2 feb 2014Thesis Martens-de Kemp.indd - VU Research Portal
To uncover therapeutic targets for. CCNE1-amplified tumors, we undertook genome-scale CRISPR/Cas9-based synthetic lethality screens in cellular ...
Head and Neck Cancer Functional Kinomics Identifies Candidate ...synthetic lethal screen technology is the use of ... Bazewicz, C. G., Dinavahi, S. S., Schell, T. D., & Robertson, G. P. (2019). ... HNSCC cells. ALDH3A1 ... FANCD2 promotes mitotic rescue from transcription-mediated ... - HALMoreover, other studies have shown synthetic lethal targeting to sensitize HNSCC cells to DDAs with other inhibitors [137,140,141]. Because of ... Elimination of head and neck cancer initiating cells through targeting ...Objective: The prognosis of head and neck squamous cell carcinoma (HNSCC) remains disappointing and the development of novel anti-cancer agents is urgently ...
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