???????

2 ??. ??. ??????. ????. ?????????????????????. ??????????????????????. ???????????????? ...

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?????????????????????????

?????????????????????????????????????. ???????????????????????NPC1L1???????????. ?????? ...

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?????????????????????????

?????????????????????????????????????. ???????????????????????NPC1L1???????????. ?????? ...

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1 3 ?? - ?????

BDNF ????????? ???????????????????????? ??????????????????????13??

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????????????????????????? NS ???? ...

????????????????????????? ??. ?????????????????????????????????? ?. ????????????? ...

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2010 ? 11 ? 30 ? ????????????????????? ...

???????????????????????????????. LDL ??????????????????????????????? 61??????????. ??? ...

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????????????????

????????????????????????????????1)??????????. ??????Chronic Kidney Disease?CKD????????????????? ...

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1 ??3 ????????????????????????? ...

LDL???????1 mmol/L?39 mg/dL??????????2010??????????. ???vs.?????????????vs.??????? ...

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???????????2020 ??? - ?????

????????????????????. ?????????? Fouta Djallon ???. ????????????????????. ?????????????

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G.????

?????????????????Smit et al, 1991???????????????????. ?????????Singer et al, 1990??????????????? ...

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?????????????????? - ??????

?????????????????????????. ??????? 13 ... ??????????? 6?12 ???. ??????????????? CT ??? ...

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???????????????????2018 ?????

... ??????? i. ???????????????????????. 3)??????????????????,????????????,????????????.

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?????????????????

??????????????????????????. LDL??????????????100??101?? HDL?????????????????????. ??? ...

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JP 2020?535142 A 2020.12.3 10 (57)???? ??????? ...

... LDL???????. 38.7 mg/dL?????????????21???????. ????114)?????????????ESTABLISH?. ?115) ?JAPAN-ACS??116)???? ...

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???????????????

????????????????????????????????? Co-A?HMG-CoA??????. ????????????????????????? ...

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????????????????? - ??????

???????????????????????????. ????????????????????1993 ????????????????????. ???????????? ...

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??????????????????????? ??????? ...

????????????????????????. ????????????????????????????????????????????. ?????? 165??

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J-ISCP??

??????.????????? JAERI?M???????.?????? L???. ???????.??.????'???????.??? F?????????(???.

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????????? (Lactobacillus brevis 119-2) ? ??????? ...

... ???????????????????. ????????????? ... TD???????. ???????. MTP??????. ??(30Gy,??)?. ?????(30Gy ...

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?????????????????? FDG-PET?????

??????????????????????. ???????????????????????. ?????? LDL ??????????????. ???????? ...

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?????????????????? FDG-PET?????

??????????????????????. ???????????????????????. ?????? LDL ??????????????. ???????? ...

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HDL ?????????? ABCA1?? ??????????

?2006?Chromosome Science,. 9,65?73. ?? ??1?2??? ??2?. ?? ??1??? ??1. ?1 ?????????????. ??????????? ...

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JP 2017?505285 A 2017.2.16 (57)???? MTP???

???????????????????????? ... TD. 5 ???????????. ????????? ... LDL??????? HDL??????. ???? ...

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