An integrated methylation and gene expression microarray analysis ...
Drugs that, when administered in combination with cisplatin, provoke a synthetic lethality effect on tumor cells (such as the co-inhibition of NRF2 to cause ...
2 feb 2014Thesis Martens-de Kemp.indd - VU Research PortalTo uncover therapeutic targets for. CCNE1-amplified tumors, we undertook genome-scale CRISPR/Cas9-based synthetic lethality screens in cellular ... Head and Neck Cancer Functional Kinomics Identifies Candidate ...synthetic lethal screen technology is the use of ... Bazewicz, C. G., Dinavahi, S. S., Schell, T. D., & Robertson, G. P. (2019). ... HNSCC cells. ALDH3A1 ... FANCD2 promotes mitotic rescue from transcription-mediated ... - HALMoreover, other studies have shown synthetic lethal targeting to sensitize HNSCC cells to DDAs with other inhibitors [137,140,141]. Because of ...
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