‰¾‰‰ÉЉé‰ö¬ö]¬/Yöœ¬öÎ
¬ÆkdTu$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—é‰ë‰ï‰û‰ÿ‰Šöù¬ö÷¬ö¬ö]¬/¬Ækd>v$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—Š
Š Š"Š&Š2Š6Šöœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—6Š7ŠDŠYŠ[Š_Š8¬/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækd(w$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö_ŠkŠoŠpŠ}ŠœŠö¬ö]¬/¬öœ¬öÎ
¬Ækdx$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—œŠžŠ¢Š­Š¶Š·Šöù¬ö÷¬ö¬ö]¬/YÆkdüx$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—·ŠĊçŠéŠíŠùŠýŠöœ¬öÎ
¬öù¬ö÷¬ö¬ö]¬ $Ifgd¦
—ýŠþŠ
‹.‹0‹4‹8Y/œ¬/Î
¬/ù¬/÷¬ $Ifgd¦
—Ækdæy$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö4‹@‹D‹E‹R‹x‹ö¬ö]¬/Yöœ¬öÎ
¬ÆkdÐz$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—x‹z‹~‹‹‹‹‹öù¬ö÷¬ö÷¬ö¬ö]¬ $Ifgd¦
—‹‹‘‹’‹£‹8Y3n#¬3n#¬+n#¬$a$gd¦
—gd¦
—Ækdº{$$If–FÖֈ”ÿ®N¥Ú#F„ƒjD
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö£‹¤‹Ëċҋê‹ì‹ð‹ü‹Œ÷n#¬òn#¬òn#¬éó¬é
¬éñ¬éù¬é¬é[¬ $Ifgd¦
—gd¦
—$a$gd¦
— ŒŒŒ3Œ5Œ:Œ:¬1ó¬1
¬1ñ¬1ù¬ $Ifgd¦
—Åkd¤|$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö:ŒFŒNŒOŒ\ŒoŒö¬ö[¬1Yöó¬ö
¬Åkd‹}$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—oŒqŒvŒŒ…Œ†Œöñ¬öù¬ö¬ö[¬1¬Åkdr~$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—†Œ“Œ¢Œ¤Œ¨Œ´Œ¸Œöó¬ö
¬öñ¬öù¬ö¬ö[¬ $Ifgd¦
—¸Œ¹ŒºŒêŒëŒ:¬5n#¬5n#¬5n#¬gd¦
—ÅkdY$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöºŒêŒ\ŽjŽkŽŽ…Ž“Ž˜Ž§Ž¯Ž°Ž±Ž¾ŽÀŽɎ͎ΎَåŽîŽðŽñŽûŽ¶·¿@AWŠ‹“¡¦µ½¾¿̐ΐאېܐçóüþÿ ‘ëÝÍݼ§’§€§€’§€§€’§€§€’§€’§€’§€’€§’§€§€’§€§€’§€§€’§#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u!h¤Vùh¦
—5\mHnHsH uh¤Vùh¦
—CJmHnHsH uh¤Vùh¦
—mHnHsH u'h¤Vùh¦
—5B*mHnHphsH u2ëŒúŒ#/8öó¬ö
¬öñ¬öù¬ö¬ö[¬ $Ifgd¦
—89Fegk:Y1ó¬1
¬1ñ¬1ù¬ $Ifgd¦
—Åkd@€$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laökw{|‰›ö¬ö[¬1Yöó¬ö
¬Åkd'$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—›¡­±²öñ¬öù¬ö¬ö[¬1¬Åkd‚$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—²¿؍ڍލêîöó¬ö
¬öñ¬öù¬ö¬ö[¬ $Ifgd¦
—îïû ŽŽŽ:Y1ó¬1
¬1ñ¬1ù¬ $Ifgd¦
—Åkdõ‚$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöŽŽ"Ž#Ž/ŽCŽö¬ö[¬1¬öó¬ö
¬Åkd܃$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—CŽEŽIŽUŽYŽZŽöñ¬öù¬ö¬ö[¬1¬ÅkdÄ$$If–FÖֈ”ÿ_¶P§Ú#¼€„jC
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ZŽ[Ž\ŽjŽkŽ~ŽŽ…Ž’Ž“Ž˜Ž§Ž¯Ž°Žún#¬ún#¬õn#¥ún#¬ún#¬ún#¬ì[sì;sssì[sìUsìsì
sykdª…$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
—gd¦
—
°Ž±Ž¾ŽÀŽɎ͎`sW[sWUsWsW
s $Ifgd¦
—Ÿkd†$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö͎ΎَåŽîŽðŽ`sW[sWUsWsW
s $Ifgd¦
—Ÿkdr‡$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöðŽñŽûŽ¶`sW[sK;s $$Ifa$gd¦
— $Ifgd¦
—ŸkdWˆ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¶·¿@†„Z}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd—†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd,¤$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö>—?—G—³—†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdó¤$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö³—´—ɗؗ†ç}[s};s $Ifgd¦
—ykdº¥$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöؗٗï—F˜†s}[s};s $Ifgd¦
—ykd¦$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöF˜G˜H˜d˜e˜k˜„˜†çn#¬n#¬n#¬x[sx;s $Ifgd¦
—gd¦
—ykdH§$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö„˜…˜Š˜—˜Ÿ˜®˜†s}[s}Us}s}
s $Ifgd¦
—ykd¨$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö®˜¯˜¼˜¾˜ǘ˘`sW[sWUsWsW
s $Ifgd¦
—Ÿkdò¨$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö˘̘טã˜ì˜î˜`sW[sWUsWsW
s $Ifgd¦
—Ÿkdå©$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöî˜ï˜ú˜
™`sW[sW;s $Ifgd¦
—Ÿkdʪ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö
™™™j›†s}[sq ;s $$Ifa$gd¦
— $Ifgd¦
—ykd¯«$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöj›k››ø›Žœ†Œ}}};s};s $Ifgd¦
—ykdv¬$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö ".T†n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd=­$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöTV`zŠ¤†~s}[s}Us}s}
s $Ifgd¦
—ykd®$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¤¦Àĝ֝ޝ`sW[sWUsWsW
s $Ifgd¦
—Ÿkdç®$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöޝàöžžž`sW[sWUsWsW
s $Ifgd¦
—ŸkdÚ¯$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöàöžžžžž1ž2žöPöXöZöpöˆöšöžö ö¶öÆöÈöØöóøôøù"ù#ù%ù+ùEùJùXùúúú8úöPöXö`sW[sWUsWsW
s $Ifgd¦
—Ÿkdi0$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöXöZöpöˆöšöžö`sW[sWUsWsW
s $Ifgd¦
—Ÿkd\1$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöžö ö¶öÆö`sW[sW;s $Ifgd¦
—ŸkdA2$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÆöÈöØöóø†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd&3$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöóøôøù"ù†µ}[s};s $Ifgd¦
—ykdí3$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö"ù#ù$ù%ù+ùDù†sn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd´4$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöDùEùJùXù`ùú†s}[s}Us}s}
s $Ifgd¦
—ykd{5$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöúú8úeJebedehe:¬1¬1g
¬1ú¬1õ¬ $Ifgd¦
—ÅkdÊ$$If–FÖֈ”ÿp¯N£Ú#Å…‚iE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöhesewexe„e«eö}¬ö_¬1¬ö¬ög
¬ÅkdüÊ$$If–FÖֈ”ÿp¯N£Ú#Å…‚iE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—«e­e±e½eÁeÂeöú¬öõ¬ö}¬ö_¬1YÅkdãË$$If–FÖֈ”ÿp¯N£Ú#Å…‚iE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÂeÃeßeàeíefffffún#¬òn#¬òn#¬é¬éh
¬éú¬éù¬é}¬é[¬ $Ifgd¦
—$a$gd¦
—gd¦
— ff#fIfKfOf8¬/¬/h
¬/ú¬/ù¬ $Ifgd¦
—ÆkdÊÌ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöOfZf^f_flf~fö}¬ö[¬/Yö¬öh
¬Ækd´Í$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—~f€f„ff™fšföú¬öù¬ö}¬ö[¬/¬ÆkdžÎ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—šf§fÎfÐfÔfßfèfö¬öh
¬öú¬öù¬ö}¬ö[¬ $Ifgd¦
—èféf÷fg!g%g8Y/¬/h
¬/ú¬/ù¬ $Ifgd¦
—ÆkdˆÏ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö%g0g4g5gBgjgö}¬ö[¬/Yö¬öh
¬ÆkdrÐ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—jglgpg{gg€göú¬öù¬ö}¬ö[¬/YÆkd\Ñ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—€ggŸg¡g¥g±gµgö¬öh
¬öú¬öù¬ö}¬ö[¬ $Ifgd¦
—µg¶gÂgógõgùg8¬/¬/h
¬/ú¬/ù¬ $Ifgd¦
—ÆkdFÒ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöùgh h
hh'hö}¬ö[¬/§ö¬öh
¬Ækd0Ó$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—'h)h-h9h:h;höú¬öù¬ö}¬ö[¬/¬ÆkdÔ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—;hGhjhlhph{hhö¬öh
¬öú¬öù¬ö}¬ö[¬ $Ifgd¦
—h€hh»h½hÁh8Y/¬/h
¬/ú¬/ù¬ $Ifgd¦
—ÆkdÕ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÁhÌhÐhÑhÞhiö}¬ö[¬/Yö¬öÆkdîÕ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—iiiiiiöú¬öù¬ö}¬ö[¬/ÆkdØÖ$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—i#i7i9i=iIiMiö¬öh
¬öú¬öù¬ö}¬ö[¬ $Ifgd¦
—MiNi[iqisiwi8Š¬/¬/h
¬/ú¬/ù¬ $Ifgd¦
—ÆkdÂ×$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöwiƒi‡iˆi•i¾iö}¬ö[¬/¬ö¬öh
¬Ækd¬Ø$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—¾iÀiÅiÑiÕiÖiöú¬öù¬ö}¬ö[¬/YÆkd–Ù$$If–FÖֈ”ÿo¯R§Ú#Ä…„iC
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—Öi×iôiõij!j#j'j2j6jún#¬òn#¬ún#¬é¬ég
¬éù¬é÷¬é}¬é_¬ $Ifgd¦
—$a$gd¦
—gd¦
— 6j7jDjajcjgj8Y/¬/g
¬/ù¬/÷¬ $Ifgd¦
—Ækd€Ú$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laögjsj|j}jŠjjö}¬ö_¬/¬ö¬ög
¬ÆkdjÛ$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—jŸj¥j°j¹jºjöù¬ö÷¬ö}¬ö_¬/¬ÆkdTÜ$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ºjÆjÚjÞjßjëjïjö¬ög
¬öù¬ö÷¬ö}¬ö_¬ $Ifgd¦
—ïjðjñjòjkk8¬3n#¬3n#¬.n#¥3n#¬gd¦
—gd¦
—Ækd>Ý$$If–FÖֈ”ÿo®N£Ú#Å„ƒiE
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laökkkk(k)k.k=kEkFkún#¬ún#¬ñ[sñ;sxsñ[sñUsñsñ
sykd(Þ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
— FkGkTkVk_kck`sW[sWUsWsW
s $Ifgd¦
—ŸkdýÞ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöckdkok{k„k†k`sW[sWUsWsW
s $Ifgd¦
—Ÿkdðß$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö†k‡k‘kLl`sW[sK;s $$Ifa$gd¦
— $Ifgd¦
—ŸkdÕà$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö‘kLlMlUlÖl×líl m!m#m)mAmFmSmn6n8nRnVnhnpnrnˆn n²n¶n¸nÎnônöno0q1qCqPqQqgqArBrDrJrXr]rlrtrurvrƒr…rŽr’r“ržrªr³rµr¶rÀrss
sWsXsms|s}sœs«s¬sÂs t ttt"t't6t>tíØÃíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØÃíØíÃØÃíÃ)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uMLlMlUlÖl†„Z}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdºá$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÖl×líl m†ç}[s};s $Ifgd¦
—ykdâ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö m!m"m#m)m@m†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdHã$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö@mAmFmSm[m6n†s}[s}Us}s}
s $Ifgd¦
—ykdä$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö6n8nRnVnhnpn`sW[sWUsWsW
s $Ifgd¦
—Ÿkdòä$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöpnrnˆn n²n¶n`sW[sWUsWsW
s $Ifgd¦
—Ÿkdåå$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¶n¸nÎnôn`sW[sW;s $Ifgd¦
—ŸkdÊæ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöônöno0q†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd¯ç$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö0q1qCqPq†µ}[s};s $Ifgd¦
—ykdvè$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöPqQqgqÝqAr†s}[s};s};s $Ifgd¦
—ykd=é$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöArBrCrDrJrWr†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdê$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöWrXr]rlrtrur†s}[s}Us}s}
s $Ifgd¦
—ykdÙê$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöurvrƒr…rŽr’r`sW[sWUsWsW
s $Ifgd¦
—Ÿkd®ë$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö’r“ržrªr³rµr`sW[sWUsWsW
s $Ifgd¦
—Ÿkd¡ì$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöµr¶rÀrs`sW[sK;s $$Ifa$gd¦
— $Ifgd¦
—Ÿkd†í$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöss
sWs†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdkî$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöWsXsms|s†s}[s};s $Ifgd¦
—ykd2ï$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö|s}sœs«s†s}[s};s $Ifgd¦
—ykdùï$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö«s¬sÂs t†ç}[s};s $Ifgd¦
—ykdÀð$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö t t
ttt!t†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd‡ñ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö!t"t't6t>t?t†s}[s}Us}s}
s $Ifgd¦
—ykd\ò$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö>t?t@tMtOtXt\t]thttt}tt€tŠtëtìtôtOuPueutuuu‹uâuäuåuëuùuþu
vvvv$v'v0v4v5v@vLvUvWvXvbvÅvÆvÎv:w;wPw_w`wvwÍwÎwÐwÖwïwôwxx x
xxx"x&x'x2x=xFxHxIxTx^x_xix-yíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃí)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uM?t@tMtOtXt\t`sW[sWUsWsW
