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STAT3?????????? - ???? ??????????????3 (STAT3) ??????????????????????????. ???????????????STAT3 ??????  WORLD CHINESE JOURNAL OF DIGESTOLOGY Shijie Huaren ... ??DNA???DNA?????G2 DNA?????. ?? ???????????????????????. ???????????????[67]. ??CRISPR/Cas9 ?????ssODN ????tau-V337M ???? ?????Rad51 ??????????. ?????ssODN ?????DNA ????. ?????????????DNA ?????. ?????Rad51 ???RS-1 ???????. ???DNA??????????????? ??????????????????DNA?mtDNA?????DNA?nDNA?????????????????. ??????????????mtDNA???????????????  2021 ?2??13??2???78?Volume 13 Number 2 ... - ???? ???DNA double?strand breaks?DSBs??????. ??????????????????homology? directed repair?HDR??????????non?ho?. ???????? ?????????????? HRR ?DNA ????????NHEJ?????. ??DSB ????[48?49]??????????????????????NHEJ. ?????????????DSB ????HRR  Sirtuins??????DNA????????? - SciEngine SIRT6??????. ??????????????DNA??????. ?. DNA????????????????. Kaidi. ??[52]????, SIRT6????RPA???DNA?. ??????????? - ???? ??????????????. ????????????????????. ???????????????????. ??????????????????  ????????? - ????? ??. ???????????????????????????????????262. ???????? ?????????????????????????. ???. ?????  ???????? ?????????????????????????????????. ???????????????????????????????????. ???  ??????????(??) ???????????????????????????????????????????. ????????????????????????????  PREFACE ?? ????????????????????????????????????. ???????????????????????????????????  ????????????????? ????????????????????????????????????. ??????????????????????????????????????. ????  2022 annual report On April 6, 2023, Mr. XU Nuojin, an executive Director and the chairman of the Board, tendered his resignation to the Board and resigned as  ?? ??. Anyang Guangming Mansion. ?????. Underground. ??. 98,709. Hebi. ??. Hebi No.7 Courtyard. ?????. Residential. ??. 30,711. Untitled ??. 3,127. 4,441. ?30%. 602. 660. ?9%. Hebi. ??. 1,953. 1,503. 30%. 357. 234. 53%. Xinxiang. ??. 2,201. 3,670. ?40%. 369. 567. ?35%. Jiaozuo. ??. 2,042.