Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-?

Abstract: ?-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum.







biomolecules - CONICET
?-Lactamases enable resistance to almost all ?-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as 'transition state ...
Structural basis of metallo-?-lactamase, serine-?-lactamase and ...
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