s $Ifgd¦
—Ÿkd1ó$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö\t]thttt}tt`sW[sWUsWsW
s $Ifgd¦
—Ÿkd$ô$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöt€tŠtët`sW[sK;s $$Ifa$gd¦
— $Ifgd¦
—Ÿkd õ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöëtìtôtOu†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdîõ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöOuPueutu†ç}[s};s $Ifgd¦
—ykdµö$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laötuuu‹uâu†s}[s};s $Ifgd¦
—ykd|÷$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöâuãuäuåuëuøu†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdCø$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöøuùuþu
vvv†s}[s}Us}s}
s $Ifgd¦
—ykdù$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laövv$v'v0v4v`sW[sWUsWsW
s $Ifgd¦
—Ÿkdíù$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö4v5v@vLvUvWv`sW[sWUsWsW
s $Ifgd¦
—Ÿkdàú$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöWvXvbvÅv`sW[sK;s $$Ifa$gd¦
— $Ifgd¦
—ŸkdÅû$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÅvÆvÎv:w†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdªü$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö:w;wPw_w†ç}[s};s $Ifgd¦
—ykdqý$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö_w`wvwÍw†s}[s};s $Ifgd¦
—ykd8þ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÍwÎwÏwÐwÖwîw†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdÿþ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöîwïwôwxx x†s}[s}Us}s}
s $Ifgd¦
—ykdÔÿ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö x
xxx"x&x`sW[sWUsWsW
s $Ifgd¦
—Ÿkd©$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö&x'x2x=xFxHx`sW[sWUsWsW
s $Ifgd¦
—Ÿkdœ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöHxIxTx^x`sW[sW;s $Ifgd¦
—Ÿkd$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö^x_xix-y†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdf$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö-y.y6y²y†„Z}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd-$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö-y.y6y²y³yÉyíyîyïyõy:zDz\zlzf{h{‚{†{˜{ {¢{¸{Ð{â{æ{è{þ{|||m|n|v|D~E~[~TUsy’Ÿ€€€6€:€L€T€V€l€„€–€š€œ€²€؀ڀî€U‚V‚^‚C…D…Z…ø…ù…û…†P†êÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃê²ÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÃÕê!h¤Vùh¦
—5\mHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uF²y³yÉyíy†ç}[s};s $Ifgd¦
—ykdô$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöíyîyïyõy8z†çn#sx[sx;s $Ifgd¦
—gd¦
—ykd»$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö8z:zDz\zlzf{†s}[s}Us}s}
s $Ifgd¦
—ykd$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöf{h{‚{†{˜{ {`Î W[sWUsWsW
s $Ifgd¦
—Ÿkde$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö {¢{¸{Ð{â{æ{`sW[sWUsWsW
s $Ifgd¦
—ŸkdX$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöæ{è{þ{|`sW[sW;s $Ifgd¦
—Ÿkd= $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö|||m|†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd"
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöm|n|v|D~†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdé
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöD~E~[~¸~T†‰(}[s};s};s $Ifgd¦
—ykd° $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöTUVrsyŒ††A n#¬n#¬n#¬x[sx;s $Ifgd¦
—gd¦
—ykdw $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŒ’Ÿ§€†s}[s}Us}s}
s $Ifgd¦
—ykdL
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö€€6€:€L€T€`sW[sWUsWsW
s $Ifgd¦
—Ÿkd!$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöT€V€l€„€–€š€`sW[sWUsWsW
s $Ifgd¦
—Ÿkd$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöš€œ€²€؀`sW[sW;s $Ifgd¦
—Ÿkdù$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö؀ڀî€U‚†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdÞ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöU‚V‚^‚C…†„Z}[sq
;s $$Ifa$gd¦
— $Ifgd¦
—ykd¥$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöC…D…Z…£…ø…†
ƒ}[s};s};s $Ifgd¦
—ykdl$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöø…ù…ú…û…†N††„Zn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd3$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöN†P†Z†r†‚†œ††s}[s}Us}s}
s $Ifgd¦
—ykd$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöP†Z†r†‚†œ†ž†¸†¼†Άֆ؆‡‡‡2‡B‡D‡T‡*‰+‰A‰£‰¤‰¦‰¬‰¿‰ĉщىæ‰ç‰ô‰ö‰ÿ‰ŠŠŠŠ$Š)Š*Š5ŠHŠIŠSŠV‹W‹_‹ 
;óSó†s}[s}Us}s}
s $Ifgd¦
—ykd¯á$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöSóTóaócólópó`sW[sWUsWsW
s $Ifgd¦
—Ÿkd„â$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöpóqó|óˆó‘ó“ó`sW[sWUsWsW
s $Ifgd¦
—Ÿkdwã$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö“ó”óŸó²ó`sW[sW;s $Ifgd¦
—Ÿkd\ä$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö²ó³ó½ópô†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdAå$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöpôqôyôÕö†„Z}[sq ;s $$Ifa$gd¦
— $Ifgd¦
—ykdæ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÕöÖöìö|÷†Œ}[s};s $Ifgd¦
—ykdÏæ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö|÷}÷~÷÷…÷¡÷†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd–ç$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¡÷¢÷§÷³÷»÷È÷†s}[s}Us}s}
s $Ifgd¦
—ykdkè$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÈ÷É÷Ö÷Ø÷á÷å÷`sW[sWUsWsW
s $Ifgd¦
—Ÿkd@é$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöå÷æ÷ñ÷ý÷øø`sW[sWUsWsW
s $Ifgd¦
—Ÿkd3ê$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöø øø'ø`sW[sW;s $Ifgd¦
—Ÿkdë$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö'ø(ø2øDù†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdýë$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöDùEùMù–ú†Î }[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdÄì$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöMù–ú—ú­ú‚ûƒû…û‹û£û¨û´û¼ûÊûËûØûÚûãûçûèûóûÿûü
üüü,ü-ü7üØüÙüáüªý«ýÁý’þ“þ•þ›þ®þ³þÀþÈþÕþÖþãþåþîþòþóþþþ
ÿÿÿÿ!ÿ4ÿ5ÿ?ÿBCKøù '(>)*,2FKV^stíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØíÃØÃíÃíØÃíÃíØÃíÃíØÃíØÃíØÃíØÃíØÃíØíÃØÃíÃíØÃ)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uM–ú—ú­ú
û‚û††A }[s};s};s $Ifgd¦
—ykd‹í$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‚ûƒû„û…û‹û¢û†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdRî$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¢û£û¨û´û¼ûÊû†s}[s}Us}s}
s $Ifgd¦
—ykd'ï$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÊûËûØûÚûãûçû`sW[sWUsWsW
s $Ifgd¦
—Ÿkdüï$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöçûèûóûÿûü
ü`sW[sWUsWsW
s $Ifgd¦
—Ÿkdïð$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö
üüü,ü`sW[sW;s $Ifgd¦
—ŸkdÔñ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö,ü-ü7üØü†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd¹ò$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöØüÙüáüªý†„Z}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd€ó$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöªý«ýÁýþý’þ†„Z}[s};s};s $Ifgd¦
—ykdGô$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö’þ“þ”þ•þ›þ­þ†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdõ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö­þ®þ³þÀþÈþÕþ†s}[s}Us}s}
s $Ifgd¦
—ykdãõ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÕþÖþãþåþîþòþ`sW[sWUsWsW
s $Ifgd¦
—Ÿkd¸ö$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöòþóþþþ
ÿÿÿ`sW[sWUsWsW
s $Ifgd¦
—Ÿkd«÷$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÿÿ!ÿ4ÿ`sW[sW;s $Ifgd¦
—Ÿkdø$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö4ÿ5ÿ?ÿB†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykduù$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöBCKø†Î }[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd}¿ù)†s}[s};s};s};s};s $Ifgd¦
—ykdÊû$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö)*+,2E†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd‘ü$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöEFKV^s†s}[s}Us}s}
s $Ifgd¦
—ykdfý$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöstƒŒ`sW[sWUsWsW
s $Ifgd¦
—Ÿkd;þ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöƒŒ‘œ¨±¶·ÂÕÖà"#+ÑÒÓÔê{|•ª¯¼ÄÒÓàâëïðû!45?  g h i j € N P T ` –   ¸ È ä æ  íØíÃØíØíÃØíÃØíÃØí´íÃØíãØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØí´íÃØíÃíØÃØíØíÃØ!h¤Vùh¦
—5\mHnHsH uh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u@‘œ¨±¶`sW[sWUsWsW
s $Ifgd¦
—Ÿkd.ÿ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¶·ÂÕ`sW[sW;s $Ifgd¦
—Ÿkd$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÕÖà"†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdø$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö"#+ÒÓ†s}[sq;sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd¿$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÓÔêE{†Î }[s};s};s $Ifgd¦
—ykd†$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö{|}Ž•©†„Zn#¬n#¬n#¬x[sx;s $Ifgd¦
—gd¦
—ykdM$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö©ª¯¼ÄÒ†s}[s}Us}s}
s $Ifgd¦
—ykd"$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÒÓàâëï`sW[sWUsWsW
s $Ifgd¦
—Ÿkd÷$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöïðû`sW[sWUsWsW
s $Ifgd¦
—Ÿkdê$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö!4`sW[sW;s $Ifgd¦
—ŸkdÏ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö45? †s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd´$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö  h i †‰(}[sq;sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd{$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöi j € 
º
N †µ}[s};s};s};s $Ifgd¦
—ykdB $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöN P R T ` ” ††A n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö” –   ¸ È ä †s}[s}Us}s}
s $Ifgd¦
—ykdÞ
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöä æ     `sW[sWUsWsW
s $Ifgd¦
—Ÿkd³ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö      ' 0 2 3 > Q R Z 


#
)
Z
_
j
48JTj‚”š°Øì¸Èï
# !1íØíÃØíØíÃØíÃØí´íÃØÃØíØíØíØíØíØíØíØíØíØíØí „vh¤Vùh¦
—mHnHsH uh¦
—mHnHsH u h¦
—5CJaJmHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u-   ' 0 2 `sW[sWUsWsW
s $Ifgd¦
—Ÿkd¦ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö2 3 > Q `sW[sW;s $Ifgd¦
—Ÿkd‹
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöQ R Z 

†s}[sq;sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdp$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
!
