Mechanisms of DNA damage, repair and mutagenesis - CORE
These DNA lesions/adducts arise from a vari- ety of endogenous and exogenous sources, including chemical mutagens, UV radiation, reactive oxygen ...
1 DNA damage response defects induced by the formation of TDP ...Endogenous metabolites and exogenous agents such as UV light induce a variety of chemical alterations in the primary structure of DNA. These ... Compartmentalization of the DNA damage response - IghSources and Consequences of DNA Damage. DNA damage can be induced by exogenous physical agents, by endogenous chemical genotoxic agents that ... Targeting DNA Damage and Repair (DDR) PathwaysDNA in any cell type is susceptible to oxidative damage due to endogenous (e.g., aerobic respiration) and exogenous (i.e., exposure to oxidants) oxidative ...
Autres Cours:
