Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
Lysosomal degradation of ubiquitinated TM-proteins typically involves their transport to endosomes, followed by the formation of so-called multi ...
Site-specific ubiquitination affects protein energetics ... - eScholarshipFirst, the ubiquitin-activating enzyme, or E1, forms a high energy thiol ester bond with ubiquitin in an ATP-dependent reaction. The next step is transfer of ... Role of Ubiquitin and SUMO in Intracellular TraffickingRegulation of ubiquitin-binding domains?? By contrast, the UBA domain in the full-length P47 protein binds to ubiquitin more effectively when p47 is associated ... UBIQUITIN BINDING DOMAINS(a) Ubiquitin can modify the activity of the protein transport ... and this effect can be reversed by ubiquitin overexpression (e.g., Losko et al.
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