"
#
)
Y
†Î n#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd7$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöY
Z
_
j
r
†s}[s}Us}s}
s $Ifgd¦
—ykd $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö48JR`sW[sWUsWsW
s $Ifgd¦
—Ÿkdá$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöRTj‚”˜`sW[sWUsWsW
s $Ifgd¦
—ŸkdÔ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö˜š°Ö`sW[sW;s $Ifgd¦
—Ÿkd¹$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÖØ춆s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdž$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¶¸Èî†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykde$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöîï †Î }[s};s $Ifgd¦
—ykd,$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö 
#[t­¹†s}[s};s};s};s};s};s $Ifgd¦
—ykdó$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö 
  
†µn#sn#sn#sn#sn#sn#sn#sn#sn#sn#sn#sn#sn#sgd¦
—ykdº$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö 1~‘’èéüý !#'37ún#sún#sún#sún#sún#sún#sún#sún#sún#sún#sún#sõõn#¥ún#¥ún#¥ún#¬ún#¬ín#¬ín#¬äO¬ä ¬äø¬äø¬ä|¬ä`¬ $Ifgd¦
—$a$gd¦
—gd¦
—gd¦
—1~’ýÿý„•þÿ,2HMYaop}ˆŒ˜¤­¯°»ÎïÛËÀ²¤Ë¤Ë¤À¤ï¤“~i~W~Wi~W~Wi~W~Wi~W#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u!h¤Vùh¦
—5\mHnHsH uh¤Vùh¦
—mHnHsH uheA’h¦
—mHnHsH uh¦
—mHnHsH uh¤Vùh¦
—5mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uh¤Vùh¦
—CJmHnHsH u"78ERTX8¬/O¬/ ¬/ø¬/ø¬ $Ifgd¦
—Ækd$$If–FÖֈ”ÿ»®~N¢Ú#(ô ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöXdhivƒö|¬ö`¬/¬öO¬ö ¬Ækdk$$If–FÖֈ”ÿ»®~N¢Ú#(ô ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ƒ…‰•™šöø¬öø¬ö|¬ö`¬/¬ÆkdG$$If–FÖֈ”ÿ»®~N¢Ú#(ô ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—š§´¶ºÆÊöO¬ö ¬öø¬öø¬ö|¬ö`¬ $Ifgd¦
—ÊËØåèì8¬/O¬/ ¬/ø¬/ø¬ $Ifgd¦
—Ækd#$$If–FÖֈ”ÿ»®~N¢Ú#(ô ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöìøüýþö|¬ö`¬/¬'n#¬$a$gd¦
—Ækdÿ$$If–FÖֈ”ÿ»®~N¢Ú#(ô ÐÐT8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—þ'BNS÷n#¬òn#¬éT¬é ¬éù¬é÷¬éx¬é_¬ $Ifgd¦
—gd¦
—$a$gd¦
—STb{}:¬1T¬1 ¬1ù¬1÷¬ $Ifgd¦
—ÅkdÛ$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö’“Ÿ¸öx¬ö_¬1¬öT¬ö ¬ÅkdÂ$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—¸º¾ÊÏÐöù¬ö÷¬öx¬ö_¬1¬Åkd©$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ÐÜôöúöT¬ö ¬öù¬ö÷¬öx¬ö_¬ $Ifgd¦
—.04:¬1T¬1 ¬1ù¬1÷¬ $Ifgd¦
—Åkd$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö4@EFSsöx¬ö_¬1¬öT¬ö ¬Åkdw$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—suy„‰Šöù¬ö÷¬öx¬ö_¬1YÅkd^ $$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—Š—¦¨¬¸½öT¬ö ¬öù¬ö÷¬öx¬ö_¬ $Ifgd¦
—½¾Êûý:¬1T¬1 ¬1ù¬1÷¬ $Ifgd¦
—ÅkdE!$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö*öx¬ö_¬1§öT¬ö ¬Åkd,"$$If–FÖֈ”ÿÀ³„S£Ú#fo„ƒfE
tàÖ0ÿÿÿÿÿÿöˆööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—*,0IT]_`kuv€þÿêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃ)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uMbdz’¤¨`sW[sWUsWsW
s $Ifgd¦
—Ÿkd!¿$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¨ªÀæ`sW[sW;s $Ifgd¦
—ŸkdÀ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöæèø¥†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdëÀ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥¦»È†Î }[s};s $Ifgd¦
—ykd²Á$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÈÉß( u †s}[s};s};s $Ifgd¦
—ykdyÂ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöu v w x ~ ¥ †„Zn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd@Ã$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥ ¦ « ¹ Á å †s}[s}Us}s}
s $Ifgd¦
—ykdÄ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöå æ ó õ þ 
`sW[sWUsWsW
s $Ifgd¦
—ŸkdêÄ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö



#
%
`sW[sWUsWsW
s $Ifgd¦
—ŸkdÝÅ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö%
&
1
;
`sW[sW;s $Ifgd¦
—ŸkdÂÆ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö;
<
F
ö
†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd§Ç$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöö
÷
ÿ
™
†„Z}[sq ;s $$Ifa$gd¦
— $Ifgd¦
—ykdnÈ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö™
š
¬
º
†Œ}[s};s $Ifgd¦
—ykd5É$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöº
»
¼
Â
ã
†sn#sx[sx;s $Ifgd¦
—gd¦
—ykdüÉ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöã
ä
é
ö
þ
 †s}[s}Us}s}
s $Ifgd¦
—ykdÑÊ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö !.09=`sW[sWUsWsW
s $Ifgd¦
—Ÿkd¦Ë$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö=>IT]_`sW[sWUsWsW
s $Ifgd¦
—Ÿkd™Ì$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö_`ku`sW[sW;s $Ifgd¦
—Ÿkd~Í$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöuv€þ†s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdcÎ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöþÿ†ç}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykd*Ï$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'4†Î }[s};s $Ifgd¦
—ykdñÏ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'457=ejx€Ÿ¨¬­¸ÄÍÏÐÛåæð ¡©CDcqrtz¢§µ½ÌÍÚÜåéêõ
 
"#-ÝÞ态 ®¯ÍÓý5êØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØòêÃêØêØ!h¤Vùh¦
—5\mHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uF4567=d†sn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykd¸Ð$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laödejx€†s}[s}Us}s}
s $Ifgd¦
—ykdÑ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŸ¨¬`sW[sWUsWsW
s $Ifgd¦
—ŸkdbÒ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¬­¸ÄÍÏ`sW[sWUsWsW
s $Ifgd¦
—ŸkdUÓ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÏÐÛå`sW[sW;s $Ifgd¦
—Ÿkd:Ô$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöåæ𠆁s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdÕ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö ¡©C†„Z}[sq ;s $$Ifa$gd¦
— $Ifgd¦
—ykdæÕ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöCDcq†Œ}[s};s $Ifgd¦
—ykd­Ö$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöqrstz¡†çn#sn#sx[sx;s $Ifgd¦
—gd¦
—ykdt×$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¡¢§µ½Ì†s}[s}Us}s}
s $Ifgd¦
—ykdIØ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÌÍÚÜåé`sW[sWUsWsW
s $Ifgd¦
—ŸkdÙ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöéêõ
 `sW[sWUsWsW
s $Ifgd¦
—ŸkdÚ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö 
"`sW[sW;s $Ifgd¦
—ŸkdöÚ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö"#-݆s}[sq;s $$Ifa$gd¦
— $Ifgd¦
—ykdÛÛ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÝÞ怆„Z}[sq ;s $$Ifa$gd¦
— $Ifgd¦
—ykd¢Ü$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö€ ®†Œ}[s};s $Ifgd¦
—ykdiÝ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö®¯°ÌÍÓü†çn#¬n#¬n#¬x[sx;s $Ifgd¦
—gd¦
—ykd0Þ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöüý5†s}[s}Us}s}
s $Ifgd¦
—ykdß$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö56CENR`sW[sWUsWsW
s $Ifgd¦
—ŸkdÚß$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö56CENRS^jsxy„—˜ "/028IN[cwx…‡”• ¬µ·¸ÃÖ×á@AI¥¦¸ÔÕëSTV\†‹˜ b d ~ ‚ ” œ ž ´ Ì Þ è ê !&!(!@P@X@`WWWW $Ifgd¦
—Ÿkd2# $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöX@Z@p@ˆ@š@ž@`WWWW $Ifgd¦
—Ÿkd%$ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöž@ @¶@Æ@`WW $Ifgd¦
—Ÿkd
% $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÆ@È@Ü@ÚA†}q $$Ifa$gd¦
— $Ifgd¦
—ykdï% $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÚAÜAìA4B†}q $$Ifa$gd¦
— $Ifgd¦
—ykd¶& $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö4B5BKBºB†}} $Ifgd¦
—ykd}' $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöºB»B¼B½BÃBíB†xx $Ifgd¦
—gd¦
—ykdD( $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöíBîBóBCC`D†}}}} $Ifgd¦
—ykd) $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö`DbD|D€D’DšD`WWWW $Ifgd¦
—Ÿkdî) $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöšDœD²DÊDÜDàD`WWWW $Ifgd¦
—Ÿkdá* $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöàDâDøDE`WW $Ifgd¦
—ŸkdÆ+ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöE E4EjF†}q $$Ifa$gd¦
— $Ifgd¦
—ykd«, $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöjFkFsFäG†}q $$Ifa$gd¦
— $Ifgd¦
—ykdr- $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöäGåGûGH†}} $Ifgd¦
—ykd9. $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöHHHH"H>H†xx $Ifgd¦
—gd¦
