Structural basis of ferroportin inhibition by minihepcidin PR73
Synthetic hepcidin triggered hypoferremia in control but not iron-loaded wt animals. 29. Furthermore, it dramatically decreased hepatic and ...
Molecular model of the ferroportin intracellular gate and implications ...Our data uncovered a crosstalk between hepcidin and the IRE/IRP system that controls ferroportin expression in the liver and spleen, and thereby ... A crosstalk between hepcidin and IRE/IRP pathways controls ...hepcidin/ferroportin plays a key role in the uptake of iron in enterocytes by an interaction between basal and apical localised ferroportin. In contrast in ... A crosstalk between hepcidin and IRE/IRP pathways controls ... - eLifeGenetic defects in the hepcidin pathway promote increased iron absorption and lead to the development of systemic iron overload (hemochromatosis) ...
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