—ykd/ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöHH"H?HDHQHYHmHnH{H}H†HŠH‹H–H¡HªH¬H­H¸HÂHÃHÍH*I+I3I¢J£J¹JÞJßJáJçJKKKLLL6L:LLLTLVLlL„L–LšLœL²LØLÚLîL|M~MŽMlOuOpPqPrPtPuP{PªP¯P½PÅPÆPÇPÔPÖPíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØíØí´íÃíØÃØíØíÃØíh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uG>H?HDHQHYHmH†}}}} $Ifgd¦
—ykdÕ/ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laömHnH{H}H†HŠH`WWWW $Ifgd¦
—Ÿkdª0 $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöŠH‹H–H¡HªH¬H`WWWW $Ifgd¦
—Ÿkd1 $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¬H­H¸HÂH`WW $Ifgd¦
—Ÿkd‚2 $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÂHÃHÍH*I†}q $$Ifa$gd¦
— $Ifgd¦
—ykdg3 $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö*I+I3IwJ¢J†}qq $$Ifa$gd¦
— $Ifgd¦
—ykd.4 $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¢J£J¹JÞJ†}} $Ifgd¦
—ykdõ4 $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÞJßJàJáJçJK†xx $Ifgd¦
—gd¦
—ykd¼5 $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöKKKKKL†}}}} $Ifgd¦
—ykd‘6 $$If–FÖ    Ö0”ÿÆÚ#i      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöLL6L:LLLTL`WWWW $Ifgd¦
—Ÿkdf7 $$If–FÖ    Ö\”ÿÆóçÚ#i  ñ « ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöTLVLlL„L–LšL`WWWW $Ifgd¦
—ŸkdY8 $$If–FÖ    Ö\”ÿÆóçÚ#i ñ«ƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöšLœL²LØL`WW $Ifgd¦
—Ÿkd>9 $$If–FÖ    Ö\”ÿÆóçÚ#i ñ«ƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöØLÚLîL|M†}q $$Ifa$gd¦
— $Ifgd¦
—ykd#: $$If–FÖ    Ö0”ÿÆÚ#i  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö|M~MŽMqPrP†}qq $$Ifa$gd¦
— $Ifgd¦
—ykdê: $$If–FÖ    Ö0”ÿÆÚ#i  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laörPsPtPuP{P©P†xx $Ifgd¦
—gd¦
—ykd±; $$If–FÖ    Ö0”ÿÆÚ#i    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö©PªP¯P½PÅPÆP†}}}} $Ifgd¦
—ykd†< $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÆPÇPÔPÖPßPãP`WWWW $Ifgd¦
—Ÿkd[= $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÖPßPãPäPïPúPQQ QQQQ)QàQáQéQTSUSjSxSySS¦T¨T¬T¸TU$U:UJUbUdU~U‚U”UœUžU´UÌUÞUâUäUúUVVV€VV‰V“W”W¦W±W²WÈW¬X­X¯XµXÚXßXìXôXYYYYY#Y$Y/Y;YDYFYGYRYeYfYêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃ)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uMãPäPïPúPQQ`WWWW $Ifgd¦
—ŸkdN> $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöQ QQQ`WW $Ifgd¦
—Ÿkd3? $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöQQ)QàQ†}q $$Ifa$gd¦
— $Ifgd¦
—ykd@ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöàQáQéQTS†}q $$Ifa$gd¦
— $Ifgd¦
—ykdß@ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöTSUSjSxS†}} $Ifgd¦
—ykd¦A $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöxSySSêS¦T†}}} $Ifgd¦
—ykdmB $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¦T¨TªT¬T¸TU†xx $Ifgd¦
—gd¦
—ykd4C $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöUU$U:UJUbU†}}}} $Ifgd¦
—ykd D $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöbUdU~U‚U”UœU`WWWW $Ifgd¦
—ŸkdÞD $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöœUžU´UÌUÞUâU`WWWW $Ifgd¦
—ŸkdÑE $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöâUäUúUV`WW $Ifgd¦
—Ÿkd¶F $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöVVV€V†}q $$Ifa$gd¦
— $Ifgd¦
—ykd›G $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö€VV‰V“W†}q $$Ifa$gd¦
— $Ifgd¦
—ykdbH $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö“W”W¦W±W†}} $Ifgd¦
—ykd)I $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö±W²WÈWXXRX^X¬X†}}}}}} $Ifgd¦
—ykdðI $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¬X­X®X¯XµXÙX†xx $Ifgd¦
—gd¦
—ykd·J $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÙXÚXßXìXôXY†}}}} $Ifgd¦
—ykdŒK $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöYYYYY#Y`WWWW $Ifgd¦
—ŸkdaL $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö#Y$Y/Y;YDYFY`WWWW $Ifgd¦
—ŸkdTM $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöFYGYRYeY`WW $Ifgd¦
—Ÿkd9N $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöeYfYpYÑY†}q $$Ifa$gd¦
— $Ifgd¦
—ykdO $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöfYpYÑYÒYÚY!["[8[*\,\-\3\K\P\]\e\y\z\‡\‰\’\–\—\¢\®\·\¹\º\Å\Ø\Ù\ã\5]6]>]…^†^˜^¥^¦^¼^z_{_}_ƒ_ž_£_°_¸_Æ_Ç_Ô_Ö_ß_ã_ä_ï_ú_``````$`fagaiaoa‘a–a£a«aÉaÊa×aÙaâaêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃØêÃêØêØÃêØê)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uMÑYÒYÚY![†}q $$Ifa$gd¦
— $Ifgd¦
—ykdåO $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö!["[8[L[ˆ[ï[*\†}}}}} $Ifgd¦
—ykd¬P $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö*\+\,\-\3\J\†xx $Ifgd¦
—gd¦
—ykdsQ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöJ\K\P\]\e\y\†}}}} $Ifgd¦
—ykdHR $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöy\z\‡\‰\’\–\`WWWW $Ifgd¦
—ŸkdS $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö–\—\¢\®\·\¹\`WWWW $Ifgd¦
—ŸkdT $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¹\º\Å\Ø\`WW $Ifgd¦
—ŸkdõT $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöØ\Ù\ã\5]†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÚU $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö5]6]>]…^†}q $$Ifa$gd¦
— $Ifgd¦
—ykd¡V $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö…^†^˜^¥^†}} $Ifgd¦
—ykdhW $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥^¦^¼^_z_†}}} $Ifgd¦
—ykd/X $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöz_{_|_}_ƒ__†xx $Ifgd¦
—gd¦
—ykdöX $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö_ž_£_°_¸_Æ_†}}}} $Ifgd¦
—ykdËY $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÆ_Ç_Ô_Ö_ß_ã_`WWWW $Ifgd¦
—Ÿkd Z $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöã_ä_ï_ú_```WWWW $Ifgd¦
—Ÿkd“[ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö`````WW $Ifgd¦
—Ÿkdx\ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö``$`fa†}q $$Ifa$gd¦
— $Ifgd¦
—ykd]] $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöfagahaiaoaa†xx $Ifgd¦
—gd¦
—ykd$^ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöa‘a–a£a«aÉa†}}}} $Ifgd¦
—ykdù^ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÉaÊa×aÙaâaæa`WWWW $Ifgd¦
—ŸkdÎ_ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöâaæaçaòaþab b
bb+b,b6bˆb‰b‘b2c3cEcRcScic,e-e.e0e1e7eReWedeleze{eˆeŠe“e—e˜e£e¯e¸e½e¾eÉeÜeÝeçetBtTt\t^tttŠtœt t¢t¸tÌtÎtâtAvBvJvÎvÏváv w w"w½B½C½öööö/Ækd
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—C½P½f½i½m½y½~½öööööö $Ifgd¦
—~½½‹½ž½ ½¤½8//// $Ifgd¦
—Ækd 
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¤½°½µ½¶½ýнöö/ööÆkdó
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—нÒ½Ö½â½ç½è½öööö/ÆkdÝ
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—è½ô½ ¾
¾¾¾"¾öööööö $Ifgd¦
—"¾#¾/¾>¾@¾D¾8//// $Ifgd¦
—ÆkdÇ
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöD¾P¾U¾V¾c¾z¾öö/ööÆkd±
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—z¾|¾€¾Œ¾‘¾’¾öööö/Ækd›
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—’¾¾;ϾӾ߾ã¾öööööö $Ifgd¦
—ã¾ä¾ï¾þ¾¿¿8//// $Ifgd¦
—Ækd…
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¿¿¿¿!¿?¿öö/ööÆkdo
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—?¿A¿E¿Q¿V¿W¿öööö/ÆkdY
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—W¿d¿q¿s¿w¿ƒ¿ˆ¿öööööö $Ifgd¦
—ˆ¿‰¿–¿£¿¦¿«¿8//// $Ifgd¦
—ÆkdC
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö«¿·¿»¿¼¿½¿öö/*gd¦
—Ækd-
$$If–FÖֈ”ÿ
±ÍžñÚ#Ð#„h¥
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—½¿Ù¿Ú¿æ¿ö¿ø¿ü¿ ÀÀ÷òéééééé $Ifgd¦
—gd¦
—$a$gd¦
—ÀÀÀ1À3À7À8//// $Ifgd¦
—Ækd
$$If–FÖֈ”ÿ¯ËœïÚ#Ð#„h¦
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö7ÀDÀNÀOÀ[ÀtÀöö/ööÆkd
$$If–FÖֈ”ÿ¯ËœïÚ#Ð#„h¦
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—tÀvÀzÀ‡ÀŒÀÀöööö/Ækdë
$$If–FÖֈ”ÿ¯ËœïÚ#Ð#„h¦
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—À™À©À«À¯À¼ÀÁÀöööööö $Ifgd¦
—ÁÀÂÀÍÀáÀãÀçÀ8//// $Ifgd¦
—ÆkdÕ
$$If–FÖֈ”ÿ¯ËœïÚ#Ð#„h¦
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöçÀôÀøÀùÀúÀöö/*gd¦
—Ækd¿
$$If–FÖֈ”ÿ¯ËœïÚ#Ð#„h¦
tàÖ0ÿÿÿÿÿÿöˆ6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—úÀÁÁ$Á.Á0Á4ÁAÁJÁ÷òéééééé $Ifgd¦
—gd¦
—$a$gd¦
—JÁKÁWÁ[Á]ÁaÁ8//// $Ifgd¦
—Ækd©
$$If–FÖֈ”ÿ®ÊšîÚ#t¨ ÐTì
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöaÁnÁwÁxÁ…Á£Áöö/ööÆkd“
$$If–FÖֈ”ÿ®ÊšîÚ#t¨ ÐTì
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—£Á¥Á©Á¶ÁºÁ»Áöööö/Ækd}!
$$If–FÖֈ”ÿ®ÊšîÚ#t¨ ÐTì
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—»ÁÈÁÞÁàÁäÁðÁõÁöööööö $Ifgd¦
—õÁöÁÂRÂVÂ^Â8//// $Ifgd¦
—Ækdg"
$$If–FÖֈ”ÿ®ÊšîÚ#t¨ ÐTì
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö^Âx‚„ Âöö/*gd¦
—ÆkdQ#
$$If–FÖֈ”ÿ®ÊšîÚ#t¨ ÐTì
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
— Â¢ÂÈÂÊÂÖ ÃÃÃ2ÃBÄÃúúúññxññññykd;$
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
—
Ã2ÃBÄÆàäöþÃÀÃÖÃîÃÄÄÄÄ!Ä"Ä*ģŤźÅÆÆÆ(ÆhÆrƊƚƲƴÆÎÆÒÆäÆìÆîÆÇÇ.Ç2Ç4ÇJÇZÇ\ÇpÇZÈ[ÈcÈmÉnɀɌɍÉÊFÊJÊLÊXÊrÊ|Ê’Ê¢ÊêÊìÊË
ËË$Ë&Ë@TJ†}q $$Ifa$gd¦
— $Ifgd¦
—ykdAÀ
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöJKS„†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÁ
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö„…›ó†}} $Ifgd¦
—ykdÏÁ
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöóôõ6†xx $Ifgd¦
—gd¦
—ykd–Â
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö67R8//// $Ifgd¦
—ÆkdBM $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö>RJRNROR[RRöö/ööÆkd,N $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—RR…RR”R•Röööö/ÆkdO $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—•R¡R´R¶RºRÆRÊRöööööö $Ifgd¦
—ÊRËR×RîRðRôR8//// $Ifgd¦
—ÆkdP $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöôRS S
SS(Söö/ööÆkdêP $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—(S*S.S:SCSDSöööö/ÆkdÔQ $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—DSOSaScSgSsS|Söööööö $Ifgd¦
—|S}S~S›SœS83+3$a$gd¦
—gd¦
—Ækd¾R $$If–FÖֈ”ÿú~ÿ¢Ú#tô „£8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöœS¨SÆSÈSÌS×SÛSöööööö $Ifgd¦
—ÛSÜSÝSëSìSÿS83.33gd¦
—gd¦
—Ækd¨S $$If–FÖֈ”ÿú~¢Ú#tô „„ 8
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÿST TBTDTNThTxTºTúññxññññykd„T $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö $Ifgd¦
—gd¦
—ºT¼TÖTÚTìTôT`WWWW $Ifgd¦
—ŸkdYU $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöôTöT U$U6U:U`WWWW $Ifgd¦
—ŸkdLV $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöôTöT U$U6U:UW?WUWYYY"YW?WUW¥W€XY†}}}} $Ifgd¦
—ykdÝX $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöYYYY"Y:Y†xx $Ifgd¦
—gd¦
—ykd¤Y $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö:YcGcIcJcUchcicsc d
dd(f)f?f
g g
gg(g-g8g@gLgMgZg\gegigjguggŠgŒgg˜g«g¬g´guhvhŒh7iVi\i~iƒii˜i¥i¦i³iµi¾iÂiÃiÎiÚiãiåiêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕêÕÃÕÃêÕÃÕÃêÕÃÕÃ#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uM°b±b²b³b¹bÜb†xx $Ifgd¦
—gd¦
—ykdªh $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÜbÝbâbïb÷b c†}}}} $Ifgd¦
—ykdi $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö c
ccc"c&c`WWWW $Ifgd¦
—ŸkdTj $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö&c'c2c>cGcIc`WWWW $Ifgd¦
—ŸkdGk $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöIcJcUchc`WW $Ifgd¦
—Ÿkd,l $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöhcicsc d†}q $$Ifa$gd¦
— $Ifgd¦
—ykdm $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö d
dd(f†}q $$Ifa$gd¦
— $Ifgd¦
—ykdØm $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö(f)f?fÑf
g†}}} $Ifgd¦
—ykdŸn $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
g g g
gg'g†xx $Ifgd¦
—gd¦
—ykdfo $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'g(g-g8g@gLg†}}}} $Ifgd¦
—ykd;p $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöLgMgZg\gegig`WWWW $Ifgd¦
—Ÿkdq $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöigjguggŠgŒg`WWWW $Ifgd¦
—Ÿkdr $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöŒgg˜g«g`WW $Ifgd¦
—Ÿkdèr $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö«g¬g´guh†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÍs $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöuhvhŒháh7i†}}} $Ifgd¦
—ykd”t $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö7i8i9iUiVi\i}i†xx $Ifgd¦
—gd¦
—ykd[u $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö}i~iƒii˜i¥i†}}}} $Ifgd¦
—ykd0v $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥i¦i³iµi¾iÂi`WWWW $Ifgd¦
—Ÿkdw $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÂiÃiÎiÚiãiåi`WWWW $Ifgd¦
—Ÿkdøw $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöåiæiñiùi`WW $Ifgd¦
—ŸkdÝx $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöåiæiñiùiúij'k(k>kwkžk,l-l/l5l_ldlplxl—l˜l¥l§l°l´lµlÀlÌlÕl×lØlãlöl÷lÿlnooooŽoo‘o—o¥oªoµopBpDp^pbptp|p~p”p¬p¾pÈpÊpàpðpòpqrqtq„qUrVrlrs\sysêÕÃêÕÃêÕñÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕñÃ#h_eMh¦
—CJaJmHnHsHu#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uFùiúij'k†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÂy $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'k(k>k“kèk,l†}}}} $Ifgd¦
—ykd‰z $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö,l-l.l/l5l^l†xx $Ifgd¦
—gd¦
—ykdP{ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö^l_ldlplxl—l†}}}} $Ifgd¦
—ykd%| $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö—l˜l¥l§l°l´l`WWWW $Ifgd¦
—Ÿkdú| $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö´lµlÀlÌlÕl×l`WWWW $Ifgd¦
—Ÿkdí} $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö×lØlãlöl`WW $Ifgd¦
—ŸkdÒ~ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laööl÷lÿlno†}q $$Ifa$gd¦
— $Ifgd¦
—ykd· $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laönooooŽo†}} $Ifgd¦
—ykd~€ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŽooo‘o—o¤o†xx $Ifgd¦
—gd¦
—ykdE $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¤o¥oªoµo½oBp†}}}} $Ifgd¦
—ykd‚ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöBpDp^pbptp|p`WWWW $Ifgd¦
—Ÿkdï‚ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö|p~p”p¬p¾pÈp`WWWW $Ifgd¦
—Ÿkd⃠$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÈpÊpàpðp`WW $Ifgd¦
—ŸkdDŽ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöðpòpqrq†}q $$Ifa$gd¦
— $Ifgd¦
—ykd¬… $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laörqtq„qUr†}q $$Ifa$gd¦
— $Ifgd¦
—ykds† $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöUrVrlrÔr1sys†}}}} $Ifgd¦
—ykd:‡ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöyszs{s|s‚s˜s†xx $Ifgd¦
—gd¦
—ykdˆ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöyszs|s‚s™sžsªs²s¿sÀsÍsÏsØsÜsÝsèsôsýsttttt!t‚tƒt‹tœuuvxxx"xDxNxfxvxx’x¬x°xÂxÊxÌxâxúx yyy.y>y@yTy'z(z0z™{š{°{ð{ñ{ò{ó{ù{||2|B|\|^|x|êØÃêÃØÃØêÃØÃØêÃØÃØêÃØêÃØêÃØêÃØêØÃêÃØÃØêÃØÃØêÃØÃØêÃØêÃØêÃØêÃØêµØÃêÃØÃØêÃh¤Vùh¦
—mHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uG˜s™sžsªs²s¿s†}}}} $Ifgd¦
—ykdֈ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¿sÀsÍsÏsØsÜs`WWWW $Ifgd¦
—Ÿkd«‰ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÜsÝsèsôsýst`WWWW $Ifgd¦
—ŸkdžŠ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laötttt`WW $Ifgd¦
—Ÿkdƒ‹ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laött!t‚t†}q $$Ifa$gd¦
— $Ifgd¦
—ykdhŒ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‚tƒt‹tœu†}q $$Ifa$gd¦
— $Ifgd¦
—ykd/ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöœuu³uŒvwx†}}}} $Ifgd¦
—ykdö $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöxxxx"xBx†xx $Ifgd¦
—gd¦
—ykd½Ž $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöBxDxNxfxvxx†}}}} $Ifgd¦
—ykd’ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöx’x¬x°xÂxÊx`WWWW $Ifgd¦
—Ÿkdg $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÊxÌxâxúx yy`WWWW $Ifgd¦
—ŸkdZ‘ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöyy.y>y`WW $Ifgd¦
—Ÿkd?’ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö>y@yTy'z†}q $$Ifa$gd¦
— $Ifgd¦
—ykd$“ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'z(z0z™{†}q $$Ifa$gd¦
— $Ifgd¦
—ykdë“ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö™{š{°{ð{†}} $Ifgd¦
—ykd²” $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöð{ñ{ò{ó{ù{|†xx $Ifgd¦
—gd¦
—ykdy• $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö|||2|B|\|†}}}} $Ifgd¦
—ykdN– $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö\|^|x|||Ž|–|`WWWW $Ifgd¦
—Ÿkd#— $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöx|||Ž|–|˜|®|Æ|Ø|â|ä|ú|
} } }~~'~67M†‡‰©®»ÃÒÓàâëïðû€€€€!€)€*€4€€€˜€Ђт҂ӂ傃ƒƒ¼„¾„¿„ńׄ܄è„ð„ý„þ„ …
…………&…2…íØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØí´íÃØíÃØíÃíØÃØíØíÃØíØíÃØíh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uG–|˜|®|Æ|Ø|â|`WWWW $Ifgd¦
—Ÿkd˜ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöâ|ä|ú|
}`WW $Ifgd¦
—Ÿkdû˜ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö
} } }~†}q $$Ifa$gd¦
— $Ifgd¦
—ykdà™ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö~~'~6†}q $$Ifa$gd¦
— $Ifgd¦
—ykd§š $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö67M††}} $Ifgd¦
—ykdn› $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö†‡ˆ‰¨†xx $Ifgd¦
—gd¦
—ykd5œ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¨©®»ÃÒ†}}}} $Ifgd¦
—ykd
 $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÒÓàâëï`WWWW $Ifgd¦
—Ÿkdߝ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöïðû€€€`WWWW $Ifgd¦
—ŸkdҞ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö€€!€)€`WW $Ifgd¦
—Ÿkd·Ÿ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö)€*€4€€†}q $$Ifa$gd¦
— $Ifgd¦
—ykdœ  $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö€€˜€т҂†}qq $$Ifa$gd¦
— $Ifgd¦
—ykdc¡ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö҂ӂ傃†}} $Ifgd¦
—ykd*¢ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöƒƒƒvƒþƒ¼„†}}}} $Ifgd¦
—ykdñ¢ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¼„½„¾„¿„ńք†xx $Ifgd¦
—gd¦
—ykd¸£ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöքׄ܄è„ð„ý„†}}}} $Ifgd¦
—ykd¤ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöý„þ„ …
………`WWWW $Ifgd¦
—Ÿkdb¥ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö……&…2…;…=…`WWWW $Ifgd¦
—ŸkdU¦ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö2…;…=…>…I…Q…R…\…††
†~‡‡‡‡‡™‡ž‡ª‡²‡À‡Á‡·Їه݇އé‡õ‡þ‡ˆˆ ˆˆ ˆ(ˆšˆ›ˆ±ˆވ߈áˆçˆûˆ‰ ‰ŠŠŠ4Š8ŠJŠRŠTŠjŠ‚Š”Š˜ŠšŠ°Š֊؊ìŠr‹t‹„‹‚ŒƒŒ˜Œ¥Œ¦Œ¼ŒëŒìŒîŒôŒ êØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØ)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uM=…>…I…Q…`WW $Ifgd¦
—Ÿkd:§ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöQ…R…\…††}q $$Ifa$gd¦
— $Ifgd¦
—ykd¨ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö††
†~‡†}q $$Ifa$gd¦
— $Ifgd¦
—ykdæ¨ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö~‡‡€‡‡‡‡˜‡†xx $Ifgd¦
—gd¦
—ykd­© $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö˜‡™‡ž‡ª‡²‡À‡†}}}} $Ifgd¦
—ykd‚ª $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÀ‡Á‡·Їه݇`WWWW $Ifgd¦
—ŸkdW« $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö݇އé‡õ‡þ‡ˆ`WWWW $Ifgd¦
—ŸkdJ¬ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöˆˆ ˆˆ`WW $Ifgd¦
—Ÿkd/­ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöˆ ˆ(ˆšˆ†}q $$Ifa$gd¦
— $Ifgd¦
—ykd® $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöšˆ›ˆ±ˆވ†}} $Ifgd¦
—ykdÛ® $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöވ߈àˆáˆçˆúˆ†xx $Ifgd¦
—gd¦
—ykd¢¯ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöúˆûˆ‰ ‰‰Š†}}}} $Ifgd¦
—ykdw° $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŠŠ4Š8ŠJŠRŠ`WWWW $Ifgd¦
—ŸkdL± $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöRŠTŠjŠ‚Š”Š˜Š`WWWW $Ifgd¦
—Ÿkd?² $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö˜ŠšŠ°Š֊`WW $Ifgd¦
—Ÿkd$³ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö֊؊ìŠr‹†}q $$Ifa$gd¦
— $Ifgd¦
—ykd ´ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laör‹t‹„‹‚Œ†}q $$Ifa$gd¦
— $Ifgd¦
—ykdд $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‚ŒƒŒ˜Œ¥Œ†}} $Ifgd¦
—ykd—µ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥Œ¦Œ¼ŒëŒ†}} $Ifgd¦
—ykd^¶ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöëŒìŒíŒîŒôŒ †xx $Ifgd¦
—gd¦
—ykd%· $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö  %8†}}}} $Ifgd¦
—ykdú· $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö%89FHQUVamv{|‡š›¥Ž Ž(Ž  *+Ž” ƐАæö‘‘8‘89FHQU`WWWW $Ifgd¦
—Ÿkdϸ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöUVamv{`WWWW $Ifgd¦
—Ÿkd¹ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö{|‡š`WW $Ifgd¦
—Ÿkd§º $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöš›¥Ž†}q $$Ifa$gd¦
— $Ifgd¦
—ykdŒ» $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŽ Ž(Ž †}q $$Ifa$gd¦
— $Ifgd¦
—ykdS¼ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö  *†}} $Ifgd¦
—ykd½ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö*+AŽ†}} $Ifgd¦
—ykdá½ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŽ’” Đ†xx $Ifgd¦
—gd¦
—ykd¨¾ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöĐƐАæö‘†}}}} $Ifgd¦
—ykd}¿ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‘‘8‘@Jfv¶†}}}} $Ifgd¦
—ykd8Î $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¶¸ÒÖèð`WWWW $Ifgd¦
—Ÿkd
Ï $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöðò`WWWW $Ifgd¦
—ŸkdÐ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö'/`WW $Ifgd¦
—ŸkdåÐ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö/0:{†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÊÑ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö{|„¯†}q $$Ifa$gd¦
— $Ifgd¦
—ykd‘Ò $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¯°Æ g†}}} $Ifgd¦
—ykdXÓ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöghijp †xx $Ifgd¦
—gd¦
—ykdÔ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö ¡¦²ºß†}}}} $Ifgd¦
—ykdôÔ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¡¦²ºßàíïøüý +34>†‡de{d0139JO] @ B \ ` r z | ’ ª ¼ À  Ø è ê þ Ä!Æ!Ö!É#Ê#ß#í#î#$¥$¦$¨$®$À$Å$Ð$Ø$è$é$êØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêرØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃ#h_eMh¦
—CJaJmHnHsHu)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uFßàíïøü`WWWW $Ifgd¦
—ŸkdÉÕ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöüý`WWWW $Ifgd¦
—Ÿkd¼Ö $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö +3`WW $Ifgd¦
—Ÿkd¡× $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö34>††}q $$Ifa$gd¦
— $Ifgd¦
—ykd†Ø $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö†‡d†}q $$Ifa$gd¦
— $Ifgd¦
—ykdMÙ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöde{Ïdç0†}}}}}}} $Ifgd¦
—ykdÚ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö01239I†xx $Ifgd¦
—gd¦
—ykdÛÚ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöIJO]e@ †}}}} $Ifgd¦
—ykd°Û $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö@ B \ ` r z `WWWW $Ifgd¦
—Ÿkd…Ü $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöz | ’ ª ¼ À `WWWW $Ifgd¦
—ŸkdxÝ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÀ Â Ø è `WW $Ifgd¦
—Ÿkd]Þ $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöè ê þ Ä!†}q $$Ifa$gd¦
— $Ifgd¦
—ykdBß $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÄ!Æ!Ö!É#†}q $$Ifa$gd¦
— $Ifgd¦
—ykd à $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÉ#Ê#ß#í#†}} $Ifgd¦
—ykdÐà $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöí#î#$^$¥$†}}} $Ifgd¦
—ykd—á $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¥$¦$§$¨$®$¿$†xx $Ifgd¦
—gd¦
—ykd^â $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¿$À$Å$Ð$Ø$è$†}}}} $Ifgd¦
—ykd3ã $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöè$é$ö$ø$%%`WWWW $Ifgd¦
—Ÿkdä $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöé$ö$ø$%%%%%%%'%(%3%=%>%H%Ù%Ú%â%3&4&J&‘&’&“&¯&°&¶&à&å&ò&ú&V(X(r(v(ˆ((’(¨(À(Ò(Ö(Ø(î())*)˜)š)ª)----ô-õ-÷-ý--.2.êØêØÃêØêØÃêØÃêØÃêØÃêØõ¥”êÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃê!h¤Vùh¦
—5\mHnHsH uh¤Vùh¦
—5mHnHsH uh¤Vùh¦
—mHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u:%%%%%%'%`WWWW $Ifgd¦
—Ÿkdûä $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö'%(%3%=%`WW $Ifgd¦
—Ÿkdàå $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö=%>%H%Ù%†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÅæ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÙ%Ú%â%3&†}q $$Ifa$gd¦
— $Ifgd¦
—ykdŒç $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö3&4&J&‘&†}} $Ifgd¦
—ykdSè $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‘&’&“&¯&°&¶&ß&†xx $Ifgd¦
—gd¦
—ykdé $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöß&à&å&ò&ú&V(†}}}} $Ifgd¦
—ykdïé $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöV(X(r(v(ˆ((`WWWW $Ifgd¦
—ŸkdÄê $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö(’(¨(À(Ò(Ö(`WWWW $Ifgd¦
—Ÿkd·ë $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÖ(Ø(î()`WW $Ifgd¦
—Ÿkdœì $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö))*)˜)†}q $$Ifa$gd¦
— $Ifgd¦
—ykdí $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö˜)š)ª)-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdHî $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö----Ž-ô-†}}} $Ifgd¦
—ykdï $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöô-õ-ö-÷-ý-,.†xx $Ifgd¦
—gd¦
—ykdÖï $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö,.-.2.>.F.k.†}}}} $Ifgd¦
—ykd«ð $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö2.>.F.k.l.y.{.„.ˆ.‰.”. .©.ª.«.¶.¾.¿.É.2/3/;/°0±0Æ0Ô0Õ0ë0#1q1Ô1Õ1×1Ý122*2:2v2x2’2–2¨2°2²2È2à2ò2ô2ö2 33323ˆ4‰4‘42535H5U5V5X5^5s5x5„5Œ55Ž5›5íØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃØí±íÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØ#h_eMh¦
—CJaJmHnHsHu)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uFk.l.y.{.„.ˆ.`WWWW $Ifgd¦
—Ÿkd€ñ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöˆ.‰.”. .©.ª.`WWWW $Ifgd¦
—Ÿkdsò $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöª.«.¶.¾.`WW $Ifgd¦
—ŸkdXó $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¾.¿.É.2/†}q $$Ifa$gd¦
— $Ifgd¦
—ykd=ô $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö2/3/;/°0†}q $$Ifa$gd¦
— $Ifgd¦
—ykdõ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö°0±0Æ0Ô0†}} $Ifgd¦
—ykdËõ $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÔ0Õ0ë0#131q1±1Ô1†}}}}}} $Ifgd¦
—ykd’ö $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÔ1Õ1Ö1×1Ý12†xx $Ifgd¦
—gd¦
—ykdY÷ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö222*2:2v2†}}}} $Ifgd¦
—ykd.ø $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöv2x2’2–2¨2°2`WWWW $Ifgd¦
—Ÿkdù $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö°2²2È2à2ò2ô2`WWWW $Ifgd¦
—Ÿkdöù $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöô2ö2 33`WW $Ifgd¦
—ŸkdÛú $$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö3323ˆ4†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÀû $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöˆ4‰4‘425†}q $$Ifa$gd¦
— $Ifgd¦
—ykd‡ü $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö2535H5U5†}} $Ifgd¦
—ykdNý $$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöU5V5W5X5^5r5†xx $Ifgd¦
—gd¦
—ykdþ $$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laör5s5x5„5Œ55†}}}} $Ifgd¦
—ykdêþ $$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö5Ž5›55¦5ª5`WWWW $Ifgd¦
—Ÿkd¿ÿ $$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö›55¦5ª5«5¶5Á5Ê5Ë5Ì5×5á5â5ì5š6›6£6õ6ö6 7S7T7V7\7q7v7‚7Š7‹7Œ7™7›7¤7¨7©7´7¿7È7É7Ê7Õ7ß7à7ê7˜8™8¡8ó8ô8
9Q9R9T9Z9f9k9w99°9±9¾9À9É9Í9Î9Ù9å9î9ï9ð9û9:::Ë:Ì:Ô:?íØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØí)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uMª5«5¶5Á5Ê5Ë5`WWWW $Ifgd¦
—Ÿkd²
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöË5Ì5×5á5`WW $Ifgd¦
—Ÿkd—
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöá5â5ì5š6†}q $$Ifa$gd¦
— $Ifgd¦
—ykd|
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöš6›6£6õ6†}q $$Ifa$gd¦
— $Ifgd¦
—ykdC
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöõ6ö6 7S7†}} $Ifgd¦
—ykd

$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöS7T7U7V7\7p7†xx $Ifgd¦
—gd¦
—ykdÑ
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöp7q7v7‚7Š7‹7†}}}} $Ifgd¦
—ykd¦
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‹7Œ7™7›7¤7¨7`WWWW $Ifgd¦
—Ÿkd{
$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¨7©7´7¿7È7É7`WWWW $Ifgd¦
—Ÿkdn
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÉ7Ê7Õ7ß7`WW $Ifgd¦
—ŸkdS
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöß7à7ê7˜8†}q $$Ifa$gd¦
— $Ifgd¦
—ykd8
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö˜8™8¡8ó8†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÿ
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöó8ô8
9Q9†}} $Ifgd¦
—ykdÆ
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöQ9R9S9T9Z9e9†xx $Ifgd¦
—gd¦
—ykd
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöe9f9k9w99°9†}}}} $Ifgd¦
—ykdb
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö°9±9¾9À9É9Í9`WWWW $Ifgd¦
—Ÿkd7

$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÍ9Î9Ù9å9î9ï9`WWWW $Ifgd¦
—Ÿkd*
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöï9ð9û9:`WW $Ifgd¦
—Ÿkd
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö:::Ë:†}q $$Ifa$gd¦
— $Ifgd¦
—ykdô
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöË:Ì:Ô:ªOKOSObP†}}}} $Ifgd¦
—ykdG-
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö>OKOPbPdP~P‚P”PœPžP´PÌPÞPàPâPøPQ Q4QjRkRsRäSåSûSTTT"TBTGTST[TgThTuTwT€T„T…TTœT¥T¦T§T²TÅTÆTÎTGXHXIXJX\X€XX—XÞXýX Y?Y¾YÜYtZuZwZ}Z’Z—Z£Z«Z¬ZíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØí´íÃØíÃØí´í´í´íÃíØÃØíØíh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uGbPdP~P‚P”PœP`WWWW $Ifgd¦
—Ÿkd.
$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöœPžP´PÌPÞPàP`WWWW $Ifgd¦
—Ÿkd/
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöàPâPøPQ`WW $Ifgd¦
—Ÿkdô/
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöQ Q4QjR†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÙ0
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöjRkRsRäS†}q $$Ifa$gd¦
— $Ifgd¦
—ykd 1
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöäSåSûST†}} $Ifgd¦
—ykdg2
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöTTTT"TAT†xx $Ifgd¦
—gd¦
—ykd.3
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöATBTGTST[TgT†}}}} $Ifgd¦
—ykd4
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laögThTuTwT€T„T`WWWW $Ifgd¦
—ŸkdØ4
$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö„T…TTœT¥T¦T`WWWW $Ifgd¦
—ŸkdË5
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¦T§T²TÅT`WW $Ifgd¦
—Ÿkd°6
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÅTÆTÎTHXIX†}qq $$Ifa$gd¦
— $Ifgd¦
—ykd•7
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöIXJX\X€X†}} $Ifgd¦
—ykd\8
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö€XX—XþX@YÝYtZ†}}}}} $Ifgd¦
—ykd#9
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laötZuZvZwZ}Z‘Z†xx $Ifgd¦
—gd¦
—ykdê9
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö‘Z’Z—Z£Z«Z¬Z†}}}} $Ifgd¦
—ykd¿:
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¬Z­ZºZ¼ZÅZÉZ`WWWW $Ifgd¦
—Ÿkd”;
$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¬Z­ZºZ¼ZÅZÉZÊZÕZàZéZêZëZöZ[[ [¹[º[Â[\\+\r\t\u\{\©\®\º\Â\ç\è\õ\÷\]]]]]%]&]']2]:];]E]±]²]º]D^E^W^o^p^†^­_®_¯_°_±_â_êÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÕÃ굪µšh¤Vùh¦
—CJmHnHsH uh¦
—mHnHsH uh¤Vùh¦
—mHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¹[º[Â[\†}q $$Ifa$gd¦
— $Ifgd¦
—ykd?
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö\\+\r\†}} $Ifgd¦
—ykdß?
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laör\s\t\u\{\¨\†xx $Ifgd¦
—gd¦
—ykd¦@
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¨\©\®\º\Â\ç\†}}}} $Ifgd¦
—ykd{A
$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöç\è\õ\÷\]]`WWWW $Ifgd¦
—ŸkdPB
$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö]]]]%]&]`WWWW $Ifgd¦
—ŸkdCC
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö&]']2]:]`WW $Ifgd¦
—Ÿkd(D
$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö:];]E]±]†}q $$Ifa$gd¦
— $Ifgd¦
—ykd
E
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö±]²]º]D^†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÔE
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöD^E^W^o^†}} $Ifgd¦
—ykd›F
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöo^p^†^Å^ë^%_a_n_­_†}}}}}}} $Ifgd¦
—ykdbG
$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö­_®_¯_°_±_â_õ_ö_H`I`\`]`j`†|tk $Ifgd¦
—$a$gd¦
—gd¦
—gd¦
—ykd)H
$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö â_ö_I`[`\`Ž``˜`c5c®cÔc2djdÄdýdAg^g4i8i:iViXi€iŒiìÜÏ¿±¦˜±Ü±ˆ±ˆ±ˆ±Ü±¦±x±gR)h¤Vùh¦
—6CJ]aJmHnHsH u!h¤Vùh¦
—5\mHnHsH uh¤Vùh¦
—CJmHnHsH uh¤Vùh¦
—\mHnHsH uheA’h¦
—mHnHsH uh¦
—mHnHsH uh¤Vùh¦
—mHnHsH uh•oäh¦
—5mHnHsH uh¦
—5mHnHsH uh¤Vùh¦
—5mHnHsH u&h¤Vùh¦
—5CJaJmHnHsH uj`w`y`}`‰``ööööö $Ifgd¦
—`Ž`œ`²`´`¸`8//// $Ifgd¦
—ÆkdþH
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö¸`Ä`È`É`Õ`ì`öö/ööÆkdÚI
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ì`î`ó`ÿ`aaöööö/Ækd¶J
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—aa,a.a2a>aBaöööööö $Ifgd¦
—BaCaPagaiama8//// $Ifgd¦
—Ækd’K
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laömaya}a~a‰aŸaöö/ööÆkdnL
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—Ÿa¡a¥a±aµa¶aöööö/ÆkdJM
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—¶aÃaÒaÔaØaäaèaîååååå $Ifgd¦
—„”ÿ„l$If^„”ÿ`„lgd¦
—èaéaöabbb8//// $Ifgd¦
—Ækd&N
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöb b&b'b3bPböö/ööÆkdO
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—PbRbVbbbhbiböööö/ÆkdÞO
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ibvbžb b¤b°b´böööööö $Ifgd¦
—´bµbÂbÏbÑbÕb8//// $Ifgd¦
—ÆkdºP
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laöÕbábåbæbóbcöö/ööÆkd–Q
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—ccccccöööö/ÆkdrR
$$If–FÖֈ”ÿ2N¥Ú#tW5
tàÖ0ÿÿÿÿÿÿö6ööÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿÖÿÿÿÿÿÿ4Ö4Ö
laö $Ifgd¦
—cc5cÐ,?Ð,UÐ,ÂÐ,Ñ,}Ñ,íÑ,îÑ,†}}}}}} $Ifgd¦
—ykdÈk$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöîÑ,ïÑ,ðÑ,ñÑ,÷Ñ,Ò,†xx $Ifgd¦
—gd¦
—ykdl$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÒ,Ò,!Ò,-Ò,5Ò,PÒ,†}}}} $Ifgd¦
—ykddm$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöPÒ,QÒ,^Ò,`Ò,iÒ,mÒ,`WWWW $Ifgd¦
—Ÿkd9n$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö`Ò,iÒ,mÒ,nÒ,yÒ,…Ò,ŽÒ,Ò,‘Ò,œÒ,¤Ò,¥Ò,­Ò,ÙÔ,ÚÔ,ïÔ,úÔ,ûÔ,Õ,°Õ,±Õ,²Õ,³Õ,µÕ,»Õ,ÕÕ,ÚÕ,æÕ,Ö,xÖ,zÖ,”Ö,˜Ö,ªÖ,²Ö,´Ö,ÊÖ,âÖ,ôÖ,øÖ,úÖ,×,6×,8×,H×,[Û,\Û,nÛ,zÛ,{Û,‘Û,,Ý,-Ý,/Ý,5Ý,XÝ,]Ý,hÝ,pÝ,}Ý,~Ý,‹Ý,Ý,–Ý,šÝ,›Ý,¦Ý,²Ý,»Ý,½Ý,¾Ý,ÉÝ,êØÃêØêØÃêØÃêØÃêØÃêØ´ØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêh¦
—CJaJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uGmÒ,nÒ,yÒ,…Ò,ŽÒ,Ò,`WWWW $Ifgd¦
—Ÿkd,o$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÒ,‘Ò,œÒ,¤Ò,`WW $Ifgd¦
—Ÿkdp$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¤Ò,¥Ò,­Ò,ÙÔ,†}q $$Ifa$gd¦
— $Ifgd¦
—ykdöp$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÙÔ,ÚÔ,ïÔ,úÔ,†}} $Ifgd¦
—ykd½q$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöúÔ,ûÔ,Õ,gÕ,±Õ,²Õ,†}}}} $Ifgd¦
—ykd„r$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö²Õ,³Õ,´Õ,µÕ,»Õ,ÔÕ,†xx $Ifgd¦
—gd¦
—ykdKs$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÔÕ,ÕÕ,ÚÕ,æÕ,îÕ,xÖ,†}}}} $Ifgd¦
—ykd t$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöxÖ,zÖ,”Ö,˜Ö,ªÖ,²Ö,`WWWW $Ifgd¦
—Ÿkdõt$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö²Ö,´Ö,ÊÖ,âÖ,ôÖ,øÖ,`WWWW $Ifgd¦
—Ÿkdèu$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöøÖ,úÖ,×,6×,`WW $Ifgd¦
—ŸkdÍv$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö6×,8×,H×,œ×,ÐÙ,[Û,†}qqq $$Ifa$gd¦
— $Ifgd¦
—ykd²w$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö[Û,\Û,nÛ,zÛ,†}} $Ifgd¦
—ykdyx$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laözÛ,{Û,‘Û,ëÛ,aÜ,ÛÜ,,Ý,†}}}}} $Ifgd¦
—ykd@y$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö,Ý,-Ý,.Ý,/Ý,5Ý,WÝ,†xx $Ifgd¦
—gd¦
—ykdz$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöWÝ,XÝ,]Ý,hÝ,pÝ,}Ý,†}}}} $Ifgd¦
—ykdÜz$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö}Ý,~Ý,‹Ý,Ý,–Ý,šÝ,`WWWW $Ifgd¦
—Ÿkd±{$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöšÝ,›Ý,¦Ý,²Ý,»Ý,½Ý,`WWWW $Ifgd¦
—Ÿkd¤|$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö½Ý,¾Ý,ÉÝ,ÑÝ,`WW $Ifgd¦
—Ÿkd‰}$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÉÝ,ÑÝ,ÒÝ,ÚÝ,lß,mß,‚ß,Žß,ß,¥ß, à, à,à,à,3à,8à,Dà,Là,Mà,Nà,[à,]à,fà,jà,kà,và,à,Šà,Œà,à,˜à,¢à,£à,­à,äá,åá,íá,:å,-?-J-V-_-a-b-m-€--‰-Ü-Ý-ò-ÿ---+-,-.-4-B-G-R-Z-h-i-v-êØÃêØêØêØêØêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃê)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uMèú,éú,ÿú,Uû,¬û,8ü,òü,†}}}}} $Ifgd¦
—ykd¹ª$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöòü,ôü,öü,øü,ý,Šý,†xx $Ifgd¦
—gd¦
—ykd€«$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŠý,Œý,–ý,®ý,¾ý,Øý,†}}}} $Ifgd¦
—ykdU¬$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöØý,Úý,ôý,øý,þ, þ,`WWWW $Ifgd¦
—Ÿkd*­$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö þ,
þ,þ,!þ,*þ,,þ,`WWWW $Ifgd¦
—Ÿkd®$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö,þ,-þ,8þ,@þ,`WW $Ifgd¦
—Ÿkd¯$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö@þ,Aþ,Iþ,Èÿ,†}q $$Ifa$gd¦
— $Ifgd¦
—ykdç¯$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÈÿ,Éÿ,Êÿ,Ëÿ,Ñÿ,êÿ,†xx $Ifgd¦
—gd¦
—ykd®°$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöêÿ,ëÿ,ðÿ,ýÿ,-!-†}}}} $Ifgd¦
—ykdƒ±$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö!-"-/-1-:->-`WWWW $Ifgd¦
—ŸkdX²$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö>-?-J-V-_-a-`WWWW $Ifgd¦
—ŸkdK³$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöa-b-m-€-`WW $Ifgd¦
—Ÿkd0´$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö€--‰-Ü-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdµ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÜ-Ý-ò-ÿ-†}} $Ifgd¦
—ykdܵ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÿ---+-†}} $Ifgd¦
—ykd£¶$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö+-,---.-4-A-†xx $Ifgd¦
—gd¦
—ykdj·$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöA-B-G-R-Z-h-†}}}} $Ifgd¦
—ykd?¸$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöh-i-v-x--…-`WWWW $Ifgd¦
—Ÿkd¹$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöv-x--…-†-‘--¦-¨-©-´-Ç-È-Ð-û-ü- -u -v -x -~ -® -³ -¾ -
-
-
-8
-<
-N
-V
-X
-n
-†
-˜
-œ
-ž
-´
-Ú
-Ü
-ð
-¼ -¾ -Î -}-~-“-Ÿ- -¶---- -:-?-L-T-p-q-~-€-‰--Ž-™-¥-®-°-±-¼-Ï-Ð-Ø-+-,-A-N-íØíÃØíØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØíÃØíÃØíÃíØÃØíØíÃØíØíÃØíØíÃØíÃØíÃØí)h¤Vùh¦
—5CJ\aJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH uM…-†-‘--¦-¨-`WWWW $Ifgd¦
—Ÿkdº$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¨-©-´-Ç-`WW $Ifgd¦
—Ÿkdìº$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÇ-È-Ð--û-†}qq $$Ifa$gd¦
— $Ifgd¦
—ykdÑ»$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöû-ü- -$ -u -†}}} $Ifgd¦
—ykd˜¼$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöu -v -w -x -~ -­ -†xx $Ifgd¦
—gd¦
—ykd_½$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö­ -® -³ -¾ -Æ -
-†}}}} $Ifgd¦
—ykd4¾$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
-
-8
-<
-N
-V
-`WWWW $Ifgd¦
—Ÿkd ¿$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöV
-X
-n
-†
-˜
-œ
-`WWWW $Ifgd¦
—Ÿkdü¿$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöœ
-ž
-´
-Ú
-`WW $Ifgd¦
—ŸkdáÀ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÚ
-Ü
-ð
-¼ -†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÆÁ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¼ -¾ -Î -}-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÂ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö}-~-“-Ÿ-†}} $Ifgd¦
—ykdTÃ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöŸ- -¶--†}} $Ifgd¦
—ykdÄ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö---- -9-†xx $Ifgd¦
—gd¦
—ykdâÄ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö9-:-?-L-T-p-†}}}} $Ifgd¦
—ykd·Å$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöp-q-~-€-‰--`WWWW $Ifgd¦
—ŸkdŒÆ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö-Ž-™-¥-®-°-`WWWW $Ifgd¦
—ŸkdÇ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö°-±-¼-Ï-`WW $Ifgd¦
—ŸkddÈ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÏ-Ð-Ø-+-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdIÉ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö+-,-A-N-†}} $Ifgd¦
—ykdÊ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöN-O-m-z-†}} $Ifgd¦
—ykd×Ê$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöN-O-m-z-{-}-ƒ-§-¬-¹--- -:->-P-X-Z-p-ˆ-š-ž- -¶-Æ-È-Ü---&---2-Æ-È-É-Ï-ø-ý- --'-(-5-7-@-D-E-P-\-e-g-h-s-†-‡-‘- -
--Î-Ï-á-ï-ð--- -6---
--%-*-7-?-a-êÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃ#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uMz-{-|-}-ƒ-¦-†xx $Ifgd¦
—gd¦
—ykdžË$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¦-§-¬-¹-Á--†}}}} $Ifgd¦
—ykdsÌ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö- -:->-P-X-`WWWW $Ifgd¦
—ŸkdHÍ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöX-Z-p-ˆ-š-ž-`WWWW $Ifgd¦
—Ÿkd;Î$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöž- -¶-Æ-`WW $Ifgd¦
—Ÿkd Ï$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÆ-È-Ü--†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÐ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö--&--†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÌÐ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö--2-x-Æ-†}}} $Ifgd¦
—ykd“Ñ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÆ-Ç-È-É-Ï-÷-†xx $Ifgd¦
—gd¦
—ykdZÒ$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö÷-ø-ý- --'-†}}}} $Ifgd¦
—ykd/Ó$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'-(-5-7-@-D-`WWWW $Ifgd¦
—ŸkdÔ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöD-E-P-\-e-g-`WWWW $Ifgd¦
—Ÿkd÷Ô$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laög-h-s-†-`WW $Ifgd¦
—ŸkdÜÕ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö†-‡-‘- -†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÁÖ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö -
--Î-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdˆ×$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÎ-Ï-á-ï-†}} $Ifgd¦
—ykdOØ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöï-ð---†}} $Ifgd¦
—ykdÙ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö- -6-v-º--†}}}} $Ifgd¦
—ykdÝÙ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö-- -
--$-†xx $Ifgd¦
—gd¦
—ykd¤Ú$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö$-%-*-7-?-a-†}}}} $Ifgd¦
—ykdyÛ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöa-b-o-q-z-~-`WWWW $Ifgd¦
—ŸkdNÜ$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöa-b-o-q-z-~--Š-–-Ÿ-¡-¢-­-À-Á-Ë-(-)-1-¹ -º -Ï -Ý -Þ -ô -t"-v"-z"-†"-¶"-À"-Ú"-ê"- #-#-(#-,#->#-F#-H#-^#-v#-ˆ#-Œ#-Ž#-¤#-Ê#-Ì#-Ü#-Á%-Â%-×%-
&- &-&-&-p&-z&-”&-¤&-'-'-"'-&'-8'-@'-B'-X'-p'-‚'-†'-ˆ'-ž'-Ä'-Æ'-Ú'-$(-%(-êÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃêÕÃêÃÕêÕÃÕÃêÕÃÕÃêÕÃÕÃêÕÃêÕÃê#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH u)h¤Vùh¦
—5CJ\aJmHnHsH uM~--Š-–-Ÿ-¡-`WWWW $Ifgd¦
—ŸkdAÝ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö¡-¢-­-À-`WW $Ifgd¦
—Ÿkd&Þ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÀ-Á-Ë-(-†}q $$Ifa$gd¦
— $Ifgd¦
—ykd ß$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö(-)-1-¹ -†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÒß$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¹ -º -Ï -Ý -†}} $Ifgd¦
—ykd™à$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÝ -Þ -ô -G!-†!-t"-†}}}} $Ifgd¦
—ykd`á$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöt"-v"-x"-z"-†"-´"-†xx $Ifgd¦
—gd¦
—ykd'â$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö´"-¶"-À"-Ú"-ê"- #-†}}}} $Ifgd¦
—ykdüâ$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö #-#-(#-,#->#-F#-`WWWW $Ifgd¦
—ŸkdÑã$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöF#-H#-^#-v#-ˆ#-Œ#-`WWWW $Ifgd¦
—ŸkdÄä$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöŒ#-Ž#-¤#-Ê#-`WW $Ifgd¦
—Ÿkd©å$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÊ#-Ì#-Ü#-Á%-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdŽæ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÁ%-Â%-×%-
&-†}} $Ifgd¦
—ykdUç$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö
&- &-&-&-&-n&-†xx $Ifgd¦
—gd¦
—ykdè$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laön&-p&-z&-”&-¤&-'-†}}}} $Ifgd¦
—ykdñè$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö'-'-"'-&'-8'-@'-`WWWW $Ifgd¦
—ŸkdÆé$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö@'-B'-X'-p'-‚'-†'-`WWWW $Ifgd¦
—Ÿkd¹ê$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö†'-ˆ'-ž'-Ä'-`WW $Ifgd¦
—Ÿkdžë$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÄ'-Æ'-Ú'-$(-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdƒì$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö$(-%(--(-n+-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdJí$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö%(--(-n+-o+-…+-L,-M,-O,-U,-f,-k,-x,-€,-”,-•,-¢,-¤,-­,-±,-²,-½,-É,-Ò,-Ô,-Õ,-à,-ó,-ô,-þ,-]--^--f--Â.-Ã.-Õ.-ñ.-ò.-/-p/-q/-s/-y/-½/-Â/-Î/-0-0-0-60-:0-L0-T0-V0-l0-„0-–0-š0-œ0-²0-Â0-Ä0-Ô0-é2-ê2-ì2-ò2-3-"3-/3-4-b4-d4-~4-‚4-”4-œ4-ž4-´4-êØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃêØÃêØÃêØÃØêÃêØêØÃêØêØÃêØêØÃêØÃêØÃØêÃêØêØÃêØêØÃê)h¤Vùh¦
—5CJ\aJmHnHsH u#h¤Vùh¦
—CJaJmHnHsH u)h¤Vùh¦
—6CJ]aJmHnHsH uMn+-o+-…+-æ+-L,-†}}} $Ifgd¦
—ykdî$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöL,-M,-N,-O,-U,-e,-†xx $Ifgd¦
—gd¦
—ykdØî$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöe,-f,-k,-x,-€,-”,-†}}}} $Ifgd¦
—ykd­ï$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö”,-•,-¢,-¤,-­,-±,-`WWWW $Ifgd¦
—Ÿkd‚ð$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö±,-²,-½,-É,-Ò,-Ô,-`WWWW $Ifgd¦
—Ÿkduñ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÔ,-Õ,-à,-ó,-`WW $Ifgd¦
—ŸkdZò$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöó,-ô,-þ,-]--†}q $$Ifa$gd¦
— $Ifgd¦
—ykd?ó$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö]--^--f--Â.-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdô$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöÂ.-Ã.-Õ.-ñ.-†}} $Ifgd¦
—ykdÍô$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöñ.-ò.-/-p/-†}} $Ifgd¦
—ykd”õ$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöp/-q/-r/-s/-y/-¼/-†xx $Ifgd¦
—gd¦
—ykd[ö$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö¼/-½/-Â/-Î/-Ö/-0-†}}}} $Ifgd¦
—ykd0÷$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö0-0-60-:0-L0-T0-`WWWW $Ifgd¦
—Ÿkdø$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöT0-V0-l0-„0-–0-š0-`WWWW $Ifgd¦
—Ÿkdøø$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöš0-œ0-²0-Â0-`WW $Ifgd¦
—ŸkdÝù$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöÂ0-Ä0-Ô0-é2-†}q $$Ifa$gd¦
— $Ifgd¦
—ykdÂú$$If–FÖ    Ö0”ÿÇÚ#j  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöé2-ê2-ë2-ì2-ò2-3-†xx $Ifgd¦
—gd¦
—ykd‰û$$If–FÖ    Ö0”ÿÇÚ#j    
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laö3-3-"3-/3-73-b4-†}}}} $Ifgd¦
—ykd^ü$$If–FÖ    Ö0”ÿÇÚ#j      
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÖÿÿÖÿÿÖÿÿ4Ö4Ö
laöb4-d4-~4-‚4-”4-œ4-`WWWW $Ifgd¦
—Ÿkd3ý$$If–FÖ    Ö\”ÿÇôçÚ#j  ñ ª ƒ  
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laöœ4-ž4-´4-Ì4-Þ4-â4-`WWWW $Ifgd¦
—Ÿkd&þ$$If–FÖ    Ö\”ÿÇôçÚ#j ñªƒ 
tàÖ0ÿ ÿ ÿ ÿ ÿÿöˆööÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿÖÿÿÿÿ4Ö4Ö
laö´4-Ì4-Þ4-â4-ä4-ú4- 5-"5-65-k6-l6-t6-å7-æ7-ü7-8-8-8-#8-L8-Q8-_8-g8-{8-|8-‰8-‹8-”8-˜8-™8-¤8-°8-¹8-»8-¼8-Ç8-Ú8-Û8-ã8-M:-N:-c:-q:-r:-ˆ:-^;-_;-`;-a;-c;-i;-;-’;-Ÿ;-§;-¨;-©;-¶;-¸;-Á;-Å;-Æ;-Ñ;-Ü;-å;-ç;-è;-ó;-ý;-þ;-
 :